UniProtKB - P54792 (DVLP1_HUMAN)
Protein
Putative segment polarity protein dishevelled homolog DVL1P1
Gene
DVL1P1
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in the signal transduction pathway mediated by multiple Wnt genes.
Miscellaneous
Part of that gene may be located in interstitial deletions of chromosome 22 associated with DiGeorge syndrome (DGS).
Caution
Product of a dubious gene prediction. Pizzuti et al (PubMed:8644734) identified this gene on chromosome 22, however it is not currently present in the reference genome assembly (GRCh37/hg19).1 Publication
GO - Molecular functioni
- frizzled binding Source: GO_Central
GO - Biological processi
- canonical Wnt signaling pathway Source: GO_Central
- heart development Source: BHF-UCL
- intracellular signal transduction Source: InterPro
- planar cell polarity pathway involved in neural tube closure Source: GO_Central
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | P54792 |
SIGNORi | P54792 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative segment polarity protein dishevelled homolog DVL1P1Alternative name(s): DSH homolog 1-like Segment polarity protein dishevelled homolog DVL-1-like Short name: Dishevelled-1-like |
Gene namesi | Name:DVL1P1 Synonyms:DVL, DVL1, DVL1L1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3085, DVL1P1 |
MIMi | 601225, gene |
neXtProti | NX_P54792 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Cytosol
- cytosol Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
GeneReviewsi | DVL1 |
Miscellaneous databases
Pharosi | P54792, Tdark |
Genetic variation databases
BioMutai | HGNC:3085 |
DMDMi | 1706528 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000145741 | 1 – 670 | Putative segment polarity protein dishevelled homolog DVL1P1Add BLAST | 670 |
Proteomic databases
jPOSTi | P54792 |
MassIVEi | P54792 |
MaxQBi | P54792 |
PeptideAtlasi | P54792 |
PRIDEi | P54792 |
ProteomicsDBi | 56718 [P54792-1] 56719 [P54792-2] |
PTM databases
iPTMneti | P54792 |
PhosphoSitePlusi | P54792 |
Expressioni
Tissue specificityi
Expressed in thymus, heart, liver, kidney, brain, skeletal muscle, and pancreas.1 Publication
Interactioni
Binary interactionsi
P54792
With | #Exp. | IntAct |
---|---|---|
APC [P25054] | 2 | EBI-7848109,EBI-727707 |
GO - Molecular functioni
- frizzled binding Source: GO_Central
Protein-protein interaction databases
IntActi | P54792, 6 interactors |
MINTi | P54792 |
Miscellaneous databases
RNActi | P54792, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 85 | DIXPROSITE-ProRule annotationAdd BLAST | 85 | |
Domaini | 251 – 323 | PDZPROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 400 – 474 | DEPPROSITE-ProRule annotationAdd BLAST | 75 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 221 – 224 | Poly-Arg | 4 |
Sequence similaritiesi
Belongs to the DSH family.Curated
Phylogenomic databases
InParanoidi | P54792 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 2.30.42.10, 1 hit 3.10.20.380, 1 hit |
InterProi | View protein in InterPro IPR000591, DEP_dom IPR024580, Dishevelled_C-dom IPR008339, Dishevelled_fam IPR003351, Dishevelled_protein_dom IPR001158, DIX IPR038207, DIX_dom_sf IPR015506, Dsh/Dvl-rel IPR008340, DVL-1 IPR001478, PDZ IPR036034, PDZ_sf IPR029071, Ubiquitin-like_domsf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10878, PTHR10878, 1 hit PTHR10878:SF5, PTHR10878:SF5, 1 hit |
Pfami | View protein in Pfam PF00610, DEP, 1 hit PF02377, Dishevelled, 1 hit PF00778, DIX, 1 hit PF12316, Dsh_C, 1 hit PF00595, PDZ, 1 hit |
PRINTSi | PR01760, DISHEVELLED |
