UniProtKB - P54296 (MYOM2_HUMAN)
Protein
Myomesin-2
Gene
MYOM2
Organism
Homo sapiens (Human)
Status
Functioni
Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
GO - Molecular functioni
- actin filament binding Source: GO_Central
- kinase binding Source: CAFA
- structural constituent of muscle Source: ProtInc
GO - Biological processi
- extraocular skeletal muscle development Source: Ensembl
- muscle contraction Source: GO_Central
Keywordsi
Molecular function | Muscle protein |
Enzyme and pathway databases
PathwayCommonsi | P54296 |
SIGNORi | P54296 |
Names & Taxonomyi
Protein namesi | Recommended name: Myomesin-2Alternative name(s): 165 kDa connectin-associated protein 165 kDa titin-associated protein M-protein Myomesin family member 2 |
Gene namesi | Name:MYOM2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7614, MYOM2 |
MIMi | 603509, gene |
neXtProti | NX_P54296 |
VEuPathDBi | HostDB:ENSG00000036448.9 |
Subcellular locationi
Other locations
- M line By similarity
Mitochondrion
- mitochondrion Source: UniProtKB
Other locations
- M band Source: GO_Central
- myosin filament Source: UniProtKB-KW
- sarcomere Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Thick filamentPathology & Biotechi
Organism-specific databases
DisGeNETi | 9172 |
PharmGKBi | PA31419 |
Miscellaneous databases
Pharosi | P54296, Tbio |
Genetic variation databases
BioMutai | MYOM2 |
DMDMi | 224471842 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072686 | 1 – 1465 | Myomesin-2Add BLAST | 1465 |
Proteomic databases
MassIVEi | P54296 |
MaxQBi | P54296 |
PaxDbi | P54296 |
PeptideAtlasi | P54296 |
PRIDEi | P54296 |
ProteomicsDBi | 56680 |
PTM databases
iPTMneti | P54296 |
PhosphoSitePlusi | P54296 |
Expressioni
Gene expression databases
Bgeei | ENSG00000036448, Expressed in apex of heart and 183 other tissues |
ExpressionAtlasi | P54296, baseline and differential |
Genevisiblei | P54296, HS |
Organism-specific databases
HPAi | ENSG00000036448, Group enriched (heart muscle, skeletal muscle) |
Interactioni
Subunit structurei
Interacts with TTN/titin.
By similarityBinary interactionsi
Hide detailsP54296
With | #Exp. | IntAct |
---|---|---|
ACTN2 [P35609] | 2 | EBI-5357134,EBI-77797 |
DYSF [O75923] | 3 | EBI-5357134,EBI-2799016 |
RYR1 [P21817] | 2 | EBI-5357134,EBI-1221290 |
TTN [Q8WZ42] | 2 | EBI-5357134,EBI-681210 |
GO - Molecular functioni
- actin filament binding Source: GO_Central
- kinase binding Source: CAFA
Protein-protein interaction databases
BioGRIDi | 114612, 3 interactors |
IntActi | P54296, 18 interactors |
STRINGi | 9606.ENSP00000262113 |
Miscellaneous databases
RNActi | P54296, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 154 – 245 | Ig-like C2-type 1Add BLAST | 92 | |
Domaini | 266 – 371 | Ig-like C2-type 2Add BLAST | 106 | |
Domaini | 385 – 480 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 513 – 608 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 614 – 707 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 710 – 812 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 815 – 912 | Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 904 – 1002 | Ig-like C2-type 3Add BLAST | 99 | |
Domaini | 1130 – 1211 | Ig-like C2-type 4Add BLAST | 82 | |
Domaini | 1345 – 1434 | Ig-like C2-type 5Add BLAST | 90 |
Keywords - Domaini
Immunoglobulin domain, RepeatPhylogenomic databases
eggNOGi | ENOG502QS6D, Eukaryota |
HOGENOMi | CLU_004753_1_0_1 |
InParanoidi | P54296 |
OrthoDBi | 57219at2759 |
PhylomeDBi | P54296 |
TreeFami | TF331825 |
Family and domain databases
CDDi | cd00063, FN3, 5 hits |
Gene3Di | 2.60.40.10, 12 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF00041, fn3, 5 hits PF07679, I-set, 3 hits |
