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UniProtKB - P54826 (GAS1_HUMAN)
Protein
Growth arrest-specific protein 1
Gene
GAS1
Organism
Homo sapiens (Human)
Status
Functioni
Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.
1 PublicationGO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell fate commitment Source: UniProtKB
- cellular response to vascular endothelial growth factor stimulus Source: UniProtKB
- developmental growth Source: UniProtKB
- negative regulation of mitotic cell cycle Source: UniProtKB
- negative regulation of protein processing Source: UniProtKB
- regulation of apoptotic process Source: UniProtKB
- regulation of ER to Golgi vesicle-mediated transport Source: UniProtKB
- regulation of smoothened signaling pathway Source: UniProtKB
Keywordsi
Biological process | Cell cycle, Growth arrest |
Enzyme and pathway databases
PathwayCommonsi | P54826 |
Reactomei | R-HSA-5632681, Ligand-receptor interactions R-HSA-5635838, Activation of SMO |
SignaLinki | P54826 |
SIGNORi | P54826 |
Names & Taxonomyi
Protein namesi | Recommended name: Growth arrest-specific protein 1Short name: GAS-1 |
Gene namesi | Name:GAS1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4165, GAS1 |
MIMi | 139185, gene |
neXtProti | NX_P54826 |
VEuPathDBi | HostDB:ENSG00000180447 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; GPI-anchor By similarity
Plasma Membrane
- anchored component of plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 2619 |
GeneReviewsi | GAS1 |
MalaCardsi | GAS1 |
OpenTargetsi | ENSG00000180447 |
Orphaneti | 93925, Alobar holoprosencephaly 93924, Lobar holoprosencephaly 280200, Microform holoprosencephaly 93926, Midline interhemispheric variant of holoprosencephaly 220386, Semilobar holoprosencephaly 280195, Septopreoptic holoprosencephaly |
PharmGKBi | PA28578 |
Miscellaneous databases
Pharosi | P54826, Tbio |
Genetic variation databases
BioMutai | GAS1 |
DMDMi | 218512049 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 39 | Sequence analysisAdd BLAST | 39 | |
ChainiPRO_0000021318 | 40 – 318 | Growth arrest-specific protein 1Add BLAST | 279 | |
PropeptideiPRO_0000021319 | 319 – 345 | Removed in mature formSequence analysisAdd BLAST | 27 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 117 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 318 | GPI-anchor amidated serineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, GPI-anchor, LipoproteinProteomic databases
jPOSTi | P54826 |
MassIVEi | P54826 |
MaxQBi | P54826 |
PaxDbi | P54826 |
PeptideAtlasi | P54826 |
PRIDEi | P54826 |
ProteomicsDBi | 56734 |
PTM databases
GlyGeni | P54826, 1 site |
iPTMneti | P54826 |
PhosphoSitePlusi | P54826 |
Expressioni
Gene expression databases
Bgeei | ENSG00000180447, Expressed in germinal epithelium of ovary and 243 other tissues |
Genevisiblei | P54826, HS |
Organism-specific databases
HPAi | ENSG00000180447, Tissue enhanced (endometrium) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 108889, 7 interactors |
IntActi | P54826, 1 interactor |
MINTi | P54826 |
STRINGi | 9606.ENSP00000298743 |
Miscellaneous databases
RNActi | P54826, protein |
Structurei
3D structure databases
AlphaFoldDBi | P54826 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 254 – 328 | DisorderedSequence analysisAdd BLAST | 75 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QSF7, Eukaryota |
GeneTreei | ENSGT00390000001195 |
HOGENOMi | CLU_068697_1_0_1 |
InParanoidi | P54826 |
OMAi | TAGDSQY |
OrthoDBi | 1071951at2759 |
PhylomeDBi | P54826 |
TreeFami | TF329660 |
Family and domain databases
InterProi | View protein in InterPro IPR039596, GAS1 IPR016017, GDNF/GAS1 |
PANTHERi | PTHR16840, PTHR16840, 1 hit |
Pfami | View protein in Pfam PF02351, GDNF, 1 hit |
SMARTi | View protein in SMART SM00907, GDNF, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P54826-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVAALLGGGG EARGGTVPGA WLCLMALLQL LGSAPRGSGL AHGRRLICWQ
60 70 80 90 100
ALLQCQGEPE CSYAYNQYAE ACAPVLAQHG GGDAPGAAAA AFPASAASFS
110 120 130 140 150
SRWRCPSHCI SALIQLNHTR RGPALEDCDC AQDENCKSTK RAIEPCLPRT
160 170 180 190 200
