GAS1

Functionⁱ

Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.1 Publication

GO - Biological processⁱ

cell cycle arrest Source: UniProtKB-KW
cell fate commitment Source: UniProtKB
cellular response to vascular endothelial growth factor stimulus
Source: UniProtKB
Inferred from expression patternⁱ
- 15070677
developmental growth Source: UniProtKB
negative regulation of mitotic cell cycle
Source: UniProtKB
Inferred from direct assayⁱ
- 8127893
negative regulation of protein processing
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21357679
regulation of apoptotic process Source: UniProtKB
regulation of ER to Golgi vesicle-mediated transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21357679
regulation of smoothened signaling pathway Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Growth arrest

Biological process

Cell cycle, Growth arrest

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5632681 Ligand-receptor interactions R-HSA-5635838 Activation of SMO
SignaLinkⁱ	P54826

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Growth arrest-specific protein 1 Short name: GAS-1
Gene namesⁱ	Name:GAS1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000180447.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4165 GAS1
MIMⁱ	139185 gene
neXtProtⁱ	NX_P54826

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2619
MalaCards human disease database More...MalaCardsⁱ	GAS1
Open Targets More...OpenTargetsⁱ	ENSG00000180447
Orphanetⁱ	93925 Alobar holoprosencephaly 93924 Lobar holoprosencephaly 280200 Microform holoprosencephaly 93926 Midline interhemispheric variant of holoprosencephaly 220386 Semilobar holoprosencephaly 280195 Septopreoptic holoprosencephaly
PharmGKBⁱ	PA28578

Polymorphism and mutation databases

BioMutaⁱ	GAS1
DMDMⁱ	218512049

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 39	Sequence analysisAdd BLAST	39
ChainⁱPRO_0000021318	40 – 318	Growth arrest-specific protein 1Add BLAST	279
PropeptideⁱPRO_0000021319	319 – 345	Removed in mature formSequence analysisAdd BLAST	27

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	117	N-linked (GlcNAc...) asparagineSequence analysis		1
Lipidationⁱ	318	GPI-anchor amidated serineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P54826
PaxDbⁱ	P54826
PeptideAtlas More...PeptideAtlasⁱ	P54826
PRIDEⁱ	P54826
ProteomicsDBⁱ	56734

PTM databases

iPTMnetⁱ	P54826
PhosphoSitePlusⁱ	P54826

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000180447 Expressed in 230 organ(s), highest expression level in germinal epithelium of ovary
CleanExⁱ	HS_GAS1
Genevisibleⁱ	P54826 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB024164 HPA036085 HPA066902

HPAⁱ

CAB024164
HPA036085
HPA066902

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	108889, 3 interactors
IntActⁱ	P54826, 1 interactor
Molecular INTeraction database More...MINTⁱ	P54826
STRINGⁱ	9606.ENSP00000298743

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P54826
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	87 – 91	Poly-Ala	5
Compositional biasⁱ	285 – 288	Poly-Asp	4
Compositional biasⁱ	319 – 322	Poly-Gly	4
Compositional biasⁱ	337 – 341	Poly-Leu	5

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IW52 Eukaryota ENOG4111JS0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001195
HOGENOMⁱ	HOG000233688
HOVERGENⁱ	HBG005804
InParanoidⁱ	P54826
KEGG Orthology (KO) More...KOⁱ	K06232
OMAⁱ	PECSYAY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MBW
PhylomeDBⁱ	P54826
TreeFamⁱ	TF329660

Family and domain databases

InterProⁱ	View protein in InterPro IPR039596 GAS1 IPR016017 GDNF/GAS1
PANTHERⁱ	PTHR16840 PTHR16840, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02351 GDNF, 1 hit
SMARTⁱ	View protein in SMART SM00907 GDNF, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P54826-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVAALLGGGG EARGGTVPGA WLCLMALLQL LGSAPRGSGL AHGRRLICWQ 
        60         70         80         90        100
ALLQCQGEPE CSYAYNQYAE ACAPVLAQHG GGDAPGAAAA AFPASAASFS 
       110        120        130        140        150
SRWRCPSHCI SALIQLNHTR RGPALEDCDC AQDENCKSTK RAIEPCLPRT 
       160        170        180        190        200
SGGGAGGPGA GGVMGCTEAR RRCDRDSRCN LALSRYLTYC GKVFNGLRCT 
       210        220        230        240        250
DECRTVIEDM LAMPKAALLN DCVCDGLERP ICESVKENMA RLCFGAELGN 
       260        270        280        290        300
GPGSSGSDGG LDDYYDEDYD DEQRTGGAGG EQPLDDDDGV PHPPRPGSGA 
       310        320        330        340 
AASGGRGDLP YGPGRRSSGG GGRLAPRGAW TPLASILLLL LGPLF

