UniProtKB - P54646 (AAPK2_HUMAN)
5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2
Functioni
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357).
In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:17307971, PubMed:17712357).
AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:17307971, PubMed:17712357).
Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:7959015).
Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (PubMed:34077757).
Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (By similarity).
Involved in insulin receptor/INSR internalization (PubMed:25687571).
AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity).
Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11554766, PubMed:11518699, PubMed:15866171, PubMed:17711846, PubMed:18184930).
Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity).
In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity).
Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (PubMed:14651849, PubMed:20160076, PubMed:21205641).
In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (PubMed:21205641).
In that process also activates WDR45/WIPI4 (PubMed:28561066).
Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (PubMed:32029622).
AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity).
May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity).
Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:17486097).
Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:12519745, PubMed:20074060).
Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation (By similarity).
Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity).
2 PublicationsBy similarity16 PublicationsCatalytic activityi
- EC:2.7.11.11 Publication
- EC:2.7.11.1By similarity
- ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H+ + O-phospho-L-seryl-[acetyl-CoA carboxylase]By similarityEC:2.7.11.27By similarity
- ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] = ADP + H+ + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]By similarityEC:2.7.11.31By similarity
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 45 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 139 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 22 – 30 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- [acetyl-CoA carboxylase] kinase activity Source: UniProtKB-EC
- [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity Source: UniProtKB-EC
- AMP-activated protein kinase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- chromatin binding Source: UniProtKB
- histone serine kinase activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- protein kinase activity Source: ProtInc
- protein serine/threonine/tyrosine kinase activity Source: MGI
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
GO - Biological processi
- autophagy Source: UniProtKB-KW
- cellular response to calcium ion Source: ARUK-UCL
- cellular response to glucose starvation Source: UniProtKB
- cellular response to glucose stimulus Source: ARUK-UCL
- cellular response to nutrient levels Source: ComplexPortal
- cellular response to oxidative stress Source: ARUK-UCL
- cellular response to prostaglandin E stimulus Source: Ensembl
- cellular response to xenobiotic stimulus Source: Ensembl
- cholesterol biosynthetic process Source: UniProtKB-KW
- chromatin organization Source: UniProtKB-KW
- energy homeostasis Source: UniProtKB
- fatty acid biosynthetic process Source: UniProtKB-KW
- fatty acid homeostasis Source: UniProtKB
- glucose homeostasis Source: UniProtKB
- intracellular signal transduction Source: GO_Central
- lipid biosynthetic process Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of gene expression Source: ARUK-UCL
- negative regulation of TOR signaling Source: UniProtKB
- negative regulation of tubulin deacetylation Source: ARUK-UCL
- positive regulation of autophagy Source: UniProtKB
- positive regulation of glycolytic process Source: UniProtKB
- positive regulation of macroautophagy Source: ParkinsonsUK-UCL
- positive regulation of peptidyl-lysine acetylation Source: ARUK-UCL
- positive regulation of protein localization Source: ARUK-UCL
