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Protein

Growth arrest-specific protein 1

Gene

GAS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.1 Publication

GO - Biological processi

Keywordsi

Biological processCell cycle, Growth arrest

Enzyme and pathway databases

ReactomeiR-HSA-5632681 Ligand-receptor interactions
R-HSA-5635838 Activation of SMO
SignaLinkiP54826

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest-specific protein 1
Short name:
GAS-1
Gene namesi
Name:GAS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000180447.6
HGNCiHGNC:4165 GAS1
MIMi139185 gene
neXtProtiNX_P54826

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2619
MalaCardsiGAS1
OpenTargetsiENSG00000180447
Orphaneti93925 Alobar holoprosencephaly
93924 Lobar holoprosencephaly
280200 Microform holoprosencephaly
93926 Midline interhemispheric variant of holoprosencephaly
220386 Semilobar holoprosencephaly
280195 Septopreoptic holoprosencephaly
PharmGKBiPA28578

Polymorphism and mutation databases

BioMutaiGAS1
DMDMi218512049

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39Sequence analysisAdd BLAST39
ChainiPRO_000002131840 – 318Growth arrest-specific protein 1Add BLAST279
PropeptideiPRO_0000021319319 – 345Removed in mature formSequence analysisAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi318GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiP54826
PaxDbiP54826
PeptideAtlasiP54826
PRIDEiP54826
ProteomicsDBi56734

PTM databases

iPTMnetiP54826
PhosphoSitePlusiP54826

Expressioni

Gene expression databases

BgeeiENSG00000180447 Expressed in 230 organ(s), highest expression level in germinal epithelium of ovary
CleanExiHS_GAS1
GenevisibleiP54826 HS

Organism-specific databases

HPAiCAB024164
HPA036085
HPA066902

Interactioni

Protein-protein interaction databases

BioGridi108889, 3 interactors
IntActiP54826, 1 interactor
MINTiP54826
STRINGi9606.ENSP00000298743

Structurei

3D structure databases

ProteinModelPortaliP54826
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi87 – 91Poly-Ala5
Compositional biasi285 – 288Poly-Asp4
Compositional biasi319 – 322Poly-Gly4
Compositional biasi337 – 341Poly-Leu5

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW52 Eukaryota
ENOG4111JS0 LUCA
GeneTreeiENSGT00390000001195
HOGENOMiHOG000233688
HOVERGENiHBG005804
InParanoidiP54826
KOiK06232
OMAiPECSYAY
OrthoDBiEOG091G0MBW
PhylomeDBiP54826
TreeFamiTF329660

Family and domain databases

InterProiView protein in InterPro
IPR039596 GAS1
IPR016017 GDNF/GAS1
PANTHERiPTHR16840 PTHR16840, 1 hit
PfamiView protein in Pfam
PF02351 GDNF, 1 hit
SMARTiView protein in SMART
SM00907 GDNF, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54826-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAALLGGGG EARGGTVPGA WLCLMALLQL LGSAPRGSGL AHGRRLICWQ
60 70 80 90 100
ALLQCQGEPE CSYAYNQYAE ACAPVLAQHG GGDAPGAAAA AFPASAASFS
110 120 130 140 150
SRWRCPSHCI SALIQLNHTR RGPALEDCDC AQDENCKSTK RAIEPCLPRT
160 170 180 190 200
SGGGAGGPGA GGVMGCTEAR RRCDRDSRCN LALSRYLTYC GKVFNGLRCT
210 220 230 240 250
DECRTVIEDM LAMPKAALLN DCVCDGLERP ICESVKENMA RLCFGAELGN
260 270 280 290 300
GPGSSGSDGG LDDYYDEDYD DEQRTGGAGG EQPLDDDDGV PHPPRPGSGA
310 320 330 340
AASGGRGDLP YGPGRRSSGG GGRLAPRGAW TPLASILLLL LGPLF
Length:345
Mass (Da):35,693
Last modified:December 16, 2008 - v2
Checksum:i31A0CBEEC3632F82
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216A → V in AAA72368 (PubMed:8127893).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13698 mRNA Translation: AAA72368.1
AL158149 Genomic DNA No translation available.
BC074908 mRNA Translation: AAH74908.1
BC074809 mRNA Translation: AAH74809.1
BC132682 mRNA Translation: AAI32683.1
BC136586 mRNA Translation: AAI36587.1
CCDSiCCDS6674.1
PIRiA53138
RefSeqiNP_002039.2, NM_002048.2
UniGeneiHs.65029

