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Protein

Pancreatic lipase-related protein 2

Gene

PNLIPRP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis.3 Publications

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.1 Publication
1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates.1 Publication

Activity regulationi

CLPS stimulates triacylglycerol lipase activity. Triacylglycerol lipase activity is not inhibited by increasing bile salt concentration.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei171Nucleophile1 Publication1
Active sitei195Charge relay systemPROSITE-ProRule annotation1 Publication1
Metal bindingi206Calcium; via carbonyl oxygen1
Metal bindingi209Calcium; via carbonyl oxygen1
Metal bindingi211Calcium1
Metal bindingi214Calcium1
Active sitei282Charge relay systemPROSITE-ProRule annotation1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.26 2681
ReactomeiR-HSA-192456 Digestion of dietary lipid

Protein family/group databases

ESTHERihuman-PNLIPRP2 Pancreatic_lipase

Chemistry databases

SwissLipidsiSLP:000001434

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic lipase-related protein 2Imported (EC:3.1.1.26, EC:3.1.1.3)
Short name:
PL-RP21 Publication
Alternative name(s):
Galactolipase
Gene namesi
Name:PNLIPRP2Imported
Synonyms:PLRP21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000266200.6
HGNCiHGNC:9157 PNLIPRP2
MIMi604423 gene
neXtProtiNX_P54317

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi353N → Q: Loss of N-glycosylation. 1 Publication1

Organism-specific databases

DisGeNETi5408
OpenTargetsiENSG00000266200
PharmGKBiPA33480

Chemistry databases

ChEMBLiCHEMBL2169728

Polymorphism and mutation databases

BioMutaiPNLIPRP2
DMDMi1708840

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001779318 – 469Pancreatic lipase-related protein 2Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi21 ↔ 27PROSITE-ProRule annotation1 Publication
Disulfide bondi109 ↔ 120PROSITE-ProRule annotation1 Publication
Disulfide bondi256 ↔ 280PROSITE-ProRule annotation1 Publication
Disulfide bondi304 ↔ 315PROSITE-ProRule annotation1 Publication
Disulfide bondi318 ↔ 323PROSITE-ProRule annotation1 Publication
Glycosylationi353N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi453 ↔ 469PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP54317
PRIDEiP54317
ProteomicsDBi56684

PTM databases

iPTMnetiP54317
PhosphoSitePlusiP54317

Expressioni

Tissue specificityi

Pancreas.

Gene expression databases

BgeeiENSG00000266200 Expressed in 90 organ(s), highest expression level in body of pancreas
CleanExiHS_PNLIPRP2

Interactioni

Protein-protein interaction databases

BioGridi111409, 9 interactors

Structurei

Secondary structure

1469
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP54317
SMRiP54317
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54317

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini357 – 469PLATPROSITE-ProRule annotationAdd BLAST113

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00760000119069
HOVERGENiHBG003243
InParanoidiP54317
KOiK14075
PhylomeDBiP54317

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR002331 Lipase_panc
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00823 PANCLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit
PS50095 PLAT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P54317-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPPWTLGLL LLATVRGKEV CYGQLGCFSD EKPWAGTLQR PVKLLPWSPE
60 70 80 90 100
DIDTRFLLYT NENPNNFQLI TGTEPDTIEA SNFQLDRKTR FIIHGFLDKA
110 120 130 140 150
EDSWPSDMCK KMFEVEKVNC ICVDWRHGSR AMYTQAVQNI RVVGAETAFL
160 170 180 190 200
IQALSTQLGY SLEDVHVIGH SLGAHTAAEA GRRLGGRVGR ITGLDPAGPC
210 220 230 240 250
FQDEPEEVRL DPSDAVFVDV IHTDSSPIVP SLGFGMSQKV GHLDFFPNGG
260 270 280 290 300
KEMPGCKKNV LSTITDIDGI WEGIGGFVSC NHLRSFEYYS SSVLNPDGFL
310 320 330 340 350
GYPCASYDEF QESKCFPCPA EGCPKMGHYA DQFKGKTSAV EQTFFLNTGE
360 370 380 390 400
SGNFTSWRYK ISVTLSGKEK VNGYIRIALY GSNENSKQYE IFKGSLKPDA
410 420 430 440 450
SHTCAIDVDF NVGKIQKVKF LWNKRGINLS EPKLGASQIT VQSGEDGTEY
460
NFCSSDTVEE NVLQSLYPC
Length:469
Mass (Da):51,961
Last modified:March 28, 2018 - v2
Checksum:i3D57FC5893A52D0D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WX88A0A087WX88_HUMAN
Triacylglycerol lipase
PNLIPRP2
468Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239K → R in BAF84181 (PubMed:14702039).Curated1
Sequence conflicti352G → V in BAF84181 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080185361I → V1 PublicationCorresponds to variant dbSNP:rs4751996Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93284 mRNA Translation: AAA59533.1
AK291492 mRNA Translation: BAF84181.1
CR456949 mRNA Translation: CAG33230.1
AC016825 Genomic DNA No translation available.
FO082044 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49448.1
BC005989 mRNA Translation: AAH05989.1
PIRiB43357
RefSeqiNP_005387.2, NM_005396.4
UniGeneiHs.423598

Genome annotation databases

EnsembliENST00000591655; ENSP00000468117; ENSG00000266200
GeneIDi5408
KEGGihsa:5408

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93284 mRNA Translation: AAA59533.1
AK291492 mRNA Translation: BAF84181.1
CR456949 mRNA Translation: CAG33230.1
AC016825 Genomic DNA No translation available.
FO082044 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49448.1
BC005989 mRNA Translation: AAH05989.1
PIRiB43357
RefSeqiNP_005387.2, NM_005396.4
UniGeneiHs.423598

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OXEX-ray2.80A/B18-469[»]
2PVSX-ray3.00A/B18-469[»]
ProteinModelPortaliP54317
SMRiP54317
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111409, 9 interactors

Chemistry databases

ChEMBLiCHEMBL2169728
SwissLipidsiSLP:000001434

Protein family/group databases

ESTHERihuman-PNLIPRP2 Pancreatic_lipase

PTM databases

iPTMnetiP54317
PhosphoSitePlusiP54317

Polymorphism and mutation databases

BioMutaiPNLIPRP2
DMDMi1708840

Proteomic databases

PeptideAtlasiP54317
PRIDEiP54317
ProteomicsDBi56684

Protocols and materials databases

DNASUi5408
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000591655; ENSP00000468117; ENSG00000266200
GeneIDi5408
KEGGihsa:5408

Organism-specific databases

CTDi5408
DisGeNETi5408
EuPathDBiHostDB:ENSG00000266200.6
GeneCardsiPNLIPRP2
H-InvDBiHIX0009237
HGNCiHGNC:9157 PNLIPRP2
MIMi604423 gene
neXtProtiNX_P54317
OpenTargetsiENSG00000266200
PharmGKBiPA33480
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119069
HOVERGENiHBG003243
InParanoidiP54317
KOiK14075
PhylomeDBiP54317

Enzyme and pathway databases

BRENDAi3.1.1.26 2681
ReactomeiR-HSA-192456 Digestion of dietary lipid

Miscellaneous databases

ChiTaRSiPNLIPRP2 human
EvolutionaryTraceiP54317
GenomeRNAii5408
PROiPR:P54317
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000266200 Expressed in 90 organ(s), highest expression level in body of pancreas
CleanExiHS_PNLIPRP2

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR002331 Lipase_panc
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00823 PANCLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit
PS50095 PLAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIPR2_HUMAN
AccessioniPrimary (citable) accession number: P54317
Secondary accession number(s): A0A075B781, A8K627, Q6IB55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 28, 2018
Last modified: October 10, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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