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Entry version 205 (16 Oct 2019)
Sequence version 4 (23 Jan 2007)
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Protein

Tyrosine--tRNA ligase, cytoplasmic

Gene

YARS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei39TyrosineCombined sources1 Publication1
Binding sitei166TyrosineCombined sources1 Publication1
Binding sitei170TyrosineCombined sources1 Publication1
Binding sitei173TyrosineCombined sources1 Publication1
Binding sitei188TyrosineCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase, RNA-binding, tRNA-binding
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
6.1.1.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-379716 Cytosolic tRNA aminoacylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine--tRNA ligase, cytoplasmic (EC:6.1.1.1)
Alternative name(s):
Tyrosyl-tRNA synthetase
Short name:
TyrRS
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YARS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12840 YARS

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603623 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P54577

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Charcot-Marie-Tooth disease, dominant, intermediate type, C (CMTDIC)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. The dominant intermediate type C is characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02668141G → R in CMTDIC; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121908833EnsemblClinVar.1
Natural variantiVAR_026682153 – 156Missing in CMTDIC. 1 Publication4
Natural variantiVAR_026684196E → K in CMTDIC; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121908834EnsemblClinVar.1

Keywords - Diseasei

Charcot-Marie-Tooth disease, Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET

More...
DisGeNETi
8565

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
YARS

MalaCards human disease database

More...
MalaCardsi
YARS
MIMi608323 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000134684

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
100045 Autosomal dominant intermediate Charcot-Marie-Tooth disease type C

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37431

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P54577

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3179

Drug and drug target database

More...
DrugBanki
DB08617 4-(2,2,2-TRIFLUOROETHYL)-L-PHENYLALANINE
DB01766 Beta-(2-Naphthyl)-Alanine
DB07205 N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE
DB08371 PARA-(BENZOYL)-PHENYLALANINE
DB02709 Resveratrol
DB03978 Tyrosinal
DB00135 Tyrosine

DrugCentral

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DrugCentrali
P54577

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
YARS

Domain mapping of disease mutations (DMDM)

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DMDMi
13638438

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004232851 – 528Tyrosine--tRNA ligase, cytoplasmicAdd BLAST528
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateCombined sources2 Publications
ChainiPRO_00000556732 – 528Tyrosine--tRNA ligase, cytoplasmic, N-terminally processedAdd BLAST527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylglycine; in Tyrosine--tRNA ligase, cytoplasmic, N-terminally processedCombined sources1 Publication1
Modified residuei197N6-acetyllysineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei206N6-acetyllysineCombined sources1
Modified residuei386PhosphoserineCombined sources1
Modified residuei474N6-acetyllysineCombined sources1
Modified residuei482N6-acetyllysineCombined sources1
Modified residuei490N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-299
CPTAC-300

Encyclopedia of Proteome Dynamics

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EPDi
P54577

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P54577

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P54577

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P54577

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P54577

PeptideAtlas

More...
PeptideAtlasi
P54577

PRoteomics IDEntifications database

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PRIDEi
P54577

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
56686

2D gel databases

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00007074

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P54577

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P54577

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P54577

SwissPalm database of S-palmitoylation events

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SwissPalmi
P54577

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P54577

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000134684 Expressed in 226 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P54577 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P54577 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017936
HPA018950
HPA018954

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P098745EBI-1048893,EBI-355676

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114134, 63 interactors

Database of interacting proteins

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DIPi
DIP-50415N

Protein interaction database and analysis system

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IntActi
P54577, 20 interactors

Molecular INTeraction database

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MINTi
P54577

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362576

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P54577

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1528
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P54577

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P54577

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini364 – 468tRNA-bindingPROSITE-ProRule annotationAdd BLAST105

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi44 – 52'HIGH' region9
Motifi222 – 226'KMSKS' region5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2144 Eukaryota
KOG2241 Eukaryota
COG0073 LUCA
COG0162 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156949

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000228237

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P54577

KEGG Orthology (KO)

