UniProtKB - P54756 (EPHA5_HUMAN)
Ephrin type-A receptor 5
EPHA5
Functioni
Catalytic activityi
- EC:2.7.10.1PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 707 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 800 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 681 – 689 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ephrin receptor activity Source: UniProtKB
- GPI-linked ephrin receptor activity Source: UniProtKB
- transmembrane-ephrin receptor activity Source: GO_Central
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- axon guidance Source: UniProtKB
- cAMP-mediated signaling Source: UniProtKB
- ephrin receptor signaling pathway Source: UniProtKB
- hippocampus development Source: UniProtKB
- multicellular organism development Source: GO_Central
- neuron development Source: UniProtKB
- positive regulation of CREB transcription factor activity Source: UniProtKB
- positive regulation of kinase activity Source: GO_Central
- regulation of actin cytoskeleton organization Source: UniProtKB
- regulation of GTPase activity Source: UniProtKB
- regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Biological process | Neurogenesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 2681 |
PathwayCommonsi | P54756 |
Reactomei | R-HSA-2682334, EPH-Ephrin signaling R-HSA-3928663, EPHA-mediated growth cone collapse R-HSA-3928665, EPH-ephrin mediated repulsion of cells |
SignaLinki | P54756 |
SIGNORi | P54756 |
Names & Taxonomyi
Protein namesi | Recommended name: Ephrin type-A receptor 5 (EC:2.7.10.1)Alternative name(s): Brain-specific kinase EPH homology kinase 1 Short name: EHK-1 EPH-like kinase 7 Short name: EK7 Short name: hEK7 |
Gene namesi | Name:EPHA5 Synonyms:BSK, EHK1, HEK7, TYRO4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000145242.13 |
HGNCi | HGNC:3389, EPHA5 |
MIMi | 600004, gene |
neXtProti | NX_P54756 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
Other locations
Endoplasmic reticulum
- rough endoplasmic reticulum Source: UniProtKB
Plasma Membrane
- external side of plasma membrane Source: UniProtKB
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- axon Source: UniProtKB
- dendrite Source: UniProtKB
- neuron projection Source: GO_Central
- neuronal cell body Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 573 | ExtracellularSequence analysisAdd BLAST | 549 | |
Transmembranei | 574 – 594 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 595 – 1037 | CytoplasmicSequence analysisAdd BLAST | 443 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 2044 |
OpenTargetsi | ENSG00000145242 |
PharmGKBi | PA27821 |
Miscellaneous databases
Pharosi | P54756, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3987 |
DrugBanki | DB01254, Dasatinib DB12010, Fostamatinib |
DrugCentrali | P54756 |
GuidetoPHARMACOLOGYi | 1825 |
Polymorphism and mutation databases
BioMutai | EPHA5 |
DMDMi | 259016353 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000016812 | 25 – 1037 | Ephrin type-A receptor 5Add BLAST | 1013 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 264 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 299 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 369 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 423 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 436 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 461 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 650 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 656 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 833 | Phosphotyrosine; by autocatalysisSequence analysis | 1 | |
Modified residuei | 982 | Phosphotyrosine; by autocatalysisBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | P54756 |
jPOSTi | P54756 |
MassIVEi | P54756 |
MaxQBi | P54756 |
PaxDbi | P54756 |
PeptideAtlasi | P54756 |
PRIDEi | P54756 |
ProteomicsDBi | 56712 [P54756-1] 56713 [P54756-2] 56714 [P54756-3] |
TopDownProteomicsi | P54756-2 [P54756-2] |
PTM databases
GlyGeni | P54756, 7 sites |
iPTMneti | P54756 |
PhosphoSitePlusi | P54756 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000145242, Expressed in subventricular zone (outer) (primate) and 113 other tissues |
ExpressionAtlasi | P54756, baseline and differential |
Genevisiblei | P54756, HS |
Organism-specific databases
HPAi | ENSG00000145242, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).
