UniProtKB - P54317 (LIPR2_HUMAN)

BLAST

>sp|P54317|LIPR2_HUMAN Pancreatic lipase-related protein 2 OS=Homo sapiens OX=9606 GN=PNLIPRP2 PE=1 SV=2
MLPPWTLGLLLLATVRGKEVCYGQLGCFSDEKPWAGTLQRPVKLLPWSPEDIDTRFLLYT
NENPNNFQLITGTEPDTIEASNFQLDRKTRFIIHGFLDKAEDSWPSDMCKKMFEVEKVNC
ICVDWRHGSRAMYTQAVQNIRVVGAETAFLIQALSTQLGYSLEDVHVIGHSLGAHTAAEA
GRRLGGRVGRITGLDPAGPCFQDEPEEVRLDPSDAVFVDVIHTDSSPIVPSLGFGMSQKV
GHLDFFPNGGKEMPGCKKNVLSTITDIDGIWEGIGGFVSCNHLRSFEYYSSSVLNPDGFL
GYPCASYDEFQESKCFPCPAEGCPKMGHYADQFKGKTSAVEQTFFLNTGESGNFTSWRYK
ISVTLSGKEKVNGYIRIALYGSNENSKQYEIFKGSLKPDASHTCAIDVDFNVGKIQKVKF
LWNKRGINLSEPKLGASQITVQSGEDGTEYNFCSSDTVEENVLQSLYPC

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History
Entry version 148 (10 Oct 2018)
Sequence version 2 (28 Mar 2018)
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Protein

Pancreatic lipase-related protein 2

Gene

PNLIPRP2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis.3 Publications

Catalytic activityⁱ

Triacylglycerol + H₂O = diacylglycerol + a carboxylate.1 Publication

1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H₂O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates.1 Publication

Activity regulationⁱ

CLPS stimulates triacylglycerol lipase activity. Triacylglycerol lipase activity is not inhibited by increasing bile salt concentration.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	171	Nucleophile1 Publication	1
Active siteⁱ	195	Charge relay systemPROSITE-ProRule annotation1 Publication	1
Metal bindingⁱ	206	Calcium; via carbonyl oxygen	1
Metal bindingⁱ	209	Calcium; via carbonyl oxygen	1
Metal bindingⁱ	211	Calcium	1
Metal bindingⁱ	214	Calcium	1
Active siteⁱ	282	Charge relay systemPROSITE-ProRule annotation1 Publication	1

GO - Molecular functionⁱ

1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity Source: UniProtKB-EC
acylglycerol lipase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18702514
calcium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18702514
galactolipase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18702514
phospholipase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18702514
triglyceride lipase activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular defense response Source: Ensembl
galactolipid catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 18702514
intestinal lipid catabolic process Source: Ensembl
lipid digestion Source: Reactome
phospholipid catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 18702514
response to bacterium Source: Ensembl
triglyceride metabolic process
Source: ProtInc
Traceable author statementⁱ
- 1379598

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Lipid degradation, Lipid metabolism
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

BRENDAⁱ	3.1.1.26 2681
Reactomeⁱ	R-HSA-192456 Digestion of dietary lipid

Protein family/group databases

ESTHERⁱ	human-PNLIPRP2 Pancreatic_lipase

ESTHERⁱ

human-PNLIPRP2 Pancreatic_lipase

Chemistry databases

SwissLipidsⁱ	SLP:000001434

SwissLipidsⁱ

SLP:000001434

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pancreatic lipase-related protein 2Imported (EC:3.1.1.26, EC:3.1.1.3) Short name: PL-RP21 Publication Alternative name(s): Galactolipase
Gene namesⁱ	Name:PNLIPRP2Imported Synonyms:PLRP21 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000266200.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9157 PNLIPRP2
MIMⁱ	604423 gene
neXtProtⁱ	NX_P54317

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	353	N → Q: Loss of N-glycosylation. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5408
Open Targets More...OpenTargetsⁱ	ENSG00000266200
PharmGKBⁱ	PA33480

Chemistry databases

ChEMBLⁱ

CHEMBL2169728

Polymorphism and mutation databases

BioMutaⁱ	PNLIPRP2
DMDMⁱ	1708840

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	Sequence analysisAdd BLAST		17
ChainⁱPRO_0000017793	18 – 469	Pancreatic lipase-related protein 2Add BLAST		452

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	21 ↔ 27	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	109 ↔ 120	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	256 ↔ 280	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	304 ↔ 315	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	318 ↔ 323	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	353	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	428	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	453 ↔ 469	PROSITE-ProRule annotation1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P54317
PRIDEⁱ	P54317
ProteomicsDBⁱ	56684

PTM databases

iPTMnetⁱ	P54317
PhosphoSitePlusⁱ	P54317

Expressionⁱ

Tissue specificityⁱ

Pancreas.

