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UniProtKB - P54577 (SYYC_HUMAN)

Entry version 210 (12 Aug 2020)
Sequence version 4 (23 Jan 2007)
Previous versions | rss
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Protein

Tyrosine--tRNA ligase, cytoplasmic

Gene

YARS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei39TyrosineCombined sources1 Publication1
Binding sitei166TyrosineCombined sources1 Publication1
Binding sitei170TyrosineCombined sources1 Publication1
Binding sitei173TyrosineCombined sources1 Publication1
Binding sitei188TyrosineCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase, RNA-binding, tRNA-binding
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		6.1.1.1, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P54577

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-379716, Cytosolic tRNA aminoacylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine--tRNA ligase, cytoplasmic (EC:6.1.1.1)
Alternative name(s):
Tyrosyl-tRNA synthetase
Short name:
TyrRS
Cleaved into the following chain:
Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YARS1Imported
Synonyms:YARS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000134684.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:12840, YARS1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603623, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P54577

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Charcot-Marie-Tooth disease, dominant, intermediate type, C (CMTDIC)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. The dominant intermediate type C is characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02668141G → R in CMTDIC; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121908833EnsemblClinVar.1
Natural variantiVAR_026682153 – 156Missing in CMTDIC. 1 Publication4
Natural variantiVAR_026684196E → K in CMTDIC; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121908834EnsemblClinVar.1

Keywords - Diseasei

Charcot-Marie-Tooth disease, Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET

More...DisGeNETi		8565

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		YARS

MalaCards human disease database

More...MalaCardsi		YARS1
MIMi608323, phenotype

Open Targets

More...OpenTargetsi		ENSG00000134684

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		100045, Autosomal dominant intermediate Charcot-Marie-Tooth disease type C

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37431

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P54577, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3179

Drug and drug target database

More...DrugBanki		DB08617, 4-(2,2,2-TRIFLUOROETHYL)-L-PHENYLALANINE
DB01766, Beta-(2-Naphthyl)-Alanine
DB07205, N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE
DB08371, p-Benzoyl-L-phenylalanine
DB02709, Resveratrol
DB03978, Tyrosinal
DB00135, Tyrosine

DrugCentral

More...DrugCentrali		P54577

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		YARS

Domain mapping of disease mutations (DMDM)

More...DMDMi		13638438

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004232851 – 528Tyrosine--tRNA ligase, cytoplasmicAdd BLAST528
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateCombined sources2 Publications
ChainiPRO_00000556732 – 528Tyrosine--tRNA ligase, cytoplasmic, N-terminally processedAdd BLAST527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylglycine; in Tyrosine--tRNA ligase, cytoplasmic, N-terminally processedCombined sources1 Publication1
Modified residuei197N6-acetyllysineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei206N6-acetyllysineCombined sources1
Modified residuei386PhosphoserineCombined sources1
Modified residuei474N6-acetyllysineCombined sources1
Modified residuei482N6-acetyllysineCombined sources1
Modified residuei490N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-299
CPTAC-300

Encyclopedia of Proteome Dynamics

More...EPDi		P54577

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P54577

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P54577

MaxQB - The MaxQuant DataBase

More...MaxQBi		P54577

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P54577

PeptideAtlas

More...PeptideAtlasi		P54577

PRoteomics IDEntifications database

More...PRIDEi		P54577

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56686

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00007074

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P54577

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P54577

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P54577

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P54577

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P54577

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134684, Expressed in frontal cortex and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P54577, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P54577, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000134684, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114134, 67 interactors

Database of interacting proteins

More...DIPi		DIP-50415N

Protein interaction database and analysis system

More...IntActi		P54577, 20 interactors

Molecular INTeraction database

More...MINTi		P54577

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362576

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P54577

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P54577, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1528
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P54577

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P54577

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini364 – 468tRNA-bindingPROSITE-ProRule annotationAdd BLAST105

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi44 – 52'HIGH' region9
Motifi222 – 226'KMSKS' region5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2144, Eukaryota
KOG2241, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156949

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_035267_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P54577

KEGG Orthology (KO)

More...KOi		K01866

Identification of Orthologs from Complete Genome Data

More...OMAi		YIGFEIS

Database of Orthologous Groups

More...OrthoDBi		852081at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P54577

