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Entry version 194 (16 Oct 2019)
Sequence version 3 (22 Jul 2008)
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Protein

Potassium-transporting ATPase alpha chain 2

Gene

ATP12A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for potassium absorption in various tissues.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3914-aspartylphosphate intermediateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi732MagnesiumBy similarity1
Metal bindingi736MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processHydrogen ion transport, Ion transport, Potassium transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.3.10 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-936837 Ion transport by P-type ATPases

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.3.1.13 the p-type atpase (p-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium-transporting ATPase alpha chain 2 (EC:7.2.2.19)
Alternative name(s):
Non-gastric H(+)/K(+) ATPase subunit alpha
Proton pump
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP12A
Synonyms:ATP1AL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13816 ATP12A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
182360 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P54707

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 102CytoplasmicSequence analysisAdd BLAST102
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 146LumenalSequence analysisAdd BLAST23
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 303CytoplasmicSequence analysisAdd BLAST136
Transmembranei304 – 323HelicalSequence analysisAdd BLAST20
Topological domaini324 – 335LumenalSequence analysisAdd BLAST12
Transmembranei336 – 353HelicalSequence analysisAdd BLAST18
Topological domaini354 – 787CytoplasmicSequence analysisAdd BLAST434
Transmembranei788 – 807HelicalSequence analysisAdd BLAST20
Topological domaini808 – 817LumenalSequence analysis10
Transmembranei818 – 838HelicalSequence analysisAdd BLAST21
Topological domaini839 – 858CytoplasmicSequence analysisAdd BLAST20
Transmembranei859 – 881HelicalSequence analysisAdd BLAST23
Topological domaini882 – 933LumenalSequence analysisAdd BLAST52
Transmembranei934 – 953HelicalSequence analysisAdd BLAST20
Topological domaini954 – 967CytoplasmicSequence analysisAdd BLAST14
Transmembranei968 – 986HelicalSequence analysisAdd BLAST19
Topological domaini987 – 1001LumenalSequence analysisAdd BLAST15
Transmembranei1002 – 1022HelicalSequence analysisAdd BLAST21
Topological domaini1023 – 1039CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
479

Open Targets

More...
OpenTargetsi
ENSG00000075673

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25104

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P54707

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2933

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATP12A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
212287925

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000462601 – 1039Potassium-transporting ATPase alpha chain 2Add BLAST1039

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei958Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P54707

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P54707

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P54707

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P54707

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P54707

PeptideAtlas

More...
PeptideAtlasi
P54707

PRoteomics IDEntifications database

More...
PRIDEi
P54707

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56695 [P54707-1]
56696 [P54707-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P54707

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P54707

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P54707

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000075673 Expressed in 58 organ(s), highest expression level in epithelium of bronchus

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P54707 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039526

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106969, 85 interactors

Protein interaction database and analysis system

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IntActi
P54707, 55 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000218548

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P54707

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P54707

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0203 Eukaryota
COG0474 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159259

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000265622

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P54707

KEGG Orthology (KO)

More...
KOi
K01544

Identification of Orthologs from Complete Genome Data

More...
OMAi
TFHTAYM

Database of Orthologous Groups

More...
OrthoDBi
388324at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P54707

TreeFam database of animal gene trees

More...
TreeFami
TF312838

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02608 P-type_ATPase_Na-K_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030318 Atp12a
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005775 P-type_ATPase_IIC
IPR001757 P_typ_ATPase