Interacts (via SAM domain) with SAMD5 (via SAM domain) (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 108358, 9 interactors |
IntActi | P54756, 6 interactors |
MINTi | P54756 |
STRINGi | 9606.ENSP00000480763 |
Chemistry databases
BindingDBi | P54756 |
Miscellaneous databases
RNActi | P54756, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P54756 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P54756 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 60 – 238 | Eph LBDPROSITE-ProRule annotationAdd BLAST | 179 | |
Domaini | 357 – 467 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 111 | |
Domaini | 468 – 562 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 675 – 936 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 262 | |
Domaini | 965 – 1029 | SAMPROSITE-ProRule annotationAdd BLAST | 65 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1035 – 1037 | PDZ-bindingSequence analysis | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 220 – 354 | Cys-richAdd BLAST | 135 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0196, Eukaryota |
GeneTreei | ENSGT00940000156266 |
HOGENOMi | CLU_000288_141_4_1 |
InParanoidi | P54756 |
OrthoDBi | 933071at2759 |
PhylomeDBi | P54756 |
TreeFami | TF315608 |
Family and domain databases
CDDi | cd10483, EphR_LBD_A5, 1 hit cd00063, FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.120.260, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936, Eph_TM IPR034277, EphA5_rcpt_lig-bd IPR001090, Ephrin_rcpt_lig-bd_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR008979, Galactose-bd-like_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR011641, Tyr-kin_ephrin_A/B_rcpt-like IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016257, Tyr_kinase_ephrin_rcpt IPR001426, Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF01404, Ephrin_lbd, 1 hit PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF00536, SAM_1, 1 hit |
PIRSFi | PIRSF000666, TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00615, EPH_lbd, 1 hit SM01411, Ephrin_rec_like, 1 hit SM00060, FN3, 2 hits SM00454, SAM, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF49785, SSF49785, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01186, EGF_2, 1 hit PS51550, EPH_LBD, 1 hit PS50853, FN3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit PS00791, RECEPTOR_TYR_KIN_V_2, 1 hit PS50105, SAM_DOMAIN, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRGSGPRGAG RRRPPSGGGD TPITPASLAG CYSAPRRAPL WTCLLLCAAL
60 70 80 90 100
RTLLASPSNE VNLLDSRTVM GDLGWIAFPK NGWEEIGEVD ENYAPIHTYQ
110 120 130 140 150
VCKVMEQNQN NWLLTSWISN EGASRIFIEL KFTLRDCNSL PGGLGTCKET
160 170 180 190 200
FNMYYFESDD QNGRNIKENQ YIKIDTIAAD ESFTELDLGD RVMKLNTEVR
210 220 230 240 250
DVGPLSKKGF YLAFQDVGAC IALVSVRVYY KKCPSVVRHL AVFPDTITGA
260 270 280 290 300
DSSQLLEVSG SCVNHSVTDE PPKMHCSAEG EWLVPIGKCM CKAGYEEKNG
310 320 330 340 350
TCQVCRPGFF KASPHIQSCG KCPPHSYTHE EASTSCVCEK DYFRRESDPP
360 370 380 390 400
TMACTRPPSA PRNAISNVNE TSVFLEWIPP ADTGGRKDVS YYIACKKCNS
410 420 430 440 450
HAGVCEECGG HVRYLPRQSG LKNTSVMMVD LLAHTNYTFE IEAVNGVSDL
460 470 480 490 500
SPGARQYVSV NVTTNQAAPS PVTNVKKGKI AKNSISLSWQ EPDRPNGIIL
510 520 530 540 550
EYEIKYFEKD QETSYTIIKS KETTITAEGL KPASVYVFQI RARTAAGYGV
560 570 580 590 600
FSRRFEFETT PVFAASSDQS QIPVIAVSVT VGVILLAVVI GVLLSGSCCE
610 620 630 640 650
CGCGRASSLC AVAHPSLIWR CGYSKAKQDP EEEKMHFHNG HIKLPGVRTY
660 670 680 690 700
IDPHTYEDPN QAVHEFAKEI EASCITIERV IGAGEFGEVC SGRLKLPGKR
710 720 730 740 750
ELPVAIKTLK VGYTEKQRRD FLGEASIMGQ FDHPNIIHLE GVVTKSKPVM
760 770 780 790 800
IVTEYMENGS LDTFLKKNDG QFTVIQLVGM LRGISAGMKY LSDMGYVHRD
810 820 830 840 850
LAARNILINS NLVCKVSDFG LSRVLEDDPE AAYTTRGGKI PIRWTAPEAI
860 870 880 890 900
AFRKFTSASD VWSYGIVMWE VVSYGERPYW EMTNQDVIKA VEEGYRLPSP
910 920 930 940 950
MDCPAALYQL MLDCWQKERN SRPKFDEIVN MLDKLIRNPS SLKTLVNASC
960 970 980 990 1000
RVSNLLAEHS PLGSGAYRSV GEWLEAIKMG RYTEIFMENG YSSMDAVAQV
1010 1020 1030
