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Protein

Tyrosine-protein phosphatase non-receptor type 5

Gene

PTPN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.1 Publication

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei461SubstrateBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei496Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei540SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • phosphotyrosine residue binding Source: UniProtKB
  • protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.3.48 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9008059 Interleukin-37 signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P54829

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 5 (EC:3.1.3.48)
Alternative name(s):
Neural-specific protein-tyrosine phosphatase
Striatum-enriched protein-tyrosine phosphatase
Short name:
STEP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPN5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000110786.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9657 PTPN5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
176879 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P54829

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84867

Open Targets

More...
OpenTargetsi
ENSG00000110786

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34001

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2007628

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTPN5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373540

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003636571 – 565Tyrosine-protein phosphatase non-receptor type 5Add BLAST565

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei245Phosphoserine; by PKA1 Publication1
Modified residuei255Phosphothreonine; by MAPK1 Publication1
Modified residuei268Phosphoserine; by MAPK1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-245 by PKA deactivates PTPN5. Phosphorylation at Thr-255 and Ser-268 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P54829

PeptideAtlas

More...
PeptideAtlasi
P54829

PRoteomics IDEntifications database

More...
PRIDEi
P54829

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56735
56736 [P54829-2]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
P54829

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P54829

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P54829

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110786 Expressed in 119 organ(s), highest expression level in putamen

CleanEx database of gene expression profiles

More...
CleanExi
HS_PTPN5

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P54829 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P54829 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031014
HPA072091

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124312, 59 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P54829

Protein interaction database and analysis system

More...
IntActi
P54829, 32 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000351342

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P54829

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1565
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BIJX-ray2.05A282-563[»]
2BV5X-ray1.80A280-561[»]
2CJZX-ray1.70A282-563[»]
5OVRX-ray2.15A282-561[»]
5OVXX-ray2.10A282-563[»]
5OW1X-ray2.05A282-563[»]
6H8RX-ray1.66A282-563[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P54829

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P54829

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P54829

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini300 – 555Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST256

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni496 – 502Substrate binding7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0789 Eukaryota
COG5599 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159916

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294188

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG001594

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P54829

KEGG Orthology (KO)

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KOi
K18018

Identification of Orthologs from Complete Genome Data

More...
OMAi
CTPGCSE

Database of Orthologous Groups

More...
OrthoDBi
411281at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P54829

TreeFam database of animal gene trees

More...
TreeFami
TF331016

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR008356 Tyr_Pase_KIM-con
IPR016334 Tyr_Pase_rcpt_R/non-rcpt_5
IPR000387 TYR_PHOSPHATASE_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00102 Y_phosphatase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001997 PTPRR, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01778 KIMPTPASE
PR00700 PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P54829-1) [UniParc]FASTAAdd to basket
Also known as: STEP61

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNYEGARSER ENHAADDSEG GALDMCCSER LPGLPQPIVM EALDEAEGLQ
60 70 80 90 100
DSQREMPPPP PPSPPSDPAQ KPPPRGAGSH SLTVRSSLCL FAASQFLLAC
110 120 130 140 150
GVLWFSGYGH IWSQNATNLV SSLLTLLKQL EPTAWLDSGT WGVPSLLLVF
160 170 180 190 200
LSVGLVLVTT LVWHLLRTPP EPPTPLPPED RRQSVSRQPS FTYSEWMEEK
210 220 230 240 250
IEDDFLDLDP VPETPVFDCV MDIKPEADPT SLTVKSMGLQ ERRGSNVSLT
260 270 280 290 300
LDMCTPGCNE EGFGYLMSPR EESAREYLLS ASRVLQAEEL HEKALDPFLL
310 320 330 340 350
QAEFFEIPMN FVDPKEYDIP GLVRKNRYKT ILPNPHSRVC LTSPDPDDPL
360 370 380 390 400
SSYINANYIR GYGGEEKVYI ATQGPIVSTV ADFWRMVWQE HTPIIVMITN
410 420 430 440 450
IEEMNEKCTE YWPEEQVAYD GVEITVQKVI HTEDYRLRLI SLKSGTEERG
460 470 480 490 500
LKHYWFTSWP DQKTPDRAPP LLHLVREVEE AAQQEGPHCA PIIVHCSAGI
510 520 530 540 550
GRTGCFIATS ICCQQLRQEG VVDILKTTCQ LRQDRGGMIQ TCEQYQFVHH
560
VMSLYEKQLS HQSPE
Length:565
Mass (Da):63,538
Last modified:January 11, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE32BEFFEFF7C494
GO
Isoform 2 (identifier: P54829-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-129: Missing.

