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UniProtKB - P54819 (KAD2_HUMAN)

Entry version 199 (16 Oct 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Adenylate kinase 2, mitochondrial

Gene

AK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.UniRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei46AMPUniRule annotation1
Binding sitei51AMPUniRule annotation1
Binding sitei107AMPUniRule annotation1
Binding sitei138ATP1 Publication1
Binding sitei142ATPUniRule annotation1
Binding sitei175AMPUniRule annotation1 Publication1
Binding sitei186AMPUniRule annotation1
Binding sitei214ATP; via carbonyl oxygenUniRule annotation1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi25 – 30ATPUniRule annotation1 Publication6
Nucleotide bindingi72 – 74AMPUniRule annotation3
Nucleotide bindingi100 – 103AMPUniRule annotation4
Nucleotide bindingi151 – 152ATPUniRule annotation1 Publication2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-499943 Interconversion of nucleotide di- and triphosphates

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenylate kinase 2, mitochondrialUniRule annotation (EC:2.7.4.3UniRule annotation)
Short name:
AK 2UniRule annotation
Alternative name(s):
ATP-AMP transphosphorylase 2UniRule annotation
ATP:AMP phosphotransferaseUniRule annotation
Adenylate monophosphate kinaseUniRule annotation
Cleaved into the following chain:
Adenylate kinase 2, mitochondrial, N-terminally processedUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AK2UniRule annotation
Synonyms:ADK2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:362 AK2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		103020 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P54819

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Reticular dysgenesis (RDYS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA fatal form of severe combined immunodeficiency, characterized by absence of granulocytes, almost complete deficiency of lymphocytes in peripheral blood, hypoplasia of the thymus and secondary lymphoid organs, and lack of innate and adaptive humoral and cellular immunity, leading to fatal septicemia within days after birth. In bone marrow of individuals with reticular dysgenesis, myeloid differentiation is blocked at the promyelocytic stage, whereas erythro- and megakaryocytic maturation is generally normal. Inheritance is autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054630103R → W in RDYS. 1 PublicationCorresponds to variant dbSNP:rs267606648EnsemblClinVar.1
Natural variantiVAR_054631165D → G in RDYS. 1 PublicationCorresponds to variant dbSNP:rs267606643EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, SCID

Organism-specific databases

DisGeNET

More...DisGeNETi		204

MalaCards human disease database

More...MalaCardsi		AK2
MIMi267500 phenotype

Open Targets

More...OpenTargetsi		ENSG00000004455

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		33355 Reticular dysgenesis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24656

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P54819

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4938

Drug and drug target database

More...DrugBanki		DB00718 Adefovir dipivoxil
DB01717 Bis(Adenosine)-5'-Pentaphosphate
DB03366 Imidazole
DB14126 Tenofovir
DB09299 Tenofovir alafenamide
DB00300 Tenofovir disoproxil

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AK2

Domain mapping of disease mutations (DMDM)

More...DMDMi		1708596

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004232121 – 239Adenylate kinase 2, mitochondrialAdd BLAST239
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateUniRule annotationCombined sources1 Publication
ChainiPRO_00001589172 – 239Adenylate kinase 2, mitochondrial, N-terminally processedAdd BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei4PhosphoserineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi42 ↔ 92UniRule annotation1 Publication
Modified residuei58PhosphoserineCombined sources1
Modified residuei62N6-succinyllysineBy similarity1
Modified residuei93N6-succinyllysineBy similarity1
Modified residuei133PhosphoserineCombined sources1
Modified residuei181N6-acetyllysineBy similarity1
Modified residuei195PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P54819

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P54819

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P54819

MaxQB - The MaxQuant DataBase

More...MaxQBi		P54819

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P54819

PeptideAtlas

More...PeptideAtlasi		P54819

PRoteomics IDEntifications database

More...PRIDEi		P54819

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56726 [P54819-1]
56727 [P54819-2]
56728 [P54819-3]
56729 [P54819-4]
56730 [P54819-5]
56731 [P54819-6]

