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Protein

Osteocalcin-related protein

Gene

Bglap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds strongly to apatite and calcium.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Calcium 3By similarity1
Metal bindingi66Calcium 2By similarity1
Metal bindingi69Calcium 1By similarity1
Metal bindingi69Calcium 2By similarity1
Metal bindingi75Calcium 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processBiomineralization
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-159740 Gamma-carboxylation of protein precursors
R-MMU-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-MMU-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocalcin-related protein1 Publication
Alternative name(s):
Gamma-carboxyglutamic acid-containing protein 3Curated
Nephrocalcin1 Publication
OC-XImported
Gene namesi
Name:Bglap3Imported
Synonyms:Bglap-rs1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:88155 Bglap3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000001109024 – 49CuratedAdd BLAST26
ChainiPRO_000001109150 – 95Osteocalcin-related proteinAdd BLAST46

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei664-carboxyglutamatePROSITE-ProRule annotation1
Disulfide bondi68 ↔ 74PROSITE-ProRule annotation
Modified residuei694-carboxyglutamatePROSITE-ProRule annotation1

Post-translational modificationi

Gamma-carboxyglutamic acid residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid

Proteomic databases

PaxDbiP54615
PRIDEiP54615

Expressioni

Tissue specificityi

Expressed in kidney and lung, but not in bone.1 Publication

Gene expression databases

BgeeiENSMUSG00000074489
GenevisibleiP54615 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074965

Structurei

3D structure databases

ProteinModelPortaliP54615
SMRiP54615
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 92GlaPROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J11Z Eukaryota
ENOG410ZS6W LUCA
GeneTreeiENSGT00410000026290
HOGENOMiHOG000115820
HOVERGENiHBG003085
InParanoidiP54615
KOiK22609
OrthoDBiEOG091G13UG
PhylomeDBiP54615
TreeFamiTF330920

Family and domain databases

InterProiView protein in InterPro
IPR035972 GLA-like_dom_SF
IPR000294 GLA_domain
IPR039176 Osteocalcin
IPR002384 Osteocalcin/MGP
PANTHERiPTHR14235 PTHR14235, 1 hit
PRINTSiPR00002 GLABONE
SMARTiView protein in SMART
SM00069 GLA, 1 hit
SUPFAMiSSF57630 SSF57630, 1 hit
PROSITEiView protein in PROSITE
PS00011 GLA_1, 1 hit
PS50998 GLA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLSLLTLL ALAALCLSDL TDATPTGPES DKAFMSKQEG NKVVNRLRRY
60 70 80 90
LGASVPSPDP LEPTRELCEL DPACDELSNQ YGLKTAYRRI YGITI
Length:95
Mass (Da):10,459
Last modified:October 1, 1996 - v1
Checksum:i231968AA8B55848E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26T → S in AAH31815 (PubMed:15489334).Curated1
Sequence conflicti26T → S in AAH55868 (PubMed:15489334).Curated1
Sequence conflicti26T → S in AAI00688 (PubMed:15489334).Curated1
Sequence conflicti26T → S in AAI01949 (PubMed:15489334).Curated1
Sequence conflicti26T → S in AAI41239 (PubMed:15489334).Curated1
Sequence conflicti26T → S in AAI45566 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24430 Genomic DNA Translation: AAA39855.1
S67456 Genomic DNA Translation: AAB29146.1
U11541 Unassigned DNA Translation: AAB60445.1
BC031815 mRNA Translation: AAH31815.1
BC055868 mRNA Translation: AAH55868.1
BC100687 mRNA Translation: AAI00688.1
BC101948 mRNA Translation: AAI01949.1
BC141238 mRNA Translation: AAI41239.1
BC145565 mRNA Translation: AAI45566.1
CCDSiCCDS17472.1
PIRiI61188
RefSeqiNP_001292377.1, NM_001305448.1
NP_001292378.1, NM_001305449.1
NP_001292379.1, NM_001305450.1
NP_112736.3, NM_031368.5
UniGeneiMm.482191

Genome annotation databases

EnsembliENSMUST00000075523; ENSMUSP00000074965; ENSMUSG00000074489
ENSMUST00000107542; ENSMUSP00000103166; ENSMUSG00000074489
ENSMUST00000107543; ENSMUSP00000103167; ENSMUSG00000074489
GeneIDi12095
KEGGimmu:12095
UCSCiuc008puv.3 mouse
uc012cru.2 mouse

Similar proteinsi

Entry informationi

Entry nameiOSTR_MOUSE
AccessioniPrimary (citable) accession number: P54615
Secondary accession number(s): Q78H72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 18, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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