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UniProtKB - P54733 (CCNE_DROME)

Entry version 183 (23 Feb 2022)
Sequence version 2 (01 Dec 2000)
Previous versions | rss
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Protein

G1/S-specific cyclin-E

Gene

CycE

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the control of the cell cycle at the G1/S (start) transition. Targeted by archipelago for degradation by the SFC ubiquitin ligase complex.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-1538133, G0 and Early G1
R-DME-187577, SCF(Skp2)-mediated degradation of p27/p21
R-DME-2559586, DNA Damage/Telomere Stress Induced Senescence
R-DME-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-DME-69017, CDK-mediated phosphorylation and removal of Cdc6
R-DME-69200, Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-DME-69202, Cyclin E associated events during G1/S transition
R-DME-69231, Cyclin D associated events in G1
R-DME-69563, p53-Dependent G1 DNA Damage Response
R-DME-9706019, RHOBTB3 ATPase cycle

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P54733

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G1/S-specific cyclin-E
Short name:
DmCycE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CycE
ORF Names:CG3938
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0010382, CycE

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0010382

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000804591 – 709G1/S-specific cyclin-EAdd BLAST709

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei114Phosphoserine1 Publication1
Modified residuei115Phosphoserine1 Publication1
Modified residuei117Phosphoserine1 Publication1
Modified residuei129Phosphoserine1 Publication1
Modified residuei187Phosphoserine1 Publication1
Modified residuei192Phosphoserine1 Publication1
Modified residuei195Phosphoserine1 Publication1
Modified residuei198Phosphoserine1 Publication1
Modified residuei651PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P54733

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P54733

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform II is ubiquitous in early embryos and, prior to mitosis 14, is rapidly degraded in all cells except the pole (germ) cells. Expressed during G1 phase in proliferating peripheral nervous system cells. Constitutive expression in embryonic cycles lacking a G1 phase.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform II is expressed maternally and isoform I zygotically in larvae.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0010382, Expressed in embryo and 83 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P54733, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P54733, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex (PubMed:11565033). The cyclin subunit imparts substrate specificity to the complex (PubMed:11565033).

Interacts (via C-terminus) with Z600 (via C-terminus) (PubMed:17431409).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		60939, 171 interactors

Database of interacting proteins

More...DIPi		DIP-18331N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P54733

Protein interaction database and analysis system

More...IntActi		P54733, 24 interactors

Molecular INTeraction database

More...MINTi		P54733

STRING: functional protein association networks

More...STRINGi		7227.FBpp0294012

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P54733

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30
Regioni43 – 150DisorderedSequence analysisAdd BLAST108
Regioni162 – 205DisorderedSequence analysisAdd BLAST44
Regioni221 – 289DisorderedSequence analysisAdd BLAST69
Regioni642 – 709DisorderedSequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi60 – 108Polar residuesSequence analysisAdd BLAST49
Compositional biasi231 – 259Acidic residuesSequence analysisAdd BLAST29
Compositional biasi261 – 280Polar residuesSequence analysisAdd BLAST20
Compositional biasi672 – 709Polar residuesSequence analysisAdd BLAST38

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin E subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0655, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000169122

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P54733

Identification of Orthologs from Complete Genome Data

More...OMAi		ALYGSDQ

Database for complete collections of gene phylogenies

More...PhylomeDBi		P54733

Family and domain databases

Conserved Domains Database

More...CDDi		cd00043, CYCLIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR004367, Cyclin_C-dom
IPR006671, Cyclin_N

The PANTHER Classification System

More...PANTHERi		PTHR10177, PTHR10177, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00385, CYCLIN, 1 hit
SM01332, Cyclin_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47954, SSF47954, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00292, CYCLINS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform II (identifier: P54733-1) [UniParc]FASTAAdd to basket
Also known as: A, C

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLNAKSVCS TSSTEPNGSI VTTAPSNGEV SSSIVVVVSS SSISSSSDSP 
        60         70         80         90        100
IAILPHPDPI PSTSFSSASQ RSEEELPGTS AASRTDEMCS CDSQNLAAST 
       110        120        130        140        150
AATSNGNKRK RRLSSDSNED PELGFEPPSA KRQQRLPALY GSEQGNLSSV 
       160        170        180        190        200
ASSVYTSPVV SVDGQSTQEL LSIRSSPAED LSEAPHSPLP DSPDSPPSPD 
       210        220        230        240        250
RGSKQTPVVV RYAAEQVVTS TVVTQKTEDD DLLDDSCEDY SYDEDDEDDV 
       260        270        280        290        300
EEEDDDVEIY SSTISPASSG CSQQQAVNGE RTPGLPKHQE QIHHPVSDLM 
       310        320        330        340        350
INMRTPMSPA VENGLRQCPL PALAWANAAD VWRLMCHRDE QDSRLRSISM 
       360        370        380        390        400
LEQHPGLQPR MRAILLDWLI EVCEVYKLHR ETFYLAVDYL DRYLHVAHKV 
       410        420        430        440        450
QKTHLQLIGI TCLFVAAKVE EIYPPKIGEF AYVTDGACTE RDILNHEKIL 
       460        470        480        490        500
LQALDWDISP ITITGWLGVY MQLNVNNRTP ASFSQIGRQK SAEADDAFIY 
       510        520        530        540        550
PQFSGFEFVQ TSQLLDLCTL DVGMANYSYS VLAAAAISHT FSREMALRCS 
       560        570        580        590        600
GLDWQVIQPC ARWMEPFFRV ISQKAPYLQL NEQNEQVSNK FGLGLICPNI 
       610        620        630        640        650
VTDDSHIIQT HTTTMDMYDE VLMAQDAAHA MRARIQASPA TALRAPESLL 
       660        670        680        690        700
TPPASSHKPD EYLGDEGDET GARSGISSTT TCCNTAASNK GGKSSSNNSV 