The PANTHER Classification System

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PANTHERi
PTHR43294:SF1 PTHR43294:SF1, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00831 Cation_ATPase_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01106 ATPase-IIC_X-K, 1 hit
TIGR01494 ATPase_P-type, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P54707-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHQKTPEIYS VELSGTKDIV KTDKGDGKEK YRGLKNNCLE LKKKNHKEEF
60 70 80 90 100
QKELHLDDHK LSNRELEEKY GTDIIMGLSS TRAAELLARD GPNSLTPPKQ
110 120 130 140 150
TPEIVKFLKQ MVGGFSILLW VGAFLCWIAY GIQYSSDKSA SLNNVYLGCV
160 170 180 190 200
LGLVVILTGI FAYYQEAKST NIMSSFNKMI PQQALVIRDS EKKTIPSEQL
210 220 230 240 250
VVGDIVEVKG GDQIPADIRV LSSQGCRVDN SSLTGESEPQ PRSSEFTHEN
260 270 280 290 300
PLETKNICFY STTCLEGTVT GMVINTGDRT IIGHIASLAS GVGNEKTPIA
310 320 330 340 350
IEIEHFVHIV AGVAVSIGIL FFIIAVSLKY QVLDSIIFLI GIIVANVPEG
360 370 380 390 400
LLATVTVTLS LTAKRMAKKN CLVKNLEAVE TLGSTSIICS DKTGTLTQNR
410 420 430 440 450
MTVAHLWFDN QIFVADTSED HSNQVFDQSS RTWASLSKII TLCNRAEFKP
460 470 480 490 500
GQENVPIMKK AVIGDASETA LLKFSEVILG DVMEIRKRNR KVAEIPFNST
510 520 530 540 550
NKFQLSIHEM DDPHGKRFLM VMKGAPERIL EKCSTIMING EEHPLDKSTA
560 570 580 590 600
KTFHTAYMEL GGLGERVLGF CHLYLPADEF PETYSFDIDA MNFPTSNLCF
610 620 630 640 650
VGLLSMIDPP RSTVPDAVTK CRSAGIKVIM VTGDHPITAK AIAKSVGIIS
660 670 680 690 700
ANSETVEDIA HRLNIAVEQV NKRDAKAAVV TGMELKDMSS EQLDEILANY
710 720 730 740 750
QEIVFARTSP QQKLIIVEGC QRQDAVVAVT GDGVNDSPAL KKADIGIAMG
760 770 780 790 800
IAGSDAAKNA ADMVLLDDNF ASIVTGVEEG RLIFDNLKKT IAYSLTKNIA
810 820 830 840 850
ELCPFLIYII VGLPLPIGTI TILFIDLGTD IIPSIALAYE KAESDIMNRK
860 870 880 890 900
PRHKNKDRLV NQPLAVYSYL HIGLMQALGA FLVYFTVYAQ EGFLPRTLIN
910 920 930 940 950
LRVEWEKDYV NDLKDSYGQE WTRYQREYLE WTGYTAFFVG ILVQQIADLI
960 970 980 990 1000
IRKTRRNSIF QQGLFRNKVI WVGITSQIII GLILSYGLGS VTALSFTMLR
1010 1020 1030
AQYWFVAVPH AILIWVYDEV RKLFIRLYPG SWWDKNMYY
Length:1,039
Mass (Da):115,511
Last modified:July 22, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC906897E11FA406C
GO
Isoform 2 (identifier: P54707-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-266: E → EASTSPV

Note: No experimental confirmation available.
Show »
Length:1,045
Mass (Da):116,053
Checksum:i15088FC158FB580A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3Q → QLFQ in AAC37589 (PubMed:8838794).Curated1
Sequence conflicti145V → VRLWGVQV in CAA49477 (PubMed:1847115).Curated1
Sequence conflicti225 – 227Missing in CAA49477 (PubMed:1847115).Curated3
Sequence conflicti266E → V in CAA49477 (PubMed:1847115).Curated1
Sequence conflicti382L → P in AAA35576 (PubMed:3036582).Curated1
Sequence conflicti724 – 727DAVV → VGGQ in CAA49478 (PubMed:1847115).Curated4
Sequence conflicti772 – 773SI → LH in CAA49478 (PubMed:1847115).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020186863P → L. Corresponds to variant dbSNP:rs2289909Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034640266E → EASTSPV in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U02076 mRNA Translation: AAB37755.1
L42563
, L42558, L42559, L42565, L42566, L42567, L42560, L42561, L42568, L42562, L42569 Genomic DNA Translation: AAC37589.2
AK292968 mRNA Translation: BAF85657.1
AL157364 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08346.1
CH471075 Genomic DNA Translation: EAX08345.1
BC031609 mRNA Translation: AAH31609.1
X69823 Genomic DNA Translation: CAA49477.1
X69824 Genomic DNA Translation: CAA49478.1
M16797 mRNA Translation: AAA51802.1
M27574 Genomic DNA Translation: AAA35576.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31948.1 [P54707-1]
CCDS53858.1 [P54707-2]

