UniProtKB - P54754 (EPHB3_MOUSE)

BLAST

>sp|P54754|EPHB3_MOUSE Ephrin type-B receptor 3 OS=Mus musculus OX=10090 GN=Ephb3 PE=1 SV=2
MAGARPPPGLLPLLAPLLLPLLLPAGCWALEETLMDTKWVTSELAWTSHPESGWEEVSGY
DEAMNPIRTYQVCNVRESSQNNWLRTGFIWRREVQRVYVELKFTVRDCNSIPNIPGSCKE
TFNLFYYEADSDVASASSPFWMENPYVKVDTIAPDESFSRLDAGRVNTKVRSFGPLSKAG
FYLAFQDQGACMSLISVRAFYKKCASTTAGFALFPETLTGAEPTSLVIAPGTCIANAVEV
SVPLKLYCNGDGEWMVPVGACTCATGHEPAAKESQCRACPPGSYKAKQGEGPCLPCPPNS
RTTSPAASICTCHNNFYRADSDSADSACTTVPSPPRGVISNVNETSLILEWSEPRDLGGR
DDLLYNVICKKCRGSSGAGGPATCSRCDDNVEFVPRQLGLTERRVHISHLLAHTRYTFEV
QAVNGVSGKSPLPPRYAAVNITTNQAAPSEVPTLHLHSSSGSSLTLSWAPPERPNGVILD
YEMKYFEKSKGIASTVTSQKNSVQLDGLQPDARYVVQVRARTVAGYGQYSHPAEFETTSE
RGSGAQQLQEQLPLIVGSTVAGFVFMVVVVVIALVCLRKQRHGPDAEYTEKLQQYIAPGM
KVYIDPFTYEDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKLPGRREVFVAIK
TLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRL
NDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLED
DPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQ
DVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNAASLKVT
ASAPSGMSQPLLDRTVPDYTTFTTVGDWLDAIKMGRYKESFVGAGFASFDLVAQMTAEDL
LRIGVTLAGHQKKILCSIQDMRLQMNQTLPVQV

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History
Entry version 174 (07 Nov 2018)
Sequence version 2 (27 Jul 2011)
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Protein

Ephrin type-B receptor 3

Gene

Ephb3

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.6 Publications

Catalytic activityⁱ

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	660	ATPPROSITE-ProRule annotation		1
Active siteⁱ	753	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	634 – 642	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
axon guidance receptor activity
Source: MGI
Inferred from direct assayⁱ
- 11532925
ephrin receptor activity Source: UniProtKB
protein tyrosine kinase activity Source: MGI
transmembrane-ephrin receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transmembrane receptor protein tyrosine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transmembrane signaling receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9990854
axonal fasciculation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8947026
axon guidance
Source: MGI
Inferred from direct assayⁱ
- 11532925
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell migration
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12408869
central nervous system projection neuron axonogenesis
Source: MGI
Inferred from direct assayⁱ
- 12971893
corpus callosum development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8947026
dendritic spine development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 14691139
dendritic spine morphogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 14691139
digestive tract morphogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12408869
ephrin receptor signaling pathway Source: UniProtKB
negative regulation of apoptotic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of ERK1 and ERK2 cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of synapse assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 14691139
protein autophosphorylation Source: UniProtKB
regulation of axonogenesis
Source: UniProtKB
Inferred from direct assayⁱ
- 17719550
regulation of cell-cell adhesion Source: UniProtKB
regulation of GTPase activity Source: UniProtKB
retinal ganglion cell axon guidance
Source: MGI
Inferred from direct assayⁱ
- 12971893
roof of mouth development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8947026
substrate adhesion-dependent cell spreading Source: UniProtKB
thymus development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19598115
urogenital system development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15223334

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological process	Angiogenesis, Neurogenesis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.10.1 3474
Reactomeⁱ	R-MMU-2682334 EPH-Ephrin signaling R-MMU-3928662 EPHB-mediated forward signaling R-MMU-3928664 Ephrin signaling R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ephrin type-B receptor 3 (EC:2.7.10.1) Alternative name(s): Developmental kinase 5 Short name: mDK-5 Tyrosine-protein kinase receptor SEK-4
Gene namesⁱ	Name:Ephb3 Synonyms:Etk2, Mdk5, Sek4
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 16

Organism-specific databases

MGIⁱ	MGI:104770 Ephb3

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	30 – 554	ExtracellularSequence analysisAdd BLAST	525
Transmembraneⁱ	555 – 575	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	576 – 993	CytoplasmicSequence analysisAdd BLAST	418

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice are viable and fertile and show no obvious abnormal behavior. The corpus callosum, the main axon tract connecting the left and right cerebral hemispheres, is not formed in a significant fraction of newborns. This is associated with defects in guidance of callosal axons across the midline.1 Publication

