AK2

Functionⁱ

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.UniRule annotation1 Publication

Catalytic activityⁱ

ATP + AMP = 2 ADP.UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	46	AMPUniRule annotation	1
Binding siteⁱ	51	AMPUniRule annotation	1
Binding siteⁱ	107	AMPUniRule annotation	1
Binding siteⁱ	138	ATP1 Publication	1
Binding siteⁱ	142	ATPUniRule annotation	1
Binding siteⁱ	175	AMPUniRule annotation1 Publication	1
Binding siteⁱ	186	AMPUniRule annotation	1
Binding siteⁱ	214	ATP; via carbonyl oxygenUniRule annotation1 Publication	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	25 – 30	ATPUniRule annotation1 Publication	6
Nucleotide bindingⁱ	72 – 74	AMPUniRule annotation	3
Nucleotide bindingⁱ	100 – 103	AMPUniRule annotation	4
Nucleotide bindingⁱ	151 – 152	ATPUniRule annotation1 Publication	2

GO - Molecular functionⁱ

adenylate kinase activity
Source: Reactome
Inferred from experimentⁱ
- 6182143
ATP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ADP biosynthetic process Source: UniProtKB-UniRule
AMP metabolic process Source: UniProtKB-UniRule
ATP metabolic process Source: UniProtKB-UniRule
nucleobase-containing small molecule interconversion Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-499943 Interconversion of nucleotide di- and triphosphates

Reactomeⁱ

R-HSA-499943 Interconversion of nucleotide di- and triphosphates

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Adenylate kinase 2, mitochondrialUniRule annotation (EC:2.7.4.3UniRule annotation) Short name: AK 2UniRule annotation Alternative name(s): ATP-AMP transphosphorylase 2UniRule annotation ATP:AMP phosphotransferaseUniRule annotation Adenylate monophosphate kinaseUniRule annotation Cleaved into the following chain: Adenylate kinase 2, mitochondrial, N-terminally processedUniRule annotation
Gene namesⁱ	Name:AK2UniRule annotation Synonyms:ADK2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000004455.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:362 AK2
MIMⁱ	103020 gene
neXtProtⁱ	NX_P54819

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Reticular dysgenesis (RDYS)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA fatal form of severe combined immunodeficiency, characterized by absence of granulocytes, almost complete deficiency of lymphocytes in peripheral blood, hypoplasia of the thymus and secondary lymphoid organs, and lack of innate and adaptive humoral and cellular immunity, leading to fatal septicemia within days after birth. In bone marrow of individuals with reticular dysgenesis, myeloid differentiation is blocked at the promyelocytic stage, whereas erythro- and megakaryocytic maturation is generally normal. Inheritance is autosomal recessive.

Keywords - Diseaseⁱ

Disease mutation, SCID

Organism-specific databases

DisGeNET More...DisGeNETⁱ	204
MalaCards human disease database More...MalaCardsⁱ	AK2
MIMⁱ	267500 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000004455
Orphanetⁱ	33355 Reticular dysgenesis
PharmGKBⁱ	PA24656

Chemistry databases

ChEMBLⁱ	CHEMBL4938
Drug and drug target database More...DrugBankⁱ	DB00718 Adefovir Dipivoxil DB01717 Bis(Adenosine)-5'-Pentaphosphate DB00300 Tenofovir

Polymorphism and mutation databases

BioMutaⁱ	AK2
DMDMⁱ	1708596

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000423212	1 – 239	Adenylate kinase 2, mitochondrialAdd BLAST	239
Initiator methionineⁱ		Removed; alternateUniRule annotationCombined sources1 Publication
ChainⁱPRO_0000158917	2 – 239	Adenylate kinase 2, mitochondrial, N-terminally processedAdd BLAST	238

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	4	PhosphoserineCombined sources	1
Disulfide bondⁱ	42 ↔ 92	UniRule annotation1 Publication
Modified residueⁱ	58	PhosphoserineCombined sources	1
Modified residueⁱ	62	N6-succinyllysineBy similarity	1
Modified residueⁱ	93	N6-succinyllysineBy similarity	1
Modified residueⁱ	133	PhosphoserineCombined sources	1
Modified residueⁱ	181	N6-acetyllysineBy similarity	1
Modified residueⁱ	195	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

EPDⁱ	P54819
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P54819
PaxDbⁱ	P54819
PeptideAtlas More...PeptideAtlasⁱ	P54819
PRIDEⁱ	P54819
ProteomicsDBⁱ	56726 56727 [P54819-2] 56728 [P54819-3] 56729 [P54819-4] 56730 [P54819-5] 56731 [P54819-6]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P54819
REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00218988
UCD-2DPAGEⁱ	P54819

