UniProtKB - P54733 (CCNE_DROME)
Protein
G1/S-specific cyclin-E
Gene
CycE
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Essential for the control of the cell cycle at the G1/S (start) transition. Targeted by archipelago for degradation by the SFC ubiquitin ligase complex.2 Publications
GO - Molecular functioni
GO - Biological processi
- cell proliferation involved in compound eye morphogenesis Source: FlyBase
- eggshell chorion gene amplification Source: FlyBase
- G1/S transition of mitotic cell cycle Source: UniProtKB
- mitotic cell cycle phase transition Source: GO_Central
- negative regulation of ubiquitin protein ligase activity Source: FlyBase
- neuroblast fate determination Source: FlyBase
- neuron fate specification Source: FlyBase
- peripheral nervous system development Source: UniProtKB
- pole cell development Source: UniProtKB
- positive regulation of apoptotic process Source: FlyBase
- positive regulation of G1/S transition of mitotic cell cycle Source: FlyBase
- positive regulation of receptor signaling pathway via JAK-STAT Source: FlyBase
- regulation of cell population proliferation Source: FlyBase
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- regulation of DNA replication Source: FlyBase
- regulation of establishment of blood-brain barrier Source: FlyBase
- regulation of exit from mitosis Source: FlyBase
- regulation of protein phosphorylation Source: FlyBase
- sensory organ precursor cell division Source: FlyBase
- somatic stem cell population maintenance Source: FlyBase
- ventral cord development Source: FlyBase
Keywordsi
Molecular function | Cyclin |
Biological process | Cell cycle, Cell division |
Enzyme and pathway databases
Reactomei | R-DME-1538133, G0 and Early G1 R-DME-187577, SCF(Skp2)-mediated degradation of p27/p21 R-DME-2559586, DNA Damage/Telomere Stress Induced Senescence R-DME-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-DME-69017, CDK-mediated phosphorylation and removal of Cdc6 R-DME-69200, Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-DME-69202, Cyclin E associated events during G1/S transition R-DME-69231, Cyclin D associated events in G1 R-DME-69563, p53-Dependent G1 DNA Damage Response R-DME-8849470, PTK6 Regulates Cell Cycle |
SignaLinki | P54733 |
Names & Taxonomyi
Protein namesi | Recommended name: G1/S-specific cyclin-EShort name: DmCycE |
Gene namesi | Name:CycE ORF Names:CG3938 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0010382, CycE |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytoskeleton
- centrosome Source: GO_Central
Nucleus
- nucleus Source: UniProtKB
Other locations
- cyclin E1-CDK2 complex Source: GO_Central
- cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080459 | 1 – 709 | G1/S-specific cyclin-EAdd BLAST | 709 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 114 | Phosphoserine1 Publication | 1 | |
Modified residuei | 115 | Phosphoserine1 Publication | 1 | |
Modified residuei | 117 | Phosphoserine1 Publication | 1 | |
Modified residuei | 129 | Phosphoserine1 Publication | 1 | |
Modified residuei | 187 | Phosphoserine1 Publication | 1 | |
Modified residuei | 192 | Phosphoserine1 Publication | 1 | |
Modified residuei | 195 | Phosphoserine1 Publication | 1 | |
Modified residuei | 198 | Phosphoserine1 Publication | 1 | |
