Voltage-dependent L-type calcium channel subunit beta-3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• calcium channel regulator activity Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.2

    "Ca(2+) channel modulation by recombinant auxiliary beta subunits expressed in young adult heart cells."
    Wei S.K., Colecraft H.M., DeMaria C.D., Peterson B.Z., Zhang R., Kohout T.A., Rogers T.B., Yue D.T.
    Circ. Res. 86:175-184(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
• protein kinase binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits."
    Grueter C.E., Abiria S.A., Wu Y., Anderson M.E., Colbran R.J.
    Biochemistry 47:1760-1767(2008) [PubMed] [Europe PMC] [Abstract]
• voltage-gated calcium channel activity Source: RGDInferred from mutant phenotypeⁱ
  • "The voltage-dependent calcium channel beta subunit contains two stable interacting domains."
    Opatowsky Y., Chomsky-Hecht O., Kang M.G., Campbell K.P., Hirsch J.A.
    J. Biol. Chem. 278:52323-52332(2003) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• calcium ion transmembrane transport Source: BHF-UCLInferred from direct assayⁱ
  • "Functional characterization of CaValpha2delta mutations associated with sudden cardiac death."
    Bourdin B., Shakeri B., Tetreault M.P., Sauve R., Lesage S., Parent L.
    J. Biol. Chem. 290:2854-2869(2015) [PubMed] [Europe PMC] [Abstract]
• calcium ion transmembrane transport via high voltage-gated calcium channel Source: UniProtKBInferred from direct assayⁱ
  • Ref.6

    "Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels."
    Chen Y.H., Li M.H., Zhang Y., He L.L., Yamada Y., Fitzmaurice A., Shen Y., Zhang H., Tong L., Yang J.
    Nature 429:675-680(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 16-366 ALONE AND IN COMPLEX WITH CACNA1C, SUBUNIT, FUNCTION, REGION.
• calcium ion transport Source: RGDInferred from sequence orthologyⁱ
  • "Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents."
    Bell D.C., Butcher A.J., Berrow N.S., Page K.M., Brust P.F., Nesterova A., Stauderman K.A., Seabrook G.R., Nurnberg B., Dolphin A.C.
    J. Neurophysiol. 85:816-827(2001) [PubMed] [Europe PMC] [Abstract]
• calcium ion transport into cytosol Source: BHF-UCLInferred from direct assayⁱ
  • "Functional characterization of CaValpha2delta mutations associated with sudden cardiac death."
    Bourdin B., Shakeri B., Tetreault M.P., Sauve R., Lesage S., Parent L.
    J. Biol. Chem. 290:2854-2869(2015) [PubMed] [Europe PMC] [Abstract]
• cellular response to oxygen-glucose deprivation Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "trans-Resveratrol protects ischemic PC12 Cells by inhibiting the hypoxia associated transcription factors and increasing the levels of antioxidant defense enzymes."
    Agrawal M., Kumar V., Singh A.K., Kashyap M.P., Khanna V.K., Siddiqui M.A., Pant A.B.
    ACS Chem Neurosci 4:285-294(2013) [PubMed] [Europe PMC] [Abstract]
• chemical synaptic transmission Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• detection of mechanical stimulus involved in sensory perception of pain Source: RGDInferred from mutant phenotypeⁱ
  • "Up-regulation of Cavbeta3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain."
    Li L., Cao X.H., Chen S.R., Han H.D., Lopez-Berestein G., Sood A.K., Pan H.L.
    J. Biol. Chem. 287:6002-6013(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of detection of mechanical stimulus involved in sensory perception of touch Source: RGDInferred from mutant phenotypeⁱ
  • "Up-regulation of Cavbeta3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain."
    Li L., Cao X.H., Chen S.R., Han H.D., Lopez-Berestein G., Sood A.K., Pan H.L.
    J. Biol. Chem. 287:6002-6013(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of voltage-gated calcium channel activity Source: RGDInferred from direct assayⁱ
  • "Overexpressed Ca(v)beta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivation."
    Yasuda T., Lewis R.J., Adams D.J.
    J. Gen. Physiol. 123:401-416(2004) [PubMed] [Europe PMC] [Abstract]
• neuromuscular junction development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of excitatory postsynaptic potential Source: RGDInferred from mutant phenotypeⁱ
  • "Up-regulation of Cavbeta3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain."
    Li L., Cao X.H., Chen S.R., Han H.D., Lopez-Berestein G., Sood A.K., Pan H.L.
    J. Biol. Chem. 287:6002-6013(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of high voltage-gated calcium channel activity Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.2

