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Protein

Tyrosine-protein phosphatase non-receptor type 5

Gene

PTPN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.1 Publication

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.Curated

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei461SubstrateBy similarity1
Active sitei496Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei540SubstrateBy similarity1

GO - Molecular functioni

  • phosphotyrosine residue binding Source: UniProtKB
  • protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-9008059 Interleukin-37 signaling
SIGNORiP54829

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 5 (EC:3.1.3.48)
Alternative name(s):
Neural-specific protein-tyrosine phosphatase
Striatum-enriched protein-tyrosine phosphatase
Short name:
STEP
Gene namesi
Name:PTPN5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110786.17
HGNCiHGNC:9657 PTPN5
MIMi176879 gene
neXtProtiNX_P54829

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84867
OpenTargetsiENSG00000110786
PharmGKBiPA34001

Chemistry databases

ChEMBLiCHEMBL2007628

Polymorphism and mutation databases

BioMutaiPTPN5
DMDMi317373540

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003636571 – 565Tyrosine-protein phosphatase non-receptor type 5Add BLAST565

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei245Phosphoserine; by PKA1 Publication1
Modified residuei255Phosphothreonine; by MAPK1 Publication1
Modified residuei268Phosphoserine; by MAPK1 Publication1

Post-translational modificationi

Phosphorylation at Ser-245 by PKA deactivates PTPN5. Phosphorylation at Thr-255 and Ser-268 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP54829
PeptideAtlasiP54829
PRIDEiP54829
ProteomicsDBi56735
56736 [P54829-2]

PTM databases

DEPODiP54829
iPTMnetiP54829
PhosphoSitePlusiP54829

Expressioni

Gene expression databases

BgeeiENSG00000110786 Expressed in 119 organ(s), highest expression level in putamen
CleanExiHS_PTPN5
ExpressionAtlasiP54829 baseline and differential
GenevisibleiP54829 HS

Organism-specific databases

HPAiHPA031014
HPA072091

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124312, 46 interactors
ELMiP54829
IntActiP54829, 32 interactors
STRINGi9606.ENSP00000351342

Chemistry databases

BindingDBiP54829

Structurei

Secondary structure

1565
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP54829
SMRiP54829
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54829

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini300 – 555Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST256

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni496 – 502Substrate binding7

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00920000148980
HOGENOMiHOG000294188
HOVERGENiHBG001594
InParanoidiP54829
KOiK18018
OMAiTLVWHLL
OrthoDBiEOG091G0HLB
PhylomeDBiP54829
TreeFamiTF331016

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR008356 Tyr_Pase_KIM-con
IPR016334 Tyr_Pase_rcpt_R/non-rcpt_5
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF001997 PTPRR, 1 hit
PRINTSiPR01778 KIMPTPASE
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P54829-1) [UniParc]FASTAAdd to basket
Also known as: STEP61

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNYEGARSER ENHAADDSEG GALDMCCSER LPGLPQPIVM EALDEAEGLQ
60 70 80 90 100
DSQREMPPPP PPSPPSDPAQ KPPPRGAGSH SLTVRSSLCL FAASQFLLAC
110 120 130 140 150
GVLWFSGYGH IWSQNATNLV SSLLTLLKQL EPTAWLDSGT WGVPSLLLVF
160 170 180 190 200
LSVGLVLVTT LVWHLLRTPP EPPTPLPPED RRQSVSRQPS FTYSEWMEEK
210 220 230 240 250
IEDDFLDLDP VPETPVFDCV MDIKPEADPT SLTVKSMGLQ ERRGSNVSLT
260 270 280 290 300
LDMCTPGCNE EGFGYLMSPR EESAREYLLS ASRVLQAEEL HEKALDPFLL
310 320 330 340 350
QAEFFEIPMN FVDPKEYDIP GLVRKNRYKT ILPNPHSRVC LTSPDPDDPL
360 370 380 390 400
SSYINANYIR GYGGEEKVYI ATQGPIVSTV ADFWRMVWQE HTPIIVMITN
410 420 430 440 450
IEEMNEKCTE YWPEEQVAYD GVEITVQKVI HTEDYRLRLI SLKSGTEERG
460 470 480 490 500
LKHYWFTSWP DQKTPDRAPP LLHLVREVEE AAQQEGPHCA PIIVHCSAGI
510 520 530 540 550
GRTGCFIATS ICCQQLRQEG VVDILKTTCQ LRQDRGGMIQ TCEQYQFVHH
560
VMSLYEKQLS HQSPE
Length:565
Mass (Da):63,538
Last modified:January 11, 2011 - v4
Checksum:iDE32BEFFEFF7C494
GO
Isoform 2 (identifier: P54829-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-129: Missing.