- protein phosphorylation Source: GO_Central
- regulation of circadian rhythm Source: UniProtKB
- regulation of macroautophagy Source: UniProtKB
- regulation of microtubule cytoskeleton organization Source: ARUK-UCL
- regulation of stress granule assembly Source: Ensembl
- response to muscle activity Source: Ensembl
- rhythmic process Source: UniProtKB-KW
- signal transduction Source: ProtInc
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 2.7.11.31, 2681 |
PathwayCommonsi | P54646 |
Reactomei | R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1632852, Macroautophagy R-HSA-163680, AMPK inhibits chREBP transcriptional activation activity R-HSA-200425, Carnitine metabolism R-HSA-2151209, Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-380972, Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-9613354, Lipophagy R-HSA-9619483, Activation of AMPK downstream of NMDARs |
SignaLinki | P54646 |
SIGNORi | P54646 |
Protein family/group databases
TCDBi | 8.A.104.1.1, the 5'-amp-activated protein kinase (ampk) family |
Names & Taxonomyi
Protein namesi | Recommended name: 5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC:2.7.11.11 Publication)Short name: AMPK subunit alpha-2 Alternative name(s): |
Gene namesi | Name:PRKAA2 Synonyms:AMPK, AMPK2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9377, PRKAA2 |
MIMi | 600497, gene |
neXtProti | NX_P54646 |
VEuPathDBi | HostDB:ENSG00000162409 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nuclear speck Source: HPA
- nucleoplasm Source: Reactome
- nucleus Source: ComplexPortal
Other locations
- axon Source: ARUK-UCL
- cytoplasmic stress granule Source: ARUK-UCL
- dendrite Source: ARUK-UCL
- neuronal cell body Source: ARUK-UCL
- nucleotide-activated protein kinase complex Source: ComplexPortal
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 172 | T → D: Phosphomimetic mutant. | 1 |
Organism-specific databases
DisGeNETi | 5563 |
OpenTargetsi | ENSG00000162409 |
PharmGKBi | PA33745 |
Miscellaneous databases
Pharosi | P54646, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2116 |
DrugBanki | DB00945, Acetylsalicylic acid DB00131, Adenosine phosphate DB12010, Fostamatinib DB00273, Topiramate |
DrugCentrali | P54646 |
Genetic variation databases
BioMutai | PRKAA2 |
DMDMi | 20178276 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085594 | 1 – 552 | 5'-AMP-activated protein kinase catalytic subunit alpha-2Add BLAST | 552 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 172 | Phosphothreonine; by LKB1 and CaMKK22 Publications | 1 | |
Modified residuei | 258 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 377 | PhosphoserineCombined sources | 1 | |
Modified residuei | 491 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P54646 |
jPOSTi | P54646 |
MassIVEi | P54646 |
MaxQBi | P54646 |
PaxDbi | P54646 |
PeptideAtlasi | P54646 |
PRIDEi | P54646 |
ProteomicsDBi | 56689 |
PTM databases
GlyConnecti | 985, 2 N-Linked glycans (1 site) |
GlyGeni | P54646, 2 sites, 3 N-linked glycans (1 site), 1 O-linked glycan (1 site) |
iPTMneti | P54646 |
PhosphoSitePlusi | P54646 |
Expressioni
Gene expression databases
Bgeei | ENSG00000162409, Expressed in biceps brachii and 220 other tissues |
ExpressionAtlasi | P54646, baseline and differential |
Genevisiblei | P54646, HS |
Organism-specific databases
HPAi | ENSG00000162409, Tissue enhanced (heart muscle, skeletal muscle, tongue) |
Interactioni
Subunit structurei
AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3) (PubMed:21543851).
Interacts with FNIP1 and FNIP2. Associates with internalized insulin receptor/INSR complexes on Golgi/endosomal membranes; PRKAA2/AMPK2 together with ATIC and HACD3/PTPLAD1 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis (PubMed:25687571).
2 PublicationsBinary interactionsi
P54646
Protein-protein interaction databases
BioGRIDi | 111550, 190 interactors |
ComplexPortali | CPX-5787, AMPK complex, alpha2-beta1-gamma1 variant CPX-5790, AMPK complex, alpha2-beta2-gamma1 variant CPX-5840, AMPK complex, alpha2-beta2-gamma3 variant CPX-5843, AMPK complex, alpha2-beta1-gamma3 variant CPX-5844, AMPK complex, alpha2-beta1-gamma2 variant CPX-5845, AMPK complex, alpha2-beta2-gamma2 variant |
