UniProtKB - P54315 (LIPR1_HUMAN)
Inactive pancreatic lipase-related protein 1
PNLIPRP1
Functioni
May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).
By similarity1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 171 | Nucleophile | 1 | |
Active sitei | 194 | Charge relay system | 1 | |
Metal bindingi | 205 | Calcium; via carbonyl oxygen | 1 | |
Metal bindingi | 208 | Calcium; via carbonyl oxygen | 1 | |
Metal bindingi | 210 | Calcium | 1 | |
Metal bindingi | 213 | Calcium | 1 | |
Active sitei | 281 | Charge relay system | 1 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- triglyceride lipase activity Source: ProtInc
GO - Biological processi
- lipid metabolic process Source: InterPro
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.1.1.26, 2681 |
PathwayCommonsi | P54315 |
Reactomei | R-HSA-192456, Digestion of dietary lipid |
SignaLinki | P54315 |
Protein family/group databases
ESTHERi | human-PNLIPRP1, Pancreatic_lipase |
Names & Taxonomyi
Protein namesi | Recommended name: Inactive pancreatic lipase-related protein 1Short name: PL-RP1 |
Gene namesi | Name:PNLIPRP1 Synonyms:PLRP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9156, PNLIPRP1 |
MIMi | 604422, gene |
neXtProti | NX_P54315 |
VEuPathDBi | HostDB:ENSG00000187021 |
Subcellular locationi
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- extracellular region Source: ProtInc
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 5407 |
OpenTargetsi | ENSG00000187021 |
PharmGKBi | PA33479 |
Miscellaneous databases
Pharosi | P54315, Tbio |
Genetic variation databases
BioMutai | PNLIPRP1 |
DMDMi | 1708837 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000017790 | 18 – 467 | Inactive pancreatic lipase-related protein 1Add BLAST | 450 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 21 ↔ 27 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 109 ↔ 120 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 255 ↔ 279 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 303 ↔ 314 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 317 ↔ 322 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 451 ↔ 467 | PROSITE-ProRule annotation1 Publication |
Keywords - PTMi
Disulfide bondProteomic databases
MassIVEi | P54315 |
PaxDbi | P54315 |
PeptideAtlasi | P54315 |
PRIDEi | P54315 |
ProteomicsDBi | 56681 [P54315-1] 56682 [P54315-2] 56683 [P54315-3] |
PTM databases
PhosphoSitePlusi | P54315 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000187021, Expressed in pancreas and 105 other tissues |
ExpressionAtlasi | P54315, baseline and differential |
Genevisiblei | P54315, HS |
Organism-specific databases
HPAi | ENSG00000187021, Tissue enriched (pancreas) |
Interactioni
Binary interactionsi
P54315
Protein-protein interaction databases
BioGRIDi | 111408, 167 interactors |
IntActi | P54315, 48 interactors |
MINTi | P54315 |
STRINGi | 9606.ENSP00000433933 |
Miscellaneous databases
RNActi | P54315, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P54315 |
SMRi | P54315 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P54315 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 356 – 467 | PLATPROSITE-ProRule annotationAdd BLAST | 112 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QUK7, Eukaryota |
GeneTreei | ENSGT00940000162375 |
HOGENOMi | CLU_027171_0_2_1 |
InParanoidi | P54315 |
OMAi | NMFKVEE |
OrthoDBi | 534956at2759 |
PhylomeDBi | P54315 |
TreeFami | TF324997 |
Family and domain databases
CDDi | cd00707, Pancreat_lipase_like, 1 hit |
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR013818, Lipase IPR016272, Lipase_LIPH IPR033906, Lipase_N IPR002331, Lipase_panc IPR001024, PLAT/LH2_dom IPR036392, PLAT/LH2_dom_sf IPR000734, TAG_lipase |
