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Entry version 147 (07 Apr 2021)
Sequence version 1 (01 Oct 1996)
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Protein

PTS system maltose-specific EIICB component

Gene

malP

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in maltose transport.

1 Publication

Miscellaneous

Maltose uptake in B.subtilis occurs only via the malP-encoded specific PTS-dependent EIICB(Mal) and not via another transport mechanism.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=5 µM for maltose1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei471Phosphocysteine intermediate; for EIIB activityPROSITE-ProRule annotation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    Biological processPhosphotransferase system, Sugar transport, Transport

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    BSUB:BSU08200-MONOMER

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P54715

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    4.A.1.1.8, the pts glucose-glucoside (glc) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    PTS system maltose-specific EIICB component1 Publication
    Including the following 2 domains:
    Maltose permease IIC component1 Publication
    Alternative name(s):
    PTS system maltose-specific EIIC component1 Publication
    Maltose-specific phosphotransferase enzyme IIB component1 Publication (EC:2.7.1.2081 Publication)
    Alternative name(s):
    PTS system maltose-specific EIIB component1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:malP1 Publication
    Synonyms:glv-2, glvC1 Publication, glvCB, yfiB
    Ordered Locus Names:BSU08200
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei59 – 79HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei93 – 113HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei132 – 152HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei173 – 193HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei200 – 220HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei224 – 244HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei276 – 296HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei305 – 325HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei326 – 346HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei357 – 377HelicalPROSITE-ProRule annotationAdd BLAST21
    Transmembranei382 – 402HelicalPROSITE-ProRule annotationAdd BLAST21

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Cells lacking this gene show no maltose uptake.1 Publication

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001865821 – 527PTS system maltose-specific EIICB componentAdd BLAST527

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P54715

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    By maltose; repressed by glucose.1 Publication

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    224308.BSU08200

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P54715

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 418PTS EIIC type-1PROSITE-ProRule annotationAdd BLAST418
    Domaini449 – 527PTS EIIB type-1PROSITE-ProRule annotationAdd BLAST79

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The EIIC domain type-1 forms the PTS system translocation channel and contains the specific substrate-binding site.PROSITE-ProRule annotation
    The PTS EIIB type-1 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    COG1263, Bacteria
    COG1264, Bacteria

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P54715

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    WIPMFHN

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P54715

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00212, PTS_IIB_glc, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.1360.60, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR036878, Glu_permease_IIB
    IPR018113, PTrfase_EIIB_Cys
    IPR003352, PTS_EIIC
    IPR013013, PTS_EIIC_1
    IPR001996, PTS_IIB_1
    IPR010975, PTS_IIBC_a_glc
    IPR004719, PTS_maltose/Glc_sub_IIC

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00367, PTS_EIIB, 1 hit
    PF02378, PTS_EIIC, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF55604, SSF55604, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00826, EIIB_glc, 1 hit
    TIGR00852, pts-Glc, 1 hit
    TIGR02005, PTS-IIBC-alpha, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51098, PTS_EIIB_TYPE_1, 1 hit
    PS01035, PTS_EIIB_TYPE_1_CYS, 1 hit
    PS51103, PTS_EIIC_TYPE_1, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P54715-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MMQKIQRFGS AMFVPVLLFA FAGIIVGIST LFKNKTLMGP LADPDGFWYQ
    60 70 80 90 100
    CWYIIEQGGW TVFNQMPLLF AIGIPVALAK KAQARACLEA LTVYLTFNYF
    110 120 130 140 150
    VSAILTVWGG AFGVDMNQEV GGTSGLTMIA GIKTLDTNII GAIFISSIVV
    160 170 180 190 200
    FLHNRYFDKK LPDFLGIFQG STYIVMISFF IMIPIALAVS YIWPMVQSGI
    210 220 230 240 250
    GSLQSFLVAS GAVGVWIYTF LERILIPTGL HHFIYTPFIY GPAVAEGGIV
    260 270 280 290 300
    TYWAQHLGEY SQSAKPLKEL FPQGGFALHG NSKIFGIPGI ALAFYVTAKK
    310 320 330 340 350
    EKKKLVAGLL IPVTLTAIVA GITEPIEFTF LFISPFLFAV HAVLAATMST
    360 370 380 390 400
    VMYMAGVVGN MGGGLIEAVT LNWIPLFGSH GMTYVYQILI GLSFTAIYFF
    410 420 430 440 450
    VFRFLILKFN IATPGREKDE QQETKLYSKK EYRERKNKDE TASAAETADD
    460 470 480 490 500
    TAFLYIEALG GKDNITEVTN CATRLRVSVK DETKVEPDSV FRALGAHGVV
    510 520
    RNGKAFQVII GLSVPQMRER VEKILNQ
    Length:527
    Mass (Da):58,055
    Last modified:October 1, 1996 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD708C38048D4D63C
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    D50543 Genomic DNA Translation: BAA09105.1
    AL009126 Genomic DNA Translation: CAB12649.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    G69635

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_388701.1, NC_000964.3
    WP_003233606.1, NZ_JNCM01000032.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    CAB12649; CAB12649; BSU_08200

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    939713

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    bsu:BSU08200

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|224308.179.peg.886

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    D50543 Genomic DNA Translation: BAA09105.1
    AL009126 Genomic DNA Translation: CAB12649.1
    PIRiG69635
    RefSeqiNP_388701.1, NC_000964.3
    WP_003233606.1, NZ_JNCM01000032.1

    3D structure databases

    SMRiP54715
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi224308.BSU08200

    Protein family/group databases

    TCDBi4.A.1.1.8, the pts glucose-glucoside (glc) family

    Proteomic databases

    PaxDbiP54715

    Genome annotation databases

    EnsemblBacteriaiCAB12649; CAB12649; BSU_08200
    GeneIDi939713
    KEGGibsu:BSU08200
    PATRICifig|224308.179.peg.886

    Phylogenomic databases

    eggNOGiCOG1263, Bacteria
    COG1264, Bacteria
    InParanoidiP54715
    OMAiWIPMFHN
    PhylomeDBiP54715

    Enzyme and pathway databases

    BioCyciBSUB:BSU08200-MONOMER
    SABIO-RKiP54715

    Family and domain databases

    CDDicd00212, PTS_IIB_glc, 1 hit
    Gene3Di3.30.1360.60, 1 hit
    InterProiView protein in InterPro
    IPR036878, Glu_permease_IIB
    IPR018113, PTrfase_EIIB_Cys
    IPR003352, PTS_EIIC
    IPR013013, PTS_EIIC_1
    IPR001996, PTS_IIB_1
    IPR010975, PTS_IIBC_a_glc
    IPR004719, PTS_maltose/Glc_sub_IIC
    PfamiView protein in Pfam
    PF00367, PTS_EIIB, 1 hit
    PF02378, PTS_EIIC, 1 hit
    SUPFAMiSSF55604, SSF55604, 1 hit
    TIGRFAMsiTIGR00826, EIIB_glc, 1 hit
    TIGR00852, pts-Glc, 1 hit
    TIGR02005, PTS-IIBC-alpha, 1 hit
    PROSITEiView protein in PROSITE
    PS51098, PTS_EIIB_TYPE_1, 1 hit
    PS01035, PTS_EIIB_TYPE_1_CYS, 1 hit
    PS51103, PTS_EIIC_TYPE_1, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTOCB_BACSU
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54715
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: April 7, 2021
    This is version 147 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome
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