PTM databases

iPTMnetⁱ	P54819
PhosphoSitePlusⁱ	P54819
SwissPalmⁱ	P54819

Expressionⁱ

Tissue specificityⁱ

Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000004455 Expressed in 216 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_AK2
ExpressionAtlasⁱ	P54819 baseline and differential
Genevisibleⁱ	P54819 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA018479

HPAⁱ

HPA018479

Interactionⁱ

Subunit structureⁱ

Monomer.UniRule annotation

Protein-protein interaction databases

BioGridⁱ	106707, 41 interactors
CORUMⁱ	P54819
IntActⁱ	P54819, 20 interactors
Molecular INTeraction database More...MINTⁱ	P54819
STRINGⁱ	9606.ENSP00000346921

Chemistry databases

BindingDBⁱ

P54819

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	16 – 21	Combined sources	6
Helixⁱ	28 – 39	Combined sources	12
Beta strandⁱ	42 – 45	Combined sources	4
Helixⁱ	46 – 56	Combined sources	11
Helixⁱ	59 – 69	Combined sources	11
Helixⁱ	76 – 87	Combined sources	12
Helixⁱ	90 – 92	Combined sources	3
Beta strandⁱ	95 – 100	Combined sources	6
Helixⁱ	105 – 117	Combined sources	13
Beta strandⁱ	124 – 129	Combined sources	6
Helixⁱ	132 – 140	Combined sources	9
Turnⁱ	146 – 148	Combined sources	3
Beta strandⁱ	151 – 153	Combined sources	3
Turnⁱ	154 – 156	Combined sources	3
Beta strandⁱ	166 – 168	Combined sources	3
Helixⁱ	180 – 203	Combined sources	24
Beta strandⁱ	207 – 211	Combined sources	5
Helixⁱ	216 – 230	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	P54819
SMRⁱ	P54819
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P54819

EvolutionaryTraceⁱ

P54819

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	45 – 74	NMPbindUniRule annotation1 PublicationAdd BLAST		30
Regionⁱ	141 – 178	LIDUniRule annotation1 PublicationAdd BLAST		38

Domainⁱ

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.UniRule annotation1 Publication

Sequence similaritiesⁱ

Belongs to the adenylate kinase family. AK2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3078 Eukaryota COG0563 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00830000128340
HOVERGENⁱ	HBG000458
InParanoidⁱ	P54819
KEGG Orthology (KO) More...KOⁱ	K00939
OMAⁱ	EKFTSQG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06BH
PhylomeDBⁱ	P54819
TreeFamⁱ	TF300896

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01428 ADK, 1 hit
HAMAPⁱ	MF_00235 Adenylate_kinase_Adk, 1 hit MF_03168 Adenylate_kinase_AK2, 1 hit
InterProⁱ	View protein in InterPro IPR006259 Adenyl_kin_sub IPR000850 Adenylat/UMP-CMP_kin IPR033690 Adenylat_kinase_CS IPR007862 Adenylate_kinase_lid-dom IPR028587 AK2 IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR23359 PTHR23359, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05191 ADK_lid, 1 hit
PRINTSⁱ	PR00094 ADENYLTKNASE
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR01351 adk, 1 hit
PROSITEⁱ	View protein in PROSITE PS00113 ADENYLATE_KINASE, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P54819-1) [UniParc]FASTA Add to basket

Also known as: AK2A, AK2isoA

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPSVPAAEP EYPKGIRAVL LGPPGAGKGT QAPRLAENFC VCHLATGDML 
        60         70         80         90        100
RAMVASGSEL GKKLKATMDA GKLVSDEMVV ELIEKNLETP LCKNGFLLDG 
       110        120        130        140        150
FPRTVRQAEM LDDLMEKRKE KLDSVIEFSI PDSLLIRRIT GRLIHPKSGR 
       160        170        180        190        200
SYHEEFNPPK EPMKDDITGE PLIRRSDDNE KALKIRLQAY HTQTTPLIEY 
       210        220        230 
YRKRGIHSAI DASQTPDVVF ASILAAFSKA TCKDLVMFI

Length:239

Mass (Da):26,478

Last modified:January 23, 2007 - v2

Checksum:ⁱ86FA94F9EE33629F

GO

Isoform 2 (identifier: P54819-2) [UniParc]FASTA Add to basket

Also known as: AK2B, AK2isoB

The sequence of this isoform differs from the canonical sequence as follows:
232-239: CKDLVMFI → S