PANTHERi | PTHR11610, PTHR11610, 1 hit |
Pfami | View protein in Pfam PF00151, Lipase, 1 hit PF01477, PLAT, 1 hit |
PIRSFi | PIRSF000865, Lipoprotein_lipase_LIPH, 1 hit |
PRINTSi | PR00823, PANCLIPASE PR00821, TAGLIPASE |
SMARTi | View protein in SMART SM00308, LH2, 1 hit |
SUPFAMi | SSF49723, SSF49723, 1 hit SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00120, LIPASE_SER, 1 hit PS50095, PLAT, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLIFWTITLF LLGAAKGKEV CYEDLGCFSD TEPWGGTAIR PLKILPWSPE
60 70 80 90 100
KIGTRFLLYT NENPNNFQIL LLSDPSTIEA SNFQMDRKTR FIIHGFIDKG
110 120 130 140 150
DESWVTDMCK KLFEVEEVNC ICVDWKKGSQ ATYTQAANNV RVVGAQVAQM
160 170 180 190 200
LDILLTEYSY PPSKVHLIGH SLGAHVAGEA GSKTPGLSRI TGLDPVEASF
210 220 230 240 250
ESTPEEVRLD PSDADFVDVI HTDAAPLIPF LGFGTNQQMG HLDFFPNGGE
260 270 280 290 300
SMPGCKKNAL SQIVDLDGIW AGTRDFVACN HLRSYKYYLE SILNPDGFAA
310 320 330 340 350
YPCTSYKSFE SDKCFPCPDQ GCPQMGHYAD KFAGRTSEEQ QKFFLNTGEA
360 370 380 390 400
SNFARWRYGV SITLSGRTAT GQIKVALFGN KGNTHQYSIF RGILKPGSTH
410 420 430 440 450
SYEFDAKLDV GTIEKVKFLW NNNVINPTLP KVGATKITVQ KGEEKTVYNF
460
CSEDTVREDT LLTLTPC
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PRT6 | E9PRT6_HUMAN | Triacylglycerol lipase | PNLIPRP1 | 467 | Annotation score: | ||
E7EX42 | E7EX42_HUMAN | Triacylglycerol lipase | PNLIPRP1 | 118 | Annotation score: | ||
E9PJC9 | E9PJC9_HUMAN | Inactive pancreatic lipase-related ... | PNLIPRP1 | 163 | Annotation score: | ||
E9PMA6 | E9PMA6_HUMAN | Inactive pancreatic lipase-related ... | PNLIPRP1 | 131 | Annotation score: | ||
E9PMX6 | E9PMX6_HUMAN | Inactive pancreatic lipase-related ... | PNLIPRP1 | 185 | Annotation score: | ||
E9PR20 | E9PR20_HUMAN | Inactive pancreatic lipase-related ... | PNLIPRP1 | 191 | Annotation score: | ||
H0YDY1 | H0YDY1_HUMAN | Inactive pancreatic lipase-related ... | PNLIPRP1 | 179 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049820 | 61 | N → D. Corresponds to variant dbSNP:rs11197744Ensembl. | 1 | |
Natural variantiVAR_036379 | 129 | S → C in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_022082 | 271 | A → V. Corresponds to variant dbSNP:rs2305205Ensembl. | 1 | |
Natural variantiVAR_022659 | 414 | E → D1 PublicationCorresponds to variant dbSNP:rs2305204Ensembl. | 1 | |
Natural variantiVAR_014915 | 461 | L → P. Corresponds to variant dbSNP:rs1049125Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014097 | 111 – 186 | KLFEV…SKTPG → VGASSDPCGQLRPTLLLTSL HHFMHSRNLYILGNFMQLKC FSSQKLKCLSMFPHYICTLK QPHLLLEKYSYYLISG in isoform 2. 1 PublicationAdd BLAST | 76 | |
Alternative sequenceiVSP_014098 | 111 – 117 | KLFEVEE → PGASPRA in isoform 3. 1 Publication | 7 | |
Alternative sequenceiVSP_014099 | 118 – 467 | Missing in isoform 3. 1 PublicationAdd BLAST | 350 | |
Alternative sequenceiVSP_014100 | 187 – 467 | Missing in isoform 2. 1 PublicationAdd BLAST | 281 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M93283 mRNA Translation: AAA59532.1 CR749299 mRNA Translation: CAH18154.1 CR749524 mRNA Translation: CAH18337.1 BC005233 mRNA Translation: AAH05233.1 BC025784 mRNA Translation: AAH25784.1 |
CCDSi | CCDS7595.1 [P54315-1] |
PIRi | A43357 |
RefSeqi | NP_001290064.1, NM_001303135.1 [P54315-1] NP_006220.1, NM_006229.3 [P54315-1] XP_011538170.1, XM_011539868.1 |
Genome annotation databases
Ensembli | ENST00000358834.9; ENSP00000351695.4; ENSG00000187021.15 ENST00000528052.5; ENSP00000433933.1; ENSG00000187021.15 |
GeneIDi | 5407 |
KEGGi | hsa:5407 |
MANE-Selecti | ENST00000358834.9; ENSP00000351695.4; NM_006229.4; NP_006220.1 |