Gene expression databases

Bgeeⁱ	ENSG00000266200 Expressed in 90 organ(s), highest expression level in body of pancreas
CleanExⁱ	HS_PNLIPRP2

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	111409, 9 interactors

BioGridⁱ

111409, 9 interactors

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	19 – 21	Combined sources	3
Helixⁱ	23 – 25	Combined sources	3
Beta strandⁱ	27 – 29	Combined sources	3
Turnⁱ	32 – 34	Combined sources	3
Beta strandⁱ	35 – 37	Combined sources	3
Helixⁱ	49 – 52	Combined sources	4
Beta strandⁱ	55 – 59	Combined sources	5
Beta strandⁱ	61 – 66	Combined sources	6
Beta strandⁱ	68 – 70	Combined sources	3
Beta strandⁱ	72 – 74	Combined sources	3
Helixⁱ	76 – 80	Combined sources	5
Beta strandⁱ	87 – 93	Combined sources	7
Helixⁱ	104 – 112	Combined sources	9
Turnⁱ	113 – 115	Combined sources	3
Beta strandⁱ	118 – 124	Combined sources	7
Helixⁱ	126 – 129	Combined sources	4
Helixⁱ	133 – 158	Combined sources	26
Helixⁱ	162 – 164	Combined sources	3
Beta strandⁱ	165 – 170	Combined sources	6
Helixⁱ	173 – 183	Combined sources	11
Turnⁱ	184 – 186	Combined sources	3
Beta strandⁱ	188 – 195	Combined sources	8
Turnⁱ	199 – 203	Combined sources	5
Turnⁱ	206 – 208	Combined sources	3
Helixⁱ	212 – 214	Combined sources	3
Beta strandⁱ	215 – 221	Combined sources	7
Beta strandⁱ	223 – 226	Combined sources	4
Beta strandⁱ	228 – 230	Combined sources	3
Beta strandⁱ	234 – 236	Combined sources	3
Beta strandⁱ	241 – 247	Combined sources	7
Turnⁱ	248 – 251	Combined sources	4
Helixⁱ	276 – 278	Combined sources	3
Helixⁱ	280 – 294	Combined sources	15
Beta strandⁱ	298 – 300	Combined sources	3
Helixⁱ	307 – 311	Combined sources	5
Turnⁱ	312 – 315	Combined sources	4
Beta strandⁱ	325 – 327	Combined sources	3
Helixⁱ	330 – 332	Combined sources	3
Turnⁱ	334 – 337	Combined sources	4
Beta strandⁱ	338 – 346	Combined sources	9
Beta strandⁱ	357 – 369	Combined sources	13
Beta strandⁱ	371 – 380	Combined sources	10
Beta strandⁱ	385 – 396	Combined sources	12
Beta strandⁱ	401 – 410	Combined sources	10
Beta strandⁱ	417 – 423	Combined sources	7
Beta strandⁱ	434 – 443	Combined sources	10
Turnⁱ	444 – 446	Combined sources	3
Beta strandⁱ	449 – 453	Combined sources	5
Beta strandⁱ	464 – 468	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P54317
SMRⁱ	P54317
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P54317

EvolutionaryTraceⁱ

P54317

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	357 – 469	PLATPROSITE-ProRule annotationAdd BLAST		113

Sequence similaritiesⁱ

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119069
HOVERGENⁱ	HBG003243
InParanoidⁱ	P54317
KEGG Orthology (KO) More...KOⁱ	K14075
PhylomeDBⁱ	P54317

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00707 Pancreat_lipase_like, 1 hit
Gene3Dⁱ	3.40.50.1820, 1 hit
InterProⁱ	View protein in InterPro IPR029058 AB_hydrolase IPR013818 Lipase/vitellogenin IPR016272 Lipase_LIPH IPR033906 Lipase_N IPR002331 Lipase_panc IPR001024 PLAT/LH2_dom IPR036392 PLAT/LH2_dom_sf IPR000734 TAG_lipase
PANTHERⁱ	PTHR11610 PTHR11610, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00151 Lipase, 1 hit PF01477 PLAT, 1 hit
PIRSFⁱ	PIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSⁱ	PR00823 PANCLIPASE PR00821 TAGLIPASE
SMARTⁱ	View protein in SMART SM00308 LH2, 1 hit
SUPFAMⁱ	SSF49723 SSF49723, 1 hit SSF53474 SSF53474, 1 hit
PROSITEⁱ	View protein in PROSITE PS00120 LIPASE_SER, 1 hit PS50095 PLAT, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P54317-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MLPPWTLGLL LLATVRGKEV CYGQLGCFSD EKPWAGTLQR PVKLLPWSPE 
        60         70         80         90        100
DIDTRFLLYT NENPNNFQLI TGTEPDTIEA SNFQLDRKTR FIIHGFLDKA 
       110        120        130        140        150
EDSWPSDMCK KMFEVEKVNC ICVDWRHGSR AMYTQAVQNI RVVGAETAFL 
       160        170        180        190        200
IQALSTQLGY SLEDVHVIGH SLGAHTAAEA GRRLGGRVGR ITGLDPAGPC 
       210        220        230        240        250
FQDEPEEVRL DPSDAVFVDV IHTDSSPIVP SLGFGMSQKV GHLDFFPNGG 
       260        270        280        290        300
KEMPGCKKNV LSTITDIDGI WEGIGGFVSC NHLRSFEYYS SSVLNPDGFL 
       310        320        330        340        350
GYPCASYDEF QESKCFPCPA EGCPKMGHYA DQFKGKTSAV EQTFFLNTGE 
       360        370        380        390        400
SGNFTSWRYK ISVTLSGKEK VNGYIRIALY GSNENSKQYE IFKGSLKPDA 
       410        420        430        440        450
SHTCAIDVDF NVGKIQKVKF LWNKRGINLS EPKLGASQIT VQSGEDGTEY 
       460 
NFCSSDTVEE NVLQSLYPC

Length:469

Mass (Da):51,961

Last modified:March 28, 2018 - v2

Checksum:ⁱ3D57FC5893A52D0D

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A087WX88	A0A087WX88_HUMAN		Triacylglycerol lipase Triacylglycerol lipase, EC 3.1.1.3 (Pancreatic lipase)	PNLIPRP2	468	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	239	K → R in BAF84181 (PubMed:14702039).Curated		1
Sequence conflictⁱ	352	G → V in BAF84181 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_080185	361	I → V1 PublicationCorresponds to variant dbSNP:rs4751996Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M93284 mRNA Translation: AAA59533.1 AK291492 mRNA Translation: BAF84181.1 CR456949 mRNA Translation: CAG33230.1 AC016825 Genomic DNA No translation available. FO082044 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49448.1 BC005989 mRNA Translation: AAH05989.1
PIRⁱ	B43357
NCBI Reference Sequences More...RefSeqⁱ	NP_005387.2, NM_005396.4
UniGeneⁱ	Hs.423598

Genome annotation databases

Ensemblⁱ	ENST00000591655; ENSP00000468117; ENSG00000266200
GeneIDⁱ	5408
KEGGⁱ	hsa:5408

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P54317	Triacylglycerol lipase		PANTR		469	UniRef90_P54317
Triacylglycerol lipase		PANPA		469
Triacylglycerol lipase		PONAB		469
Triacylglycerol lipase		NOMLE		469
Triacylglycerol lipase		GORGO		469
+10

Protein	Similar proteins		Species	Score	Length	Source
P54317	Pancreatic lipase-related protein 2	)	RAT		468	UniRef50_P54318
Pancreatic lipase-related protein 2		MOUSE		482
Inactive pancreatic lipase-related protein 1	)	CANLF		467
Pancreatic lipase-related protein 2		MYOCO		470
Pancreatic triacylglycerol lipase (Fragment)		FELCA		25
+407