« Hide

        10         20         30         40         50
MAPSVPAAEP EYPKGIRAVL LGPPGAGKGT QAPRLAENFC VCHLATGDML 
        60         70         80         90        100
RAMVASGSEL GKKLKATMDA GKLVSDEMVV ELIEKNLETP LCKNGFLLDG 
       110        120        130        140        150
FPRTVRQAEM LDDLMEKRKE KLDSVIEFSI PDSLLIRRIT GRLIHPKSGR 
       160        170        180        190        200
SYHEEFNPPK EPMKDDITGE PLIRRSDDNE KALKIRLQAY HTQTTPLIEY 
       210        220        230 
YRKRGIHSAI DASQTPDVVF ASILAAFSKA TS

Show »

Length:232

Mass (Da):25,615

Checksum:ⁱ64AEE1A97D81D401

GO

Isoform 3 (identifier: P54819-3) [UniParc]FASTA Add to basket

Also known as: AK2C

The sequence of this isoform differs from the canonical sequence as follows:
178-239: DNEKALKIRL...ATCKDLVMFI → IGQAKRSFLRLAKISFDVLIKKALA

« Hide

        10         20         30         40         50
MAPSVPAAEP EYPKGIRAVL LGPPGAGKGT QAPRLAENFC VCHLATGDML 
        60         70         80         90        100
RAMVASGSEL GKKLKATMDA GKLVSDEMVV ELIEKNLETP LCKNGFLLDG 
       110        120        130        140        150
FPRTVRQAEM LDDLMEKRKE KLDSVIEFSI PDSLLIRRIT GRLIHPKSGR 
       160        170        180        190        200
SYHEEFNPPK EPMKDDITGE PLIRRSDIGQ AKRSFLRLAK ISFDVLIKKA 

LA

Show »

Length:202

Mass (Da):22,265

Checksum:ⁱAE7593A8ADBD00CF

GO

Isoform 4 (identifier: P54819-4) [UniParc]FASTA Add to basket

Also known as: AK2D

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     177-178: DD → GL
     179-239: Missing.

« Hide

        10         20         30         40         50
MLRAMVASGS ELGKKLKATM DAGKLVSDEM VVELIEKNLE TPLCKNGFLL 
        60         70         80         90        100
DGFPRTVRQA EMLDDLMEKR KEKLDSVIEF SIPDSLLIRR ITGRLIHPKS 
       110        120        130
GRSYHEEFNP PKEPMKDDIT GEPLIRRSGL

Show »

Length:130

Mass (Da):14,709

Checksum:ⁱC6FEB90B2BFF7845

GO

Isoform 5 (identifier: P54819-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
135-142: Missing.
232-239: CKDLVMFI → S

« Hide

        10         20         30         40         50
MAPSVPAAEP EYPKGIRAVL LGPPGAGKGT QAPRLAENFC VCHLATGDML 
        60         70         80         90        100
RAMVASGSEL GKKLKATMDA GKLVSDEMVV ELIEKNLETP LCKNGFLLDG 
       110        120        130        140        150
FPRTVRQAEM LDDLMEKRKE KLDSVIEFSI PDSLLIHPKS GRSYHEEFNP 
       160        170        180        190        200
PKEPMKDDIT GEPLIRRSDD NEKALKIRLQ AYHTQTTPLI EYYRKRGIHS 
       210        220 
AIDASQTPDV VFASILAAFS KATS

Note: No experimental confirmation available.

Show »

Length:224

Mass (Da):24,648

Checksum:ⁱ1A769D71DDBB0B8A

GO

Isoform 6 (identifier: P54819-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-48: Missing.

« Hide

        10         20         30         40         50
MLRAMVASGS ELGKKLKATM DAGKLVSDEM VVELIEKNLE TPLCKNGFLL 
        60         70         80         90        100
DGFPRTVRQA EMLDDLMEKR KEKLDSVIEF SIPDSLLIRR ITGRLIHPKS 
       110        120        130        140        150
GRSYHEEFNP PKEPMKDDIT GEPLIRRSDD NEKALKIRLQ AYHTQTTPLI 
       160        170        180        190 
EYYRKRGIHS AIDASQTPDV VFASILAAFS KATCKDLVMF I

Note: No experimental confirmation available.