UCSCi | uc001lco.2, human [P54315-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M93283 mRNA Translation: AAA59532.1 CR749299 mRNA Translation: CAH18154.1 CR749524 mRNA Translation: CAH18337.1 BC005233 mRNA Translation: AAH05233.1 BC025784 mRNA Translation: AAH25784.1 |
CCDSi | CCDS7595.1 [P54315-1] |
PIRi | A43357 |
RefSeqi | NP_001290064.1, NM_001303135.1 [P54315-1] NP_006220.1, NM_006229.3 [P54315-1] XP_011538170.1, XM_011539868.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2PPL | X-ray | 2.20 | A | 18-467 | [»] | |
AlphaFoldDBi | P54315 | |||||
SMRi | P54315 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111408, 167 interactors |
IntActi | P54315, 48 interactors |
MINTi | P54315 |
STRINGi | 9606.ENSP00000433933 |
Protein family/group databases
ESTHERi | human-PNLIPRP1, Pancreatic_lipase |
PTM databases
PhosphoSitePlusi | P54315 |
Genetic variation databases
BioMutai | PNLIPRP1 |
DMDMi | 1708837 |
Proteomic databases
MassIVEi | P54315 |
PaxDbi | P54315 |
PeptideAtlasi | P54315 |
PRIDEi | P54315 |
ProteomicsDBi | 56681 [P54315-1] 56682 [P54315-2] 56683 [P54315-3] |
Protocols and materials databases
Antibodypediai | 35303, 74 antibodies from 16 providers |
DNASUi | 5407 |
Genome annotation databases
Ensembli | ENST00000358834.9; ENSP00000351695.4; ENSG00000187021.15 ENST00000528052.5; ENSP00000433933.1; ENSG00000187021.15 |
GeneIDi | 5407 |
KEGGi | hsa:5407 |
MANE-Selecti | ENST00000358834.9; ENSP00000351695.4; NM_006229.4; NP_006220.1 |
UCSCi | uc001lco.2, human [P54315-1] |
Organism-specific databases
CTDi | 5407 |
DisGeNETi | 5407 |
GeneCardsi | PNLIPRP1 |
HGNCi | HGNC:9156, PNLIPRP1 |
HPAi | ENSG00000187021, Tissue enriched (pancreas) |
MIMi | 604422, gene |
neXtProti | NX_P54315 |
OpenTargetsi | ENSG00000187021 |
PharmGKBi | PA33479 |
VEuPathDBi | HostDB:ENSG00000187021 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUK7, Eukaryota |
GeneTreei | ENSGT00940000162375 |
HOGENOMi | CLU_027171_0_2_1 |
InParanoidi | P54315 |
OMAi | NMFKVEE |
OrthoDBi | 534956at2759 |
PhylomeDBi | P54315 |
TreeFami | TF324997 |
Enzyme and pathway databases
BRENDAi | 3.1.1.26, 2681 |
PathwayCommonsi | P54315 |
Reactomei | R-HSA-192456, Digestion of dietary lipid |
SignaLinki | P54315 |
Miscellaneous databases
BioGRID-ORCSi | 5407, 9 hits in 1069 CRISPR screens |
ChiTaRSi | PNLIPRP1, human |
EvolutionaryTracei | P54315 |
GenomeRNAii | 5407 |
Pharosi | P54315, Tbio |
PROi | PR:P54315 |
RNActi | P54315, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000187021, Expressed in pancreas and 105 other tissues |
ExpressionAtlasi | P54315, baseline and differential |
Genevisiblei | P54315, HS |
Family and domain databases
CDDi | cd00707, Pancreat_lipase_like, 1 hit |
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR013818, Lipase IPR016272, Lipase_LIPH IPR033906, Lipase_N IPR002331, Lipase_panc IPR001024, PLAT/LH2_dom IPR036392, PLAT/LH2_dom_sf IPR000734, TAG_lipase |
PANTHERi | PTHR11610, PTHR11610, 1 hit |
Pfami | View protein in Pfam PF00151, Lipase, 1 hit PF01477, PLAT, 1 hit |
PIRSFi | PIRSF000865, Lipoprotein_lipase_LIPH, 1 hit |
PRINTSi | PR00823, PANCLIPASE PR00821, TAGLIPASE |
SMARTi | View protein in SMART SM00308, LH2, 1 hit |
SUPFAMi | SSF49723, SSF49723, 1 hit SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00120, LIPASE_SER, 1 hit PS50095, PLAT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LIPR1_HUMAN | |
Accessioni | P54315Primary (citable) accession number: P54315 Secondary accession number(s): Q68D83 Q9BS82 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 184 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families