TSCSSRSNP
Length:709
Mass (Da):77,221
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4E6CE53C6E30170
GO
Isoform I (identifier: P54733-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.
     108-119: KRKRRLSSDSNE → MKLEQKRKFIEM

Show »
Length:602
Mass (Da):66,733
Checksum:i0EF379437F9A3ED6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A4V0R4A4V0R4_DROME
Cyclin E, isoform C
CycE 3938, BG:DS07108.3, br37, CDI7, Cdi7
709Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NDQ2M9NDQ2_DROME
Cyclin E, isoform F
CycE 3938, BG:DS07108.3, br37, CDI7, Cdi7
712Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti633A → S in CAA52934 (PubMed:8187637).Curated1
Sequence conflicti644 – 645RA → P in CAA52934 (PubMed:8187637).Curated2
Sequence conflicti691G → V in CAA52934 (PubMed:8187637).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0012541 – 107Missing in isoform I. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_001255108 – 119KRKRR…SDSNE → MKLEQKRKFIEM in isoform I. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X75026 mRNA Translation: CAA52934.1
X75027 mRNA Translation: CAA52935.1
AE014134 Genomic DNA Translation: AAF53477.1
AE014134 Genomic DNA Translation: AAF53479.1
AY069507 mRNA Translation: AAL39652.1
AY061233 mRNA Translation: AAL28781.1

Protein sequence database of the Protein Information Resource

More...PIRi		S41755
S41756

NCBI Reference Sequences

More...RefSeqi		NP_476959.1, NM_057611.5 [P54733-1]
NP_476960.1, NM_057612.5 [P54733-2]
NP_723924.1, NM_165123.3 [P54733-1]
NP_723925.1, NM_165124.3 [P54733-1]
NP_723926.1, NM_165125.3 [P54733-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0080773; FBpp0080331; FBgn0010382 [P54733-1]
FBtr0080774; FBpp0080332; FBgn0010382 [P54733-1]
FBtr0080775; FBpp0080333; FBgn0010382 [P54733-1]
FBtr0080776; FBpp0080334; FBgn0010382 [P54733-1]
FBtr0080777; FBpp0080335; FBgn0010382 [P54733-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		34924

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG3938

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75026 mRNA Translation: CAA52934.1
X75027 mRNA Translation: CAA52935.1
AE014134 Genomic DNA Translation: AAF53477.1
AE014134 Genomic DNA Translation: AAF53479.1
AY069507 mRNA Translation: AAL39652.1
AY061233 mRNA Translation: AAL28781.1
PIRiS41755
S41756
RefSeqiNP_476959.1, NM_057611.5 [P54733-1]
NP_476960.1, NM_057612.5 [P54733-2]
NP_723924.1, NM_165123.3 [P54733-1]
NP_723925.1, NM_165124.3 [P54733-1]
NP_723926.1, NM_165125.3 [P54733-1]

3D structure databases

SMRiP54733
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi60939, 171 interactors
DIPiDIP-18331N
ELMiP54733
IntActiP54733, 24 interactors
MINTiP54733
STRINGi7227.FBpp0294012

PTM databases

iPTMnetiP54733

Proteomic databases

PaxDbiP54733

Genome annotation databases

EnsemblMetazoaiFBtr0080773; FBpp0080331; FBgn0010382 [P54733-1]
FBtr0080774; FBpp0080332; FBgn0010382 [P54733-1]
FBtr0080775; FBpp0080333; FBgn0010382 [P54733-1]
FBtr0080776; FBpp0080334; FBgn0010382 [P54733-1]
FBtr0080777; FBpp0080335; FBgn0010382 [P54733-2]
GeneIDi34924
KEGGidme:Dmel_CG3938

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		34924
FlyBaseiFBgn0010382, CycE
VEuPathDBiVectorBase:FBgn0010382

Phylogenomic databases

eggNOGiKOG0655, Eukaryota
GeneTreeiENSGT00940000169122
InParanoidiP54733
OMAiALYGSDQ
PhylomeDBiP54733

Enzyme and pathway databases

ReactomeiR-DME-1538133, G0 and Early G1
R-DME-187577, SCF(Skp2)-mediated degradation of p27/p21
R-DME-2559586, DNA Damage/Telomere Stress Induced Senescence
R-DME-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-DME-69017, CDK-mediated phosphorylation and removal of Cdc6
R-DME-69200, Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-DME-69202, Cyclin E associated events during G1/S transition
R-DME-69231, Cyclin D associated events in G1
R-DME-69563, p53-Dependent G1 DNA Damage Response
R-DME-9706019, RHOBTB3 ATPase cycle
SignaLinkiP54733

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		34924, 1 hit in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		34924

Protein Ontology

More...PROi		PR:P54733

Gene expression databases

BgeeiFBgn0010382, Expressed in embryo and 83 other tissues
ExpressionAtlasiP54733, baseline and differential
GenevisibleiP54733, DM

Family and domain databases

CDDicd00043, CYCLIN, 1 hit
InterProiView protein in InterPro
IPR039361, Cyclin
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR004367, Cyclin_C-dom
IPR006671, Cyclin_N
PANTHERiPTHR10177, PTHR10177, 1 hit
PfamiView protein in Pfam
PF02984, Cyclin_C, 1 hit
PF00134, Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385, CYCLIN, 1 hit
SM01332, Cyclin_C, 1 hit
SUPFAMiSSF47954, SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292, CYCLINS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCNE_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54733
Secondary accession number(s): Q24479
, Q95RP5, Q9V3B3, Q9V456
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 1, 2000
Last modified: February 23, 2022
This is version 183 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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