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Entry version 172 (31 Jul 2019)
Sequence version 3 (23 Jan 2002)
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Protein

Sodium/potassium-transporting ATPase subunit gamma

Gene

FXYD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5578775 Ion homeostasis
R-HSA-936837 Ion transport by P-type ATPases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P54710

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.27.2.1 the phospholemman (plm) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit gamma
Short name:
Na(+)/K(+) ATPase subunit gamma
Alternative name(s):
FXYD domain-containing ion transport regulator 2
Sodium pump gamma chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FXYD2
Synonyms:ATP1C, ATP1G1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4026 FXYD2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601814 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P54710

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 46HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypomagnesemia 2 (HOMG2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder due to primary renal wasting of magnesium. Plasma levels of other electrolytes are normal. The only abnormality found, in addition to low magnesium levels, is lowered renal excretion of calcium resulting in hypocalciuria.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01328041G → R in HOMG2; fails to localize to plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs28938168Ensembl.1

Keywords - Diseasei

Disease mutation, Primary hypomagnesemia

Organism-specific databases

DisGeNET

More...
DisGeNETi
486

MalaCards human disease database

More...
MalaCardsi
FXYD2
MIMi154020 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000137731

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
34528 Autosomal dominant primary hypomagnesemia with hypocalciuria

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28442

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2095186

Drug and drug target database

More...
DrugBanki
DB00606 Cyclothiazide
DB09479 Rubidium chloride Rb-82

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FXYD2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20141251

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001481851 – 66Sodium/potassium-transporting ATPase subunit gammaAdd BLAST66

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P54710

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P54710

PeptideAtlas

More...
PeptideAtlasi
P54710

PRoteomics IDEntifications database

More...
PRIDEi
P54710

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56698 [P54710-1]
56699 [P54710-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P54710

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the distal convoluted tubule in the kidney. Found on basolateral membranes of nephron epithelial cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137731 Expressed in 98 organ(s), highest expression level in cortex of kidney

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P54710 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA064218
HPA068838

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

By similarity

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-125 Sodium:potassium-exchanging ATPase complex

Protein interaction database and analysis system

More...
IntActi
P54710, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000292079

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P54710

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J35I Eukaryota
ENOG410Z10F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153062

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234468

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P54710

KEGG Orthology (KO)

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KOi
K01538

Identification of Orthologs from Complete Genome Data

More...
OMAi
KKHRQVN

Database of Orthologous Groups

More...
OrthoDBi
1409318at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P54710

TreeFam database of animal gene trees

More...
TreeFami
TF333443

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000272 Ion-transport_regulator_FXYD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02038 ATP1G1_PLM_MAT8, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01310 FXYD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P54710-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTGLSMDGGG SPKGDVDPFY YDYETVRNGG LIFAGLAFIV GLLILLSRRF
60
RCGGNKKRRQ INEDEP
Length:66
Mass (Da):7,283
Last modified:January 23, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD00F21B5C01ACE75
GO
Isoform 2 (identifier: P54710-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MTGLSMDG → MDRWYL

Show »
Length:64
Mass (Da):7,355
Checksum:iBB644F4CF05C2170
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB09425 differs from that shown. Reason: Frameshift at position 12.Curated
The sequence CAA60152 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01328041G → R in HOMG2; fails to localize to plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs28938168Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0015801 – 8MTGLSMDG → MDRWYL in isoform 2. 3 Publications8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U50743 mRNA Translation: AAB09425.1 Frameshift.
AF316896 Genomic DNA Translation: AAG37906.1
AF316896 Genomic DNA Translation: AAG37907.1
AF241235 Genomic DNA Translation: AAG34359.1
AF241235 Genomic DNA Translation: AAG34360.1
AF241236 mRNA Translation: AAG34361.1
X86400 mRNA Translation: CAA60152.1 Sequence problems.
BT006721 mRNA Translation: AAP35367.1
BC013289 mRNA Translation: AAH13289.1
BC005302 mRNA Translation: AAH05302.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8385.1 [P54710-2]
CCDS8386.1 [P54710-1]

Protein sequence database of the Protein Information Resource

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PIRi
S54159

NCBI Reference Sequences

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RefSeqi
NP_001671.2, NM_001680.4 [P54710-1]
NP_067614.1, NM_021603.3 [P54710-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000260287; ENSP00000260287; ENSG00000137731 [P54710-2]
ENST00000292079; ENSP00000292079; ENSG00000137731 [P54710-1]
ENST00000528014; ENSP00000432430; ENSG00000137731 [P54710-2]
ENST00000532119; ENSP00000436414; ENSG00000137731 [P54710-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
486

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:486

UCSC genome browser

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UCSCi
uc001prj.2 human [P54710-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50743 mRNA Translation: AAB09425.1 Frameshift.
AF316896 Genomic DNA Translation: AAG37906.1
AF316896 Genomic DNA Translation: AAG37907.1
AF241235 Genomic DNA Translation: AAG34359.1
AF241235 Genomic DNA Translation: AAG34360.1
AF241236 mRNA Translation: AAG34361.1
X86400 mRNA Translation: CAA60152.1 Sequence problems.
BT006721 mRNA Translation: AAP35367.1
BC013289 mRNA Translation: AAH13289.1
BC005302 mRNA Translation: AAH05302.1
CCDSiCCDS8385.1 [P54710-2]
CCDS8386.1 [P54710-1]
PIRiS54159
RefSeqiNP_001671.2, NM_001680.4 [P54710-1]
NP_067614.1, NM_021603.3 [P54710-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MKVNMR-A9-66[»]
SMRiP54710
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-125 Sodium:potassium-exchanging ATPase complex
IntActiP54710, 2 interactors
STRINGi9606.ENSP00000292079

Chemistry databases

ChEMBLiCHEMBL2095186
DrugBankiDB00606 Cyclothiazide
DB09479 Rubidium chloride Rb-82

Protein family/group databases

TCDBi1.A.27.2.1 the phospholemman (plm) family

PTM databases

iPTMnetiP54710

Polymorphism and mutation databases

BioMutaiFXYD2
DMDMi20141251

Proteomic databases

MaxQBiP54710
PaxDbiP54710
PeptideAtlasiP54710
PRIDEiP54710
ProteomicsDBi56698 [P54710-1]
56699 [P54710-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
486
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260287; ENSP00000260287; ENSG00000137731 [P54710-2]
ENST00000292079; ENSP00000292079; ENSG00000137731 [P54710-1]
ENST00000528014; ENSP00000432430; ENSG00000137731 [P54710-2]
ENST00000532119; ENSP00000436414; ENSG00000137731 [P54710-2]
GeneIDi486
KEGGihsa:486
UCSCiuc001prj.2 human [P54710-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
486
DisGeNETi486

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FXYD2
HGNCiHGNC:4026 FXYD2
HPAiHPA064218
HPA068838
MalaCardsiFXYD2
MIMi154020 phenotype
601814 gene
neXtProtiNX_P54710
OpenTargetsiENSG00000137731
Orphaneti34528 Autosomal dominant primary hypomagnesemia with hypocalciuria
PharmGKBiPA28442

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J35I Eukaryota
ENOG410Z10F LUCA
GeneTreeiENSGT00940000153062
HOGENOMiHOG000234468
InParanoidiP54710
KOiK01538
OMAiKKHRQVN
OrthoDBi1409318at2759
PhylomeDBiP54710
TreeFamiTF333443

Enzyme and pathway databases

ReactomeiR-HSA-5578775 Ion homeostasis
R-HSA-936837 Ion transport by P-type ATPases
SIGNORiP54710

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FXYD2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FXYD2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
486

Protein Ontology

More...
PROi
PR:P54710

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137731 Expressed in 98 organ(s), highest expression level in cortex of kidney
GenevisibleiP54710 HS

Family and domain databases

InterProiView protein in InterPro
IPR000272 Ion-transport_regulator_FXYD
PfamiView protein in Pfam
PF02038 ATP1G1_PLM_MAT8, 1 hit
PROSITEiView protein in PROSITE
PS01310 FXYD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATNG_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54710
Secondary accession number(s): Q15332
, Q53YC1, Q9GZP3, Q9GZQ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2002
Last modified: July 31, 2019
This is version 172 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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