Genome annotation databases

EnsembliENST00000298743; ENSP00000298743; ENSG00000180447
GeneIDi2619
KEGGihsa:2619
UCSCiuc004aox.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13698 mRNA Translation: AAA72368.1
AL158149 Genomic DNA No translation available.
BC074908 mRNA Translation: AAH74908.1
BC074809 mRNA Translation: AAH74809.1
BC132682 mRNA Translation: AAI32683.1
BC136586 mRNA Translation: AAI36587.1
CCDSiCCDS6674.1
PIRiA53138
RefSeqiNP_002039.2, NM_002048.2
UniGeneiHs.65029

3D structure databases

ProteinModelPortaliP54826
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108889, 3 interactors
IntActiP54826, 1 interactor
MINTiP54826
STRINGi9606.ENSP00000298743

PTM databases

iPTMnetiP54826
PhosphoSitePlusiP54826

Polymorphism and mutation databases

BioMutaiGAS1
DMDMi218512049

Proteomic databases

MaxQBiP54826
PaxDbiP54826
PeptideAtlasiP54826
PRIDEiP54826
ProteomicsDBi56734

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298743; ENSP00000298743; ENSG00000180447
GeneIDi2619
KEGGihsa:2619
UCSCiuc004aox.5 human

Organism-specific databases

CTDi2619
DisGeNETi2619
EuPathDBiHostDB:ENSG00000180447.6
GeneCardsiGAS1
H-InvDBiHIX0034867
HGNCiHGNC:4165 GAS1
HPAiCAB024164
HPA036085
HPA066902
MalaCardsiGAS1
MIMi139185 gene
neXtProtiNX_P54826
OpenTargetsiENSG00000180447
Orphaneti93925 Alobar holoprosencephaly
93924 Lobar holoprosencephaly
280200 Microform holoprosencephaly
93926 Midline interhemispheric variant of holoprosencephaly
220386 Semilobar holoprosencephaly
280195 Septopreoptic holoprosencephaly
PharmGKBiPA28578
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW52 Eukaryota
ENOG4111JS0 LUCA
GeneTreeiENSGT00390000001195
HOGENOMiHOG000233688
HOVERGENiHBG005804
InParanoidiP54826
KOiK06232
OMAiPECSYAY
OrthoDBiEOG091G0MBW
PhylomeDBiP54826
TreeFamiTF329660

Enzyme and pathway databases

ReactomeiR-HSA-5632681 Ligand-receptor interactions
R-HSA-5635838 Activation of SMO
SignaLinkiP54826

Miscellaneous databases

GeneWikiiGAS1
GenomeRNAii2619
PROiPR:P54826
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180447 Expressed in 230 organ(s), highest expression level in germinal epithelium of ovary
CleanExiHS_GAS1
GenevisibleiP54826 HS

Family and domain databases

InterProiView protein in InterPro
IPR039596 GAS1
IPR016017 GDNF/GAS1
PANTHERiPTHR16840 PTHR16840, 1 hit
PfamiView protein in Pfam
PF02351 GDNF, 1 hit
SMARTiView protein in SMART
SM00907 GDNF, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGAS1_HUMAN
AccessioniPrimary (citable) accession number: P54826
Secondary accession number(s): B9EGM4, Q6B086
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 16, 2008
Last modified: November 7, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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