CORUMi | P54646 |
DIPi | DIP-39796N |
IntActi | P54646, 142 interactors |
MINTi | P54646 |
STRINGi | 9606.ENSP00000360290 |
Chemistry databases
BindingDBi | P54646 |
Miscellaneous databases
RNActi | P54646, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P54646 |
SMRi | P54646 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P54646 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 268 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 253 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 291 – 376 | AISBy similarityAdd BLAST | 86 | |
Regioni | 477 – 521 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 498 – 521 | Polar residuesSequence analysisAdd BLAST | 24 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0583, Eukaryota |
GeneTreei | ENSGT00940000156945 |
HOGENOMi | CLU_000288_59_3_1 |
OrthoDBi | 1127668at2759 |
PhylomeDBi | P54646 |
TreeFami | TF314032 |
Family and domain databases
CDDi | cd12200, AMPKA2_C, 1 hit cd14404, UBA_AID_AAPK2, 1 hit |
IDEALi | IID00661 |
InterProi | View protein in InterPro IPR032270, AMPK_C IPR039148, AMPKA2_C IPR028375, KA1/Ssp2_C IPR011009, Kinase-like_dom_sf IPR028783, PRKAA2 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF16579, AdenylateSensor, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF103243, SSF103243, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAEKQKHDGR VKIGHYVLGD TLGVGTFGKV KIGEHQLTGH KVAVKILNRQ
60 70 80 90 100
KIRSLDVVGK IKREIQNLKL FRHPHIIKLY QVISTPTDFF MVMEYVSGGE
110 120 130 140 150
LFDYICKHGR VEEMEARRLF QQILSAVDYC HRHMVVHRDL KPENVLLDAH
160 170 180 190 200
MNAKIADFGL SNMMSDGEFL RTSCGSPNYA APEVISGRLY AGPEVDIWSC
210 220 230 240 250
GVILYALLCG TLPFDDEHVP TLFKKIRGGV FYIPEYLNRS VATLLMHMLQ
260 270 280 290 300
VDPLKRATIK DIREHEWFKQ DLPSYLFPED PSYDANVIDD EAVKEVCEKF
310 320 330 340 350
ECTESEVMNS LYSGDPQDQL AVAYHLIIDN RRIMNQASEF YLASSPPSGS
360 370 380 390 400
FMDDSAMHIP PGLKPHPERM PPLIADSPKA RCPLDALNTT KPKSLAVKKA
410 420 430 440 450
KWHLGIRSQS KPYDIMAEVY RAMKQLDFEW KVVNAYHLRV RRKNPVTGNY
460 470 480 490 500
VKMSLQLYLV DNRSYLLDFK SIDDEVVEQR SGSSTPQRSC SAAGLHRPRS
510 520 530 540 550
SFDSTTAESH SLSGSLTGSL TGSTLSSVSP RLGSHTMDFF EMCASLITTL
AR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WXX9 | A0A087WXX9_HUMAN | 5'-AMP-activated protein kinase cat... | PRKAA2 | 552 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 180 | A → T in AAA64745 (PubMed:7959015).Curated | 1 | |
Sequence conflicti | 271 | D → G in AAA64745 (PubMed:7959015).Curated | 1 | |
Sequence conflicti | 403 – 404 | HL → RQ in AAA64745 (PubMed:7959015).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035623 | 371 | P → T in breast cancer samples; infiltrating ductal carcinoma; somatic mutation. 2 Publications | 1 | |
Natural variantiVAR_040355 | 407 | R → Q in a gastric adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_035624 | 523 | S → G in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U06454 mRNA Translation: AAA64745.1 AL035705 Genomic DNA No translation available. BC069680 mRNA Translation: AAH69680.1 BC069740 mRNA Translation: AAH69740.1 BC069823 mRNA Translation: AAH69823.1 |
CCDSi | CCDS605.1 |
PIRi | S51025 |
RefSeqi | NP_006243.2, NM_006252.3 |
Genome annotation databases
Ensembli | ENST00000371244; ENSP00000360290; ENSG00000162409 |
GeneIDi | 5563 |
KEGGi | hsa:5563 |
MANE-Selecti | ENST00000371244.9; ENSP00000360290.4; NM_006252.4; NP_006243.2 |
UCSCi | uc001cyk.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U06454 mRNA Translation: AAA64745.1 AL035705 Genomic DNA No translation available. BC069680 mRNA Translation: AAH69680.1 BC069740 mRNA Translation: AAH69740.1 BC069823 mRNA Translation: AAH69823.1 |
CCDSi | CCDS605.1 |
PIRi | S51025 |
RefSeqi | NP_006243.2, NM_006252.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2H6D | X-ray | 1.85 | A | 6-279 | [»] | |
2LTU | NMR | - | A | 282-339 | [»] | |
2YZA | X-ray | 3.02 | A | 6-279 | [»] | |
3AQV | X-ray | 2.08 | A | 6-279 | [»] | |
4CFE | X-ray | 3.02 | A/C | 1-552 | [»] | |
4CFF | X-ray | 3.92 | A/C | 1-552 | [»] | |
4ZHX | X-ray | 2.99 | A/C | 2-552 | [»] | |
5EZV | X-ray | 2.99 | A/C | 2-347 | [»] | |
