UniProtKB - P54283 (CACB1_RAT)
Voltage-dependent L-type calcium channel subunit beta-1
Cacnb1
Functioni
Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity).
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (Probable). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (By similarity).
By similarity1 PublicationGO - Molecular functioni
- high voltage-gated calcium channel activity Source: RGD
- identical protein binding Source: IntAct
- phosphoprotein binding Source: RGD
- protein domain specific binding Source: RGD
- protein kinase binding Source: RGD
- voltage-gated calcium channel activity Source: RGD
GO - Biological processi
- calcium ion transport Source: RGD
- cellular response to amyloid-beta Source: RGD
- chemical synaptic transmission Source: GO_Central
- neuromuscular junction development Source: GO_Central
- protein targeting to membrane Source: RGD
- regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source: RGD
- regulation of voltage-gated calcium channel activity Source: GO_Central
Keywordsi
Molecular function | Calcium channel, Ion channel, Voltage-gated channel |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Enzyme and pathway databases
Reactomei | R-RNO-112308, Presynaptic depolarization and calcium channel opening R-RNO-5576892, Phase 0 - rapid depolarisation R-RNO-5576893, Phase 2 - plateau phase |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent L-type calcium channel subunit beta-1Short name: CAB1 Alternative name(s): Calcium channel voltage-dependent subunit beta 1 |
Gene namesi | Name:Cacnb1 Synonyms:Cacnlb1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 68382, Cacnb1 |
Subcellular locationi
Plasma membrane
- sarcolemma By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
- Cell membrane By similarity; Peripheral membrane protein By similarity
Endoplasmic reticulum
- sarcoplasmic reticulum Source: RGD
Plasma Membrane
- T-tubule Source: RGD
- voltage-gated calcium channel complex Source: RGD
Other locations
- glutamatergic synapse Source: SynGO
- postsynapse Source: SynGO
- presynapse Source: RGD
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144049 | 1 – 597 | Voltage-dependent L-type calcium channel subunit beta-1Add BLAST | 597 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 44 | PhosphoserineCombined sources | 1 | |
Modified residuei | 47 | PhosphoserineCombined sources | 1 | |
Modified residuei | 73 | PhosphoserineCombined sources | 1 | |
Modified residuei | 186 | PhosphoserineCombined sources | 1 | |
Modified residuei | 193 | PhosphoserineCombined sources | 1 | |
Modified residuei | 499 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 547 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P54283 |
PRIDEi | P54283 |
PTM databases
iPTMneti | P54283 |
PhosphoSitePlusi | P54283 |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
Regulatory subunit of L-type calcium channels that consist of a pore-forming alpha subunit and auxiliary beta, gamma and delta subunits (PubMed:21127204).
Interacts with CACNA1A, CACNA1B, CACNA1C and CACNA1S (By similarity).
Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1.
Identified in a complex with CACNA1C (By similarity).
Identified in a complex with the L-type calcium channel subunits CACNA1C, CACNA2D1, CACNB1 and one of the gamma subunits (CACNG4, CACNG6, CACNG7, or CACNG8) (PubMed:21127204).
Part of a L-type calcium channel complex that contains CACNA1D, CACNA2D1 and CACNB1.
Part of a L-type calcium channel complex that contains CACNA1B, CACNA2D1 and CACNB1 (By similarity).
Interacts with JSRP1.
Interacts with RYR1 (By similarity).
Interacts with CBARP (PubMed:24751537).