Modified residuei | 651 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P54733 |
PTM databases
iPTMneti | P54733 |
Expressioni
Tissue specificityi
Isoform II is ubiquitous in early embryos and, prior to mitosis 14, is rapidly degraded in all cells except the pole (germ) cells. Expressed during G1 phase in proliferating peripheral nervous system cells. Constitutive expression in embryonic cycles lacking a G1 phase.1 Publication
Developmental stagei
Isoform II is expressed maternally and isoform I zygotically in larvae.1 Publication
Gene expression databases
Bgeei | FBgn0010382, Expressed in embryo and 83 other tissues |
ExpressionAtlasi | P54733, baseline and differential |
Genevisiblei | P54733, DM |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 60939, 168 interactors |
DIPi | DIP-18331N |
ELMi | P54733 |
IntActi | P54733, 24 interactors |
MINTi | P54733 |
STRINGi | 7227.FBpp0294012 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0655, Eukaryota |
GeneTreei | ENSGT00940000169122 |
InParanoidi | P54733 |
OMAi | ALYGSDQ |
PhylomeDBi | P54733 |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform II (identifier: P54733-1) [UniParc]FASTAAdd to basket
Also known as: A, C
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGLNAKSVCS TSSTEPNGSI VTTAPSNGEV SSSIVVVVSS SSISSSSDSP
60 70 80 90 100
IAILPHPDPI PSTSFSSASQ RSEEELPGTS AASRTDEMCS CDSQNLAAST
110 120 130 140 150
AATSNGNKRK RRLSSDSNED PELGFEPPSA KRQQRLPALY GSEQGNLSSV
160 170 180 190 200
ASSVYTSPVV SVDGQSTQEL LSIRSSPAED LSEAPHSPLP DSPDSPPSPD
210 220 230 240 250
RGSKQTPVVV RYAAEQVVTS TVVTQKTEDD DLLDDSCEDY SYDEDDEDDV
260 270 280 290 300
EEEDDDVEIY SSTISPASSG CSQQQAVNGE RTPGLPKHQE QIHHPVSDLM
310 320 330 340 350
INMRTPMSPA VENGLRQCPL PALAWANAAD VWRLMCHRDE QDSRLRSISM
360 370 380 390 400
LEQHPGLQPR MRAILLDWLI EVCEVYKLHR ETFYLAVDYL DRYLHVAHKV
410 420 430 440 450
QKTHLQLIGI TCLFVAAKVE EIYPPKIGEF AYVTDGACTE RDILNHEKIL
460 470 480 490 500
LQALDWDISP ITITGWLGVY MQLNVNNRTP ASFSQIGRQK SAEADDAFIY
510 520 530 540 550
PQFSGFEFVQ TSQLLDLCTL DVGMANYSYS VLAAAAISHT FSREMALRCS
560 570 580 590 600
GLDWQVIQPC ARWMEPFFRV ISQKAPYLQL NEQNEQVSNK FGLGLICPNI
610 620 630 640 650
VTDDSHIIQT HTTTMDMYDE VLMAQDAAHA MRARIQASPA TALRAPESLL
660 670 680 690 700
TPPASSHKPD EYLGDEGDET GARSGISSTT TCCNTAASNK GGKSSSNNSV
TSCSSRSNP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA4V0R4 | A4V0R4_DROME | Cyclin E, isoform C | CycE 3938, BG:DS07108.3, br37, CDI7, Cdi7 | 709 | Annotation score: | ||
M9NDQ2 | M9NDQ2_DROME | Cyclin E, isoform F | CycE 3938, BG:DS07108.3, br37, CDI7, Cdi7 | 712 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 633 | A → S in CAA52934 (PubMed:8187637).Curated | 1 | |
Sequence conflicti | 644 – 645 | RA → P in CAA52934 (PubMed:8187637).Curated | 2 | |
Sequence conflicti | 691 | G → V in CAA52934 (PubMed:8187637).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001254 | 1 – 107 | Missing in isoform I. 1 PublicationAdd BLAST | 107 | |
Alternative sequenceiVSP_001255 | 108 – 119 | KRKRR…SDSNE → MKLEQKRKFIEM in isoform I. 1 PublicationAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X75026 mRNA Translation: CAA52934.1 X75027 mRNA Translation: CAA52935.1 AE014134 Genomic DNA Translation: AAF53477.1 AE014134 Genomic DNA Translation: AAF53479.1 AY069507 mRNA Translation: AAL39652.1 AY061233 mRNA Translation: AAL28781.1 |
