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Protein

FAS-associated factor 1

Gene

Faf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ubiquitin-binding protein (By similarity). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (By similarity). Potentiates but cannot initiate FAS-induced apoptosis (PubMed:8524870).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
FAS-associated factor 1
Gene namesi
Name:Faf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:109419 Faf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002110391 – 649FAS-associated factor 1Add BLAST649

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei319PhosphoserineCombined sources1
Modified residuei579PhosphothreonineBy similarity1
Modified residuei581PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP54731
MaxQBiP54731
PaxDbiP54731
PeptideAtlasiP54731
PRIDEiP54731

PTM databases

iPTMnetiP54731
PhosphoSitePlusiP54731

Expressioni

Gene expression databases

BgeeiENSMUSG00000010517 Expressed in 289 organ(s), highest expression level in ureter
CleanExiMM_FAF1
GenevisibleiP54731 MM

Interactioni

Subunit structurei

Interacts with CDT1 and ATPase VCP/p97. Interacts (via UBA domain) with FAS (via death domain). Interacts (via UBA domain) with NLRP12 (via DAPIN/PYRIN domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199588, 5 interactors
IntActiP54731, 2 interactors
MINTiP54731
STRINGi10090.ENSMUSP00000099785

Structurei

3D structure databases

ProteinModelPortaliP54731
SMRiP54731
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 57UBABy similarityAdd BLAST57
Domaini568 – 645UBXPROSITE-ProRule annotationAdd BLAST78

Phylogenomic databases

eggNOGiENOG410IPG5 Eukaryota
ENOG410Z9BT LUCA
GeneTreeiENSGT00530000063422
HOGENOMiHOG000043073
HOVERGENiHBG002876
InParanoidiP54731
KOiK20703
OMAiMEIFSAQ
OrthoDBiEOG091G04LQ
TreeFamiTF314172

Family and domain databases

CDDicd01771 Faf1_UBX, 1 hit
InterProiView protein in InterPro
IPR033043 FAF1_UBX
IPR036249 Thioredoxin-like_sf
IPR006577 UAS
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF00789 UBX, 1 hit
SMARTiView protein in SMART
SM00594 UAS, 1 hit
SM00166 UBX, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF54236 SSF54236, 3 hits
PROSITEiView protein in PROSITE
PS50033 UBX, 1 hit

Sequencei

Sequence statusi: Complete.

P54731-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASNMDREMI LADFQACTGI ENIDEAITLL EQNNWDLVAA INGVIPQENG
60 70 80 90 100
ILQSDFGGET MPGPTFDPAS HPAPASTPSS SAFRPVMPSR QIVERQPRML
110 120 130 140 150
DFRVEYRDRN VDVVLEDSCT VGEIKQILEN ELQIPVPKML LKGWKTGDVE
160 170 180 190 200
DSTVLKSLHL PKNNSLYVLT PDLPPPSSSS HAGALQESLN QNFMLIITHR
210 220 230 240 250
EVQREYNLNF SGSSTVQEVK RNVYDLTSIP VRHQLWEGWP ASATDDSMCL
260 270 280 290 300
AESGLSYPCH RLTVGRRTSP VQTREQSEEQ STDVHMVSDS DGDDFEDASE
310 320 330 340 350
FGVDDGEVFG MASSTLRKSP MMPENAENEG DALLQFTAEF SSRYGDCHPV
360 370 380 390 400
FFIGSLEAAF QEAFYVKARD RKLLAIYLHH DESVLTNVFC SQMLCAESIV
410 420 430 440 450
SYLSQNFITW AWDLTKDTNR ARFLTMCNRH FGSVIAQTIR TQKTDQFPLF
460 470 480 490 500
LIIMGKRSSN EVLNVIQGNT TVDELMMRLM AAMEIFSAQQ QEDIKDEDER
510 520 530 540 550
EARENVKREQ DEAYRLSLEA DRAKREAHER EMAEQFRLEQ IRKEQEEERE
560 570 580 590 600
AIRLSLEQAL PPEPKEENAE PVSKLRIRTP SGEFLERRFL ASNKLQIVFD
610 620 630 640
FVASKGFPWD EFKLLSTFPR RDVTQLDPNK SLLEVNLFPQ ETLFLQAKE
Length:649
Mass (Da):73,863
Last modified:July 27, 2011 - v2
Checksum:i0DA48081312EFE8D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7 – 8RE → LP in AAA92091 (PubMed:8524870).Curated2
Sequence conflicti345G → S in AAA92091 (PubMed:8524870).Curated1
Sequence conflicti352F → Y in AAA92091 (PubMed:8524870).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39643 mRNA Translation: AAA92091.1
AL627188, AL627392 Genomic DNA Translation: CAM13709.1
AL627392, AL627188 Genomic DNA Translation: CAM16845.1
CH466527 Genomic DNA Translation: EDL30696.1
BC065098 mRNA Translation: AAH65098.1
CCDSiCCDS18468.1
RefSeqiNP_032009.2, NM_007983.2
UniGeneiMm.318259

Genome annotation databases

EnsembliENSMUST00000102724; ENSMUSP00000099785; ENSMUSG00000010517
GeneIDi14084
KEGGimmu:14084
UCSCiuc008uct.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39643 mRNA Translation: AAA92091.1
AL627188, AL627392 Genomic DNA Translation: CAM13709.1
AL627392, AL627188 Genomic DNA Translation: CAM16845.1
CH466527 Genomic DNA Translation: EDL30696.1
BC065098 mRNA Translation: AAH65098.1
CCDSiCCDS18468.1
RefSeqiNP_032009.2, NM_007983.2
UniGeneiMm.318259

3D structure databases

ProteinModelPortaliP54731
SMRiP54731
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199588, 5 interactors
IntActiP54731, 2 interactors
MINTiP54731
STRINGi10090.ENSMUSP00000099785

PTM databases

iPTMnetiP54731
PhosphoSitePlusiP54731

Proteomic databases

EPDiP54731
MaxQBiP54731
PaxDbiP54731
PeptideAtlasiP54731
PRIDEiP54731

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102724; ENSMUSP00000099785; ENSMUSG00000010517
GeneIDi14084
KEGGimmu:14084
UCSCiuc008uct.1 mouse

Organism-specific databases

CTDi11124
MGIiMGI:109419 Faf1

Phylogenomic databases

eggNOGiENOG410IPG5 Eukaryota
ENOG410Z9BT LUCA
GeneTreeiENSGT00530000063422
HOGENOMiHOG000043073
HOVERGENiHBG002876
InParanoidiP54731
KOiK20703
OMAiMEIFSAQ
OrthoDBiEOG091G04LQ
TreeFamiTF314172

Miscellaneous databases

ChiTaRSiFaf1 mouse
PROiPR:P54731
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000010517 Expressed in 289 organ(s), highest expression level in ureter
CleanExiMM_FAF1
GenevisibleiP54731 MM

Family and domain databases

CDDicd01771 Faf1_UBX, 1 hit
InterProiView protein in InterPro
IPR033043 FAF1_UBX
IPR036249 Thioredoxin-like_sf
IPR006577 UAS
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF00789 UBX, 1 hit
SMARTiView protein in SMART
SM00594 UAS, 1 hit
SM00166 UBX, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF54236 SSF54236, 3 hits
PROSITEiView protein in PROSITE
PS50033 UBX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFAF1_MOUSE
AccessioniPrimary (citable) accession number: P54731
Secondary accession number(s): Q6P1F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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