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Protein

Myomesin-2

Gene

MYOM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • kinase binding Source: CAFA
  • muscle alpha-actinin binding Source: GO_Central
  • structural constituent of muscle Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionMuscle protein

Enzyme and pathway databases

SIGNORiP54296

Names & Taxonomyi

Protein namesi
Recommended name:
Myomesin-2
Alternative name(s):
165 kDa connectin-associated protein
165 kDa titin-associated protein
M-protein
Myomesin family member 2
Gene namesi
Name:MYOM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000036448.9
HGNCiHGNC:7614 MYOM2
MIMi603509 gene
neXtProtiNX_P54296

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Thick filament

Pathology & Biotechi

Organism-specific databases

DisGeNETi9172
PharmGKBiPA31419

Polymorphism and mutation databases

BioMutaiMYOM2
DMDMi224471842

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000726861 – 1465Myomesin-2Add BLAST1465

Proteomic databases

MaxQBiP54296
PaxDbiP54296
PeptideAtlasiP54296
PRIDEiP54296
ProteomicsDBi56680

PTM databases

iPTMnetiP54296
PhosphoSitePlusiP54296

Expressioni

Gene expression databases

BgeeiENSG00000036448 Expressed in 168 organ(s), highest expression level in apex of heart
CleanExiHS_MYOM2
ExpressionAtlasiP54296 baseline and differential
GenevisibleiP54296 HS

Organism-specific databases

HPAiHPA001765
HPA005953

Interactioni

Subunit structurei

Interacts with TTN/titin.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114612, 2 interactors
IntActiP54296, 14 interactors
STRINGi9606.ENSP00000262113

Structurei

3D structure databases

ProteinModelPortaliP54296
SMRiP54296
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini154 – 245Ig-like C2-type 1Add BLAST92
Domaini266 – 371Ig-like C2-type 2Add BLAST106
Domaini385 – 480Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini513 – 608Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini614 – 707Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94
Domaini710 – 812Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST103
Domaini815 – 912Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST98
Domaini904 – 1002Ig-like C2-type 3Add BLAST99
Domaini1130 – 1211Ig-like C2-type 4Add BLAST82
Domaini1345 – 1434Ig-like C2-type 5Add BLAST90

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IJ5G Eukaryota
ENOG410ZSRR LUCA
HOGENOMiHOG000293283
HOVERGENiHBG004977
InParanoidiP54296
OrthoDBiEOG091G00GW
PhylomeDBiP54296
TreeFamiTF331825

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.10, 12 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 5 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P54296-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLVTVPFYQ KRHRHFDQSY RNIQTRYLLD EYASKKRAST QASSQKSLSQ
60 70 80 90 100
RSSSQRASSQ TSLGGTICRV CAKRVSTQED EEQENRSRYQ SLVAAYGEAK
110 120 130 140 150
RQRFLSELAH LEEDVHLARS QARDKLDKYA IQQMMEDKLA WERHTFEERI
160 170 180 190 200
SRAPEILVRL RSHTVWERMS VKLCFTVQGF PTPVVQWYKD GSLICQAAEP
210 220 230 240 250
GKYRIESNYG VHTLEINRAD FDDTATYSAV ATNAHGQVST NAAVVVRRFR
260 270 280 290 300
GDEEPFRSVG LPIGLPLSSM IPYTHFDVQF LEKFGVTFRR EGETVTLKCT
310 320 330 340 350
MLVTPDLKRV QPRAEWYRDD VLLKESKWTK MFFGEGQASL SFSHLHKDDE
360 370 380 390 400
GLYTLRIVSR GGVSDHSAFL FVRDADPLVT GAPGAPMDLQ CHDANRDYVI
410 420 430 440 450
VTWKPPNTTT ESPVMGYFVD RCEVGTNNWV QCNDAPVKIC KYPVTGLFEG
460 470 480 490 500
RSYIFRVRAV NSAGISRPSR VSDAVAALDP LDLRRLQAVH LEGEKEIAIY
510 520 530 540 550
QDDLEGDAQV PGPPTGVHAS EISRNYVVLS WEPPTPRGKD PLMYFIEKSV
560 570 580 590 600
VGSGSWQRVN AQTAVRSPRY AVFDLMEGKS YVFRVLSANR HGLSEPSEIT
610 620 630 640 650
SPIQAQDVTV VPSAPGRVLA SRNTKTSVVV QWDRPKHEED LLGYYVDCCV
660 670 680 690 700
AGTNLWEPCN HKPIGYNRFV VHGLTTGEQY IFRVKAVNAV GMSENSQESD
710 720 730 740 750
VIKVQAALTV PSHPYGITLL NCDGHSMTLG WKVPKFSGGS PILGYYLDKR
760 770 780 790 800
EVHHKNWHEV NSSPSKPTIL TVDGLTEGSL YEFKIAAVNL AGIGEPSDPS
810 820 830 840 850
EHFKCEAWTM PEPGPAYDLT FCEVRDTSLV MLWKAPVYSG SSPVSGYFVD
860 870 880 890 900
FREEDAGEWI TVNQTTTANR YLKVSDLQQG KTYVFRVRAV NANGVGKPSD
910 920 930 940 950
TSEPVLVEAR PGTKEISAGV DEQGNIYLGF DCQEMTDASQ FTWCKSYEEI
960 970 980 990 1000
SDDERFKIET VGDHSKLYLK NPDKEDLGTY SVSVSDTDGV SSSFVLDPEE
1010 1020 1030 1040 1050
LERLMALSNE IKNPTIPLKS ELAYEIFDKG RVRFWLQAEH LSPDASYRFI
1060 1070 1080 1090 1100
INDREVSDSE IHRIKCDKAT GIIEMVMDRF SIENEGTYTV QIHDGKAKSQ
1110 1120 1130 1140 1150
SSLVLIGDAF KTVLEEAEFQ RKEFLRKQGP HFAEYLHWDV TEECEVRLVC
1160 1170 1180 1190 1200
KVANTKKETV FKWLKDDVLY ETETLPNLER GICELLIPKL SKKDHGEYKA
1210 1220 1230 1240 1250
TLKDDRGQDV SILEIAGKVY DDMILAMSRV CGKSASPLKV LCTPEGIRLQ
1260 1270 1280 1290 1300
CFMKYFTDEM KVNWCHKDAK ISSSEHMRIG GSEEMAWLQI CEPTEKDKGK
1310 1320 1330 1340 1350
YTFEIFDGKD NHQRSLDLSG QAFDEAFAEF QQFKAAAFAE KNRGRLIGGL
1360 1370 1380 1390 1400
PDVVTIMEGK TLNLTCTVFG NPDPEVIWFK NDQDIQLSEH FSVKVEQAKY
1410 1420 1430 1440 1450
VSMTIKGVTS EDSGKYSINI KNKYGGEKID VTVSVYKHGE KIPDMAPPQQ
1460
AKPKLIPASA SAAGQ
Length:1,465
Mass (Da):164,896
Last modified:March 3, 2009 - v2
Checksum:i71C6B11FCB066A8B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EWH9E7EWH9_HUMAN
Myomesin-2
MYOM2
890Annotation score:
A0A0J9YVV7A0A0J9YVV7_HUMAN
Myomesin-2
MYOM2
890Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102 – 103QR → HG in CAA48832 (PubMed:7505783).Curated2
Sequence conflicti364S → T in CAA48832 (PubMed:7505783).Curated1
Sequence conflicti555S → T in CAA48832 (PubMed:7505783).Curated1
Sequence conflicti863N → D in CAA48832 (PubMed:7505783).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03361381E → K. Corresponds to variant dbSNP:rs35985218Ensembl.1
Natural variantiVAR_033614182T → M. Corresponds to variant dbSNP:rs17064618Ensembl.1
Natural variantiVAR_033615321V → L1 PublicationCorresponds to variant dbSNP:rs2272720Ensembl.1
Natural variantiVAR_033616363V → I. Corresponds to variant dbSNP:rs34316994Ensembl.1
Natural variantiVAR_033617601S → Y. Corresponds to variant dbSNP:rs36089594Ensembl.1
Natural variantiVAR_033618701V → I. Corresponds to variant dbSNP:rs35335787Ensembl.1
Natural variantiVAR_020083776T → M1 PublicationCorresponds to variant dbSNP:rs2294066Ensembl.1
Natural variantiVAR_054501869N → S2 PublicationsCorresponds to variant dbSNP:rs968381Ensembl.1
Natural variantiVAR_0200841022L → F. Corresponds to variant dbSNP:rs2280896Ensembl.1
Natural variantiVAR_0613201168V → A2 PublicationsCorresponds to variant dbSNP:rs17854780Ensembl.1
Natural variantiVAR_0336191284E → D. Corresponds to variant dbSNP:rs34735757Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69089 mRNA Translation: CAA48832.1
AC125453 Genomic DNA No translation available.
BC052969 mRNA Translation: AAH52969.1
CCDSiCCDS5957.1
PIRiS43529
RefSeqiNP_003961.3, NM_003970.3
UniGeneiHs.443683

Genome annotation databases

EnsembliENST00000262113; ENSP00000262113; ENSG00000036448
ENST00000616680; ENSP00000478322; ENSG00000274137
GeneIDi9172
KEGGihsa:9172
UCSCiuc033azy.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69089 mRNA Translation: CAA48832.1
AC125453 Genomic DNA No translation available.
BC052969 mRNA Translation: AAH52969.1
CCDSiCCDS5957.1
PIRiS43529
RefSeqiNP_003961.3, NM_003970.3
UniGeneiHs.443683

3D structure databases

ProteinModelPortaliP54296
SMRiP54296
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114612, 2 interactors
IntActiP54296, 14 interactors
STRINGi9606.ENSP00000262113

PTM databases

iPTMnetiP54296
PhosphoSitePlusiP54296

Polymorphism and mutation databases

BioMutaiMYOM2
DMDMi224471842

Proteomic databases

MaxQBiP54296
PaxDbiP54296
PeptideAtlasiP54296
PRIDEiP54296
ProteomicsDBi56680

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262113; ENSP00000262113; ENSG00000036448
ENST00000616680; ENSP00000478322; ENSG00000274137
GeneIDi9172
KEGGihsa:9172
UCSCiuc033azy.2 human

Organism-specific databases

CTDi9172
DisGeNETi9172
EuPathDBiHostDB:ENSG00000036448.9
GeneCardsiMYOM2
H-InvDBiHIX0025666
HGNCiHGNC:7614 MYOM2
HPAiHPA001765
HPA005953
MIMi603509 gene
neXtProtiNX_P54296
PharmGKBiPA31419
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ5G Eukaryota
ENOG410ZSRR LUCA
HOGENOMiHOG000293283
HOVERGENiHBG004977
InParanoidiP54296
OrthoDBiEOG091G00GW
PhylomeDBiP54296
TreeFamiTF331825

Enzyme and pathway databases

SIGNORiP54296

Miscellaneous databases

ChiTaRSiMYOM2 human
GeneWikiiMYOM2
GenomeRNAii9172
PROiPR:P54296
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000036448 Expressed in 168 organ(s), highest expression level in apex of heart
CleanExiHS_MYOM2
ExpressionAtlasiP54296 baseline and differential
GenevisibleiP54296 HS

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.10, 12 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 5 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMYOM2_HUMAN
AccessioniPrimary (citable) accession number: P54296
Secondary accession number(s): Q7Z3Y2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 3, 2009
Last modified: November 7, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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