Note: No experimental confirmation available.
Show »
Length:533
Mass (Da):60,035
Checksum:iA27BA66C3292C132
GO
Isoform 3 (identifier: P54829-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Note: No experimental confirmation available.
Show »
Length:541
Mass (Da):60,961
Checksum:iFE808E1908C2AB58
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MXF1A8MXF1_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN5
171Annotation score:
E9PLZ4E9PLZ4_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN5
369Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32 – 34PGL → LGR in AAA87555 (PubMed:7490079).Curated3
Sequence conflicti104W → R in BAC03548 (PubMed:14702039).Curated1
Sequence conflicti107G → A in CAD38632 (PubMed:17974005).Curated1
Sequence conflicti110H → D in CAD38632 (PubMed:17974005).Curated1
Sequence conflicti111I → M in AAA87555 (PubMed:7490079).Curated1
Sequence conflicti134A → S in AAA87555 (PubMed:7490079).Curated1
Sequence conflicti145S → G in AAA87555 (PubMed:7490079).Curated1
Sequence conflicti162V → L in CAD38632 (PubMed:17974005).Curated1
Sequence conflicti313D → V in AAA87555 (PubMed:7490079).Curated1
Sequence conflicti322 – 323LV → RC in AAA87555 (PubMed:7490079).Curated2
Sequence conflicti541T → H in AAA87555 (PubMed:7490079).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054369170P → A2 PublicationsCorresponds to variant dbSNP:rs4757707Ensembl.1
Natural variantiVAR_054370561H → R. Corresponds to variant dbSNP:rs11024773Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0545611 – 24Missing in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_04265498 – 129Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090923 mRNA Translation: BAC03548.1
AK127312 mRNA Translation: BAG54479.1
AK295604 mRNA Translation: BAH12122.1
AK316270 mRNA Translation: BAH14641.1
AL832541 mRNA Translation: CAD38632.2
AC103974 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68363.1
CH471064 Genomic DNA Translation: EAW68365.1
CH471064 Genomic DNA Translation: EAW68367.1
BC064807 mRNA Translation: AAH64807.1
U27831 mRNA Translation: AAA87555.1
CCDSiCCDS41626.1 [P54829-2]
CCDS60746.1 [P54829-3]
CCDS7845.1 [P54829-1]
RefSeqiNP_001035059.1, NM_001039970.1 [P54829-2]
NP_001265165.1, NM_001278236.1 [P54829-2]
NP_001265167.1, NM_001278238.1 [P54829-3]
NP_001265168.1, NM_001278239.1
NP_008837.1, NM_006906.1 [P54829-1]
NP_116170.3, NM_032781.3 [P54829-1]
UniGeneiHs.79092