SMARTi | View protein in SMART SM00060, FN3, 5 hits SM00409, IG, 5 hits SM00408, IGc2, 3 hits |
SUPFAMi | SSF48726, SSF48726, 6 hits SSF49265, SSF49265, 3 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 5 hits PS50835, IG_LIKE, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P54296-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLVTVPFYQ KRHRHFDQSY RNIQTRYLLD EYASKKRAST QASSQKSLSQ
60 70 80 90 100
RSSSQRASSQ TSLGGTICRV CAKRVSTQED EEQENRSRYQ SLVAAYGEAK
110 120 130 140 150
RQRFLSELAH LEEDVHLARS QARDKLDKYA IQQMMEDKLA WERHTFEERI
160 170 180 190 200
SRAPEILVRL RSHTVWERMS VKLCFTVQGF PTPVVQWYKD GSLICQAAEP
210 220 230 240 250
GKYRIESNYG VHTLEINRAD FDDTATYSAV ATNAHGQVST NAAVVVRRFR
260 270 280 290 300
GDEEPFRSVG LPIGLPLSSM IPYTHFDVQF LEKFGVTFRR EGETVTLKCT
310 320 330 340 350
MLVTPDLKRV QPRAEWYRDD VLLKESKWTK MFFGEGQASL SFSHLHKDDE
360 370 380 390 400
GLYTLRIVSR GGVSDHSAFL FVRDADPLVT GAPGAPMDLQ CHDANRDYVI
410 420 430 440 450
VTWKPPNTTT ESPVMGYFVD RCEVGTNNWV QCNDAPVKIC KYPVTGLFEG
460 470 480 490 500
RSYIFRVRAV NSAGISRPSR VSDAVAALDP LDLRRLQAVH LEGEKEIAIY
510 520 530 540 550
QDDLEGDAQV PGPPTGVHAS EISRNYVVLS WEPPTPRGKD PLMYFIEKSV
560 570 580 590 600
VGSGSWQRVN AQTAVRSPRY AVFDLMEGKS YVFRVLSANR HGLSEPSEIT
610 620 630 640 650
SPIQAQDVTV VPSAPGRVLA SRNTKTSVVV QWDRPKHEED LLGYYVDCCV
660 670 680 690 700
AGTNLWEPCN HKPIGYNRFV VHGLTTGEQY IFRVKAVNAV GMSENSQESD
710 720 730 740 750
VIKVQAALTV PSHPYGITLL NCDGHSMTLG WKVPKFSGGS PILGYYLDKR
760 770 780 790 800
EVHHKNWHEV NSSPSKPTIL TVDGLTEGSL YEFKIAAVNL AGIGEPSDPS
810 820 830 840 850
EHFKCEAWTM PEPGPAYDLT FCEVRDTSLV MLWKAPVYSG SSPVSGYFVD
860 870 880 890 900
FREEDAGEWI TVNQTTTANR YLKVSDLQQG KTYVFRVRAV NANGVGKPSD
910 920 930 940 950
TSEPVLVEAR PGTKEISAGV DEQGNIYLGF DCQEMTDASQ FTWCKSYEEI
960 970 980 990 1000
SDDERFKIET VGDHSKLYLK NPDKEDLGTY SVSVSDTDGV SSSFVLDPEE
1010 1020 1030 1040 1050
LERLMALSNE IKNPTIPLKS ELAYEIFDKG RVRFWLQAEH LSPDASYRFI
1060 1070 1080 1090 1100
INDREVSDSE IHRIKCDKAT GIIEMVMDRF SIENEGTYTV QIHDGKAKSQ
1110 1120 1130 1140 1150
SSLVLIGDAF KTVLEEAEFQ RKEFLRKQGP HFAEYLHWDV TEECEVRLVC
1160 1170 1180 1190 1200
KVANTKKETV FKWLKDDVLY ETETLPNLER GICELLIPKL SKKDHGEYKA
1210 1220 1230 1240 1250
TLKDDRGQDV SILEIAGKVY DDMILAMSRV CGKSASPLKV LCTPEGIRLQ
1260 1270 1280 1290 1300
CFMKYFTDEM KVNWCHKDAK ISSSEHMRIG GSEEMAWLQI CEPTEKDKGK
1310 1320 1330 1340 1350
YTFEIFDGKD NHQRSLDLSG QAFDEAFAEF QQFKAAAFAE KNRGRLIGGL
1360 1370 1380 1390 1400
PDVVTIMEGK TLNLTCTVFG NPDPEVIWFK NDQDIQLSEH FSVKVEQAKY
1410 1420 1430 1440 1450
VSMTIKGVTS EDSGKYSINI KNKYGGEKID VTVSVYKHGE KIPDMAPPQQ
1460
AKPKLIPASA SAAGQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EWH9 | E7EWH9_HUMAN | Myomesin-2 | MYOM2 | 890 | Annotation score: | ||
A0A0J9YVV7 | A0A0J9YVV7_HUMAN | Myomesin-2 | MYOM2 | 890 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 102 – 103 | QR → HG in CAA48832 (PubMed:7505783).Curated | 2 | |
Sequence conflicti | 364 | S → T in CAA48832 (PubMed:7505783).Curated | 1 | |
Sequence conflicti | 555 | S → T in CAA48832 (PubMed:7505783).Curated | 1 | |
Sequence conflicti | 863 | N → D in CAA48832 (PubMed:7505783).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033613 | 81 | E → K. Corresponds to variant dbSNP:rs35985218Ensembl. | 1 | |
Natural variantiVAR_033614 | 182 | T → M. Corresponds to variant dbSNP:rs17064618Ensembl. | 1 | |
Natural variantiVAR_033615 | 321 | V → L1 PublicationCorresponds to variant dbSNP:rs2272720Ensembl. | 1 | |
Natural variantiVAR_033616 | 363 | V → I. Corresponds to variant dbSNP:rs34316994Ensembl. | 1 | |
Natural variantiVAR_033617 | 601 | S → Y. Corresponds to variant dbSNP:rs36089594Ensembl. | 1 | |
Natural variantiVAR_033618 | 701 | V → I. Corresponds to variant dbSNP:rs35335787Ensembl. | 1 | |
