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Protein

Protein ZDS2

Gene

ZDS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a negative regulator of polarized growth via an alternative mechanism to ZDS1. In heat-stressed cells appears to play a role in localizing BCY1 to the cytoplasm. Seems to interact with, and down-regulate, CDC42. Also acts as a suppressor of PKC1. May act as an integration point for distinct signaling pathways helping to maintain a balance among these different pathways.2 Publications

Miscellaneous

'ZDS' means 'zillion different screens' as both ZDS1 and ZDS2 have been found by a wide variety of genetic screens.
Present with 105 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • chromatin silencing Source: GO_Central
  • chromatin silencing at rDNA Source: SGD
  • establishment of cell polarity Source: SGD
  • positive regulation of G2/M transition of mitotic cell cycle Source: SGD
  • regulation of protein localization Source: SGD
  • replicative cell aging Source: SGD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-32692-MONOMER

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
P54786 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein ZDS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZDS2
Synonyms:MCS1
Ordered Locus Names:YML109W
ORF Names:YM8339.10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000004577 ZDS2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000665701 – 942Protein ZDS2Add BLAST942

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei50PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P54786

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P54786

PRoteomics IDEntifications database

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PRIDEi
P54786

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P54786

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P54786

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SKG6.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
35095, 105 interactors

Database of interacting proteins

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DIPi
DIP-1517N

Protein interaction database and analysis system

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IntActi
P54786, 57 interactors

Molecular INTeraction database

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MINTi
P54786

STRING: functional protein association networks

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STRINGi
4932.YML109W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P54786

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P54786

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

To yeast ZDS1/NRC1/CES1.Curated

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000176802

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000144432

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P54786

Identification of Orthologs from Complete Genome Data

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OMAi
SKFNTYK

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR040206 Zds1/2
IPR013941 ZDS1_C

The PANTHER Classification System

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PANTHERi
PTHR28089 PTHR28089, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08632 Zds_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01327 Zds_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P54786-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLMEDMQNK DGHNTVENSS GGTDSNNNIQ MRRMRKTQLS KKELFEKRKS
60 70 80 90 100
DVLIAAKSLD TEIQNVKNLK RLSIGSMDLV IDPELEFKVN SRNSYSSDSS
110 120 130 140 150
KESLQESLHE ENIIRSEQKE EQGSEDNDAY EEGDATNVDD SIDITQTEYL
160 170 180 190 200
HDEETLEKEK IIRNASSSTS SSARVTSRNR RLSGVKTLAH DVVLDVENDH
210 220 230 240 250
DSKMVDLTQN LLWVPADQHP NVKPENYLEL IQDTLQNIQI STNQDIDENK
260 270 280 290 300
LELGNNHVIS NRKRTGSVVR RPSRLKTSYT KFDDEPPLAD KPQEGEIQVD
310 320 330 340 350
KRISSSDIKT IRSVSLKEIT EELTKISNNA GLTDSDAVTL ARSLSMSGSF
360 370 380 390 400
TNESLHLNGN HTENDNEFAS NMFNETGLTI PERSSLRRSK FNTYKIRLEG
410 420 430 440 450
SSLPQAVKLN SLMNIQTNDN RRSASSPASY TQVPQEQASL NDFHEIFDHY
460 470 480 490 500
RRTSTDWSTE NEKYVDSTNY YSDEEDLTHA SISQESSLLS TDSSNNSVLI
510 520 530 540 550
KPHNTGSMIS EKLDQHVSSS EKSNTNNSEA NHGWSWLNSS NGSLNANEQT
560 570 580 590 600
YQQLTDDEDD EECVDNEKAD FVNLSVSRRA KSTKRASERI NHSKNRHSPI
610 620 630 640 650
FQIHSEEAKS VVITPSVVSS SESQPSKPTA PAVVEKKVEL PTDTQASTHK
660 670 680 690 700
KNSLEKRLAK LFKRKQHNGT CKSDVKVIKK SVKKELKKKA SHSSLSKFRK
710 720 730 740 750
SPKKKPQEAE VERPSSPTKT ITTEDIDTAS VIEPEVRSSN ASTLLPDSHT
760 770 780 790 800
SHSSEFVVET ISELDGDDSF DISGGDVNYD VEVHSSISRD TTAGLEEDIG
810 820 830 840 850
AEREDNTSPT APQISTLPPR KLTFEDVVKP DYSNAPIKFT DSAFGFPLPM
860 870 880 890 900
ITNSTVIMFD HRLGINVERA IYRLSHLKLS DPGRELRQQV LLSNFMYSYL
910 920 930 940
NLVNHTLYME QVGTGDIAFN GDSALGMMDK NDSDGTILIP DI
Length:942
Mass (Da):105,496
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1C9DD9A539E4291
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7M → V in AAB37541 (PubMed:8816438).Curated1
Sequence conflicti23T → S in AAB37541 (PubMed:8816438).Curated1
Sequence conflicti530A → P in AAB37541 (PubMed:8816438).Curated1
Sequence conflicti546A → G in AAB37541 (PubMed:8816438).Curated1
Sequence conflicti633V → A in AAB37541 (PubMed:8816438).Curated1
Sequence conflicti668N → S in AAB37541 (PubMed:8816438).Curated1
Sequence conflicti711V → VNC in AAB37541 (PubMed:8816438).Curated1
Sequence conflicti723Missing in AAB37541 (PubMed:8816438).Curated1
Sequence conflicti729A → E in AAB37541 (PubMed:8816438).Curated1
Sequence conflicti833S → P in AAB37541 (PubMed:8816438).Curated1
Sequence conflicti914 – 942TGDIA…LIPDI → HWRYSLQW in AAB37541 (PubMed:8816438).CuratedAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U32938 Genomic DNA Translation: AAB37541.1
Z49210 Genomic DNA Translation: CAA89109.1
BK006946 Genomic DNA Translation: DAA09789.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S53963

NCBI Reference Sequences

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RefSeqi
NP_013598.1, NM_001182471.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YML109W_mRNA; YML109W_mRNA; YML109W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854931

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YML109W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32938 Genomic DNA Translation: AAB37541.1
Z49210 Genomic DNA Translation: CAA89109.1
BK006946 Genomic DNA Translation: DAA09789.1
PIRiS53963
RefSeqiNP_013598.1, NM_001182471.1

3D structure databases

ProteinModelPortaliP54786
SMRiP54786
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35095, 105 interactors
DIPiDIP-1517N
IntActiP54786, 57 interactors
MINTiP54786
STRINGi4932.YML109W

Protein family/group databases

MoonDBiP54786 Predicted

PTM databases

CarbonylDBiP54786
iPTMnetiP54786

Proteomic databases

MaxQBiP54786
PaxDbiP54786
PRIDEiP54786

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML109W_mRNA; YML109W_mRNA; YML109W
GeneIDi854931
KEGGisce:YML109W

Organism-specific databases

SGDiS000004577 ZDS2

Phylogenomic databases

GeneTreeiENSGT00940000176802
HOGENOMiHOG000144432
InParanoidiP54786
OMAiSKFNTYK

Enzyme and pathway databases

BioCyciYEAST:G3O-32692-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P54786

Family and domain databases

InterProiView protein in InterPro
IPR040206 Zds1/2
IPR013941 ZDS1_C
PANTHERiPTHR28089 PTHR28089, 1 hit
PfamiView protein in Pfam
PF08632 Zds_C, 1 hit
SMARTiView protein in SMART
SM01327 Zds_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZDS2_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54786
Secondary accession number(s): D6W0H5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 16, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
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