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1832

GuidetoPHARMACOLOGYⁱ

1832

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 29	Sequence analysisAdd BLAST		29
ChainⁱPRO_0000016832	30 – 993	Ephrin type-B receptor 3Add BLAST		964

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	73 ↔ 191	By similarity
Glycosylationⁱ	343	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	440	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	609	Phosphotyrosine; by autocatalysisBy similarity	1

Post-translational modificationⁱ

Phosphorylated. Autophosphorylates upon ligand-binding. Autophosphorylation on Tyr-609 is required for interaction with SH2 domain-containing proteins (By similarity).By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P54754
PaxDbⁱ	P54754
PeptideAtlas More...PeptideAtlasⁱ	P54754
PRIDEⁱ	P54754

PTM databases

iPTMnetⁱ	P54754
PhosphoSitePlusⁱ	P54754

Expressionⁱ

Tissue specificityⁱ

Expressed in cells of the retinal ganglion cell layer during retinal axon guidance to the optic disk. Expressed by Paneth and progenitor cells in the crypts of the intestinal epithelium (at protein level). Expressed in myogenic progenitor cells (PubMed:27446912).3 Publications

Developmental stageⁱ

Expressed during development in yolk sacs and by embryonic endothelial cells. Expressed in the developing intestinal epithelium at the bottom of the intervillus pockets where undifferentiated cells are allocated (at protein level). In myogenic progenitor cells, highly expressed during early development (E11.5) and progressively repressed as developments proceeds (PubMed:27446912).3 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000005958 Expressed in 260 organ(s), highest expression level in membranous labyrinth
CleanExⁱ	MM_EPHB3
ExpressionAtlasⁱ	P54754 baseline and differential
Genevisibleⁱ	P54754 MM

Interactionⁱ

Subunit structureⁱ

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).By similarity

Protein-protein interaction databases

BioGridⁱ	199477, 4 interactors
STRINGⁱ	10090.ENSMUSP00000006112

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P54754
SMRⁱ	P54754
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	31 – 209	Eph LBDPROSITE-ProRule annotationAdd BLAST	179
Domainⁱ	331 – 446	Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST	116
Domainⁱ	447 – 540	Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST	94
Domainⁱ	628 – 891	Protein kinasePROSITE-ProRule annotationAdd BLAST	264
Domainⁱ	920 – 984	SAMPROSITE-ProRule annotationAdd BLAST	65

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	991 – 993	PDZ-bindingSequence analysis		3

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	191 – 328	Cys-richAdd BLAST		138

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0196 Eukaryota COG0515 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118975
HOGENOMⁱ	HOG000233856
HOVERGENⁱ	HBG062180
InParanoidⁱ	P54754
KEGG Orthology (KO) More...KOⁱ	K05112
OMAⁱ	KKCSVER
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00W0
TreeFamⁱ	TF315608

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10478 EphR_LBD_B3, 1 hit cd00063 FN3, 2 hits
Gene3Dⁱ	2.60.120.260, 1 hit 2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR027936 Eph_TM IPR034245 EphB3_rcpt_lig-bd IPR001090 Ephrin_rcpt_lig-bd_dom IPR003961 FN3_dom IPR036116 FN3_sf IPR008979 Galactose-bd-like_sf IPR013783 Ig-like_fold IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001660 SAM IPR013761 SAM/pointed_sf IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR011641 Tyr-kin_ephrin_A/B_rcpt-like IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR016257 Tyr_kinase_ephrin_rcpt IPR001426 Tyr_kinase_rcpt_V_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14575 EphA2_TM, 1 hit PF01404 Ephrin_lbd, 1 hit PF07699 Ephrin_rec_like, 1 hit PF00041 fn3, 2 hits PF07714 Pkinase_Tyr, 1 hit PF00536 SAM_1, 1 hit
PIRSFⁱ	PIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSⁱ	PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00615 EPH_lbd, 1 hit SM01411 Ephrin_rec_like, 1 hit SM00060 FN3, 2 hits SM00454 SAM, 1 hit SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF47769 SSF47769, 1 hit SSF49265 SSF49265, 1 hit SSF49785 SSF49785, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51550 EPH_LBD, 1 hit PS50853 FN3, 2 hits PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit PS50105 SAM_DOMAIN, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