Natural variantiVAR_020083 | 776 | T → M1 PublicationCorresponds to variant dbSNP:rs2294066Ensembl. | 1 | |
Natural variantiVAR_054501 | 869 | N → S2 PublicationsCorresponds to variant dbSNP:rs968381Ensembl. | 1 | |
Natural variantiVAR_020084 | 1022 | L → F. Corresponds to variant dbSNP:rs2280896Ensembl. | 1 | |
Natural variantiVAR_061320 | 1168 | V → A2 PublicationsCorresponds to variant dbSNP:rs17854780Ensembl. | 1 | |
Natural variantiVAR_033619 | 1284 | E → D. Corresponds to variant dbSNP:rs34735757Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69089 mRNA Translation: CAA48832.1 AC125453 Genomic DNA No translation available. BC052969 mRNA Translation: AAH52969.1 |
CCDSi | CCDS5957.1 |
PIRi | S43529 |
RefSeqi | NP_003961.3, NM_003970.3 |
Genome annotation databases
Ensembli | ENST00000262113; ENSP00000262113; ENSG00000036448 ENST00000616680; ENSP00000478322; ENSG00000274137 |
GeneIDi | 9172 |
KEGGi | hsa:9172 |
UCSCi | uc033azy.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69089 mRNA Translation: CAA48832.1 AC125453 Genomic DNA No translation available. BC052969 mRNA Translation: AAH52969.1 |
CCDSi | CCDS5957.1 |
PIRi | S43529 |
RefSeqi | NP_003961.3, NM_003970.3 |
3D structure databases
SMRi | P54296 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114612, 3 interactors |
IntActi | P54296, 18 interactors |
STRINGi | 9606.ENSP00000262113 |
PTM databases
iPTMneti | P54296 |
PhosphoSitePlusi | P54296 |
Genetic variation databases
BioMutai | MYOM2 |
DMDMi | 224471842 |
Proteomic databases
MassIVEi | P54296 |
MaxQBi | P54296 |
PaxDbi | P54296 |
PeptideAtlasi | P54296 |
PRIDEi | P54296 |
ProteomicsDBi | 56680 |
Protocols and materials databases
Antibodypediai | 940, 136 antibodies |
Genome annotation databases
Ensembli | ENST00000262113; ENSP00000262113; ENSG00000036448 ENST00000616680; ENSP00000478322; ENSG00000274137 |
GeneIDi | 9172 |
KEGGi | hsa:9172 |
UCSCi | uc033azy.2, human |
Organism-specific databases
CTDi | 9172 |
DisGeNETi | 9172 |
GeneCardsi | MYOM2 |
HGNCi | HGNC:7614, MYOM2 |
HPAi | ENSG00000036448, Group enriched (heart muscle, skeletal muscle) |
MIMi | 603509, gene |
neXtProti | NX_P54296 |
PharmGKBi | PA31419 |
VEuPathDBi | HostDB:ENSG00000036448.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QS6D, Eukaryota |
HOGENOMi | CLU_004753_1_0_1 |
InParanoidi | P54296 |
OrthoDBi | 57219at2759 |
PhylomeDBi | P54296 |
TreeFami | TF331825 |
Enzyme and pathway databases
PathwayCommonsi | P54296 |
SIGNORi | P54296 |
Miscellaneous databases
BioGRID-ORCSi | 9172, 3 hits in 874 CRISPR screens |
ChiTaRSi | MYOM2, human |
GeneWikii | MYOM2 |
GenomeRNAii | 9172 |
Pharosi | P54296, Tbio |
PROi | PR:P54296 |
RNActi | P54296, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000036448, Expressed in apex of heart and 183 other tissues |
ExpressionAtlasi | P54296, baseline and differential |
Genevisiblei | P54296, HS |
Family and domain databases
CDDi | cd00063, FN3, 5 hits |
Gene3Di | 2.60.40.10, 12 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF00041, fn3, 5 hits PF07679, I-set, 3 hits |
SMARTi | View protein in SMART SM00060, FN3, 5 hits SM00409, IG, 5 hits SM00408, IGc2, 3 hits |
SUPFAMi | SSF48726, SSF48726, 6 hits SSF49265, SSF49265, 3 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 5 hits PS50835, IG_LIKE, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYOM2_HUMAN | |
Accessioni | P54296Primary (citable) accession number: P54296 Secondary accession number(s): Q7Z3Y2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | March 3, 2009 | |
Last modified: | February 10, 2021 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM