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Entry version 120 (07 Apr 2021)
Sequence version 2 (04 Dec 2007)
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Protein

AP-2 complex subunit mu

Gene

apm2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • clathrin adaptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-437239, Recycling pathway of L1
R-DDI-8856825, Cargo recognition for clathrin-mediated endocytosis
R-DDI-8856828, Clathrin-mediated endocytosis
R-DDI-8866427, VLDLR internalisation and degradation
R-DDI-8964038, LDL clearance

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AP-2 complex subunit mu
Alternative name(s):
Clathrin assembly protein complex 2 mu medium chain
Clathrin coat assembly protein AP50
Clathrin coat-associated protein AP50
Clathrin-adaptor medium chain Apm2
Mu2-adaptin
Plasma membrane adaptor AP-2 50 kDa protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:apm2
Synonyms:apm1, apmA
ORF Names:DDB_G0277139
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0277139, apm2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Coated pit, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001937921 – 439AP-2 complex subunit muAdd BLAST439

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P54672

PRoteomics IDEntifications database

More...
PRIDEi
P54672

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type and beta-type subunits), a medium adaptin (mu-type subunit AP50) and a small adaptin (sigma-type subunit AP17).

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0191267

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini172 – 438MHDPROSITE-ProRule annotationAdd BLAST267

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0938, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026996_5_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P54672

Identification of Orthologs from Complete Genome Data

More...
OMAi
ALVFEFC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P54672

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09251, AP-2_Mu2_Cterm, 1 hit
cd14836, AP2_Mu_N, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036168, AP2_Mu_C_sf
IPR043532, AP2_Mu_N
IPR022775, AP_mu_sigma_su
IPR001392, Clathrin_mu
IPR018240, Clathrin_mu_CS
IPR011012, Longin-like_dom_sf
IPR028565, MHD
IPR043512, Mu2_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00928, Adap_comp_sub, 1 hit
PF01217, Clat_adaptor_s, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005992, Clathrin_mu, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00314, CLATHRINADPT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49447, SSF49447, 1 hit
SSF64356, SSF64356, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00990, CLAT_ADAPTOR_M_1, 1 hit
PS00991, CLAT_ADAPTOR_M_2, 1 hit
PS51072, MHD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P54672-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISALFLMNG KGEVLISRIY RDDISRGVAN AFRLEVIGSQ ETRSPVKLIG
60 70 80 90 100
STSFMYIKVG NIYIVGVSRQ NVNACMVFEV LHQLVDIFKS YFDNLDEDSI
110 120 130 140 150
RNNFVLVYEL LDEILDFGYP QNCSTDVLKL YITQGQGKLK SLDKLKQDKI
160 170 180 190 200
SKITIQATGT TPWRTPDIKY KRNELYIDVV ESVNLLMSAE GNILRADVSG
210 220 230 240 250
QVMMKCFLSG MPECKFGMND KVIMDREKST NGGSAARSGA RRANGIEIDD
260 270 280 290 300
ITFHQCVRLG KFDSDRTVSF IPPDGEFELM RYRTTEHINL PFKVIPIVRE
310 320 330 340 350
MGRTRLECSV TVKSNFSSKM FGANVKVIIP TPKNTAVCKI VVAAGKAKYM
360 370 380 390 400
PEQDAIIWRI RRFPGDTEFT LRAEVELMAS VNLDKKAWSR PPISMEFQVT
410 420 430
MFTASGFSVR FLKVVEKSNY TPIKWVRYLT KAGTYQNRI
Length:439
Mass (Da):49,785
Last modified:December 4, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49AD576E060E6B31
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29A → G in AAB41282 (PubMed:8996086).Curated1
Sequence conflicti39S → V in AAB41282 (PubMed:8996086).Curated1
Sequence conflicti156Q → H in AAB41282 (PubMed:8996086).Curated1
Sequence conflicti240A → R in AAB41282 (PubMed:8996086).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U44890 mRNA Translation: AAB41282.1
AAFI02000019 Genomic DNA Translation: EAL68755.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5719

NCBI Reference Sequences

More...
RefSeqi
XP_642749.1, XM_637657.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL68755; EAL68755; DDB_G0277139

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8620939

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0277139

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44890 mRNA Translation: AAB41282.1
AAFI02000019 Genomic DNA Translation: EAL68755.1
PIRiJC5719
RefSeqiXP_642749.1, XM_637657.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi44689.DDB0191267

Proteomic databases

PaxDbiP54672
PRIDEiP54672

Genome annotation databases

EnsemblProtistsiEAL68755; EAL68755; DDB_G0277139
GeneIDi8620939
KEGGiddi:DDB_G0277139

Organism-specific databases

dictyBaseiDDB_G0277139, apm2

Phylogenomic databases

eggNOGiKOG0938, Eukaryota
HOGENOMiCLU_026996_5_2_1
InParanoidiP54672
OMAiALVFEFC
PhylomeDBiP54672

Enzyme and pathway databases

ReactomeiR-DDI-437239, Recycling pathway of L1
R-DDI-8856825, Cargo recognition for clathrin-mediated endocytosis
R-DDI-8856828, Clathrin-mediated endocytosis
R-DDI-8866427, VLDLR internalisation and degradation
R-DDI-8964038, LDL clearance

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P54672

Family and domain databases

CDDicd09251, AP-2_Mu2_Cterm, 1 hit
cd14836, AP2_Mu_N, 1 hit
InterProiView protein in InterPro
IPR036168, AP2_Mu_C_sf
IPR043532, AP2_Mu_N
IPR022775, AP_mu_sigma_su
IPR001392, Clathrin_mu
IPR018240, Clathrin_mu_CS
IPR011012, Longin-like_dom_sf
IPR028565, MHD
IPR043512, Mu2_C
PfamiView protein in Pfam
PF00928, Adap_comp_sub, 1 hit
PF01217, Clat_adaptor_s, 1 hit
PIRSFiPIRSF005992, Clathrin_mu, 1 hit
PRINTSiPR00314, CLATHRINADPT
SUPFAMiSSF49447, SSF49447, 1 hit
SSF64356, SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00990, CLAT_ADAPTOR_M_1, 1 hit
PS00991, CLAT_ADAPTOR_M_2, 1 hit
PS51072, MHD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAP2M_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54672
Secondary accession number(s): Q54ZW7, Q86AQ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 4, 2007
Last modified: April 7, 2021
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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