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Entry version 94 (08 May 2019)
Sequence version 3 (05 Oct 2010)
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Protein

Myosin-H heavy chain

Gene

myoH

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Myosin is a protein that binds to actin and has ATPase activity that is activated by actin.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi154 – 161ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin-H heavy chain
Alternative name(s):
Myosin-5a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:myoH
Synonyms:myo5A
ORF Names:DDB_G0289447
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0289447 myoH

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001233711 – 1771Myosin-H heavy chainAdd BLAST1771

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P54696

PRoteomics IDEntifications database

More...
PRIDEi
P54696

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Myosin I heavy chain is single-headed. Dimer of a heavy and a light chain. Inability to self-assemble into filaments.

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0233685

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P54696

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 57Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST51
Domaini61 – 840Myosin motorPROSITE-ProRule annotationAdd BLAST780
Domaini843 – 872IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini866 – 895IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini940 – 969IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini1427 – 1695DilutePROSITE-ProRule annotationAdd BLAST269

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni690 – 712Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1180 – 1224Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1169 – 1172Poly-Asp4
Compositional biasi1259 – 1264Poly-Gln6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0160 Eukaryota
COG5022 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P54696

KEGG Orthology (KO)

More...
KOi
K10357

Identification of Orthologs from Complete Genome Data

More...
OMAi
ISELEHW

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P54696

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002710 Dilute_dom
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01843 DIL, 1 hit
PF00612 IQ, 2 hits
PF00063 Myosin_head, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01132 DIL, 1 hit
SM00015 IQ, 3 hits
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51126 DILUTE, 1 hit
PS50096 IQ, 2 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P54696-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMIDNNCGKE KVWVPNPEKG WINGDLIKEI PGEGWLVRDE NGKEIKIEKD
60 70 80 90 100
ELRMQNPVIQ EGIDDMTSLS HLHEAAVIHN LIKRYEINSI YTYTGSILIA
110 120 130 140 150
INPYTKLPIY SKEMIESFCD QPVSKLAPHV YSIAESAYRE MLNFQKNQSI
160 170 180 190 200
LVSGESGAGK TETTKFLLQY FAAMGEKGNG VNTSLISEED IVEGNNIETQ
210 220 230 240 250
VIKSTPILEA FGNSKTLRND NSSRFGKFIE IHFDKIKGTI VGAKLETYLL
260 270 280 290 300
EKSRIVKPPE NERGYHIFYQ LIKGFNNSCC LKNSSNNNKD EDSSSSSNNN
310 320 330 340 350
IDDLKSLLKC KASDFNYLIS SGCDSIDGVD DSQVFIKTEN ALKVMGLSND
360 370 380 390 400
ELIGIYKILL SILHIGNIEF EKGKEEDSSI IKYGNSSFGE SFSDDDAGGY
410 420 430 440 450
NPLEISCKLL GCSVDSLKST FCSRKMKAGN ESYTINHTVE QASQARDSLS
460 470 480 490 500
MFLYSRLFDW LVVRINQSID KIGTEKKDNS FLFIGILDIY GFESFESNSY
510 520 530 540 550
EQFTINYANE KLQNQFNHQI FKLEQLEYEK EKIDWSYIEF SDNQECIDLI
560 570 580 590 600
EKKPLGILSI LDEESQFPKS TPSTLCTKLY NNHSKSKNFE KPRFSQTHFI
610 620 630 640 650
IDHYAGKVEY DTNLFLEKNK DFIISEQVSA LESSNWKFLT NLFQILSKKM