A/C | 397-552 | [»] | ||||
5ISO | X-ray | 2.63 | A/C | 1-552 | [»] | |
6B1U | X-ray | 2.77 | A/C | 2-552 | [»] | |
6B2E | X-ray | 3.80 | A | 2-552 | [»] | |
6BX6 | X-ray | 2.90 | A | 6-279 | [»] | |
BMRBi | P54646 | |||||
SMRi | P54646 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111550, 190 interactors |
ComplexPortali | CPX-5787, AMPK complex, alpha2-beta1-gamma1 variant CPX-5790, AMPK complex, alpha2-beta2-gamma1 variant CPX-5840, AMPK complex, alpha2-beta2-gamma3 variant CPX-5843, AMPK complex, alpha2-beta1-gamma3 variant CPX-5844, AMPK complex, alpha2-beta1-gamma2 variant CPX-5845, AMPK complex, alpha2-beta2-gamma2 variant |
CORUMi | P54646 |
DIPi | DIP-39796N |
IntActi | P54646, 142 interactors |
MINTi | P54646 |
STRINGi | 9606.ENSP00000360290 |
Chemistry databases
BindingDBi | P54646 |
ChEMBLi | CHEMBL2116 |
DrugBanki | DB00945, Acetylsalicylic acid DB00131, Adenosine phosphate DB12010, Fostamatinib DB00273, Topiramate |
DrugCentrali | P54646 |
Protein family/group databases
TCDBi | 8.A.104.1.1, the 5'-amp-activated protein kinase (ampk) family |
PTM databases
GlyConnecti | 985, 2 N-Linked glycans (1 site) |
GlyGeni | P54646, 2 sites, 3 N-linked glycans (1 site), 1 O-linked glycan (1 site) |
iPTMneti | P54646 |
PhosphoSitePlusi | P54646 |
Genetic variation databases
BioMutai | PRKAA2 |
DMDMi | 20178276 |
Proteomic databases
EPDi | P54646 |
jPOSTi | P54646 |
MassIVEi | P54646 |
MaxQBi | P54646 |
PaxDbi | P54646 |
PeptideAtlasi | P54646 |
PRIDEi | P54646 |
ProteomicsDBi | 56689 |
Protocols and materials databases
Antibodypediai | 3399, 823 antibodies from 43 providers |
DNASUi | 5563 |
Genome annotation databases
Ensembli | ENST00000371244; ENSP00000360290; ENSG00000162409 |
GeneIDi | 5563 |
KEGGi | hsa:5563 |
MANE-Selecti | ENST00000371244.9; ENSP00000360290.4; NM_006252.4; NP_006243.2 |
UCSCi | uc001cyk.5, human |
Organism-specific databases
CTDi | 5563 |
DisGeNETi | 5563 |
GeneCardsi | PRKAA2 |
HGNCi | HGNC:9377, PRKAA2 |
HPAi | ENSG00000162409, Tissue enhanced (heart muscle, skeletal muscle, tongue) |
MIMi | 600497, gene |
neXtProti | NX_P54646 |
OpenTargetsi | ENSG00000162409 |
PharmGKBi | PA33745 |
VEuPathDBi | HostDB:ENSG00000162409 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0583, Eukaryota |
GeneTreei | ENSGT00940000156945 |
HOGENOMi | CLU_000288_59_3_1 |
OrthoDBi | 1127668at2759 |
PhylomeDBi | P54646 |
TreeFami | TF314032 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 2.7.11.31, 2681 |
PathwayCommonsi | P54646 |
Reactomei | R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1632852, Macroautophagy R-HSA-163680, AMPK inhibits chREBP transcriptional activation activity R-HSA-200425, Carnitine metabolism R-HSA-2151209, Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-380972, Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-9613354, Lipophagy R-HSA-9619483, Activation of AMPK downstream of NMDARs |
SignaLinki | P54646 |
SIGNORi | P54646 |
Miscellaneous databases
BioGRID-ORCSi | 5563, 7 hits in 1068 CRISPR screens |
ChiTaRSi | PRKAA2, human |
EvolutionaryTracei | P54646 |
GeneWikii | PRKAA2 |
GenomeRNAii | 5563 |
Pharosi | P54646, Tchem |
PROi | PR:P54646 |
RNActi | P54646, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162409, Expressed in biceps brachii and 220 other tissues |
ExpressionAtlasi | P54646, baseline and differential |
Genevisiblei | P54646, HS |
Family and domain databases
CDDi | cd12200, AMPKA2_C, 1 hit cd14404, UBA_AID_AAPK2, 1 hit |
IDEALi | IID00661 |
InterProi | View protein in InterPro IPR032270, AMPK_C IPR039148, AMPKA2_C IPR028375, KA1/Ssp2_C IPR011009, Kinase-like_dom_sf IPR028783, PRKAA2 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF16579, AdenylateSensor, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF103243, SSF103243, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AAPK2_HUMAN | |
Accessioni | P54646Primary (citable) accession number: P54646 Secondary accession number(s): Q9H1E8, Q9UD43 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | April 16, 2002 | |
Last modified: | February 23, 2022 | |
This is version 212 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families