By similarity2 PublicationsBinary interactionsi
P54283
With | #Exp. | IntAct |
---|---|---|
itself | 2 | EBI-349245,EBI-349245 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- phosphoprotein binding Source: RGD
- protein domain specific binding Source: RGD
- protein kinase binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 248426, 4 interactors |
DIPi | DIP-33255N |
IntActi | P54283, 1 interactor |
STRINGi | 10116.ENSRNOP00000006098 |
Chemistry databases
BindingDBi | P54283 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 100 – 169 | SH3PROSITE-ProRule annotationAdd BLAST | 70 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 79 | DisorderedSequence analysisAdd BLAST | 79 | |
Regioni | 179 – 223 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 466 – 597 | DisorderedSequence analysisAdd BLAST | 132 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 43 – 69 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 179 – 216 | Polar residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 500 – 514 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
SH3 domainPhylogenomic databases
eggNOGi | KOG3812, Eukaryota |
InParanoidi | P54283 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR008145, GK/Ca_channel_bsu IPR027417, P-loop_NTPase IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR005443, VDCC_L_b1su IPR000584, VDCC_L_bsu |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF12052, VGCC_beta4Aa_N, 1 hit |
PRINTSi | PR01626, LCACHANNELB PR01627, LCACHANNELB1 |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MVQKSGMSRG PYPPSQEIPM EVFDPSPQGK YSKRKGRFKR SDGSTSSDTT
60 70 80 90 100
SNSFVRQGSA ESYTSRPSDS DVSLEEDREA LRKEAERQAL AQLEKAKTKP
110 120 130 140 150
VAFAVRTNVG YNPSPGDEVP VQGVAITFEP KDFLHIKEKY NNDWWIGRLV
160 170 180 190 200
KEGCEVGFIP SPVKLDSLRL LQEQTLRQNR LSSSKSGDNS SSSLGDVVTG
210 220 230 240 250
TRRPTPPASA KQKQKSTEHV PPYDVVPSMR PIILVGPSLK GYEVTDMMQK
260 270 280 290 300
ALFDFLKHRF DGRISITRVT ADISLAKRSV LNNPSKHIII ERSNTRSSLA
310 320 330 340 350
EVQSEIERIF ELARTLQLVA LDADTINHPA QLSKTSLAPI IVYIKITSPK
360 370 380 390 400
VLQRLIKSRG KSQSKHLNVQ IAASEKLAQC PPEMFDIILD ENQLEDACEH
410 420 430 440 450
LAEYLEAYWK ATHPPSRTPP NPLLNRTMAT AALAVSPAPV SNLQGPYLVS
460 470 480 490 500
GDQPLDRATG EHASVHEYPG ELGQPPGLYP SNHPPGRAGT LWALSRQDTF
510 520 530 540 550
DADTPGSRNS VYTEPGDSCV DMETDPSEGP GPGDPAGGGT PPARQGSWEE
560 570 580 590
EEDYEEEMTD NRNRGRNKAR YCAEGGGPVL GRNKNELEGW GQGVYIR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K4U4 | A0A0G2K4U4_RAT | Calcium channel voltage-dependent s... | Cacnb1 | 642 | Annotation score: | ||
G3V6K8 | G3V6K8_RAT | Calcium channel voltage-dependent s... | Cacnb1 rCG_34853 | 597 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X61394 mRNA Translation: CAA43665.1 |
PIRi | S18304 |
RefSeqi | NP_059042.1, NM_017346.1 |
Genome annotation databases
GeneIDi | 50688 |
KEGGi | rno:50688 |
UCSCi | RGD:68382, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X61394 mRNA Translation: CAA43665.1 |
PIRi | S18304 |
RefSeqi | NP_059042.1, NM_017346.1 |
3D structure databases
SMRi | P54283 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 248426, 4 interactors |
DIPi | DIP-33255N |
IntActi | P54283, 1 interactor |
STRINGi | 10116.ENSRNOP00000006098 |
Chemistry databases
BindingDBi | P54283 |
ChEMBLi | CHEMBL3885653 CHEMBL3988639 |
PTM databases
iPTMneti | P54283 |
PhosphoSitePlusi | P54283 |
Proteomic databases
PaxDbi | P54283 |
PRIDEi | P54283 |
Protocols and materials databases
ABCDi | P54283, 1 sequenced antibody |
Genome annotation databases
GeneIDi | 50688 |
KEGGi | rno:50688 |
UCSCi | RGD:68382, rat |
Organism-specific databases
CTDi | 782 |
RGDi | 68382, Cacnb1 |
Phylogenomic databases
eggNOGi | KOG3812, Eukaryota |
InParanoidi | P54283 |
Enzyme and pathway databases
Reactomei | R-RNO-112308, Presynaptic depolarization and calcium channel opening R-RNO-5576892, Phase 0 - rapid depolarisation R-RNO-5576893, Phase 2 - plateau phase |
Miscellaneous databases
PROi | PR:P54283 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR008145, GK/Ca_channel_bsu IPR027417, P-loop_NTPase IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR005443, VDCC_L_b1su IPR000584, VDCC_L_bsu |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF12052, VGCC_beta4Aa_N, 1 hit |
PRINTSi | PR01626, LCACHANNELB PR01627, LCACHANNELB1 |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CACB1_RAT | |
Accessioni | P54283Primary (citable) accession number: P54283 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | September 29, 2021 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families