Length:345

Mass (Da):35,693

Last modified:December 16, 2008 - v2

Checksum:ⁱ31A0CBEEC3632F82

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	216	A → V in AAA72368 (PubMed:8127893).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L13698 mRNA Translation: AAA72368.1 AL158149 Genomic DNA No translation available. BC074908 mRNA Translation: AAH74908.1 BC074809 mRNA Translation: AAH74809.1 BC132682 mRNA Translation: AAI32683.1 BC136586 mRNA Translation: AAI36587.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6674.1
PIRⁱ	A53138
NCBI Reference Sequences More...RefSeqⁱ	NP_002039.2, NM_002048.2
UniGeneⁱ	Hs.65029

Genome annotation databases

Ensemblⁱ	ENST00000298743; ENSP00000298743; ENSG00000180447
GeneIDⁱ	2619
KEGGⁱ	hsa:2619
UCSC genome browser More...UCSCⁱ	uc004aox.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P54826	GAS1 isoform 1		PANTR		345	UniRef100_P54826

Protein	Similar proteins		Species	Score	Length	Source
P54826	GAS1 isoform 1		PANTR		345	UniRef90_P54826
Growth arrest specific 1		CERAT		373
growth arrest-specific protein 1		NEOSC		350
Uncharacterized protein		PIG		349
growth arrest-specific protein 1		BALAS		125
+46

Protein	Similar proteins		Species	Score	Length	Source
P54826	Growth arrest-specific protein 1		MOUSE		343	UniRef50_Q01721
Uncharacterized protein		NEOLE		433
Growth arrest-specific 1		RAT		383
growth arrest-specific protein 1		MESAU		382
Growth arrest specific 1		CERAT		373
+62

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L13698 mRNA Translation: AAA72368.1 AL158149 Genomic DNA No translation available. BC074908 mRNA Translation: AAH74908.1 BC074809 mRNA Translation: AAH74809.1 BC132682 mRNA Translation: AAI32683.1 BC136586 mRNA Translation: AAI36587.1
CCDSⁱ	CCDS6674.1
PIRⁱ	A53138
RefSeqⁱ	NP_002039.2, NM_002048.2
UniGeneⁱ	Hs.65029

3D structure databases

ProteinModelPortalⁱ	P54826
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108889, 3 interactors
IntActⁱ	P54826, 1 interactor
MINTⁱ	P54826
STRINGⁱ	9606.ENSP00000298743

PTM databases

iPTMnetⁱ	P54826
PhosphoSitePlusⁱ	P54826

Polymorphism and mutation databases

BioMutaⁱ	GAS1
DMDMⁱ	218512049

Proteomic databases

MaxQBⁱ	P54826
PaxDbⁱ	P54826
PeptideAtlasⁱ	P54826
PRIDEⁱ	P54826
ProteomicsDBⁱ	56734

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000298743; ENSP00000298743; ENSG00000180447
GeneIDⁱ	2619
KEGGⁱ	hsa:2619
UCSCⁱ	uc004aox.5 human

Organism-specific databases

CTDⁱ	2619
DisGeNETⁱ	2619
EuPathDBⁱ	HostDB:ENSG00000180447.6
GeneCardsⁱ	GAS1
H-InvDBⁱ	HIX0034867
HGNCⁱ	HGNC:4165 GAS1
HPAⁱ	CAB024164 HPA036085 HPA066902
MalaCardsⁱ	GAS1
MIMⁱ	139185 gene
neXtProtⁱ	NX_P54826
OpenTargetsⁱ	ENSG00000180447
Orphanetⁱ	93925 Alobar holoprosencephaly 93924 Lobar holoprosencephaly 280200 Microform holoprosencephaly 93926 Midline interhemispheric variant of holoprosencephaly 220386 Semilobar holoprosencephaly 280195 Septopreoptic holoprosencephaly
PharmGKBⁱ	PA28578
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IW52 Eukaryota ENOG4111JS0 LUCA
GeneTreeⁱ	ENSGT00390000001195
HOGENOMⁱ	HOG000233688
HOVERGENⁱ	HBG005804
InParanoidⁱ	P54826
KOⁱ	K06232
OMAⁱ	PECSYAY
OrthoDBⁱ	EOG091G0MBW
PhylomeDBⁱ	P54826
TreeFamⁱ	TF329660

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5632681 Ligand-receptor interactions R-HSA-5635838 Activation of SMO
SignaLinkⁱ	P54826

Miscellaneous databases

GeneWikiⁱ	GAS1
GenomeRNAiⁱ	2619
Protein Ontology More...PROⁱ	PR:P54826
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000180447 Expressed in 230 organ(s), highest expression level in germinal epithelium of ovary
CleanExⁱ	HS_GAS1
Genevisibleⁱ	P54826 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR039596 GAS1 IPR016017 GDNF/GAS1
PANTHERⁱ	PTHR16840 PTHR16840, 1 hit
Pfamⁱ	View protein in Pfam PF02351 GDNF, 1 hit
SMARTⁱ	View protein in SMART SM00907 GDNF, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GAS1_HUMAN
Accessionⁱ	P54826Primary (citable) accession number: P54826 Secondary accession number(s): B9EGM4, Q6B086
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	December 16, 2008
	Last modified:	November 7, 2018
	This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P54826 (GAS1_HUMAN)

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Growth arrest-specific protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