TLEDLRRLGV TLVGHQKKIM NSLQEMKVQL VNGMVPL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7ZKJ3 | B7ZKJ3_HUMAN | Receptor protein-tyrosine kinase | EPHA5 hCG_1810817 | 1,038 | Annotation score: | ||
B7ZKW7 | B7ZKW7_HUMAN | Receptor protein-tyrosine kinase | EPHA5 | 1,016 | Annotation score: | ||
F8VP57 | F8VP57_HUMAN | Receptor protein-tyrosine kinase | EPHA5 | 1,004 | Annotation score: | ||
F8W9W0 | F8W9W0_HUMAN | Receptor protein-tyrosine kinase | EPHA5 | 874 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 | R → H in CAA64700 (PubMed:9191074).Curated | 1 | |
Sequence conflicti | 87 | G → D in CAD97914 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 506 | Y → H in CAA64700 (PubMed:9191074).Curated | 1 | |
Sequence conflicti | 611 | A → V in CAD97914 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 616 | S → I in CAA64700 (PubMed:9191074).Curated | 1 | |
Sequence conflicti | 820 | G → E in CAD97914 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042138 | 81 | N → T1 PublicationCorresponds to variant dbSNP:rs33932471Ensembl. | 1 | |
Natural variantiVAR_042139 | 235 | S → A1 PublicationCorresponds to variant dbSNP:rs55710198Ensembl. | 1 | |
Natural variantiVAR_042140 | 330 | E → Q1 PublicationCorresponds to variant dbSNP:rs56205382Ensembl. | 1 | |
Natural variantiVAR_042141 | 417 | R → Q in a lung adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs199614818Ensembl. | 1 | |
Natural variantiVAR_042142 | 503 | E → K in a lung large cell carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_045912 | 506 | Y → C1 PublicationCorresponds to variant dbSNP:rs56074660Ensembl. | 1 | |
Natural variantiVAR_042143 | 582 | G → E in a lung adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1057520012EnsemblClinVar. | 1 | |
Natural variantiVAR_042144 | 672 | A → T1 PublicationCorresponds to variant dbSNP:rs36050417Ensembl. | 1 | |
Natural variantiVAR_042145 | 673 | S → T1 PublicationCorresponds to variant dbSNP:rs56359290EnsemblClinVar. | 1 | |
Natural variantiVAR_042146 | 856 | T → I in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_042147 | 959 | H → R1 PublicationCorresponds to variant dbSNP:rs56312931Ensembl. | 1 | |
Natural variantiVAR_042148 | 1032 | N → S in a lung large cell carcinoma sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039118 | 1 – 69 | Missing in isoform 3. 1 PublicationAdd BLAST | 69 | |
Alternative sequenceiVSP_039119 | 563 | F → SV in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_002999 | 597 – 619 | SCCEC…PSLIW → R in isoform 2. CuratedAdd BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X95425 mRNA Translation: CAA64700.1 AC018683 Genomic DNA No translation available. AC104137 Genomic DNA No translation available. AC105923 Genomic DNA No translation available. AC115223 Genomic DNA No translation available. BX537946 mRNA Translation: CAD97914.1 L36644 mRNA Translation: AAA74245.1 |
CCDSi | CCDS3513.1 [P54756-1] CCDS3514.1 [P54756-2] |
RefSeqi | NP_001268694.1, NM_001281765.2 NP_001268695.1, NM_001281766.2 NP_001305690.1, NM_001318761.1 [P54756-3] NP_004430.4, NM_004439.7 [P54756-1] NP_872272.2, NM_182472.4 [P54756-2] |
Genome annotation databases
Ensembli | ENST00000273854; ENSP00000273854; ENSG00000145242 [P54756-1] ENST00000354839; ENSP00000346899; ENSG00000145242 [P54756-2] |
GeneIDi | 2044 |
KEGGi | hsa:2044 |
UCSCi | uc003hcy.5, human [P54756-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X95425 mRNA Translation: CAA64700.1 AC018683 Genomic DNA No translation available. AC104137 Genomic DNA No translation available. AC105923 Genomic DNA No translation available. AC115223 Genomic DNA No translation available. BX537946 mRNA Translation: CAD97914.1 L36644 mRNA Translation: AAA74245.1 |
CCDSi | CCDS3513.1 [P54756-1] CCDS3514.1 [P54756-2] |
RefSeqi | NP_001268694.1, NM_001281765.2 NP_001268695.1, NM_001281766.2 NP_001305690.1, NM_001318761.1 [P54756-3] NP_004430.4, NM_004439.7 [P54756-1] NP_872272.2, NM_182472.4 [P54756-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2R2P | X-ray | 2.40 | A | 653-939 | [»] | |