2D gel databases

USC-OGP 2-DE database

More...OGPi		P54819

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00218988

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P54819

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P54819

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P54819

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P54819

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000004455 Expressed in 216 organ(s), highest expression level in left lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P54819 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P54819 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA018479

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

UniRule annotation

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		106707, 49 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P54819

Protein interaction database and analysis system

More...IntActi		P54819, 24 interactors

Molecular INTeraction database

More...MINTi		P54819

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000346921

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P54819

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1239
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P54819

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P54819

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni45 – 74NMPbindUniRule annotation1 PublicationAdd BLAST30
Regioni141 – 178LIDUniRule annotation1 PublicationAdd BLAST38

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.UniRule annotation1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylate kinase family. AK2 subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3078 Eukaryota
COG0563 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154576

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P54819

KEGG Orthology (KO)

More...KOi		K00939

Identification of Orthologs from Complete Genome Data

More...OMAi		FHNRMRV

Database of Orthologous Groups

More...OrthoDBi		1004067at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P54819

TreeFam database of animal gene trees

More...TreeFami		TF300896

Family and domain databases

Conserved Domains Database

More...CDDi		cd01428 ADK, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00235 Adenylate_kinase_Adk, 1 hit
MF_03168 Adenylate_kinase_AK2, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006259 Adenyl_kin_sub
IPR000850 Adenylat/UMP-CMP_kin
IPR033690 Adenylat_kinase_CS
IPR007862 Adenylate_kinase_lid-dom
IPR028587 AK2
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...PANTHERi		PTHR23359 PTHR23359, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05191 ADK_lid, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00094 ADENYLTKNASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01351 adk, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00113 ADENYLATE_KINASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P54819-1) [UniParc]FASTAAdd to basket
Also known as: AK2A, AK2isoA

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPSVPAAEP EYPKGIRAVL LGPPGAGKGT QAPRLAENFC VCHLATGDML 
        60         70         80         90        100
RAMVASGSEL GKKLKATMDA GKLVSDEMVV ELIEKNLETP LCKNGFLLDG 
       110        120        130        140        150
FPRTVRQAEM LDDLMEKRKE KLDSVIEFSI PDSLLIRRIT GRLIHPKSGR 
       160        170        180        190        200
SYHEEFNPPK EPMKDDITGE PLIRRSDDNE KALKIRLQAY HTQTTPLIEY 
       210        220        230 
YRKRGIHSAI DASQTPDVVF ASILAAFSKA TCKDLVMFI
Length:239
Mass (Da):26,478
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86FA94F9EE33629F
GO
Isoform 2 (identifier: P54819-2) [UniParc]FASTAAdd to basket
Also known as: AK2B, AK2isoB

The sequence of this isoform differs from the canonical sequence as follows:
     232-239: CKDLVMFI → S

Show »
Length:232
Mass (Da):25,615
Checksum:i64AEE1A97D81D401
GO
Isoform 3 (identifier: P54819-3) [UniParc]FASTAAdd to basket
Also known as: AK2C

The sequence of this isoform differs from the canonical sequence as follows:
     178-239: DNEKALKIRL...ATCKDLVMFI → IGQAKRSFLRLAKISFDVLIKKALA

Show »
Length:202
Mass (Da):22,265
Checksum:iAE7593A8ADBD00CF
GO
Isoform 4 (identifier: P54819-4) [UniParc]FASTAAdd to basket
Also known as: AK2D

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     177-178: DD → GL
     179-239: Missing.

Show »
Length:130
Mass (Da):14,709
Checksum:iC6FEB90B2BFF7845
GO
Isoform 5 (identifier: P54819-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-142: Missing.
     232-239: CKDLVMFI → S

Note: No experimental confirmation available.
Show »
Length:224
Mass (Da):24,648
Checksum:i1A769D71DDBB0B8A
GO
Isoform 6 (identifier: P54819-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.

Note: No experimental confirmation available.
Show »
Length:191
Mass (Da):21,636
Checksum:iA6535F6453550852
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W1A4F8W1A4_HUMAN
Adenylate kinase 2, mitochondrial
AK2
232Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V213G3V213_HUMAN
Adenylate kinase 2, isoform CRA_a
AK2 hCG_2032090
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZG5F8VZG5_HUMAN
Adenylate kinase 2, mitochondrial
AK2
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VY04F8VY04_HUMAN
Adenylate kinase 2, mitochondrial
AK2
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VPP1F8VPP1_HUMAN
Adenylate kinase 2, mitochondrial
AK2
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054630103R → W in RDYS. 1 PublicationCorresponds to variant dbSNP:rs267606648EnsemblClinVar.1
Natural variantiVAR_054631165D → G in RDYS. 1 PublicationCorresponds to variant dbSNP:rs267606643EnsemblClinVar.1
Natural variantiVAR_050032209A → T. Corresponds to variant dbSNP:rs12116440EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0027921 – 48Missing in isoform 4 and isoform 6. 2 PublicationsAdd BLAST48
Alternative sequenceiVSP_036503135 – 142Missing in isoform 5. 1 Publication8
Alternative sequenceiVSP_002793177 – 178DD → GL in isoform 4. 1 Publication2
Alternative sequenceiVSP_002791178 – 239DNEKA…LVMFI → IGQAKRSFLRLAKISFDVLI KKALA in isoform 3. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_002794179 – 239Missing in isoform 4. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_002790232 – 239CKDLVMFI → S in isoform 2 and isoform 5. 5 Publications8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U39945 mRNA Translation: AAC52061.1
U84371 mRNA Translation: AAB41790.1
U54645 mRNA Translation: AAC13881.1
AB005621 mRNA Translation: BAC16747.1
AB005622 mRNA Translation: BAC16748.1
AY080899 mRNA Translation: AAL87027.1
AY080900 mRNA Translation: AAL87028.1
AK291676 mRNA Translation: BAF84365.1
AK295105 mRNA Translation: BAG58139.1
AK296863 mRNA Translation: BAG59426.1
AB451267 mRNA Translation: BAG70081.1
AB451394 mRNA Translation: BAG70208.1
AL020995 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07484.1
CH471059 Genomic DNA Translation: EAX07486.1
BC009405 mRNA Translation: AAH09405.1
BC070127 mRNA Translation: AAH70127.1
BC090040 mRNA Translation: AAH90040.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS373.1 [P54819-2]
CCDS374.1 [P54819-1]

Protein sequence database of the Protein Information Resource

More...PIRi		G02248
JC5893

NCBI Reference Sequences

More...RefSeqi		NP_001186128.1, NM_001199199.1 [P54819-5]
NP_001306068.1, NM_001319139.1
NP_001306069.1, NM_001319140.1 [P54819-6]
NP_001616.1, NM_001625.3 [P54819-1]
NP_037543.1, NM_013411.4 [P54819-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000354858; ENSP00000346921; ENSG00000004455 [P54819-1]
ENST00000373449; ENSP00000362548; ENSG00000004455 [P54819-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		204

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:204

UCSC genome browser

More...UCSCi		uc001bwo.3 human [P54819-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39945 mRNA Translation: AAC52061.1
U84371 mRNA Translation: AAB41790.1
U54645 mRNA Translation: AAC13881.1
AB005621 mRNA Translation: BAC16747.1
AB005622 mRNA Translation: BAC16748.1
AY080899 mRNA Translation: AAL87027.1
AY080900 mRNA Translation: AAL87028.1
AK291676 mRNA Translation: BAF84365.1
AK295105 mRNA Translation: BAG58139.1
AK296863 mRNA Translation: BAG59426.1
AB451267 mRNA Translation: BAG70081.1
AB451394 mRNA Translation: BAG70208.1
AL020995 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07484.1
CH471059 Genomic DNA Translation: EAX07486.1
BC009405 mRNA Translation: AAH09405.1
BC070127 mRNA Translation: AAH70127.1
BC090040 mRNA Translation: AAH90040.1
CCDSiCCDS373.1 [P54819-2]
CCDS374.1 [P54819-1]
PIRiG02248
JC5893
RefSeqiNP_001186128.1, NM_001199199.1 [P54819-5]
NP_001306068.1, NM_001319139.1
NP_001306069.1, NM_001319140.1 [P54819-6]
NP_001616.1, NM_001625.3 [P54819-1]
NP_037543.1, NM_013411.4 [P54819-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C9YX-ray2.10A1-239[»]
SMRiP54819
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi106707, 49 interactors
CORUMiP54819
IntActiP54819, 24 interactors
MINTiP54819
STRINGi9606.ENSP00000346921

Chemistry databases

BindingDBiP54819
ChEMBLiCHEMBL4938
DrugBankiDB00718 Adefovir dipivoxil
DB01717 Bis(Adenosine)-5'-Pentaphosphate
DB03366 Imidazole
DB14126 Tenofovir
DB09299 Tenofovir alafenamide
DB00300 Tenofovir disoproxil

PTM databases

iPTMnetiP54819
PhosphoSitePlusiP54819
SwissPalmiP54819

Polymorphism and mutation databases

BioMutaiAK2
DMDMi1708596

2D gel databases

OGPiP54819
REPRODUCTION-2DPAGEiIPI00218988
UCD-2DPAGEiP54819

Proteomic databases

EPDiP54819
jPOSTiP54819
MassIVEiP54819
MaxQBiP54819
PaxDbiP54819
PeptideAtlasiP54819
PRIDEiP54819
ProteomicsDBi56726 [P54819-1]
56727 [P54819-2]
56728 [P54819-3]
56729 [P54819-4]
56730 [P54819-5]
56731 [P54819-6]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		204

Genome annotation databases

EnsembliENST00000354858; ENSP00000346921; ENSG00000004455 [P54819-1]
ENST00000373449; ENSP00000362548; ENSG00000004455 [P54819-2]
GeneIDi204
KEGGihsa:204
UCSCiuc001bwo.3 human [P54819-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		204
DisGeNETi204

GeneCards: human genes, protein and diseases

More...GeneCardsi		AK2
HGNCiHGNC:362 AK2
HPAiHPA018479
MalaCardsiAK2
MIMi103020 gene
267500 phenotype
neXtProtiNX_P54819
OpenTargetsiENSG00000004455
Orphaneti33355 Reticular dysgenesis
PharmGKBiPA24656

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3078 Eukaryota
COG0563 LUCA
GeneTreeiENSGT00940000154576
InParanoidiP54819
KOiK00939
OMAiFHNRMRV
OrthoDBi1004067at2759
PhylomeDBiP54819
TreeFamiTF300896

Enzyme and pathway databases

ReactomeiR-HSA-499943 Interconversion of nucleotide di- and triphosphates

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AK2 human
EvolutionaryTraceiP54819

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		AK2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		204
PharosiP54819

Protein Ontology

More...PROi		PR:P54819

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000004455 Expressed in 216 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiP54819 baseline and differential
GenevisibleiP54819 HS

Family and domain databases

CDDicd01428 ADK, 1 hit
HAMAPiMF_00235 Adenylate_kinase_Adk, 1 hit
MF_03168 Adenylate_kinase_AK2, 1 hit
InterProiView protein in InterPro
IPR006259 Adenyl_kin_sub
IPR000850 Adenylat/UMP-CMP_kin
IPR033690 Adenylat_kinase_CS
IPR007862 Adenylate_kinase_lid-dom
IPR028587 AK2
IPR027417 P-loop_NTPase
PANTHERiPTHR23359 PTHR23359, 1 hit
PfamiView protein in Pfam
PF05191 ADK_lid, 1 hit
PRINTSiPR00094 ADENYLTKNASE
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01351 adk, 1 hit
PROSITEiView protein in PROSITE
PS00113 ADENYLATE_KINASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKAD2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54819
Secondary accession number(s): A8K6L1
, B4DHH7, B4DL64, Q16856, Q5EB54, Q5TIF7, Q8TCY2, Q8TCY3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 199 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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