PIRi | S41755 S41756 |
RefSeqi | NP_476959.1, NM_057611.5 [P54733-1] NP_476960.1, NM_057612.5 [P54733-2] NP_723924.1, NM_165123.3 [P54733-1] NP_723925.1, NM_165124.3 [P54733-1] NP_723926.1, NM_165125.3 [P54733-1] |
Genome annotation databases
EnsemblMetazoai | FBtr0080773; FBpp0080331; FBgn0010382 [P54733-1] FBtr0080774; FBpp0080332; FBgn0010382 [P54733-1] FBtr0080775; FBpp0080333; FBgn0010382 [P54733-1] FBtr0080776; FBpp0080334; FBgn0010382 [P54733-1] FBtr0080777; FBpp0080335; FBgn0010382 [P54733-2] |
GeneIDi | 34924 |
KEGGi | dme:Dmel_CG3938 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X75026 mRNA Translation: CAA52934.1 X75027 mRNA Translation: CAA52935.1 AE014134 Genomic DNA Translation: AAF53477.1 AE014134 Genomic DNA Translation: AAF53479.1 AY069507 mRNA Translation: AAL39652.1 AY061233 mRNA Translation: AAL28781.1 |
PIRi | S41755 S41756 |
RefSeqi | NP_476959.1, NM_057611.5 [P54733-1] NP_476960.1, NM_057612.5 [P54733-2] NP_723924.1, NM_165123.3 [P54733-1] NP_723925.1, NM_165124.3 [P54733-1] NP_723926.1, NM_165125.3 [P54733-1] |
3D structure databases
SMRi | P54733 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 60939, 168 interactors |
DIPi | DIP-18331N |
ELMi | P54733 |
IntActi | P54733, 24 interactors |
MINTi | P54733 |
STRINGi | 7227.FBpp0294012 |
PTM databases
iPTMneti | P54733 |
Proteomic databases
PaxDbi | P54733 |
Genome annotation databases
EnsemblMetazoai | FBtr0080773; FBpp0080331; FBgn0010382 [P54733-1] FBtr0080774; FBpp0080332; FBgn0010382 [P54733-1] FBtr0080775; FBpp0080333; FBgn0010382 [P54733-1] FBtr0080776; FBpp0080334; FBgn0010382 [P54733-1] FBtr0080777; FBpp0080335; FBgn0010382 [P54733-2] |
GeneIDi | 34924 |
KEGGi | dme:Dmel_CG3938 |
Organism-specific databases
CTDi | 34924 |
FlyBasei | FBgn0010382, CycE |
Phylogenomic databases
eggNOGi | KOG0655, Eukaryota |
GeneTreei | ENSGT00940000169122 |
InParanoidi | P54733 |
OMAi | ALYGSDQ |
PhylomeDBi | P54733 |
Enzyme and pathway databases
Reactomei | R-DME-1538133, G0 and Early G1 R-DME-187577, SCF(Skp2)-mediated degradation of p27/p21 R-DME-2559586, DNA Damage/Telomere Stress Induced Senescence R-DME-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-DME-69017, CDK-mediated phosphorylation and removal of Cdc6 R-DME-69200, Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-DME-69202, Cyclin E associated events during G1/S transition R-DME-69231, Cyclin D associated events in G1 R-DME-69563, p53-Dependent G1 DNA Damage Response R-DME-8849470, PTK6 Regulates Cell Cycle |
SignaLinki | P54733 |
Miscellaneous databases
BioGRID-ORCSi | 34924, 1 hit in 3 CRISPR screens |
GenomeRNAii | 34924 |
PROi | PR:P54733 |
Gene expression databases
Bgeei | FBgn0010382, Expressed in embryo and 83 other tissues |
ExpressionAtlasi | P54733, baseline and differential |
Genevisiblei | P54733, DM |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCNE_DROME | |
Accessioni | P54733Primary (citable) accession number: P54733 Secondary accession number(s): Q24479 Q9V456 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | December 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 179 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families