TreeFam database of animal gene trees

More...TreeFami		TF300898

Family and domain databases

Conserved Domains Database

More...CDDi		cd00805, TyrRS_core, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.620, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002305, aa-tRNA-synth_Ic
IPR012340, NA-bd_OB-fold
IPR014729, Rossmann-like_a/b/a_fold
IPR002547, tRNA-bd_dom
IPR002307, Tyr-tRNA-ligase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00579, tRNA-synt_1b, 1 hit
PF01588, tRNA_bind, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01040, TRNASYNTHTYR

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50249, SSF50249, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00234, tyrS, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50886, TRBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P54577-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDAPSPEEK LHLITRNLQE VLGEEKLKEI LKERELKIYW GTATTGKPHV 
        60         70         80         90        100
AYFVPMSKIA DFLKAGCEVT ILFADLHAYL DNMKAPWELL ELRVSYYENV 
       110        120        130        140        150
IKAMLESIGV PLEKLKFIKG TDYQLSKEYT LDVYRLSSVV TQHDSKKAGA 
       160        170        180        190        200
EVVKQVEHPL LSGLLYPGLQ ALDEEYLKVD AQFGGIDQRK IFTFAEKYLP 
       210        220        230        240        250
ALGYSKRVHL MNPMVPGLTG SKMSSSEEES KIDLLDRKED VKKKLKKAFC 
       260        270        280        290        300
EPGNVENNGV LSFIKHVLFP LKSEFVILRD EKWGGNKTYT AYVDLEKDFA 
       310        320        330        340        350
AEVVHPGDLK NSVEVALNKL LDPIREKFNT PALKKLASAA YPDPSKQKPM 
       360        370        380        390        400
AKGPAKNSEP EEVIPSRLDI RVGKIITVEK HPDADSLYVE KIDVGEAEPR 
       410        420        430        440        450
TVVSGLVQFV PKEELQDRLV VVLCNLKPQK MRGVESQGML LCASIEGINR 
       460        470        480        490        500
QVEPLDPPAG SAPGEHVFVK GYEKGQPDEE LKPKKKVFEK LQADFKISEE 
       510        520 
CIAQWKQTNF MTKLGSISCK SLKGGNIS
Length:528
Mass (Da):59,143
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00C7E88843905780
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGZ5A0A0C4DGZ5_HUMAN
Tyrosine--tRNA ligase
YARS1
388Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB39406 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti143H → R in BAD97328 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02668141G → R in CMTDIC; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121908833EnsemblClinVar.1
Natural variantiVAR_026682153 – 156Missing in CMTDIC. 1 Publication4
Natural variantiVAR_026683170Q → H. Corresponds to variant dbSNP:rs2128600Ensembl.1
Natural variantiVAR_026684196E → K in CMTDIC; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121908834EnsemblClinVar.1
Natural variantiVAR_073292274E → K Found in a patient with hereditary motor and sensory neuropathy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs758897498Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U40714 mRNA Translation: AAB39406.1 Frameshift.
U89436 mRNA Translation: AAB88409.1
AK125213 mRNA Translation: BAG54166.1
AK223608 mRNA Translation: BAD97328.1
CH471059 Genomic DNA Translation: EAX07506.1
CH471059 Genomic DNA Translation: EAX07507.1
BC001933 mRNA Translation: AAH01933.1
BC004151 mRNA Translation: AAH04151.1
BC016689 mRNA Translation: AAH16689.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS368.1

NCBI Reference Sequences

More...RefSeqi		NP_003671.1, NM_003680.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373477; ENSP00000362576; ENSG00000134684

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8565

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8565

UCSC genome browser

More...UCSCi		uc001bvy.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40714 mRNA Translation: AAB39406.1 Frameshift.
U89436 mRNA Translation: AAB88409.1
AK125213 mRNA Translation: BAG54166.1
AK223608 mRNA Translation: BAD97328.1
CH471059 Genomic DNA Translation: EAX07506.1
CH471059 Genomic DNA Translation: EAX07507.1
BC001933 mRNA Translation: AAH01933.1
BC004151 mRNA Translation: AAH04151.1
BC016689 mRNA Translation: AAH16689.1
CCDSiCCDS368.1
RefSeqiNP_003671.1, NM_003680.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N3LX-ray1.18A1-364[»]
1NTGX-ray2.21A/B/C/D359-528[»]
1Q11X-ray1.60A1-364[»]
4Q93X-ray2.10A1-364[»]
4QBTX-ray2.10A1-364[»]
5THHX-ray1.96A4-342[»]
5THLX-ray1.60A1-364[»]
SMRiP54577
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114134, 67 interactors
DIPiDIP-50415N
IntActiP54577, 20 interactors
MINTiP54577
STRINGi9606.ENSP00000362576

Chemistry databases

BindingDBiP54577
ChEMBLiCHEMBL3179
DrugBankiDB08617, 4-(2,2,2-TRIFLUOROETHYL)-L-PHENYLALANINE
DB01766, Beta-(2-Naphthyl)-Alanine
DB07205, N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE
DB08371, p-Benzoyl-L-phenylalanine
DB02709, Resveratrol
DB03978, Tyrosinal
DB00135, Tyrosine
DrugCentraliP54577

PTM databases

CarbonylDBiP54577
iPTMnetiP54577
MetOSiteiP54577
PhosphoSitePlusiP54577
SwissPalmiP54577

Polymorphism and mutation databases

BioMutaiYARS
DMDMi13638438

2D gel databases

REPRODUCTION-2DPAGEiIPI00007074

Proteomic databases

CPTACiCPTAC-299
CPTAC-300
EPDiP54577
jPOSTiP54577
MassIVEiP54577
MaxQBiP54577
PaxDbiP54577
PeptideAtlasiP54577
PRIDEiP54577
ProteomicsDBi56686

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17005, 248 antibodies

The DNASU plasmid repository

More...DNASUi		8565

Genome annotation databases

EnsembliENST00000373477; ENSP00000362576; ENSG00000134684
GeneIDi8565
KEGGihsa:8565
UCSCiuc001bvy.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8565
DisGeNETi8565
EuPathDBiHostDB:ENSG00000134684.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		YARS1
GeneReviewsiYARS
HGNCiHGNC:12840, YARS1
HPAiENSG00000134684, Low tissue specificity
MalaCardsiYARS1
MIMi603623, gene
608323, phenotype
neXtProtiNX_P54577
OpenTargetsiENSG00000134684
Orphaneti100045, Autosomal dominant intermediate Charcot-Marie-Tooth disease type C
PharmGKBiPA37431

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2144, Eukaryota
KOG2241, Eukaryota
GeneTreeiENSGT00940000156949
HOGENOMiCLU_035267_3_0_1
InParanoidiP54577
KOiK01866
OMAiYIGFEIS
OrthoDBi852081at2759
PhylomeDBiP54577
TreeFamiTF300898

Enzyme and pathway databases

BRENDAi6.1.1.1, 2681
PathwayCommonsiP54577
ReactomeiR-HSA-379716, Cytosolic tRNA aminoacylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8565, 766 hits in 881 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		YARS, human
EvolutionaryTraceiP54577

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		YARS

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8565
PharosiP54577, Tchem

Protein Ontology

More...PROi		PR:P54577
RNActiP54577, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000134684, Expressed in frontal cortex and 237 other tissues
ExpressionAtlasiP54577, baseline and differential
GenevisibleiP54577, HS

Family and domain databases

CDDicd00805, TyrRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR002305, aa-tRNA-synth_Ic
IPR012340, NA-bd_OB-fold
IPR014729, Rossmann-like_a/b/a_fold
IPR002547, tRNA-bd_dom
IPR002307, Tyr-tRNA-ligase
PfamiView protein in Pfam
PF00579, tRNA-synt_1b, 1 hit
PF01588, tRNA_bind, 1 hit
PRINTSiPR01040, TRNASYNTHTYR
SUPFAMiSSF50249, SSF50249, 1 hit
TIGRFAMsiTIGR00234, tyrS, 1 hit
PROSITEiView protein in PROSITE
PS50886, TRBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYYC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54577
Secondary accession number(s): B3KWK4
, D3DPQ4, O43276, Q53EN1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: August 12, 2020
This is version 210 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  7. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
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