Show »

Length:191

Mass (Da):21,636

Checksum:ⁱA6535F6453550852

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8W1A4	F8W1A4_HUMAN	Adenylate kinase 2, mitochondrial Adenylate kinase 2, mitochondrial, AK 2, EC 2.7.4.3 (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase)	AK2	232	Annotation score:
G3V213	G3V213_HUMAN	Adenylate kinase 2, isoform CRA_a Adenylate kinase 2, isoform CRA_a (Adenylate kinase 2, mitochondrial)	AK2 hCG_2032090	133	Annotation score:
F8VZG5	F8VZG5_HUMAN	Adenylate kinase 2, mitochondrial Adenylate kinase 2, mitochondrial	AK2	162	Annotation score:
F8VY04	F8VY04_HUMAN	Adenylate kinase 2, mitochondrial Adenylate kinase 2, mitochondrial	AK2	190	Annotation score:
F8VPP1	F8VPP1_HUMAN	Adenylate kinase 2, mitochondrial Adenylate kinase 2, mitochondrial	AK2	42	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_054630	103	R → W in RDYS. 1 PublicationCorresponds to variant dbSNP:rs267606648EnsemblClinVar.	1
Natural variantⁱVAR_054631	165	D → G in RDYS. 1 PublicationCorresponds to variant dbSNP:rs267606643EnsemblClinVar.	1
Natural variantⁱVAR_050032	209	A → T. Corresponds to variant dbSNP:rs12116440EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_002792	1 – 48	Missing in isoform 4 and isoform 6. 2 PublicationsAdd BLAST	48
Alternative sequenceⁱVSP_036503	135 – 142	Missing in isoform 5. 1 Publication	8
Alternative sequenceⁱVSP_002793	177 – 178	DD → GL in isoform 4. 1 Publication	2
Alternative sequenceⁱVSP_002791	178 – 239	DNEKA…LVMFI → IGQAKRSFLRLAKISFDVLI KKALA in isoform 3. 1 PublicationAdd BLAST	62
Alternative sequenceⁱVSP_002794	179 – 239	Missing in isoform 4. 1 PublicationAdd BLAST	61
Alternative sequenceⁱVSP_002790	232 – 239	CKDLVMFI → S in isoform 2 and isoform 5. 5 Publications	8

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U39945 mRNA Translation: AAC52061.1 U84371 mRNA Translation: AAB41790.1 U54645 mRNA Translation: AAC13881.1 AB005621 mRNA Translation: BAC16747.1 AB005622 mRNA Translation: BAC16748.1 AY080899 mRNA Translation: AAL87027.1 AY080900 mRNA Translation: AAL87028.1 AK291676 mRNA Translation: BAF84365.1 AK295105 mRNA Translation: BAG58139.1 AK296863 mRNA Translation: BAG59426.1 AB451267 mRNA Translation: BAG70081.1 AB451394 mRNA Translation: BAG70208.1 AL020995 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07484.1 CH471059 Genomic DNA Translation: EAX07486.1 BC009405 mRNA Translation: AAH09405.1 BC070127 mRNA Translation: AAH70127.1 BC090040 mRNA Translation: AAH90040.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS373.1 [P54819-2] CCDS374.1 [P54819-1]
PIRⁱ	G02248 JC5893
NCBI Reference Sequences More...RefSeqⁱ	NP_001186128.1, NM_001199199.1 [P54819-5] NP_001306068.1, NM_001319139.1 NP_001306069.1, NM_001319140.1 [P54819-6] NP_001616.1, NM_001625.3 [P54819-1] NP_037543.1, NM_013411.4 [P54819-2]
UniGeneⁱ	Hs.470907

Genome annotation databases

Ensemblⁱ	ENST00000354858; ENSP00000346921; ENSG00000004455 [P54819-1] ENST00000373449; ENSP00000362548; ENSG00000004455 [P54819-2]
GeneIDⁱ	204
KEGGⁱ	hsa:204
UCSC genome browser More...UCSCⁱ	uc001bwo.3 human [P54819-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P54819	Adenylate kinase 2, mitochondrial		PONAB		239	UniRef100_P54819
Adenylate kinase 2, mitochondrial		HUMAN		239
Adenylate kinase 2, mitochondrial		PANTR		239
Adenylate kinase 2, mitochondrial		MACMU		239
Adenylate kinase 2, mitochondrial		CHLSB		239
+10
P54819-2	Adenylate kinase 2, mitochondrial		MACMU		232	UniRef100_F7H131
Adenylate kinase 2, mitochondrial		PANTR		232
Adenylate kinase 2, mitochondrial		PONAB		232
Adenylate kinase 2, mitochondrial		CERAT		232
Adenylate kinase 2, mitochondrial		PAPAN		232
+4

