Cytoplasmic dynein 1 intermediate chain

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP-dependent microtubule motor activity, minus-end-directed Source: dictyBase <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "Tug-of-war between dissimilar teams of microtubule motors regulates transport and fission of endosomes."
    Soppina V., Rai A.K., Ramaiya A.J., Barak P., Mallik R.
    Proc Natl Acad Sci U S A 106:19381-19386(2009) [PubMed] [Europe PMC] [Abstract]
• dynactin binding Source: dictyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Dynein intermediate chain mediated dynein-dynactin interaction is required for interphase microtubule organization and centrosome replication and separation in Dictyostelium."
    Ma S., Trivinos-Lagos L., Graf R., Chisholm R.L.
    J Cell Biol 147:1261-1274(1999) [PubMed] [Europe PMC] [Abstract]
• dynein heavy chain binding Source: dictyBaseInferred from mutant phenotypeⁱ
  • "Dynein intermediate chain mediated dynein-dynactin interaction is required for interphase microtubule organization and centrosome replication and separation in Dictyostelium."
    Ma S., Trivinos-Lagos L., Graf R., Chisholm R.L.
    J Cell Biol 147:1261-1274(1999) [PubMed] [Europe PMC] [Abstract]
• dynein light chain binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• centrosome duplication Source: dictyBaseInferred from mutant phenotypeⁱ
  • "Dynein intermediate chain mediated dynein-dynactin interaction is required for interphase microtubule organization and centrosome replication and separation in Dictyostelium."
    Ma S., Trivinos-Lagos L., Graf R., Chisholm R.L.
    J Cell Biol 147:1261-1274(1999) [PubMed] [Europe PMC] [Abstract]
• centrosome separation Source: dictyBaseInferred from mutant phenotypeⁱ
  • "Dynein intermediate chain mediated dynein-dynactin interaction is required for interphase microtubule organization and centrosome replication and separation in Dictyostelium."
    Ma S., Trivinos-Lagos L., Graf R., Chisholm R.L.
    J Cell Biol 147:1261-1274(1999) [PubMed] [Europe PMC] [Abstract]
• Golgi localization Source: dictyBaseInferred from mutant phenotypeⁱ
  • "Dynein intermediate chain mediated dynein-dynactin interaction is required for interphase microtubule organization and centrosome replication and separation in Dictyostelium."
    Ma S., Trivinos-Lagos L., Graf R., Chisholm R.L.
    J Cell Biol 147:1261-1274(1999) [PubMed] [Europe PMC] [Abstract]
• microtubule-based movement Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• microtubule cytoskeleton organization Source: dictyBaseInferred from mutant phenotypeⁱ
  • "Dynein intermediate chain mediated dynein-dynactin interaction is required for interphase microtubule organization and centrosome replication and separation in Dictyostelium."
    Ma S., Trivinos-Lagos L., Graf R., Chisholm R.L.
    J Cell Biol 147:1261-1274(1999) [PubMed] [Europe PMC] [Abstract]
• minus-end-directed vesicle transport along microtubule Source: dictyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Cytoplasmic dynein-associated structures move bidirectionally in vivo."
    Ma S., Chisholm R.L.
    J Cell Sci 115:1453-1460(2002) [PubMed] [Europe PMC] [Abstract]
• transport along microtubule Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

GO - Cellular componentⁱ

• centrosome Source: dictyBase <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Molecular and functional analysis of the dictyostelium centrosome."
    Graef R., Daunderer C., Schulz I.
    Int. Rev. Cytol. 241:155-202(2004) [PubMed] [Europe PMC] [Abstract]
• cytoplasmic dynein complex Source: dictyBaseInferred from direct assayⁱ
  • "Interaction mapping of a dynein heavy chain. Identification of dimerization and intermediate-chain binding domains."
    Habura A., Tikhonenko I., Chisholm R.L., Koonce M.P.
    J Biol Chem 274:15447-15453(1999) [PubMed] [Europe PMC] [Abstract]
• early phagosome membrane Source: dictyBaseInferred by curatorⁱ
  • "Dynein Clusters into Lipid Microdomains on Phagosomes to Drive Rapid Transport toward Lysosomes."
    Rai A., Pathak D., Thakur S., Singh S., Dubey A.K., Mallik R.
    Cell 164:722-734(2016) [PubMed] [Europe PMC] [Abstract]
• microtubule Source: UniProtKB-KW
• phagolysosome membrane Source: dictyBaseInferred by curatorⁱ
  • "Dynein Clusters into Lipid Microdomains on Phagosomes to Drive Rapid Transport toward Lysosomes."
    Rai A., Pathak D., Thakur S., Singh S., Dubey A.K., Mallik R.
    Cell 164:722-734(2016) [PubMed] [Europe PMC] [Abstract]

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• dynactin binding Source: dictyBaseInferred from mutant phenotypeⁱ
  • "Dynein intermediate chain mediated dynein-dynactin interaction is required for interphase microtubule organization and centrosome replication and separation in Dictyostelium."
    Ma S., Trivinos-Lagos L., Graf R., Chisholm R.L.
    J Cell Biol 147:1261-1274(1999) [PubMed] [Europe PMC] [Abstract]
• dynein heavy chain binding Source: dictyBaseInferred from mutant phenotypeⁱ
  • "Dynein intermediate chain mediated dynein-dynactin interaction is required for interphase microtubule organization and centrosome replication and separation in Dictyostelium."
    Ma S., Trivinos-Lagos L., Graf R., Chisholm R.L.
    J Cell Biol 147:1261-1274(1999) [PubMed] [Europe PMC] [Abstract]
• dynein light chain binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDRDQKKKEL EQTKNEMRRK LEEYKERNRI MASKTTPTAT TTSTLNTAST 
        60         70         80         90        100
PSPPVAQEDF NSIMNSIDSM VPTQATPSSS STISTSTHAE SQKSNYIRPT 
       110        120        130        140        150
LTIQSLVIEH DFPPKEIPMY SKGTQTMTDA DTSNTNNTPE LEAPNKNKTK 
       160        170        180        190        200
YQLLQQQQQQ QQQQQSSLNQ DMQNLSIGTD SINGDGSSTS VANSANIDDD 
       210        220        230        240        250
DKDEIEIPEL DENEKKDILE SDSFKSFFGR SSRVIERALC LDDSIDILVD 
       260        270        280        290        300
YTISDENSKG TSKELKLLAT LSDERWTKHR SITDISWSTK HPELVVSSYS 
       310        320        330        340        350
ANEAGSHDPD GVALVWSVNN YFQKPEYVFT CQSPVMTTFF SKFHSTLIVG 
       360        370        380        390        400
GTYSGQIVIW DTRAEAKPVQ KTPLSSVGHT HPVYSMAVVG SANANSLVSI 
       410        420        430        440        450
STDAKLCSWN LENLSQPIET IELNSSNTNS ANKAGGGGSG GGAPNMSIAV 
       460        470        480        490        500
TSLVFPENEL NHFYIGTEEG VICQAGRHGN RIVMNERYKG HFGPITSVDL 
       510        520        530        540        550
HPSKGGADFS QYFLSSSTDW TCKLWSSKKE TPLYSFEDYV DYVYDARWSP 
       560        570        580        590        600
VHPSIFSTGD GSGTLSLWDL NQDLEAPIFR HKISNRSVNR LAWSHDGKRI 
       610        620        630        640        650
LVGDSGGSLS LFDSSEFSSP TSEEYSQFED VMTKMVNKSR TSDSPLLGEG 

ENQE                                                   

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Dictyostelium discoideum
   Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
2. SIMILARITY comments
   Index of protein domains and families