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KOi
K01866

Identification of Orthologs from Complete Genome Data

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OMAi
YIGFEIS

Database of Orthologous Groups

More...
OrthoDBi
852081at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P54577

TreeFam database of animal gene trees

More...
TreeFami
TF300898

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00805 TyrRS_core, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.620, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR012340 NA-bd_OB-fold
IPR014729 Rossmann-like_a/b/a_fold
IPR002547 tRNA-bd_dom
IPR002307 Tyr-tRNA-ligase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PF01588 tRNA_bind, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01040 TRNASYNTHTYR

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50249 SSF50249, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00234 tyrS, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50886 TRBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P54577-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDAPSPEEK LHLITRNLQE VLGEEKLKEI LKERELKIYW GTATTGKPHV
60 70 80 90 100
AYFVPMSKIA DFLKAGCEVT ILFADLHAYL DNMKAPWELL ELRVSYYENV
110 120 130 140 150
IKAMLESIGV PLEKLKFIKG TDYQLSKEYT LDVYRLSSVV TQHDSKKAGA
160 170 180 190 200
EVVKQVEHPL LSGLLYPGLQ ALDEEYLKVD AQFGGIDQRK IFTFAEKYLP
210 220 230 240 250
ALGYSKRVHL MNPMVPGLTG SKMSSSEEES KIDLLDRKED VKKKLKKAFC
260 270 280 290 300
EPGNVENNGV LSFIKHVLFP LKSEFVILRD EKWGGNKTYT AYVDLEKDFA
310 320 330 340 350
AEVVHPGDLK NSVEVALNKL LDPIREKFNT PALKKLASAA YPDPSKQKPM
360 370 380 390 400
AKGPAKNSEP EEVIPSRLDI RVGKIITVEK HPDADSLYVE KIDVGEAEPR
410 420 430 440 450
TVVSGLVQFV PKEELQDRLV VVLCNLKPQK MRGVESQGML LCASIEGINR
460 470 480 490 500
QVEPLDPPAG SAPGEHVFVK GYEKGQPDEE LKPKKKVFEK LQADFKISEE
510 520
CIAQWKQTNF MTKLGSISCK SLKGGNIS
Length:528
Mass (Da):59,143
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00C7E88843905780
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGZ5A0A0C4DGZ5_HUMAN
Tyrosine--tRNA ligase
YARS1
388Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB39406 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti143H → R in BAD97328 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02668141G → R in CMTDIC; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121908833EnsemblClinVar.1
Natural variantiVAR_026682153 – 156Missing in CMTDIC. 1 Publication4
Natural variantiVAR_026683170Q → H. Corresponds to variant dbSNP:rs2128600Ensembl.1
Natural variantiVAR_026684196E → K in CMTDIC; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121908834EnsemblClinVar.1
Natural variantiVAR_073292274E → K Found in a patient with hereditary motor and sensory neuropathy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs758897498Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U40714 mRNA Translation: AAB39406.1 Frameshift.
U89436 mRNA Translation: AAB88409.1
AK125213 mRNA Translation: BAG54166.1
AK223608 mRNA Translation: BAD97328.1
CH471059 Genomic DNA Translation: EAX07506.1
CH471059 Genomic DNA Translation: EAX07507.1
BC001933 mRNA Translation: AAH01933.1
BC004151 mRNA Translation: AAH04151.1
BC016689 mRNA Translation: AAH16689.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS368.1

NCBI Reference Sequences

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RefSeqi
NP_003671.1, NM_003680.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000373477; ENSP00000362576; ENSG00000134684

Database of genes from NCBI RefSeq genomes

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GeneIDi
8565

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8565

UCSC genome browser

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UCSCi
uc001bvy.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40714 mRNA Translation: AAB39406.1 Frameshift.
U89436 mRNA Translation: AAB88409.1
AK125213 mRNA Translation: BAG54166.1
AK223608 mRNA Translation: BAD97328.1
CH471059 Genomic DNA Translation: EAX07506.1
CH471059 Genomic DNA Translation: EAX07507.1
BC001933 mRNA Translation: AAH01933.1
BC004151 mRNA Translation: AAH04151.1
BC016689 mRNA Translation: AAH16689.1
CCDSiCCDS368.1
RefSeqiNP_003671.1, NM_003680.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N3LX-ray1.18A1-364[»]
1NTGX-ray2.21A/B/C/D359-528[»]
1Q11X-ray1.60A1-364[»]
4Q93X-ray2.10A1-364[»]
4QBTX-ray2.10A1-364[»]
5THHX-ray1.96A4-342[»]
5THLX-ray1.60A1-364[»]
SMRiP54577
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi114134, 63 interactors
DIPiDIP-50415N
IntActiP54577, 20 interactors
MINTiP54577
STRINGi9606.ENSP00000362576

Chemistry databases

BindingDBiP54577
ChEMBLiCHEMBL3179
DrugBankiDB08617 4-(2,2,2-TRIFLUOROETHYL)-L-PHENYLALANINE
DB01766 Beta-(2-Naphthyl)-Alanine
DB07205 N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE
DB08371 PARA-(BENZOYL)-PHENYLALANINE
DB02709 Resveratrol
DB03978 Tyrosinal
DB00135 Tyrosine
DrugCentraliP54577

PTM databases

CarbonylDBiP54577
iPTMnetiP54577
PhosphoSitePlusiP54577
SwissPalmiP54577

Polymorphism and mutation databases

BioMutaiYARS
DMDMi13638438

2D gel databases

REPRODUCTION-2DPAGEiIPI00007074

Proteomic databases

CPTACiCPTAC-299
CPTAC-300
EPDiP54577
jPOSTiP54577
MassIVEiP54577
MaxQBiP54577
PaxDbiP54577
PeptideAtlasiP54577
PRIDEiP54577
ProteomicsDBi56686

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
8565

Genome annotation databases

EnsembliENST00000373477; ENSP00000362576; ENSG00000134684
GeneIDi8565
KEGGihsa:8565
UCSCiuc001bvy.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8565
DisGeNETi8565

GeneCards: human genes, protein and diseases

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GeneCardsi
YARS
GeneReviewsiYARS
HGNCiHGNC:12840 YARS
HPAiHPA017936
HPA018950
HPA018954
MalaCardsiYARS
MIMi603623 gene
608323 phenotype
neXtProtiNX_P54577
OpenTargetsiENSG00000134684
Orphaneti100045 Autosomal dominant intermediate Charcot-Marie-Tooth disease type C
PharmGKBiPA37431

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2144 Eukaryota
KOG2241 Eukaryota
COG0073 LUCA
COG0162 LUCA
GeneTreeiENSGT00940000156949
HOGENOMiHOG000228237
InParanoidiP54577
KOiK01866
OMAiYIGFEIS
OrthoDBi852081at2759
PhylomeDBiP54577
TreeFamiTF300898

Enzyme and pathway databases

BRENDAi6.1.1.1 2681
ReactomeiR-HSA-379716 Cytosolic tRNA aminoacylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
YARS human
EvolutionaryTraceiP54577

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
YARS

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8565
PharosiP54577
PMAP-CutDBiP54577

Protein Ontology

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PROi
PR:P54577

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000134684 Expressed in 226 organ(s), highest expression level in frontal cortex
ExpressionAtlasiP54577 baseline and differential
GenevisibleiP54577 HS

Family and domain databases

CDDicd00805 TyrRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR012340 NA-bd_OB-fold
IPR014729 Rossmann-like_a/b/a_fold
IPR002547 tRNA-bd_dom
IPR002307 Tyr-tRNA-ligase
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PF01588 tRNA_bind, 1 hit
PRINTSiPR01040 TRNASYNTHTYR
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00234 tyrS, 1 hit
PROSITEiView protein in PROSITE
PS50886 TRBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYYC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54577
Secondary accession number(s): B3KWK4
, D3DPQ4, O43276, Q53EN1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 205 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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