Protein	Similar proteins		Species	Score	Length	Source
P54819	Adenylate kinase 2, mitochondrial		PONAB		239	UniRef90_P54819
Adenylate kinase 2, mitochondrial	)	BOVIN		241
Adenylate kinase 2, mitochondrial		MOUSE		239
Adenylate kinase 2, mitochondrial		HUMAN		239
Adenylate kinase 2, mitochondrial		PANTR		239
+106
P54819-2	Adenylate kinase 2, mitochondrial		RAT		239	UniRef90_P29410
Adenylate kinase 2, mitochondrial		FELCA		235
Adenylate kinase 2, mitochondrial		ODORO		234
adenylate kinase 2, mitochondrial isoform X2		BALAS		234
Adenylate kinase 2, mitochondrial		DELLE		234
+101
P54819-4	Uncharacterized protein (Fragment)		Micrurus lemniscatus carvalhoi		112	UniRef90_P54819-4
P54819-5	Adenylate kinase 2, mitochondrial		MACMU		255	UniRef90_P54819-5
Adenylate kinase 2, mitochondrial		PAPAN		255
Adenylate kinase 2, mitochondrial		CERAT		255
Adenylate kinase 2, mitochondrial		CAVPO		239
Adenylate kinase 2, mitochondrial		SHEEP		227
+19

Protein	Similar proteins		Species	Score	Length	Source
P54819	Adenylate kinase 2, mitochondrial		PONAB		239	UniRef50_P54819
Adenylate kinase 2, mitochondrial	)	BOVIN		241
Adenylate kinase 2, mitochondrial		MOUSE		239
Adenylate kinase 2, mitochondrial		HUMAN		239
Adenylate kinase 2, mitochondrial		PANTR		239
+151
P54819-2	Adenylate kinase 2, mitochondrial		RAT		239	UniRef50_P29410
Adenylate kinase 2, mitochondrial		FELCA		235
Adenylate kinase 2, mitochondrial		PIG		234
Adenylate kinase 2, mitochondrial		Yangtze finless porpoise		234
adenylate kinase 2, mitochondrial isoform X2		URSMA		234
+151
P54819-3	Uncharacterized protein		Mitosporidium daphniae		248	UniRef50_P54819-3
P54819-4	Uncharacterized protein (Fragment)		Micrurus lemniscatus carvalhoi		112	UniRef50_P54819-4
Uncharacterized protein (Fragment)		MICCO		127
Adenylate kinase 2 (Fragment)		PSEAM		126
adenylate kinase 2, mitochondrial isoform X4		DELLE		135
adenylate kinase 2, mitochondrial isoform X4		PHYCD		135
+33
P54819-5	Adenylate kinase		DROWI		240	UniRef50_P54819-5
Adenylate kinase		DROGR		238
Adenylate kinase 2, mitochondrial		SALSA		238
Adenylate kinase		AEDAE		241
Adenylate kinase 2, mitochondrial		XENLA		241
+355

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U39945 mRNA Translation: AAC52061.1 U84371 mRNA Translation: AAB41790.1 U54645 mRNA Translation: AAC13881.1 AB005621 mRNA Translation: BAC16747.1 AB005622 mRNA Translation: BAC16748.1 AY080899 mRNA Translation: AAL87027.1 AY080900 mRNA Translation: AAL87028.1 AK291676 mRNA Translation: BAF84365.1 AK295105 mRNA Translation: BAG58139.1 AK296863 mRNA Translation: BAG59426.1 AB451267 mRNA Translation: BAG70081.1 AB451394 mRNA Translation: BAG70208.1 AL020995 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07484.1 CH471059 Genomic DNA Translation: EAX07486.1 BC009405 mRNA Translation: AAH09405.1 BC070127 mRNA Translation: AAH70127.1 BC090040 mRNA Translation: AAH90040.1
CCDSⁱ	CCDS373.1 [P54819-2] CCDS374.1 [P54819-1]
PIRⁱ	G02248 JC5893
RefSeqⁱ	NP_001186128.1, NM_001199199.1 [P54819-5] NP_001306068.1, NM_001319139.1 NP_001306069.1, NM_001319140.1 [P54819-6] NP_001616.1, NM_001625.3 [P54819-1] NP_037543.1, NM_013411.4 [P54819-2]
UniGeneⁱ	Hs.470907