P54754-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGARPPPGL LPLLAPLLLP LLLPAGCWAL EETLMDTKWV TSELAWTSHP 
        60         70         80         90        100
ESGWEEVSGY DEAMNPIRTY QVCNVRESSQ NNWLRTGFIW RREVQRVYVE 
       110        120        130        140        150
LKFTVRDCNS IPNIPGSCKE TFNLFYYEAD SDVASASSPF WMENPYVKVD 
       160        170        180        190        200
TIAPDESFSR LDAGRVNTKV RSFGPLSKAG FYLAFQDQGA CMSLISVRAF 
       210        220        230        240        250
YKKCASTTAG FALFPETLTG AEPTSLVIAP GTCIANAVEV SVPLKLYCNG 
       260        270        280        290        300
DGEWMVPVGA CTCATGHEPA AKESQCRACP PGSYKAKQGE GPCLPCPPNS 
       310        320        330        340        350
RTTSPAASIC TCHNNFYRAD SDSADSACTT VPSPPRGVIS NVNETSLILE 
       360        370        380        390        400
WSEPRDLGGR DDLLYNVICK KCRGSSGAGG PATCSRCDDN VEFVPRQLGL 
       410        420        430        440        450
TERRVHISHL LAHTRYTFEV QAVNGVSGKS PLPPRYAAVN ITTNQAAPSE 
       460        470        480        490        500
VPTLHLHSSS GSSLTLSWAP PERPNGVILD YEMKYFEKSK GIASTVTSQK 
       510        520        530        540        550
NSVQLDGLQP DARYVVQVRA RTVAGYGQYS HPAEFETTSE RGSGAQQLQE 
       560        570        580        590        600
QLPLIVGSTV AGFVFMVVVV VIALVCLRKQ RHGPDAEYTE KLQQYIAPGM 
       610        620        630        640        650
KVYIDPFTYE DPNEAVREFA KEIDVSCVKI EEVIGAGEFG EVCRGRLKLP 
       660        670        680        690        700
GRREVFVAIK TLKVGYTERQ RRDFLSEASI MGQFDHPNII RLEGVVTKSR 
       710        720        730        740        750
PVMILTEFME NCALDSFLRL NDGQFTVIQL VGMLRGIAAG MKYLSEMNYV 
       760        770        780        790        800
HRDLAARNIL VNSNLVCKVS DFGLSRFLED DPSDPTYTSS LGGKIPIRWT 
       810        820        830        840        850
APEAIAYRKF TSASDVWSYG IVMWEVMSYG ERPYWDMSNQ DVINAVEQDY 
       860        870        880        890        900
RLPPPMDCPT ALHQLMLDCW VRDRNLRPKF SQIVNTLDKL IRNAASLKVT 
       910        920        930        940        950
ASAPSGMSQP LLDRTVPDYT TFTTVGDWLD AIKMGRYKES FVGAGFASFD 
       960        970        980        990 
LVAQMTAEDL LRIGVTLAGH QKKILCSIQD MRLQMNQTLP VQV

Length:993

Mass (Da):109,662

Last modified:July 27, 2011 - v2

Checksum:ⁱ07C6EF2AC98AE1B4

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E0CYA3	E0CYA3_MOUSE	Ephrin type-B receptor 3 Ephrin type-B receptor 3	Ephb3	739	Annotation score:
A0A338P6E0	A0A338P6E0_MOUSE	Ephrin type-B receptor 3 Ephrin type-B receptor 3	Ephb3	191	Annotation score:
A0A338P6F1	A0A338P6F1_MOUSE	Ephrin type-B receptor 3 Ephrin type-B receptor 3	Ephb3	79	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	200 – 201	FY → GD in CAA88910 (PubMed:7478528).Curated	2
Sequence conflictⁱ	331	V → E in CAA88910 (PubMed:7478528).Curated	1
Sequence conflictⁱ	567	V → M in CAA88910 (PubMed:7478528).Curated	1
Sequence conflictⁱ	719	R → Q in CAA53599 (PubMed:7947319).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z49086 mRNA Translation: CAA88910.1 BC014822 mRNA Translation: AAH14822.1 BC053085 mRNA Translation: AAH53085.1 X76012 mRNA Translation: CAA53599.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS28060.1
PIRⁱ	I48653 I48761
NCBI Reference Sequences More...RefSeqⁱ	NP_034273.1, NM_010143.1
UniGeneⁱ	Mm.6972

Genome annotation databases

Ensemblⁱ	ENSMUST00000006112; ENSMUSP00000006112; ENSMUSG00000005958
GeneIDⁱ	13845
KEGGⁱ	mmu:13845
UCSC genome browser More...UCSCⁱ	uc007yrg.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P54754	Ephrin type-B receptor 3		MOUSE		739	UniRef100_P54754

Protein	Similar proteins		Species	Score	Length	Source
P54754	Ephrin type-B receptor 3	)	HUMAN		998	UniRef90_P54753
EPH receptor B3		GORGO		956
Ephrin type-B receptor 3		PTEAL		1124
Ephrin type-B receptor 1-like protein		CASCN		171
Ephrin type-B receptor 3 (Fragment)		MACMU		104
+191

