Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 146 (29 Sep 2021)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
Add a publicationFeedback
Protein

3'-5' exonuclease DinG

Gene

dinG

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

3'-5' exonuclease.

UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi284 – 291ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU22400-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3'-5' exonuclease DinGUniRule annotation (EC:3.1.-.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dinGUniRule annotation
Ordered Locus Names:BSU22400
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001019951 – 9313'-5' exonuclease DinGAdd BLAST931

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P54394

PRoteomics IDEntifications database

More...
PRIDEi
P54394

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P54394, 2 interactors

STRING: functional protein association networks

More...
STRINGi
224308.BSU22400

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P54394

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 162ExonucleaseUniRule annotationAdd BLAST156
Domaini250 – 510Helicase ATP-bindingUniRule annotationAdd BLAST261
Domaini741 – 897Helicase C-terminalUniRule annotationAdd BLAST157

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi462 – 465DEAH boxUniRule annotation4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. DinG subfamily. Type 2 sub-subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0847, Bacteria
COG1199, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P54394

Identification of Orthologs from Complete Genome Data

More...
OMAi
VVTNHAM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P54394

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit
3.40.50.300, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_02206, DinG_exonucl, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006555, ATP-dep_Helicase_C
IPR006310, DinG
IPR006054, DnaQ
IPR013520, Exonuclease_RNaseT/DNA_pol3
IPR014013, Helic_SF1/SF2_ATP-bd_DinG/Rad3
IPR006935, Helicase/UvrB_N
IPR014001, Helicase_ATP-bd
IPR027417, P-loop_NTPase
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13307, Helicase_C_2, 1 hit
PF04851, ResIII, 1 hit
PF00929, RNase_T, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00479, EXOIII, 1 hit
SM00491, HELICc2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit
SSF53098, SSF53098, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01407, dinG_rel, 1 hit
TIGR00573, dnaq, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51193, HELICASE_ATP_BIND_2, 1 hit
PS51194, HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P54394-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKQRFVVID VETTGNSPKK GDKIIQIAAV VIENGQITER FSKYINPNKS
60 70 80 90 100
IPAFIEQLTG ISNQMVENEQ PFEAVAEEVF QLLDGAYFVA HNIHFDLGFV
110 120 130 140 150
KYELHKAGFQ LPDCEVLDTV ELSRIVFPGF EGYKLTELSE ELQLRHDQPH
160 170 180 190 200
RADSDAEVTG LIFLEILEKL RQLPYPTLKQ LRRLSQHFIS DLTHLLDMFI
210 220 230 240 250
NENRHTEIPG YTRFSSFSVR EPEAIDVRIN EDENFSFEIE SWEAGNEKAL
260 270 280 290 300
SELMPGYEKR DGQMMMMREV ADAFANREHA LIEAPPGIGK TIGYLIPAAL
310 320 330 340 350
FAKKSKKPVI ISTYSTLLQQ QILTKDLPIV QDLFPFPVTA AILKGQSHYL
360 370 380 390 400
CLYKFEQVLH EEDDNYDAVL TKAQLLVWLT ETNTGDVAEL NLPSGGKLLW
410 420 430 440 450
DRLAYDDDSY KRSRSEHVIG FYERAKQIAM RSDLVITNHS LLLTDEGSHK
460 470 480 490 500
KRLPESGTFI IDEAHHFERA ASEHLGKRAT YIELHTKLSR IGTLKEQGLL
510 520 530 540 550
KKMRQLFQRN SLPVDSFFEL EEWLQHVQAE SDAFFSSVHS FVKRRKPKED
560 570 580 590 600
LNRLVFKVNK ESQDKSWSIL TDGAERLCSM LTHLQQLFEA QSSLMEKHLK
610 620 630 640 650
GMKSKTVFLA DEYQRSMKGL QHYCQTLQKL FFGSDDDEAV WIEIDAKGAK
660 670 680 690 700
NAVAIYAQPL EPGELLADQF FARKNSVVLT SATLTVEGSF QFMIERLGLS
710 720 730 740 750
DFFPRTMRIE SPFSYDERMQ VMIPKEMKSI QDTGQPEFIQ DTARYIELMA
760 770 780 790 800
KEKQPKILVL FTSHDMLKKV HQELKHNMSA SGIQLLAQGI TGGSPGKLMK
810 820 830 840 850
TFKTSNQAIL LGTNHFWEGV DFPGDELTTV MIVRLPFRSP DHPLHAAKCE
860 870 880 890 900
LARKKGKNPF QTVSLPEAVL TFRQGIGRLL RSAGDKGTII ILDRRIKTAG
910 920 930
YGRLFLDALP TTSVSEMTDS ELEAYVAGEK E
Length:931
Mass (Da):106,032
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E2DE3531C18A8C4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L47709 Genomic DNA Translation: AAB38451.1
AL009126 Genomic DNA Translation: CAB14156.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G69615

NCBI Reference Sequences

More...
RefSeqi
NP_390121.1, NC_000964.3
WP_004398920.1, NZ_JNCM01000036.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB14156; CAB14156; BSU_22400

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
939031

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bsu:BSU22400

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224308.179.peg.2444

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L47709 Genomic DNA Translation: AAB38451.1
AL009126 Genomic DNA Translation: CAB14156.1
PIRiG69615
RefSeqiNP_390121.1, NC_000964.3
WP_004398920.1, NZ_JNCM01000036.1

3D structure databases

SMRiP54394
ModBaseiSearch...

Protein-protein interaction databases

IntActiP54394, 2 interactors
STRINGi224308.BSU22400

Proteomic databases

PaxDbiP54394
PRIDEiP54394

Genome annotation databases

EnsemblBacteriaiCAB14156; CAB14156; BSU_22400
GeneIDi939031
KEGGibsu:BSU22400
PATRICifig|224308.179.peg.2444

Phylogenomic databases

eggNOGiCOG0847, Bacteria
COG1199, Bacteria
InParanoidiP54394
OMAiVVTNHAM
PhylomeDBiP54394

Enzyme and pathway databases

BioCyciBSUB:BSU22400-MONOMER

Family and domain databases

Gene3Di3.30.420.10, 1 hit
3.40.50.300, 2 hits
HAMAPiMF_02206, DinG_exonucl, 1 hit
InterProiView protein in InterPro
IPR006555, ATP-dep_Helicase_C
IPR006310, DinG
IPR006054, DnaQ
IPR013520, Exonuclease_RNaseT/DNA_pol3
IPR014013, Helic_SF1/SF2_ATP-bd_DinG/Rad3
IPR006935, Helicase/UvrB_N
IPR014001, Helicase_ATP-bd
IPR027417, P-loop_NTPase
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
PfamiView protein in Pfam
PF13307, Helicase_C_2, 1 hit
PF04851, ResIII, 1 hit
PF00929, RNase_T, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00479, EXOIII, 1 hit
SM00491, HELICc2, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF53098, SSF53098, 1 hit
TIGRFAMsiTIGR01407, dinG_rel, 1 hit
TIGR00573, dnaq, 1 hit
PROSITEiView protein in PROSITE
PS51193, HELICASE_ATP_BIND_2, 1 hit
PS51194, HELICASE_CTER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDING_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54394
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 29, 2021
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again