Genome annotation databases

EnsembliENST00000358540; ENSP00000351342; ENSG00000110786 [P54829-1]
ENST00000396168; ENSP00000379471; ENSG00000110786 [P54829-3]
ENST00000396170; ENSP00000379473; ENSG00000110786 [P54829-2]
GeneIDi84867
KEGGihsa:84867
UCSCiuc001mpd.5 human [P54829-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090923 mRNA Translation: BAC03548.1
AK127312 mRNA Translation: BAG54479.1
AK295604 mRNA Translation: BAH12122.1
AK316270 mRNA Translation: BAH14641.1
AL832541 mRNA Translation: CAD38632.2
AC103974 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68363.1
CH471064 Genomic DNA Translation: EAW68365.1
CH471064 Genomic DNA Translation: EAW68367.1
BC064807 mRNA Translation: AAH64807.1
U27831 mRNA Translation: AAA87555.1
CCDSiCCDS41626.1 [P54829-2]
CCDS60746.1 [P54829-3]
CCDS7845.1 [P54829-1]
RefSeqiNP_001035059.1, NM_001039970.1 [P54829-2]
NP_001265165.1, NM_001278236.1 [P54829-2]
NP_001265167.1, NM_001278238.1 [P54829-3]
NP_001265168.1, NM_001278239.1
NP_008837.1, NM_006906.1 [P54829-1]
NP_116170.3, NM_032781.3 [P54829-1]
UniGeneiHs.79092

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BIJX-ray2.05A282-563[»]
2BV5X-ray1.80A280-561[»]
2CJZX-ray1.70A282-563[»]
5OVRX-ray2.15A282-561[»]
5OVXX-ray2.10A282-563[»]
5OW1X-ray2.05A282-563[»]
ProteinModelPortaliP54829
SMRiP54829
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124312, 46 interactors
ELMiP54829
IntActiP54829, 32 interactors
STRINGi9606.ENSP00000351342

Chemistry databases

BindingDBiP54829
ChEMBLiCHEMBL2007628

PTM databases

DEPODiP54829
iPTMnetiP54829
PhosphoSitePlusiP54829

Polymorphism and mutation databases

BioMutaiPTPN5
DMDMi317373540

Proteomic databases

PaxDbiP54829
PeptideAtlasiP54829
PRIDEiP54829
ProteomicsDBi56735
56736 [P54829-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358540; ENSP00000351342; ENSG00000110786 [P54829-1]
ENST00000396168; ENSP00000379471; ENSG00000110786 [P54829-3]
ENST00000396170; ENSP00000379473; ENSG00000110786 [P54829-2]
GeneIDi84867
KEGGihsa:84867
UCSCiuc001mpd.5 human [P54829-1]

Organism-specific databases

CTDi84867
DisGeNETi84867
EuPathDBiHostDB:ENSG00000110786.17
GeneCardsiPTPN5
HGNCiHGNC:9657 PTPN5
HPAiHPA031014
HPA072091
MIMi176879 gene
neXtProtiNX_P54829
OpenTargetsiENSG00000110786
PharmGKBiPA34001
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00920000148980
HOGENOMiHOG000294188
HOVERGENiHBG001594
InParanoidiP54829
KOiK18018
OMAiTLVWHLL
OrthoDBiEOG091G0HLB
PhylomeDBiP54829
TreeFamiTF331016

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-9008059 Interleukin-37 signaling
SIGNORiP54829

Miscellaneous databases

EvolutionaryTraceiP54829
GeneWikiiPTPN5
GenomeRNAii84867
PROiPR:P54829
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110786 Expressed in 119 organ(s), highest expression level in putamen
CleanExiHS_PTPN5
ExpressionAtlasiP54829 baseline and differential
GenevisibleiP54829 HS

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR008356 Tyr_Pase_KIM-con
IPR016334 Tyr_Pase_rcpt_R/non-rcpt_5
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF001997 PTPRR, 1 hit
PRINTSiPR01778 KIMPTPASE
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTN5_HUMAN
AccessioniPrimary (citable) accession number: P54829
Secondary accession number(s): B3KXG7
, B7Z386, B7ZAF5, D3DQY7, Q6P1Z2, Q8N2A1, Q8NDP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2011
Last modified: September 12, 2018
This is version 161 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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