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Entry version 118 (12 Aug 2020)
Sequence version 3 (02 Sep 2008)
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Protein

Phosphatidylinositol 4-kinase

Gene

pikD

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 4-kinase (EC:2.7.1.67)
Short name:
PI4-kinase
Short name:
PtdIns-4-kinase
Alternative name(s):
PI4K-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pikD
Synonyms:pik4
ORF Names:DDB_G0288485
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0288485, pikD

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000888261 – 1180Phosphatidylinositol 4-kinaseAdd BLAST1180

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P54677

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0191346

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 206PIK helicalPROSITE-ProRule annotationAdd BLAST206
Domaini919 – 1178PI3K/PI4KPROSITE-ProRule annotationAdd BLAST260

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi21 – 27Poly-Asn7
Compositional biasi38 – 43Poly-Asn6
Compositional biasi62 – 69Poly-Ser8
Compositional biasi70 – 74Poly-Asn5
Compositional biasi233 – 238Poly-Asp6
Compositional biasi271 – 287Poly-AsnAdd BLAST17
Compositional biasi290 – 293Poly-Asn4
Compositional biasi314 – 320Poly-Asn7
Compositional biasi364 – 402Poly-AsnAdd BLAST39
Compositional biasi528 – 532Poly-Asp5
Compositional biasi542 – 553Poly-ThrAdd BLAST12
Compositional biasi581 – 588Poly-Gly8
Compositional biasi777 – 783Poly-Thr7
Compositional biasi838 – 841Poly-Gln4
Compositional biasi848 – 859Poly-ThrAdd BLAST12
Compositional biasi862 – 872Poly-ThrAdd BLAST11

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0903, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_273161_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P54677

KEGG Orthology (KO)

More...
KOi
K19801

Identification of Orthologs from Complete Genome Data

More...
OMAi
CEMSVIT

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR001263, PI3K_accessory_dom
IPR015433, PI_Kinase

The PANTHER Classification System

More...
PANTHERi
PTHR10048, PTHR10048, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00454, PI3_PI4_kinase, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00146, PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit
PS51545, PIK_HELICAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P54677-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKISDTIII TSTSNEDEVD NNNNNNNLKE IDRSPRVNNN NNNILTNVNN
60 70 80 90 100
NKNNTITSSG GSDSSSSSSN NNNNKIKKSK KHKEKEHMDS IVKLYSGKFD
110 120 130 140 150
SWMVICHLFK YRDNPGIVDF LCNKMYNLED KDIDFYITQL CILLINQPHD
160 170 180 190 200
QKASFSSLAR FILDRCASSF RFAIKAYWIF QAFEEDGEKN LFSIEGSVYL
210 220 230 240 250
HSPSTSPKDV PMYSNDQIVP IDLDKIYNQS QYDDDDFDLS DDDGGFEIIK
260 270 280 290 300
KNDHHYENDH HIENDPKKDI NSNNNNNNNI NNNNSNNDDN NNNEILPNEN
310 320 330 340 350
SDNSINDENN QYGNSNNNNN ISGENDNIKI DINSQNKSDS NIETLNSTLC
360 370 380 390 400
EETKTSPIKD DMENNNNNNN NNNNNNNNNN NNNNINNNNI NNNNINNNNN
410 420 430 440 450
INYGHINGSL STLDGIGQPY ISQPNDPIEN ITQILKRNRI IYKKVEEKKE
460 470 480 490 500
LATRLREFCE MSVITCSRPL ITRPRTSSLP SPLISYNSGK IGGNYHKILS
510 520 530 540 550
PSSVDSTSLI SEDDKIIEKE EEDNVVEDDD DDEVNSEDFI PTATTTATTT
560 570 580 590 600
TTTIPNHLSK TTSGVGINSN SSTPININSA GAGAGGGGEI NHIGYDDISY
610 620 630 640 650
LDKCKTPPAE SKLSDHDFEF ELSKSHRCDY LNDILSFIQK LAHISKILLP
660 670 680 690 700
IPIDLRQAKL KHEISLLNIN LPLGLYVPLW QSSNHHCVVR IPPEEVKILN
710 720 730 740 750
SRERVPFLLV LEVIESEHEA LSSNIFEVVS SYLQYTTGNS ALKKDDIKRK
760 770 780 790 800
YYSEKFKKSF LNSSINSTIS NSSDSCTTET TTTSPVATSP TLPINIPHSK
810 820 830 840 850
LINDGSNSIS KSLPVTPTQS TVLNNLISTS TAISPPSQQQ QLPSPSNTTT
860 870 880 890 900
TTTTTTTNTN NTTTTTTTTT TTLSTSPTNE KILNENKQNS SPFGESWQEK
910 920 930 940 950
IERYKKISPF GDYPNWRLYS VIVKTGDDCR QEQMAVQLIS KFDEIWKETR
960 970 980 990 1000
LPLYLRPYSI LVTSSGGGII ETIPDTMSLH NLKKSTPGFT TLLNYFKSTY
1010 1020 1030 1040 1050
GDPSGLRFRT AQSNFIESMA AYSIVTYILQ IKDRHNGNIL IDKEGHIVHI
1060 1070 1080 1090 1100
DFGFILSNSP GNISFESAPF KLTQELVDVM GGIQSGQFQY FKVLCVRGLI
1110 1120 1130 1140 1150
EARKQVDKII SLIEIMMSGP KMSCFVGGKE VIEQLKARFF LDVNERECST
1160 1170 1180
LVENLISYSI DHFKTRYYDK YQSWLNGIYQ
Length:1,180
Mass (Da):132,681
Last modified:September 2, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1AB9290C91445F32
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti138T → N in AAA85725 (PubMed:7565716).Curated1
Sequence conflicti149H → L in AAA85725 (PubMed:7565716).Curated1
Sequence conflicti252 – 253ND → KC in AAA85725 (PubMed:7565716).Curated2
Sequence conflicti326D → N in AAA85725 (PubMed:7565716).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000112 Genomic DNA Translation: EAL63191.2
U23479 Genomic DNA Translation: AAA85725.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T18275

NCBI Reference Sequences

More...
RefSeqi
XP_636702.2, XM_631610.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL63191; EAL63191; DDB_G0288485

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8626659

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0288485

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000112 Genomic DNA Translation: EAL63191.2
U23479 Genomic DNA Translation: AAA85725.1
PIRiT18275
RefSeqiXP_636702.2, XM_631610.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi44689.DDB0191346

Proteomic databases

PaxDbiP54677

Genome annotation databases

EnsemblProtistsiEAL63191; EAL63191; DDB_G0288485
GeneIDi8626659
KEGGiddi:DDB_G0288485

Organism-specific databases

dictyBaseiDDB_G0288485, pikD

Phylogenomic databases

eggNOGiKOG0903, Eukaryota
HOGENOMiCLU_273161_0_0_1
InParanoidiP54677
KOiK19801
OMAiCEMSVIT

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P54677

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR001263, PI3K_accessory_dom
IPR015433, PI_Kinase
PANTHERiPTHR10048, PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454, PI3_PI4_kinase, 2 hits
SMARTiView protein in SMART
SM00146, PI3Kc, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit
PS51545, PIK_HELICAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPI4K_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54677
Secondary accession number(s): Q54IV1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 2, 2008
Last modified: August 12, 2020
This is version 118 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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