    "Ca(2+) channel modulation by recombinant auxiliary beta subunits expressed in young adult heart cells."
    Wei S.K., Colecraft H.M., DeMaria C.D., Peterson B.Z., Zhang R., Kohout T.A., Rogers T.B., Yue D.T.
    Circ. Res. 86:175-184(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
• positive regulation of protein targeting to membrane Source: RGDInferred from mutant phenotypeⁱ
  • "Molecular determinants of the CaVbeta-induced plasma membrane targeting of the CaV1.2 channel."
    Bourdin B., Marger F., Wall-Lacelle S., Schneider T., Klein H., Sauve R., Parent L.
    J. Biol. Chem. 285:22853-22863(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of voltage-gated calcium channel activity Source: RGDInferred from direct assayⁱ
  • "Overexpressed Ca(v)beta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivation."
    Yasuda T., Lewis R.J., Adams D.J.
    J. Gen. Physiol. 123:401-416(2004) [PubMed] [Europe PMC] [Abstract]
• protein localization to plasma membrane Source: BHF-UCLInferred from direct assayⁱ
  • "Functional characterization of CaValpha2delta mutations associated with sudden cardiac death."
    Bourdin B., Shakeri B., Tetreault M.P., Sauve R., Lesage S., Parent L.
    J. Biol. Chem. 290:2854-2869(2015) [PubMed] [Europe PMC] [Abstract]
• regulation of membrane hyperpolarization Source: RGDInferred from direct assayⁱ
  • "Overexpressed Ca(v)beta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivation."
    Yasuda T., Lewis R.J., Adams D.J.
    J. Gen. Physiol. 123:401-416(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of membrane repolarization during action potential Source: BHF-UCLInferred from direct assayⁱ
  • "Functional characterization of CaValpha2delta mutations associated with sudden cardiac death."
    Bourdin B., Shakeri B., Tetreault M.P., Sauve R., Lesage S., Parent L.
    J. Biol. Chem. 290:2854-2869(2015) [PubMed] [Europe PMC] [Abstract]
• regulation of voltage-gated calcium channel activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• T cell receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function."
    Badou A., Jha M.K., Matza D., Mehal W.Z., Freichel M., Flockerzi V., Flavell R.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:15529-15534(2006) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• protein kinase binding Source: RGDInferred from direct assayⁱ
  • "Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits."
    Grueter C.E., Abiria S.A., Wu Y., Anderson M.E., Colbran R.J.
    Biochemistry 47:1760-1767(2008) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MYDDSYVPGF EDSEAGSADS YTSRPSLDSD VSLEEDRESA RREVESQAQQ 
        60         70         80         90        100
QLERAKHKPV AFAVRTNVSY CGVLDEECPV QGSGVNFEAK DFLHIKEKYS 
       110        120        130        140        150
NDWWIGRLVK EGGDIAFIPS PQRLESIRLK QEQKARRSGN PSSLSDIGNR 
       160        170        180        190        200
RSPPPSLAKQ KQKQAEHVPP YDVVPSMRPV VLVGPSLKGY EVTDMMQKAL 
       210        220        230        240        250
FDFLKHRFDG RISITRVTAD LSLAKRSVLN NPGKRTIIER SSARSSIAEV 
       260        270        280        290        300
QSEIERIFEL AKSLQLVVLD ADTINHPAQL AKTSLAPIIV FVKVSSPKVL 
       310        320        330        340        350
QRLIRSRGKS QMKHLTVQMM AYDKLVQCPP ESFDVILDEN QLDDACEHLA 
       360        370        380        390        400
EYLEVYWRAT HHPAPGPGML GPPSAIPGLQ NQQLLGERGE EHSPLERDSL 
       410        420        430        440        450
MPSDEASESS RQAWTGSSQR SSRHLEEDYA DAYQDLYQPH RQHTSGLPSA 
       460        470        480 
NGHDPQDRLL AQDSEHDHND RNWQRNRPWP KDSY                  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families