SMARTi | View protein in SMART SM00021, DAX, 1 hit SM00049, DEP, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50186, DEP, 1 hit PS50841, DIX, 1 hit PS50106, PDZ, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform Long (identifier: P54792-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK
60 70 80 90 100
SMDQDFGVVK EEIFDDNAKL PCFNGRVVSW LVLVEGAHSD AGSQGTDSHT
110 120 130 140 150
DLPPPLERTG GIGDSRSPSF QPDVASSRDG MDNETGTESM VSHRRDRARR
160 170 180 190 200
RNREEAARTN GHPRGDRRRD VGLPPDSAST ALSSELESSS FVDSDEDDST
210 220 230 240 250
SRLSSSTEQS TSSRLIRKHK RRRRKQRLRQ ADRASSFSSM TDSTMSLNII
260 270 280 290 300
TVTLNMERHH FLGICIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM
310 320 330 340 350
LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTVP
360 370 380 390 400
RPDPVRPIDP AAWLSHTAAL TGALPRPQLE EAPLTVESDM NTVVRVMQLP
410 420 430 440 450
DSGLEIRDRM WLKITIANAV IGADVVDWLY THVEGFKERR EARKYASSLL
460 470 480 490 500
KHGFLRHTVN KITFSEQCYY VFGDLCSNLA TLNLNSGSSG TSDQDTLAPL
510 520 530 540 550
PHPAAPWPLG QGYPYQYPGP PPCFPPAYQD PGFSYGSGST GSQQSEGSKS
560 570 580 590 600
SGSTRNTLRP PACEKERRAA GSGDSDSESD HTAPSGVGSS WRERPADQLS
610 620 630 640 650
RGSSPRSQAS SYAPGLPPPH PTTKAYTVVG GPPGGPPVRE LAAVPPELTG
660 670
SRQSFQKAMG NPCEFFVDIM
Isoform Short (identifier: P54792-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
479-486: Missing.
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001320 | 479 – 486 | Missing in isoform Short. 1 Publication | 8 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U46461 mRNA Translation: AAC50682.1 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U46461 mRNA Translation: AAC50682.1 |
3D structure databases
SMRi | P54792 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P54792, 6 interactors |
MINTi | P54792 |
PTM databases
iPTMneti | P54792 |
PhosphoSitePlusi | P54792 |
Genetic variation databases
BioMutai | HGNC:3085 |
DMDMi | 1706528 |
Proteomic databases
jPOSTi | P54792 |
MassIVEi | P54792 |
MaxQBi | P54792 |
PeptideAtlasi | P54792 |
PRIDEi | P54792 |
ProteomicsDBi | 56718 [P54792-1] 56719 [P54792-2] |
Organism-specific databases
GeneCardsi | DVL1P1 |
GeneReviewsi | DVL1 |
HGNCi | HGNC:3085, DVL1P1 |
MIMi | 601225, gene |
neXtProti | NX_P54792 |
GenAtlasi | Search... |
Phylogenomic databases
InParanoidi | P54792 |
Enzyme and pathway databases
PathwayCommonsi | P54792 |
SIGNORi | P54792 |
Miscellaneous databases
Pharosi | P54792, Tdark |
PROi | PR:P54792 |
RNActi | P54792, protein |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 2.30.42.10, 1 hit 3.10.20.380, 1 hit |
InterProi | View protein in InterPro IPR000591, DEP_dom IPR024580, Dishevelled_C-dom IPR008339, Dishevelled_fam IPR003351, Dishevelled_protein_dom IPR001158, DIX IPR038207, DIX_dom_sf IPR015506, Dsh/Dvl-rel IPR008340, DVL-1 IPR001478, PDZ IPR036034, PDZ_sf IPR029071, Ubiquitin-like_domsf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10878, PTHR10878, 1 hit PTHR10878:SF5, PTHR10878:SF5, 1 hit |
Pfami | View protein in Pfam PF00610, DEP, 1 hit PF02377, Dishevelled, 1 hit PF00778, DIX, 1 hit PF12316, Dsh_C, 1 hit PF00595, PDZ, 1 hit |
PRINTSi | PR01760, DISHEVELLED |
SMARTi | View protein in SMART SM00021, DAX, 1 hit SM00049, DEP, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50186, DEP, 1 hit PS50841, DIX, 1 hit PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DVLP1_HUMAN | |
Accessioni | P54792Primary (citable) accession number: P54792 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | August 12, 2020 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families