4ET7 | X-ray | 2.60 | A | 59-235 | [»] | |
SMRi | P54756 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108358, 9 interactors |
IntActi | P54756, 6 interactors |
MINTi | P54756 |
STRINGi | 9606.ENSP00000480763 |
Chemistry databases
BindingDBi | P54756 |
ChEMBLi | CHEMBL3987 |
DrugBanki | DB01254, Dasatinib DB12010, Fostamatinib |
DrugCentrali | P54756 |
GuidetoPHARMACOLOGYi | 1825 |
PTM databases
GlyGeni | P54756, 7 sites |
iPTMneti | P54756 |
PhosphoSitePlusi | P54756 |
Polymorphism and mutation databases
BioMutai | EPHA5 |
DMDMi | 259016353 |
Proteomic databases
EPDi | P54756 |
jPOSTi | P54756 |
MassIVEi | P54756 |
MaxQBi | P54756 |
PaxDbi | P54756 |
PeptideAtlasi | P54756 |
PRIDEi | P54756 |
ProteomicsDBi | 56712 [P54756-1] 56713 [P54756-2] 56714 [P54756-3] |
TopDownProteomicsi | P54756-2 [P54756-2] |
Protocols and materials databases
ABCDi | P54756, 4 sequenced antibodies |
Antibodypediai | 12603, 515 antibodies |
Genome annotation databases
Ensembli | ENST00000273854; ENSP00000273854; ENSG00000145242 [P54756-1] ENST00000354839; ENSP00000346899; ENSG00000145242 [P54756-2] |
GeneIDi | 2044 |
KEGGi | hsa:2044 |
UCSCi | uc003hcy.5, human [P54756-1] |
Organism-specific databases
CTDi | 2044 |
DisGeNETi | 2044 |
EuPathDBi | HostDB:ENSG00000145242.13 |
GeneCardsi | EPHA5 |
HGNCi | HGNC:3389, EPHA5 |
HPAi | ENSG00000145242, Tissue enhanced (brain) |
MIMi | 600004, gene |
neXtProti | NX_P54756 |
OpenTargetsi | ENSG00000145242 |
PharmGKBi | PA27821 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0196, Eukaryota |
GeneTreei | ENSGT00940000156266 |
HOGENOMi | CLU_000288_141_4_1 |
InParanoidi | P54756 |
OrthoDBi | 933071at2759 |
PhylomeDBi | P54756 |
TreeFami | TF315608 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 2681 |
PathwayCommonsi | P54756 |
Reactomei | R-HSA-2682334, EPH-Ephrin signaling R-HSA-3928663, EPHA-mediated growth cone collapse R-HSA-3928665, EPH-ephrin mediated repulsion of cells |
SignaLinki | P54756 |
SIGNORi | P54756 |
Miscellaneous databases
BioGRID-ORCSi | 2044, 6 hits in 875 CRISPR screens |
ChiTaRSi | EPHA5, human |
EvolutionaryTracei | P54756 |
GeneWikii | EPH_receptor_A5 |
GenomeRNAii | 2044 |
Pharosi | P54756, Tchem |
PROi | PR:P54756 |
RNActi | P54756, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000145242, Expressed in subventricular zone (outer) (primate) and 113 other tissues |
ExpressionAtlasi | P54756, baseline and differential |
Genevisiblei | P54756, HS |
Family and domain databases
CDDi | cd10483, EphR_LBD_A5, 1 hit cd00063, FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.120.260, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936, Eph_TM IPR034277, EphA5_rcpt_lig-bd IPR001090, Ephrin_rcpt_lig-bd_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR008979, Galactose-bd-like_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR011641, Tyr-kin_ephrin_A/B_rcpt-like IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016257, Tyr_kinase_ephrin_rcpt IPR001426, Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF01404, Ephrin_lbd, 1 hit PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF00536, SAM_1, 1 hit |
PIRSFi | PIRSF000666, TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00615, EPH_lbd, 1 hit SM01411, Ephrin_rec_like, 1 hit SM00060, FN3, 2 hits SM00454, SAM, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF49785, SSF49785, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01186, EGF_2, 1 hit PS51550, EPH_LBD, 1 hit PS50853, FN3, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit PS00791, RECEPTOR_TYR_KIN_V_2, 1 hit PS50105, SAM_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EPHA5_HUMAN | |
Accessioni | P54756Primary (citable) accession number: P54756 Secondary accession number(s): Q7Z3F2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | September 22, 2009 | |
Last modified: | December 2, 2020 | |
This is version 205 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human and mouse protein kinases
Human and mouse protein kinases: classification and index