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M93284 mRNA Translation: AAA59533.1 AK291492 mRNA Translation: BAF84181.1 CR456949 mRNA Translation: CAG33230.1 AC016825 Genomic DNA No translation available. FO082044 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49448.1 BC005989 mRNA Translation: AAH05989.1
PIRⁱ	B43357
RefSeqⁱ	NP_005387.2, NM_005396.4
UniGeneⁱ	Hs.423598

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2OXE	X-ray	2.80	A/B	18-469	[»]
	2PVS	X-ray	3.00	A/B	18-469	[»]
ProteinModelPortalⁱ	P54317
SMRⁱ	P54317
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111409, 9 interactors

BioGridⁱ

111409, 9 interactors

Chemistry databases

ChEMBLⁱ	CHEMBL2169728
SwissLipidsⁱ	SLP:000001434

Protein family/group databases

ESTHERⁱ	human-PNLIPRP2 Pancreatic_lipase

ESTHERⁱ

human-PNLIPRP2 Pancreatic_lipase

PTM databases

iPTMnetⁱ	P54317
PhosphoSitePlusⁱ	P54317

Polymorphism and mutation databases

BioMutaⁱ	PNLIPRP2
DMDMⁱ	1708840

Proteomic databases

PeptideAtlasⁱ	P54317
PRIDEⁱ	P54317
ProteomicsDBⁱ	56684

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5408
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000591655; ENSP00000468117; ENSG00000266200
GeneIDⁱ	5408
KEGGⁱ	hsa:5408

Organism-specific databases

CTDⁱ	5408
DisGeNETⁱ	5408
EuPathDBⁱ	HostDB:ENSG00000266200.6
GeneCardsⁱ	PNLIPRP2
H-InvDBⁱ	HIX0009237
HGNCⁱ	HGNC:9157 PNLIPRP2
MIMⁱ	604423 gene
neXtProtⁱ	NX_P54317
OpenTargetsⁱ	ENSG00000266200
PharmGKBⁱ	PA33480
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00760000119069
HOVERGENⁱ	HBG003243
InParanoidⁱ	P54317
KOⁱ	K14075
PhylomeDBⁱ	P54317

Enzyme and pathway databases

BRENDAⁱ	3.1.1.26 2681
Reactomeⁱ	R-HSA-192456 Digestion of dietary lipid

Miscellaneous databases

ChiTaRSⁱ	PNLIPRP2 human
EvolutionaryTraceⁱ	P54317
GenomeRNAiⁱ	5408
Protein Ontology More...PROⁱ	PR:P54317
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000266200 Expressed in 90 organ(s), highest expression level in body of pancreas
CleanExⁱ	HS_PNLIPRP2

Family and domain databases

CDDⁱ	cd00707 Pancreat_lipase_like, 1 hit
Gene3Dⁱ	3.40.50.1820, 1 hit
InterProⁱ	View protein in InterPro IPR029058 AB_hydrolase IPR013818 Lipase/vitellogenin IPR016272 Lipase_LIPH IPR033906 Lipase_N IPR002331 Lipase_panc IPR001024 PLAT/LH2_dom IPR036392 PLAT/LH2_dom_sf IPR000734 TAG_lipase
PANTHERⁱ	PTHR11610 PTHR11610, 1 hit
Pfamⁱ	View protein in Pfam PF00151 Lipase, 1 hit PF01477 PLAT, 1 hit
PIRSFⁱ	PIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSⁱ	PR00823 PANCLIPASE PR00821 TAGLIPASE
SMARTⁱ	View protein in SMART SM00308 LH2, 1 hit
SUPFAMⁱ	SSF49723 SSF49723, 1 hit SSF53474 SSF53474, 1 hit
PROSITEⁱ	View protein in PROSITE PS00120 LIPASE_SER, 1 hit PS50095 PLAT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LIPR2_HUMAN
Accessionⁱ	P54317Primary (citable) accession number: P54317 Secondary accession number(s): A0A075B781, A8K627, Q6IB55
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	March 28, 2018
	Last modified:	October 10, 2018
	This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - P54317 (LIPR2_HUMAN)

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Pancreatic lipase-related protein 2

PNLIPRP2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

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