SGGGAGGPGA GGVMGCTEAR RRCDRDSRCN LALSRYLTYC GKVFNGLRCT
210 220 230 240 250
DECRTVIEDM LAMPKAALLN DCVCDGLERP ICESVKENMA RLCFGAELGN
260 270 280 290 300
GPGSSGSDGG LDDYYDEDYD DEQRTGGAGG EQPLDDDDGV PHPPRPGSGA
310 320 330 340
AASGGRGDLP YGPGRRSSGG GGRLAPRGAW TPLASILLLL LGPLF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 216 | A → V in AAA72368 (PubMed:8127893).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L13698 mRNA Translation: AAA72368.1 AL158149 Genomic DNA No translation available. BC074908 mRNA Translation: AAH74908.1 BC074809 mRNA Translation: AAH74809.1 BC132682 mRNA Translation: AAI32683.1 BC136586 mRNA Translation: AAI36587.1 |
CCDSi | CCDS6674.1 |
PIRi | A53138 |
RefSeqi | NP_002039.2, NM_002048.2 |
Genome annotation databases
Ensembli | ENST00000298743.9; ENSP00000298743.7; ENSG00000180447.7 |
GeneIDi | 2619 |
KEGGi | hsa:2619 |
MANE-Selecti | ENST00000298743.9; ENSP00000298743.7; NM_002048.3; NP_002039.2 |
UCSCi | uc004aox.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L13698 mRNA Translation: AAA72368.1 AL158149 Genomic DNA No translation available. BC074908 mRNA Translation: AAH74908.1 BC074809 mRNA Translation: AAH74809.1 BC132682 mRNA Translation: AAI32683.1 BC136586 mRNA Translation: AAI36587.1 |
CCDSi | CCDS6674.1 |
PIRi | A53138 |
RefSeqi | NP_002039.2, NM_002048.2 |
3D structure databases
AlphaFoldDBi | P54826 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 108889, 7 interactors |
IntActi | P54826, 1 interactor |
MINTi | P54826 |
STRINGi | 9606.ENSP00000298743 |
PTM databases
GlyGeni | P54826, 1 site |
iPTMneti | P54826 |
PhosphoSitePlusi | P54826 |
Genetic variation databases
BioMutai | GAS1 |
DMDMi | 218512049 |
Proteomic databases
jPOSTi | P54826 |
MassIVEi | P54826 |
MaxQBi | P54826 |
PaxDbi | P54826 |
PeptideAtlasi | P54826 |
PRIDEi | P54826 |
ProteomicsDBi | 56734 |
Protocols and materials databases
Antibodypediai | 13350, 250 antibodies from 31 providers |
DNASUi | 2619 |
Genome annotation databases
Ensembli | ENST00000298743.9; ENSP00000298743.7; ENSG00000180447.7 |
GeneIDi | 2619 |
KEGGi | hsa:2619 |
MANE-Selecti | ENST00000298743.9; ENSP00000298743.7; NM_002048.3; NP_002039.2 |
UCSCi | uc004aox.5, human |
Organism-specific databases
CTDi | 2619 |
DisGeNETi | 2619 |
GeneCardsi | GAS1 |
GeneReviewsi | GAS1 |
HGNCi | HGNC:4165, GAS1 |
HPAi | ENSG00000180447, Tissue enhanced (endometrium) |
MalaCardsi | GAS1 |
MIMi | 139185, gene |
neXtProti | NX_P54826 |
OpenTargetsi | ENSG00000180447 |
Orphaneti | 93925, Alobar holoprosencephaly 93924, Lobar holoprosencephaly 280200, Microform holoprosencephaly 93926, Midline interhemispheric variant of holoprosencephaly 220386, Semilobar holoprosencephaly 280195, Septopreoptic holoprosencephaly |
PharmGKBi | PA28578 |
VEuPathDBi | HostDB:ENSG00000180447 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSF7, Eukaryota |
GeneTreei | ENSGT00390000001195 |
HOGENOMi | CLU_068697_1_0_1 |
InParanoidi | P54826 |
OMAi | TAGDSQY |
OrthoDBi | 1071951at2759 |
PhylomeDBi | P54826 |
TreeFami | TF329660 |
Enzyme and pathway databases
PathwayCommonsi | P54826 |
Reactomei | R-HSA-5632681, Ligand-receptor interactions R-HSA-5635838, Activation of SMO |
SignaLinki | P54826 |
SIGNORi | P54826 |
Miscellaneous databases
BioGRID-ORCSi | 2619, 15 hits in 1074 CRISPR screens |
ChiTaRSi | GAS1, human |
GeneWikii | GAS1 |
GenomeRNAii | 2619 |
Pharosi | P54826, Tbio |
PROi | PR:P54826 |
RNActi | P54826, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000180447, Expressed in germinal epithelium of ovary and 243 other tissues |
Genevisiblei | P54826, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039596, GAS1 IPR016017, GDNF/GAS1 |
PANTHERi | PTHR16840, PTHR16840, 1 hit |
Pfami | View protein in Pfam PF02351, GDNF, 1 hit |
SMARTi | View protein in SMART SM00907, GDNF, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | GAS1_HUMAN | |
Accessioni | P54826Primary (citable) accession number: P54826 Secondary accession number(s): B9EGM4, Q6B086 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | December 16, 2008 | |
Last modified: | May 25, 2022 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot