UniProtKB - P54818 (GALC_MOUSE)

BLAST

>sp|P54818|GALC_MOUSE Galactocerebrosidase OS=Mus musculus OX=10090 GN=Galc PE=1 SV=2
MANSQPKASQQRQAKVMTAAAGSASRVAVPLLLCALLVPGGAYVLDDSDGLGREFDGIGA
VSGGGATSRLLVNYPEPYRSEILDYLFKPNFGASLHILKVEIGGDGQTTDGTEPSHMHYE
LDENYFRGYEWWLMKEAKKRNPDIILMGLPWSFPGWLGKGFSWPYVNLQLTAYYVVRWIL
GAKHYHDLDIDYIGIWNERPFDANYIKELRKMLDYQGLQRVRIIASDNLWEPISSSLLLD
QELWKVVDVIGAHYPGTYTVWNAKMSGKKLWSSEDFSTINSNVGAGCWSRILNQNYINGN
MTSTIAWNLVASYYEELPYGRSGLMTAQEPWSGHYVVASPIWVSAHTTQFTQPGWYYLKT
VGHLEKGGSYVALTDGLGNLTIIIETMSHQHSMCIRPYLPYYNVSHQLATFTLKGSLREI
QELQVWYTKLGTPQQRLHFKQLDTLWLLDGSGSFTLELEEDEIFTLTTLTTGRKGSYPPP
PSSKPFPTNYKDDFNVEYPLFSEAPNFADQTGVFEYYMNNEDREHRFTLRQVLNQRPITW
AADASSTISVIGDHHWTNMTVQCDVYIETPRSGGVFIAGRVNKGGILIRSATGVFFWIFA
NGSYRVTADLGGWITYASGHADVTAKRWYTLTLGIKGYFAFGMLNGTILWKNVRVKYPGH
GWAAIGTHTFEFAQFDNFRVEAAR

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History
Entry version 133 (12 Sep 2018)
Sequence version 2 (05 May 2009)
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Protein

Galactocerebrosidase

Gene

Galc

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.1 Publication

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.Curated

Catalytic activityⁱ

D-galactosyl-N-acylsphingosine + H₂O = D-galactose + N-acylsphingosine.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	109	Substrate	1
Binding siteⁱ	151	Substrate	1
Binding siteⁱ	197	Substrate	1
Active siteⁱ	198	Proton donor/acceptor1 Publication	1
Active siteⁱ	274	Nucleophile1 Publication	1
Binding siteⁱ	396	Substrate	1

GO - Molecular functionⁱ

galactosylceramidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8769874

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

galactosylceramide catabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8769874

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosidase, Hydrolase
Biological process	Lipid degradation, Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

BRENDAⁱ	3.2.1.46 3474
Reactomeⁱ	R-MMU-1660662 Glycosphingolipid metabolism

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GH59 Glycoside Hydrolase Family 59

CAZyⁱ

GH59 Glycoside Hydrolase Family 59

Chemistry databases

SwissLipidsⁱ	SLP:000001418

SwissLipidsⁱ

SLP:000001418

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Galactocerebrosidase (EC:3.2.1.46) Short name: GALCERase Alternative name(s): Galactocerebroside beta-galactosidase Galactosylceramidase Galactosylceramide beta-galactosidase
Gene namesⁱ	Name:Galc
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:95636 Galc

Keywords - Cellular componentⁱ

Lysosome

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Defects in Galc are the cause of the 'twitcher' phenotype; an autosomal recessive leukodystrophy similar to the human disease (Krabbe disease). This deficiency results in the insufficient catabolism of several galactolipids that are important in the production of normal myelin.

Chemistry databases

ChEMBLⁱ

CHEMBL2218

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 42	By similarityAdd BLAST		42
ChainⁱPRO_0000012232	43 – 684	GalactocerebrosidaseAdd BLAST		642

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	287 ↔ 394	1 Publication
Glycosylationⁱ	300	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	379	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	403	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	558	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	601	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	645	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P54818
PaxDbⁱ	P54818
PeptideAtlas More...PeptideAtlasⁱ	P54818
PRIDEⁱ	P54818

PTM databases

iPTMnetⁱ	P54818
PhosphoSitePlusⁱ	P54818

Expressionⁱ

Tissue specificityⁱ

Detected in brain and kidney.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000021003 Expressed in 242 organ(s), highest expression level in stroma of bone marrow
CleanExⁱ	MM_GALC
ExpressionAtlasⁱ	P54818 baseline and differential
Genevisibleⁱ	P54818 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000021390

STRINGⁱ

10090.ENSMUSP00000021390

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	42 – 45	Combined sources	4
Beta strandⁱ	51 – 54	Combined sources	4
Beta strandⁱ	57 – 62	Combined sources	6
Turnⁱ	67 – 73	Combined sources	7
Helixⁱ	78 – 87	Combined sources	10
Turnⁱ	89 – 91	Combined sources	3
Beta strandⁱ	96 – 102	Combined sources	7
Beta strandⁱ	105 – 107	Combined sources	3
Beta strandⁱ	109 – 112	Combined sources	4
Beta strandⁱ	127 – 129	Combined sources	3
Helixⁱ	130 – 140	Combined sources	11
Beta strandⁱ	145 – 151	Combined sources	7
Helixⁱ	155 – 158	Combined sources	4
Helixⁱ	168 – 186	Combined sources	19
Helixⁱ	203 – 215	Combined sources	13
Beta strandⁱ	222 – 228	Combined sources	7
Helixⁱ	233 – 239	Combined sources	7
Helixⁱ	241 – 246	Combined sources	6
Beta strandⁱ	249 – 254	Combined sources	6
Helixⁱ	261 – 266	Combined sources	6
Beta strandⁱ	269 – 276	Combined sources	8
Helixⁱ	282 – 299	Combined sources	18
Beta strandⁱ	303 – 307	Combined sources	5
Beta strandⁱ	309 – 311	Combined sources	3
Turnⁱ	318 – 321	Combined sources	4
Beta strandⁱ	323 – 326	Combined sources	4
Turnⁱ	330 – 332	Combined sources	3
Helixⁱ	340 – 348	Combined sources	9
Beta strandⁱ	356 – 359	Combined sources	4
Beta strandⁱ	369 – 374	Combined sources	6
Beta strandⁱ	376 – 378	Combined sources	3
Beta strandⁱ	380 – 385	Combined sources	6
Helixⁱ	389 – 391	Combined sources	3
Beta strandⁱ	395 – 397	Combined sources	3
Beta strandⁱ	407 – 413	Combined sources	7
Helixⁱ	415 – 417	Combined sources	3
Beta strandⁱ	422 – 429	Combined sources	8
Beta strandⁱ	437 – 446	Combined sources	10
Beta strandⁱ	449 – 451	Combined sources	3
Beta strandⁱ	453 – 458	Combined sources	6
Beta strandⁱ	460 – 468	Combined sources	9
Beta strandⁱ	488 – 492	Combined sources	5
Beta strandⁱ	500 – 503	Combined sources	4
Beta strandⁱ	508 – 512	Combined sources	5
Beta strandⁱ	514 – 518	Combined sources	5
Beta strandⁱ	526 – 531	Combined sources	6
Beta strandⁱ	545 – 552	Combined sources	8
Beta strandⁱ	558 – 567	Combined sources	10
Turnⁱ	570 – 572	Combined sources	3
Beta strandⁱ	574 – 581	Combined sources	8
Helixⁱ	585 – 590	Combined sources	6
Beta strandⁱ	592 – 599	Combined sources	8
Turnⁱ	600 – 602	Combined sources	3
Beta strandⁱ	603 – 609	Combined sources	7
Beta strandⁱ	614 – 620	Combined sources	7
Beta strandⁱ	628 – 636	Combined sources	9
Beta strandⁱ	639 – 644	Combined sources	6
Beta strandⁱ	647 – 654	Combined sources	8
Beta strandⁱ	662 – 670	Combined sources	9
Beta strandⁱ	673 – 683	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	P54818
SMRⁱ	P54818
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glycosyl hydrolase 59 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IITE Eukaryota ENOG410XTIS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003303
HOGENOMⁱ	HOG000068033
HOVERGENⁱ	HBG005800
InParanoidⁱ	P54818
KEGG Orthology (KO) More...KOⁱ	K01202
OMAⁱ	FWIFANG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04GY
PhylomeDBⁱ	P54818
TreeFamⁱ	TF312985

Family and domain databases

Gene3Dⁱ	3.20.20.70, 1 hit
InterProⁱ	View protein in InterPro IPR013785 Aldolase_TIM IPR001286 Glyco_hydro_59 IPR035394 Glyco_hydro_59_dom IPR017853 Glycoside_hydrolase_SF
PANTHERⁱ	PTHR15172 PTHR15172, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02057 Glyco_hydro_59, 1 hit PF17387 Glyco_hydro_59M, 1 hit
PRINTSⁱ	PR00850 GLHYDRLASE59
SUPFAMⁱ	SSF51445 SSF51445, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P54818-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MANSQPKASQ QRQAKVMTAA AGSASRVAVP LLLCALLVPG GAYVLDDSDG 
        60         70         80         90        100
LGREFDGIGA VSGGGATSRL LVNYPEPYRS EILDYLFKPN FGASLHILKV 
       110        120        130        140        150
EIGGDGQTTD GTEPSHMHYE LDENYFRGYE WWLMKEAKKR NPDIILMGLP 
       160        170        180        190        200
WSFPGWLGKG FSWPYVNLQL TAYYVVRWIL GAKHYHDLDI DYIGIWNERP 
       210        220        230        240        250
FDANYIKELR KMLDYQGLQR VRIIASDNLW EPISSSLLLD QELWKVVDVI 
       260        270        280        290        300
GAHYPGTYTV WNAKMSGKKL WSSEDFSTIN SNVGAGCWSR ILNQNYINGN 
       310        320        330        340        350
MTSTIAWNLV ASYYEELPYG RSGLMTAQEP WSGHYVVASP IWVSAHTTQF 
       360        370        380        390        400
TQPGWYYLKT VGHLEKGGSY VALTDGLGNL TIIIETMSHQ HSMCIRPYLP 
       410        420        430        440        450
YYNVSHQLAT FTLKGSLREI QELQVWYTKL GTPQQRLHFK QLDTLWLLDG 
       460        470        480        490        500
SGSFTLELEE DEIFTLTTLT TGRKGSYPPP PSSKPFPTNY KDDFNVEYPL 
       510        520        530        540        550
FSEAPNFADQ TGVFEYYMNN EDREHRFTLR QVLNQRPITW AADASSTISV 
       560        570        580        590        600
IGDHHWTNMT VQCDVYIETP RSGGVFIAGR VNKGGILIRS ATGVFFWIFA 
       610        620        630        640        650
NGSYRVTADL GGWITYASGH ADVTAKRWYT LTLGIKGYFA FGMLNGTILW 
       660        670        680 
KNVRVKYPGH GWAAIGTHTF EFAQFDNFRV EAAR

Length:684

Mass (Da):77,256

Last modified:May 5, 2009 - v2

Checksum:ⁱDD4BD45AE898C524

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A1Y7VM63	A0A1Y7VM63_MOUSE		Galactocerebrosidase Galactocerebrosidase	Galc	491	Annotation score:

Sequence cautionⁱ

The sequence AAB71823 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH86671 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAA07560 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	376	G → A in AAB71823 (Ref. 2) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D38557 mRNA Translation: BAA07560.1 Different initiation. AF003886 AF003885 Genomic DNA Translation: AAB71823.1 Different initiation. AK154760 mRNA Translation: BAE32809.1 CH466549 Genomic DNA Translation: EDL18937.1 BC086671 mRNA Translation: AAH86671.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36517.1
NCBI Reference Sequences More...RefSeqⁱ	NP_032105.2, NM_008079.4
UniGeneⁱ	Mm.5120

Genome annotation databases

Ensemblⁱ	ENSMUST00000021390; ENSMUSP00000021390; ENSMUSG00000021003
GeneIDⁱ	14420
KEGGⁱ	mmu:14420
UCSC genome browser More...UCSCⁱ	uc007olf.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P54818	Galactosylceramidase		RAT		684	UniRef90_P54818
UPI0007ED839F		MOUSE		568
UPI000A30D5B2		MUSPA		688
UPI000A31A8EA		MUSCR		684
Galactosylceramidase		RAT		668
+5

Protein	Similar proteins		Species	Score	Length	Source
P54818	Isoform 3 of Galactocerebrosidase		HUMAN		662	UniRef50_P54803-3
Galactocerebrosidase		CANLF		669
Galactocerebrosidase		XENTR		678
Galactocerebrosidase		XENLA		677
GALC isoform 5		PANTR		662
+378

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D38557 mRNA Translation: BAA07560.1 Different initiation. AF003886 AF003885 Genomic DNA Translation: AAB71823.1 Different initiation. AK154760 mRNA Translation: BAE32809.1 CH466549 Genomic DNA Translation: EDL18937.1 BC086671 mRNA Translation: AAH86671.1 Different initiation.
CCDSⁱ	CCDS36517.1
RefSeqⁱ	NP_032105.2, NM_008079.4
UniGeneⁱ	Mm.5120

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3ZR5	X-ray	2.10	A	40-684	[»]
	3ZR6	X-ray	2.44	A	40-684	[»]
	4CCC	X-ray	2.09	A	41-684	[»]
	4CCD	X-ray	1.97	A	41-684	[»]
	4CCE	X-ray	2.06	A	41-684	[»]
	4UFH	X-ray	2.16	A	41-684	[»]
	4UFI	X-ray	2.40	A	41-684	[»]
	4UFJ	X-ray	2.20	A	41-684	[»]
	4UFK	X-ray	2.40	A	43-684	[»]
	4UFL	X-ray	2.40	A	43-684	[»]
	4UFM	X-ray	2.40	A	43-684	[»]
	5NXB	X-ray	3.60	A/B	41-684	[»]
ProteinModelPortalⁱ	P54818
SMRⁱ	P54818
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000021390

STRINGⁱ

10090.ENSMUSP00000021390

Chemistry databases

ChEMBLⁱ	CHEMBL2218
SwissLipidsⁱ	SLP:000001418

Protein family/group databases

CAZyⁱ	GH59 Glycoside Hydrolase Family 59

CAZyⁱ

GH59 Glycoside Hydrolase Family 59

PTM databases

iPTMnetⁱ	P54818
PhosphoSitePlusⁱ	P54818

Proteomic databases

MaxQBⁱ	P54818
PaxDbⁱ	P54818
PeptideAtlasⁱ	P54818
PRIDEⁱ	P54818

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000021390; ENSMUSP00000021390; ENSMUSG00000021003
GeneIDⁱ	14420
KEGGⁱ	mmu:14420
UCSCⁱ	uc007olf.2 mouse

Organism-specific databases

CTDⁱ	2581
MGIⁱ	MGI:95636 Galc

Phylogenomic databases

eggNOGⁱ	ENOG410IITE Eukaryota ENOG410XTIS LUCA
GeneTreeⁱ	ENSGT00390000003303
HOGENOMⁱ	HOG000068033
HOVERGENⁱ	HBG005800
InParanoidⁱ	P54818
KOⁱ	K01202
OMAⁱ	FWIFANG
OrthoDBⁱ	EOG091G04GY
PhylomeDBⁱ	P54818
TreeFamⁱ	TF312985

Enzyme and pathway databases

BRENDAⁱ	3.2.1.46 3474
Reactomeⁱ	R-MMU-1660662 Glycosphingolipid metabolism

Miscellaneous databases

ChiTaRSⁱ	Galc mouse
Protein Ontology More...PROⁱ	PR:P54818
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000021003 Expressed in 242 organ(s), highest expression level in stroma of bone marrow
CleanExⁱ	MM_GALC
ExpressionAtlasⁱ	P54818 baseline and differential
Genevisibleⁱ	P54818 MM

Family and domain databases

Gene3Dⁱ	3.20.20.70, 1 hit
InterProⁱ	View protein in InterPro IPR013785 Aldolase_TIM IPR001286 Glyco_hydro_59 IPR035394 Glyco_hydro_59_dom IPR017853 Glycoside_hydrolase_SF
PANTHERⁱ	PTHR15172 PTHR15172, 1 hit
Pfamⁱ	View protein in Pfam PF02057 Glyco_hydro_59, 1 hit PF17387 Glyco_hydro_59M, 1 hit
PRINTSⁱ	PR00850 GLHYDRLASE59
SUPFAMⁱ	SSF51445 SSF51445, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GALC_MOUSE
Accessionⁱ	P54818Primary (citable) accession number: P54818 Secondary accession number(s): O35151, Q3U3H7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	May 5, 2009
	Last modified:	September 12, 2018
	This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P54818 (GALC_MOUSE)

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Galactocerebrosidase

Galc

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Lysosome

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