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UniProtKB - P54296 (MYOM2_HUMAN)

Entry version 164 (26 Feb 2020)
Sequence version 2 (03 Mar 2009)
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Protein

Myomesin-2

Gene

MYOM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMuscle protein

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...SIGNORi		P54296

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myomesin-2
Alternative name(s):
165 kDa connectin-associated protein
165 kDa titin-associated protein
M-protein
Myomesin family member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYOM2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7614 MYOM2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603509 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P54296

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Thick filament

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9172

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31419

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P54296 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MYOM2

Domain mapping of disease mutations (DMDM)

More...DMDMi		224471842

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000726861 – 1465Myomesin-2Add BLAST1465

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P54296

MaxQB - The MaxQuant DataBase

More...MaxQBi		P54296

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P54296

PeptideAtlas

More...PeptideAtlasi		P54296

PRoteomics IDEntifications database

More...PRIDEi		P54296

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56680

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P54296

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P54296

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000036448 Expressed in apex of heart and 167 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P54296 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P54296 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA001765
HPA005953

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TTN/titin.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		114612, 2 interactors

Protein interaction database and analysis system

More...IntActi		P54296, 17 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000262113

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P54296 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P54296

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini154 – 245Ig-like C2-type 1Add BLAST92
Domaini266 – 371Ig-like C2-type 2Add BLAST106
Domaini385 – 480Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini513 – 608Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini614 – 707Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94
Domaini710 – 812Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST103
Domaini815 – 912Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST98
Domaini904 – 1002Ig-like C2-type 3Add BLAST99
Domaini1130 – 1211Ig-like C2-type 4Add BLAST82
Domaini1345 – 1434Ig-like C2-type 5Add BLAST90

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IJ5G Eukaryota
ENOG410ZSRR LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004753_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P54296

Database of Orthologous Groups

More...OrthoDBi		57219at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P54296

TreeFam database of animal gene trees

More...TreeFami		TF331825

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063 FN3, 5 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 12 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 5 hits
SM00408 IGc2, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P54296-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLVTVPFYQ KRHRHFDQSY RNIQTRYLLD EYASKKRAST QASSQKSLSQ 
        60         70         80         90        100
RSSSQRASSQ TSLGGTICRV CAKRVSTQED EEQENRSRYQ SLVAAYGEAK 
       110        120        130        140        150
RQRFLSELAH LEEDVHLARS QARDKLDKYA IQQMMEDKLA WERHTFEERI 
       160        170        180        190        200
SRAPEILVRL RSHTVWERMS VKLCFTVQGF PTPVVQWYKD GSLICQAAEP 
       210        220        230        240        250
GKYRIESNYG VHTLEINRAD FDDTATYSAV ATNAHGQVST NAAVVVRRFR 
       260        270        280        290        300
GDEEPFRSVG LPIGLPLSSM IPYTHFDVQF LEKFGVTFRR EGETVTLKCT 
       310        320        330        340        350
MLVTPDLKRV QPRAEWYRDD VLLKESKWTK MFFGEGQASL SFSHLHKDDE 
       360        370        380        390        400
GLYTLRIVSR GGVSDHSAFL FVRDADPLVT GAPGAPMDLQ CHDANRDYVI 
       410        420        430        440        450
VTWKPPNTTT ESPVMGYFVD RCEVGTNNWV QCNDAPVKIC KYPVTGLFEG 
       460        470        480        490        500
RSYIFRVRAV NSAGISRPSR VSDAVAALDP LDLRRLQAVH LEGEKEIAIY 
       510        520        530        540        550
QDDLEGDAQV PGPPTGVHAS EISRNYVVLS WEPPTPRGKD PLMYFIEKSV 
       560        570        580        590        600
VGSGSWQRVN AQTAVRSPRY AVFDLMEGKS YVFRVLSANR HGLSEPSEIT 
       610        620        630        640        650
SPIQAQDVTV VPSAPGRVLA SRNTKTSVVV QWDRPKHEED LLGYYVDCCV 
       660        670        680        690        700
AGTNLWEPCN HKPIGYNRFV VHGLTTGEQY IFRVKAVNAV GMSENSQESD 
       710        720        730        740        750
VIKVQAALTV PSHPYGITLL NCDGHSMTLG WKVPKFSGGS PILGYYLDKR 
       760        770        780        790        800
EVHHKNWHEV NSSPSKPTIL TVDGLTEGSL YEFKIAAVNL AGIGEPSDPS 
       810        820        830        840        850
EHFKCEAWTM PEPGPAYDLT FCEVRDTSLV MLWKAPVYSG SSPVSGYFVD 
       860        870        880        890        900
FREEDAGEWI TVNQTTTANR YLKVSDLQQG KTYVFRVRAV NANGVGKPSD 
       910        920        930        940        950
TSEPVLVEAR PGTKEISAGV DEQGNIYLGF DCQEMTDASQ FTWCKSYEEI 
       960        970        980        990       1000
SDDERFKIET VGDHSKLYLK NPDKEDLGTY SVSVSDTDGV SSSFVLDPEE 
      1010       1020       1030       1040       1050
LERLMALSNE IKNPTIPLKS ELAYEIFDKG RVRFWLQAEH LSPDASYRFI 
      1060       1070       1080       1090       1100
INDREVSDSE IHRIKCDKAT GIIEMVMDRF SIENEGTYTV QIHDGKAKSQ 
      1110       1120       1130       1140       1150
SSLVLIGDAF KTVLEEAEFQ RKEFLRKQGP HFAEYLHWDV TEECEVRLVC 
      1160       1170       1180       1190       1200
KVANTKKETV FKWLKDDVLY ETETLPNLER GICELLIPKL SKKDHGEYKA 
      1210       1220       1230       1240       1250
TLKDDRGQDV SILEIAGKVY DDMILAMSRV CGKSASPLKV LCTPEGIRLQ 
      1260       1270       1280       1290       1300
CFMKYFTDEM KVNWCHKDAK ISSSEHMRIG GSEEMAWLQI CEPTEKDKGK 
      1310       1320       1330       1340       1350
YTFEIFDGKD NHQRSLDLSG QAFDEAFAEF QQFKAAAFAE KNRGRLIGGL 
      1360       1370       1380       1390       1400
PDVVTIMEGK TLNLTCTVFG NPDPEVIWFK NDQDIQLSEH FSVKVEQAKY 
      1410       1420       1430       1440       1450
VSMTIKGVTS EDSGKYSINI KNKYGGEKID VTVSVYKHGE KIPDMAPPQQ 
      1460 
AKPKLIPASA SAAGQ
Length:1,465
Mass (Da):164,896
Last modified:March 3, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71C6B11FCB066A8B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EWH9E7EWH9_HUMAN
Myomesin-2
MYOM2
890Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YVV7A0A0J9YVV7_HUMAN
Myomesin-2
MYOM2
890Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti102 – 103QR → HG in CAA48832 (PubMed:7505783).Curated2
Sequence conflicti364S → T in CAA48832 (PubMed:7505783).Curated1
Sequence conflicti555S → T in CAA48832 (PubMed:7505783).Curated1
Sequence conflicti863N → D in CAA48832 (PubMed:7505783).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03361381E → K. Corresponds to variant dbSNP:rs35985218Ensembl.1
Natural variantiVAR_033614182T → M. Corresponds to variant dbSNP:rs17064618Ensembl.1
Natural variantiVAR_033615321V → L1 PublicationCorresponds to variant dbSNP:rs2272720Ensembl.1
Natural variantiVAR_033616363V → I. Corresponds to variant dbSNP:rs34316994Ensembl.1
Natural variantiVAR_033617601S → Y. Corresponds to variant dbSNP:rs36089594Ensembl.1
Natural variantiVAR_033618701V → I. Corresponds to variant dbSNP:rs35335787Ensembl.1
Natural variantiVAR_020083776T → M1 PublicationCorresponds to variant dbSNP:rs2294066Ensembl.1
Natural variantiVAR_054501869N → S2 PublicationsCorresponds to variant dbSNP:rs968381Ensembl.1
Natural variantiVAR_0200841022L → F. Corresponds to variant dbSNP:rs2280896Ensembl.1
Natural variantiVAR_0613201168V → A2 PublicationsCorresponds to variant dbSNP:rs17854780Ensembl.1
Natural variantiVAR_0336191284E → D. Corresponds to variant dbSNP:rs34735757Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X69089 mRNA Translation: CAA48832.1
AC125453 Genomic DNA No translation available.
BC052969 mRNA Translation: AAH52969.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5957.1

Protein sequence database of the Protein Information Resource

More...PIRi		S43529

NCBI Reference Sequences

More...RefSeqi		NP_003961.3, NM_003970.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262113; ENSP00000262113; ENSG00000036448
ENST00000616680; ENSP00000478322; ENSG00000274137

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9172

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9172

UCSC genome browser

More...UCSCi		uc033azy.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69089 mRNA Translation: CAA48832.1
AC125453 Genomic DNA No translation available.
BC052969 mRNA Translation: AAH52969.1
CCDSiCCDS5957.1
PIRiS43529
RefSeqiNP_003961.3, NM_003970.3

3D structure databases

SMRiP54296
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114612, 2 interactors
IntActiP54296, 17 interactors
STRINGi9606.ENSP00000262113

PTM databases

iPTMnetiP54296
PhosphoSitePlusiP54296

Polymorphism and mutation databases

BioMutaiMYOM2
DMDMi224471842

Proteomic databases

MassIVEiP54296
MaxQBiP54296
PaxDbiP54296
PeptideAtlasiP54296
PRIDEiP54296
ProteomicsDBi56680

Genome annotation databases

EnsembliENST00000262113; ENSP00000262113; ENSG00000036448
ENST00000616680; ENSP00000478322; ENSG00000274137
GeneIDi9172
KEGGihsa:9172
UCSCiuc033azy.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9172
DisGeNETi9172

GeneCards: human genes, protein and diseases

More...GeneCardsi		MYOM2
HGNCiHGNC:7614 MYOM2
HPAiHPA001765
HPA005953
MIMi603509 gene
neXtProtiNX_P54296
PharmGKBiPA31419

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IJ5G Eukaryota
ENOG410ZSRR LUCA
HOGENOMiCLU_004753_1_0_1
InParanoidiP54296
OrthoDBi57219at2759
PhylomeDBiP54296
TreeFamiTF331825

Enzyme and pathway databases

SIGNORiP54296

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MYOM2 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MYOM2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9172
PharosiP54296 Tbio

Protein Ontology

More...PROi		PR:P54296
RNActiP54296 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000036448 Expressed in apex of heart and 167 other tissues
ExpressionAtlasiP54296 baseline and differential
GenevisibleiP54296 HS

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.10, 12 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 5 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYOM2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54296
Secondary accession number(s): Q7Z3Y2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 3, 2009
Last modified: February 26, 2020
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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