UniProtKB - P54556 (COAA_BACSU)
Protein
Pantothenate kinase
Gene
coaA
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Catalytic activityi
- EC:2.7.1.33
: coenzyme A biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.Proteins known to be involved in the 5 steps of the subpathway in this organism are:
- Pantothenate kinase (coaA), Pantothenate kinase (coaA), Type III pantothenate kinase (coaX)
- Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC), Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
- Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC), Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC)
- Phosphopantetheine adenylyltransferase (coaD), Phosphopantetheine adenylyltransferase (coaD)
- Dephospho-CoA kinase (coaE), Dephospho-CoA kinase (coaE)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 96 – 103 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- kinase activity Source: GO_Central
- pantothenate kinase activity Source: GO_Central
GO - Biological processi
- coenzyme A biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Coenzyme A biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | BSUB:BSU23760-MONOMER |
UniPathwayi | UPA00241;UER00352 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:coaA Synonyms:yqjS Ordered Locus Names:BSU23760 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm By similarity
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000194419 | 1 – 319 | Pantothenate kinaseAdd BLAST | 319 |
Proteomic databases
PaxDbi | P54556 |
PRIDEi | P54556 |
Family & Domainsi
Sequence similaritiesi
Belongs to the prokaryotic pantothenate kinase family.Curated
Phylogenomic databases
eggNOGi | COG1072, Bacteria |
InParanoidi | P54556 |
OMAi | RKYTQVS |
PhylomeDBi | P54556 |
Family and domain databases
CDDi | cd02025, PanK, 1 hit |
HAMAPi | MF_00215, Pantothen_kinase_1, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR004566, PanK IPR006083, PRK/URK |
PANTHERi | PTHR10285:SF139, PTHR10285:SF139, 1 hit |
Pfami | View protein in Pfam PF00485, PRK, 1 hit |
PIRSFi | PIRSF000545, Pantothenate_kin, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00554, panK_bact, 1 hit |
i Sequence
Sequence statusi: Complete.
P54556-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKNKELNLHT LYTQHNRESW SGFGGHLSIA VSEEEAKAVE GLNDYLSVEE
60 70 80 90 100
VETIYIPLVR LLHLHVKSAA ERNKHVNVFL KHPHSAKIPF IIGIAGSVAV
110 120 130 140 150
GKSTTARILQ KLLSRLPDRP KVSLITTDGF LFPTAELKKK NMMSRKGFPE
160 170 180 190 200
SYDVKALLEF LNDLKSGKDS VKAPVYSHLT YDREEGVFEV VEQADIVIIE
210 220 230 240 250
GINVLQSPTL EDDRENPRIF VSDFFDFSIY VDAEESRIFT WYLERFRLLR
260 270 280 290 300
ETAFQNPDSY FHKFKDLSDQ EADEMAASIW ESVNRPNLYE NILPTKFRSD
310
LILRKGDGHK VEEVLVRRV
Sequence cautioni
The sequence BAA12625 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D84432 Genomic DNA Translation: BAA12625.1 Different initiation. AL009126 Genomic DNA Translation: CAB14308.2 |
RefSeqi | NP_390257.2, NC_000964.3 WP_003245966.1, NZ_JNCM01000036.1 |
Genome annotation databases
EnsemblBacteriai | CAB14308; CAB14308; BSU23760 |
GeneIDi | 938704 |
KEGGi | bsu:BSU23760 |
PATRICi | fig|224308.179.peg.2589 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D84432 Genomic DNA Translation: BAA12625.1 Different initiation. AL009126 Genomic DNA Translation: CAB14308.2 |
RefSeqi | NP_390257.2, NC_000964.3 WP_003245966.1, NZ_JNCM01000036.1 |
3D structure databases
SMRi | P54556 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU23760 |
Proteomic databases
PaxDbi | P54556 |
PRIDEi | P54556 |
Genome annotation databases
EnsemblBacteriai | CAB14308; CAB14308; BSU23760 |
GeneIDi | 938704 |
KEGGi | bsu:BSU23760 |
PATRICi | fig|224308.179.peg.2589 |
Phylogenomic databases
eggNOGi | COG1072, Bacteria |
InParanoidi | P54556 |
OMAi | RKYTQVS |
PhylomeDBi | P54556 |
Enzyme and pathway databases
UniPathwayi | UPA00241;UER00352 |
BioCyci | BSUB:BSU23760-MONOMER |
Family and domain databases
CDDi | cd02025, PanK, 1 hit |
HAMAPi | MF_00215, Pantothen_kinase_1, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR004566, PanK IPR006083, PRK/URK |
PANTHERi | PTHR10285:SF139, PTHR10285:SF139, 1 hit |
Pfami | View protein in Pfam PF00485, PRK, 1 hit |
PIRSFi | PIRSF000545, Pantothenate_kin, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00554, panK_bact, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COAA_BACSU | |
Accessioni | P54556Primary (citable) accession number: P54556 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | December 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 130 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families