660 670 680 690 700
NGGGGTSGGG GAGGNKASSS AAGKSTFKFT SVSSQFKESL NSLMTTINST
710 720 730 740 750
NPHYIRCIKP NTEKRANLFD NVMVLHQLRC SGVIEQLRIS RSGYPSRLVY
760 770 780 790 800
DNFIKRYKLI VAKDFKNDDD SNESKEWNSI LKETDLNSSN GGTNNQIELK
810 820 830 840 850
RKGAELMINK LSIDISSVQF GLTKLFFKSG IIANLELLRS QTMINSATFI
860 870 880 890 900
QKIWRGYTDR KAYTSTKHSS IYFQSLIRSY LQQLEYNSMV EENSAIHLQS
910 920 930 940 950
LIRTNELEKQ FNQLLSTTIH FQSLLRRLED SKEFNTLMDR IKKIVKIQSL
960 970 980 990 1000
WRSNLAKKQL KLLKAEAKSL TNVVAEKNKL ASKLGDIQSK LDMESQLAQK
1010 1020 1030 1040 1050
IKNENEQLSS QFSNIQIEKE KLQKDFGNIN LEKEELLLKY SALESEYHQY
1060 1070 1080 1090 1100
KQQNELIISK LKQHINDLEE KQHQHSYKNN EVVGNTSFEG STTTNNGVTS
1110 1120 1130 1140 1150
PPKSSPASPI RNSINSNSDT TISGSSDDSI DNTDSLILSP KQHKGEDRKR
1160 1170 1180 1190 1200
NHEISSISPP RSRETIGHDD DDNNVDVIPR RQFNELEKEY KELKQMDETH
1210 1220 1230 1240 1250
KQYIESLKLQ ITQLEEKVKK SSSHPRSLLP GIPSNINDSP KVVYTKSSIT
1260 1270 1280 1290 1300
NDNSSSHHQQ QQQQHNISPS NSITSTTSPI NMMDSNIKSL SYKDFTNSQE
1310 1320 1330 1340 1350
IDAQQQLHQY HLNNGTNPAT STTNGSGNPL SQSSPTGSDK HIQQSTISDL
1360 1370 1380 1390 1400
VSALNFNNCQ LESGKYLVDL IIKNHDSIVS KYVPSEMGGI PEPAFILSRC
1410 1420 1430 1440 1450
FLKNIYDVDA TVIGTPNSTN SGGGSGTGVL DPIETNVNIL IYFCDKVEEV
1460 1470 1480 1490 1500
IYRDPKSNCS ALCYWFSNFY TLFNIMETYN QDTKDQLSLN DQDKALIEKL
1510 1520 1530 1540 1550
KITLQTMIVK AHKNVVKNIT DYIQPILHKS LNDTTSEIDF MDPITNYLNQ
1560 1570 1580 1590 1600
IQISLSLENC YINNNLCKLL FEQLFSFINA MIFNEILLRK DLCCLRSSIP
1610 1620 1630 1640 1650
IKMNISELEH WVKLHHGKEW SSSVCDKLRL LKEVVYILMI DKTQLQNDEL
1660 1670 1680 1690 1700
RDEICPTLSI AQLKQLLTMY SPDVDSFEDP IPLEILTSLM DSPKYNPDEN
1710 1720 1730 1740 1750
ILLDLSKIFT LKFINSNQTL SSSTSSENDL MATINLNALE SVQYACDDLV
1760 1770
SNIVKKNIEI VSLNNQKSIK K
Length:1,771
Mass (Da):200,699
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC9F967E85776177
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000141 Genomic DNA Translation: EDR41040.1
L35320 Genomic DNA Translation: AAA61402.1

NCBI Reference Sequences

More...
RefSeqi
XP_001733030.1, XM_001732978.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EDR41040; EDR41040; DDB_G0289447

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8627161

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0289447

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000141 Genomic DNA Translation: EDR41040.1
L35320 Genomic DNA Translation: AAA61402.1
RefSeqiXP_001733030.1, XM_001732978.1

3D structure databases

SMRiP54696
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0233685

Proteomic databases

PaxDbiP54696
PRIDEiP54696

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEDR41040; EDR41040; DDB_G0289447
GeneIDi8627161
KEGGiddi:DDB_G0289447

Organism-specific databases

dictyBaseiDDB_G0289447 myoH

Phylogenomic databases

eggNOGiKOG0160 Eukaryota
COG5022 LUCA
InParanoidiP54696
KOiK10357
OMAiISELEHW
PhylomeDBiP54696

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P54696

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR002710 Dilute_dom
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00612 IQ, 2 hits
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00015 IQ, 3 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50096 IQ, 2 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYOH_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54696
Secondary accession number(s): B0G166, Q54HG3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 5, 2010
Last modified: May 8, 2019
This is version 94 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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