Protein sequence database of the Protein Information Resource

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PIRi
A26641
D27795
E27397
I38401
S13028
S31504

NCBI Reference Sequences

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RefSeqi
NP_001172014.1, NM_001185085.1 [P54707-2]
NP_001667.4, NM_001676.5 [P54707-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000218548; ENSP00000218548; ENSG00000075673 [P54707-2]
ENST00000381946; ENSP00000371372; ENSG00000075673 [P54707-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
479

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:479

UCSC genome browser

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UCSCi
uc001upp.4 human [P54707-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02076 mRNA Translation: AAB37755.1
L42563
, L42558, L42559, L42565, L42566, L42567, L42560, L42561, L42568, L42562, L42569 Genomic DNA Translation: AAC37589.2
AK292968 mRNA Translation: BAF85657.1
AL157364 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08346.1
CH471075 Genomic DNA Translation: EAX08345.1
BC031609 mRNA Translation: AAH31609.1
X69823 Genomic DNA Translation: CAA49477.1
X69824 Genomic DNA Translation: CAA49478.1
M16797 mRNA Translation: AAA51802.1
M27574 Genomic DNA Translation: AAA35576.1
CCDSiCCDS31948.1 [P54707-1]
CCDS53858.1 [P54707-2]
PIRiA26641
D27795
E27397
I38401
S13028
S31504
RefSeqiNP_001172014.1, NM_001185085.1 [P54707-2]
NP_001667.4, NM_001676.5 [P54707-1]

3D structure databases

SMRiP54707
ModBaseiSearch...

Protein-protein interaction databases

BioGridi106969, 85 interactors
IntActiP54707, 55 interactors
STRINGi9606.ENSP00000218548

Chemistry databases

BindingDBiP54707
ChEMBLiCHEMBL2933

Protein family/group databases

TCDBi3.A.3.1.13 the p-type atpase (p-atpase) superfamily

PTM databases

iPTMnetiP54707
PhosphoSitePlusiP54707
SwissPalmiP54707

Polymorphism and mutation databases

BioMutaiATP12A
DMDMi212287925

Proteomic databases

EPDiP54707
jPOSTiP54707
MassIVEiP54707
MaxQBiP54707
PaxDbiP54707
PeptideAtlasiP54707
PRIDEiP54707
ProteomicsDBi56695 [P54707-1]
56696 [P54707-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
479

Genome annotation databases

EnsembliENST00000218548; ENSP00000218548; ENSG00000075673 [P54707-2]
ENST00000381946; ENSP00000371372; ENSG00000075673 [P54707-1]
GeneIDi479
KEGGihsa:479
UCSCiuc001upp.4 human [P54707-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
479
DisGeNETi479

GeneCards: human genes, protein and diseases

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GeneCardsi
ATP12A
HGNCiHGNC:13816 ATP12A
HPAiHPA039526
MIMi182360 gene
neXtProtiNX_P54707
OpenTargetsiENSG00000075673
PharmGKBiPA25104

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0203 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00940000159259
HOGENOMiHOG000265622
InParanoidiP54707
KOiK01544
OMAiTFHTAYM
OrthoDBi388324at2759
PhylomeDBiP54707
TreeFamiTF312838

Enzyme and pathway databases

BRENDAi3.6.3.10 2681
ReactomeiR-HSA-936837 Ion transport by P-type ATPases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ATP12A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ATP12A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
479
PharosiP54707

Protein Ontology

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PROi
PR:P54707

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000075673 Expressed in 58 organ(s), highest expression level in epithelium of bronchus
GenevisibleiP54707 HS

Family and domain databases

CDDicd02608 P-type_ATPase_Na-K_like, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030318 Atp12a
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005775 P-type_ATPase_IIC
IPR001757 P_typ_ATPase
PANTHERiPTHR43294:SF1 PTHR43294:SF1, 1 hit
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01106 ATPase-IIC_X-K, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT12A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54707
Secondary accession number(s): Q13816
, Q13817, Q16734, Q5W035, Q8N5U2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 22, 2008
Last modified: October 16, 2019
This is version 194 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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