Protein	Similar proteins		Species	Score	Length	Source
P54754	Ephrin type-B receptor 1	)	HUMAN		984	UniRef50_P54762
Ephrin type-B receptor 1		MOUSE		984
Ephrin type-B receptor 1		RAT		984
Ephrin type-B receptor 1-B (Fragment)		XENLA		902
Ephrin type-B receptor 2	)	CHICK		1004
+1198

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z49086 mRNA Translation: CAA88910.1 BC014822 mRNA Translation: AAH14822.1 BC053085 mRNA Translation: AAH53085.1 X76012 mRNA Translation: CAA53599.1
CCDSⁱ	CCDS28060.1
PIRⁱ	I48653 I48761
RefSeqⁱ	NP_034273.1, NM_010143.1
UniGeneⁱ	Mm.6972

3D structure databases

ProteinModelPortalⁱ	P54754
SMRⁱ	P54754
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199477, 4 interactors
STRINGⁱ	10090.ENSMUSP00000006112

Chemistry databases

GuidetoPHARMACOLOGYⁱ	1832

GuidetoPHARMACOLOGYⁱ

1832

PTM databases

iPTMnetⁱ	P54754
PhosphoSitePlusⁱ	P54754

Proteomic databases

MaxQBⁱ	P54754
PaxDbⁱ	P54754
PeptideAtlasⁱ	P54754
PRIDEⁱ	P54754

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000006112; ENSMUSP00000006112; ENSMUSG00000005958
GeneIDⁱ	13845
KEGGⁱ	mmu:13845
UCSCⁱ	uc007yrg.1 mouse

Organism-specific databases

CTDⁱ	2049
MGIⁱ	MGI:104770 Ephb3

Phylogenomic databases

eggNOGⁱ	KOG0196 Eukaryota COG0515 LUCA
GeneTreeⁱ	ENSGT00760000118975
HOGENOMⁱ	HOG000233856
HOVERGENⁱ	HBG062180
InParanoidⁱ	P54754
KOⁱ	K05112
OMAⁱ	KKCSVER
OrthoDBⁱ	EOG091G00W0
TreeFamⁱ	TF315608

Enzyme and pathway databases

BRENDAⁱ	2.7.10.1 3474
Reactomeⁱ	R-MMU-2682334 EPH-Ephrin signaling R-MMU-3928662 EPHB-mediated forward signaling R-MMU-3928664 Ephrin signaling R-MMU-3928665 EPH-ephrin mediated repulsion of cells

Miscellaneous databases

ChiTaRSⁱ	Ephb3 mouse
Protein Ontology More...PROⁱ	PR:P54754
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000005958 Expressed in 260 organ(s), highest expression level in membranous labyrinth
CleanExⁱ	MM_EPHB3
ExpressionAtlasⁱ	P54754 baseline and differential
Genevisibleⁱ	P54754 MM

Family and domain databases

CDDⁱ	cd10478 EphR_LBD_B3, 1 hit cd00063 FN3, 2 hits
Gene3Dⁱ	2.60.120.260, 1 hit 2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR027936 Eph_TM IPR034245 EphB3_rcpt_lig-bd IPR001090 Ephrin_rcpt_lig-bd_dom IPR003961 FN3_dom IPR036116 FN3_sf IPR008979 Galactose-bd-like_sf IPR013783 Ig-like_fold IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001660 SAM IPR013761 SAM/pointed_sf IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR011641 Tyr-kin_ephrin_A/B_rcpt-like IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR016257 Tyr_kinase_ephrin_rcpt IPR001426 Tyr_kinase_rcpt_V_CS
Pfamⁱ	View protein in Pfam PF14575 EphA2_TM, 1 hit PF01404 Ephrin_lbd, 1 hit PF07699 Ephrin_rec_like, 1 hit PF00041 fn3, 2 hits PF07714 Pkinase_Tyr, 1 hit PF00536 SAM_1, 1 hit
PIRSFⁱ	PIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSⁱ	PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00615 EPH_lbd, 1 hit SM01411 Ephrin_rec_like, 1 hit SM00060 FN3, 2 hits SM00454 SAM, 1 hit SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF47769 SSF47769, 1 hit SSF49265 SSF49265, 1 hit SSF49785 SSF49785, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51550 EPH_LBD, 1 hit PS50853 FN3, 2 hits PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit PS50105 SAM_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EPHB3_MOUSE
Accessionⁱ	P54754Primary (citable) accession number: P54754 Secondary accession number(s): Q62214, Q91YS9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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Annotation systems

Supporting data

UniProtKB - P54754 (EPHB3_MOUSE)

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Ephrin type-B receptor 3

Ephb3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