Note: No experimental confirmation available.
Show »
Length:533
Mass (Da):60,035
Checksum:iA27BA66C3292C132
GO
Isoform 3 (identifier: P54829-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Note: No experimental confirmation available.
Show »
Length:541
Mass (Da):60,961
Checksum:iFE808E1908C2AB58
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MXF1A8MXF1_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN5
171Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLZ4E9PLZ4_HUMAN
Tyrosine-protein phosphatase non-re...
PTPN5
369Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32 – 34PGL → LGR in AAA87555 (PubMed:7490079).Curated3
Sequence conflicti104W → R in BAC03548 (PubMed:14702039).Curated1
Sequence conflicti107G → A in CAD38632 (PubMed:17974005).Curated1
Sequence conflicti110H → D in CAD38632 (PubMed:17974005).Curated1
Sequence conflicti111I → M in AAA87555 (PubMed:7490079).Curated1
Sequence conflicti134A → S in AAA87555 (PubMed:7490079).Curated1
Sequence conflicti145S → G in AAA87555 (PubMed:7490079).Curated1
Sequence conflicti162V → L in CAD38632 (PubMed:17974005).Curated1
Sequence conflicti313D → V in AAA87555 (PubMed:7490079).Curated1
Sequence conflicti322 – 323LV → RC in AAA87555 (PubMed:7490079).Curated2
Sequence conflicti541T → H in AAA87555 (PubMed:7490079).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054369170P → A2 PublicationsCorresponds to variant dbSNP:rs4757707Ensembl.1
Natural variantiVAR_054370561H → R. Corresponds to variant dbSNP:rs11024773Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0545611 – 24Missing in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_04265498 – 129Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK090923 mRNA Translation: BAC03548.1
AK127312 mRNA Translation: BAG54479.1
AK295604 mRNA Translation: BAH12122.1
AK316270 mRNA Translation: BAH14641.1
AL832541 mRNA Translation: CAD38632.2
AC103974 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68363.1
CH471064 Genomic DNA Translation: EAW68365.1
CH471064 Genomic DNA Translation: EAW68367.1
BC064807 mRNA Translation: AAH64807.1
U27831 mRNA Translation: AAA87555.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41626.1 [P54829-2]
CCDS60746.1 [P54829-3]
CCDS7845.1 [P54829-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001035059.1, NM_001039970.1 [P54829-2]
NP_001265165.1, NM_001278236.1 [P54829-2]
NP_001265167.1, NM_001278238.1 [P54829-3]
NP_001265168.1, NM_001278239.1
NP_008837.1, NM_006906.1 [P54829-1]
NP_116170.3, NM_032781.3 [P54829-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.79092

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000358540; ENSP00000351342; ENSG00000110786 [P54829-1]
ENST00000396168; ENSP00000379471; ENSG00000110786 [P54829-3]
ENST00000396170; ENSP00000379473; ENSG00000110786 [P54829-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84867

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84867

UCSC genome browser

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UCSCi
uc001mpd.5 human [P54829-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090923 mRNA Translation: BAC03548.1
AK127312 mRNA Translation: BAG54479.1
AK295604 mRNA Translation: BAH12122.1
AK316270 mRNA Translation: BAH14641.1
AL832541 mRNA Translation: CAD38632.2
AC103974 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68363.1
CH471064 Genomic DNA Translation: EAW68365.1
CH471064 Genomic DNA Translation: EAW68367.1
BC064807 mRNA Translation: AAH64807.1
U27831 mRNA Translation: AAA87555.1
CCDSiCCDS41626.1 [P54829-2]
CCDS60746.1 [P54829-3]
CCDS7845.1 [P54829-1]
RefSeqiNP_001035059.1, NM_001039970.1 [P54829-2]
NP_001265165.1, NM_001278236.1 [P54829-2]
NP_001265167.1, NM_001278238.1 [P54829-3]
NP_001265168.1, NM_001278239.1
NP_008837.1, NM_006906.1 [P54829-1]
NP_116170.3, NM_032781.3 [P54829-1]
UniGeneiHs.79092

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BIJX-ray2.05A282-563[»]
2BV5X-ray1.80A280-561[»]
2CJZX-ray1.70A282-563[»]
5OVRX-ray2.15A282-561[»]
5OVXX-ray2.10A282-563[»]
5OW1X-ray2.05A282-563[»]
6H8RX-ray1.66A282-563[»]
ProteinModelPortaliP54829
SMRiP54829
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124312, 59 interactors
ELMiP54829
IntActiP54829, 32 interactors
STRINGi9606.ENSP00000351342

Chemistry databases

BindingDBiP54829
ChEMBLiCHEMBL2007628

PTM databases

DEPODiP54829
iPTMnetiP54829
PhosphoSitePlusiP54829

Polymorphism and mutation databases

BioMutaiPTPN5
DMDMi317373540

Proteomic databases

PaxDbiP54829
PeptideAtlasiP54829
PRIDEiP54829
ProteomicsDBi56735
56736 [P54829-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358540; ENSP00000351342; ENSG00000110786 [P54829-1]
ENST00000396168; ENSP00000379471; ENSG00000110786 [P54829-3]
ENST00000396170; ENSP00000379473; ENSG00000110786 [P54829-2]
GeneIDi84867
KEGGihsa:84867
UCSCiuc001mpd.5 human [P54829-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84867
DisGeNETi84867
EuPathDBiHostDB:ENSG00000110786.17

GeneCards: human genes, protein and diseases

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GeneCardsi
PTPN5
HGNCiHGNC:9657 PTPN5
HPAiHPA031014
HPA072091
MIMi176879 gene
neXtProtiNX_P54829
OpenTargetsiENSG00000110786
PharmGKBiPA34001

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00940000159916
HOGENOMiHOG000294188
HOVERGENiHBG001594
InParanoidiP54829
KOiK18018
OMAiCTPGCSE
OrthoDBi411281at2759
PhylomeDBiP54829
TreeFamiTF331016

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-9008059 Interleukin-37 signaling
SIGNORiP54829

Miscellaneous databases

EvolutionaryTraceiP54829

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PTPN5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84867

Protein Ontology

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PROi
PR:P54829

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110786 Expressed in 119 organ(s), highest expression level in putamen
CleanExiHS_PTPN5
ExpressionAtlasiP54829 baseline and differential
GenevisibleiP54829 HS

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR008356 Tyr_Pase_KIM-con
IPR016334 Tyr_Pase_rcpt_R/non-rcpt_5
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF001997 PTPRR, 1 hit
PRINTSiPR01778 KIMPTPASE
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTN5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54829
Secondary accession number(s): B3KXG7
, B7Z386, B7ZAF5, D3DQY7, Q6P1Z2, Q8N2A1, Q8NDP8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2011
Last modified: January 16, 2019
This is version 164 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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