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2C9Y	X-ray	2.10	A	1-239	[»]
ProteinModelPortalⁱ	P54819
SMRⁱ	P54819
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106707, 41 interactors
CORUMⁱ	P54819
IntActⁱ	P54819, 20 interactors
MINTⁱ	P54819
STRINGⁱ	9606.ENSP00000346921

Chemistry databases

BindingDBⁱ	P54819
ChEMBLⁱ	CHEMBL4938
DrugBankⁱ	DB00718 Adefovir Dipivoxil DB01717 Bis(Adenosine)-5'-Pentaphosphate DB00300 Tenofovir

PTM databases

iPTMnetⁱ	P54819
PhosphoSitePlusⁱ	P54819
SwissPalmⁱ	P54819

Polymorphism and mutation databases

BioMutaⁱ	AK2
DMDMⁱ	1708596

2D gel databases

OGPⁱ	P54819
REPRODUCTION-2DPAGEⁱ	IPI00218988
UCD-2DPAGEⁱ	P54819

Proteomic databases

EPDⁱ	P54819
MaxQBⁱ	P54819
PaxDbⁱ	P54819
PeptideAtlasⁱ	P54819
PRIDEⁱ	P54819
ProteomicsDBⁱ	56726 56727 [P54819-2] 56728 [P54819-3] 56729 [P54819-4] 56730 [P54819-5] 56731 [P54819-6]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	204
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000354858; ENSP00000346921; ENSG00000004455 [P54819-1] ENST00000373449; ENSP00000362548; ENSG00000004455 [P54819-2]
GeneIDⁱ	204
KEGGⁱ	hsa:204
UCSCⁱ	uc001bwo.3 human [P54819-1]

Organism-specific databases

CTDⁱ	204
DisGeNETⁱ	204
EuPathDBⁱ	HostDB:ENSG00000004455.16
GeneCardsⁱ	AK2
HGNCⁱ	HGNC:362 AK2
HPAⁱ	HPA018479
MalaCardsⁱ	AK2
MIMⁱ	103020 gene 267500 phenotype
neXtProtⁱ	NX_P54819
OpenTargetsⁱ	ENSG00000004455
Orphanetⁱ	33355 Reticular dysgenesis
PharmGKBⁱ	PA24656
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3078 Eukaryota COG0563 LUCA
GeneTreeⁱ	ENSGT00830000128340
HOVERGENⁱ	HBG000458
InParanoidⁱ	P54819
KOⁱ	K00939
OMAⁱ	EKFTSQG
OrthoDBⁱ	EOG091G06BH
PhylomeDBⁱ	P54819
TreeFamⁱ	TF300896

Enzyme and pathway databases

Reactomeⁱ	R-HSA-499943 Interconversion of nucleotide di- and triphosphates

Reactomeⁱ

R-HSA-499943 Interconversion of nucleotide di- and triphosphates

Miscellaneous databases

ChiTaRSⁱ	AK2 human
EvolutionaryTraceⁱ	P54819
GeneWikiⁱ	AK2
GenomeRNAiⁱ	204
Protein Ontology More...PROⁱ	PR:P54819
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000004455 Expressed in 216 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_AK2
ExpressionAtlasⁱ	P54819 baseline and differential
Genevisibleⁱ	P54819 HS

Family and domain databases

CDDⁱ	cd01428 ADK, 1 hit
HAMAPⁱ	MF_00235 Adenylate_kinase_Adk, 1 hit MF_03168 Adenylate_kinase_AK2, 1 hit
InterProⁱ	View protein in InterPro IPR006259 Adenyl_kin_sub IPR000850 Adenylat/UMP-CMP_kin IPR033690 Adenylat_kinase_CS IPR007862 Adenylate_kinase_lid-dom IPR028587 AK2 IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR23359 PTHR23359, 1 hit
Pfamⁱ	View protein in Pfam PF05191 ADK_lid, 1 hit
PRINTSⁱ	PR00094 ADENYLTKNASE
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR01351 adk, 1 hit
PROSITEⁱ	View protein in PROSITE PS00113 ADENYLATE_KINASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KAD2_HUMAN
Accessionⁱ	P54819Primary (citable) accession number: P54819 Secondary accession number(s): A8K6L1 Q8TCY3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	January 23, 2007
	Last modified:	October 10, 2018
	This is version 191 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P54819 (KAD2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Adenylate kinase 2, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Extracellular region or secreted

Mitochondrion

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