Voltage-dependent L-type calcium channel subunit beta-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• high voltage-gated calcium channel activity Source: RGDInferred from sequence orthologyⁱ
  • "Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca2+ current."
    Tsunemi T., Saegusa H., Ishikawa K., Nagayama S., Murakoshi T., Mizusawa H., Tanabe T.
    J. Biol. Chem. 277:7214-7221(2002) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntAct <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The guanylate kinase domain of the beta-subunit of voltage-gated calcium channels suffices to modulate gating."
    Gonzalez-Gutierrez G., Miranda-Laferte E., Nothmann D., Schmidt S., Neely A., Hidalgo P.
    Proc. Natl. Acad. Sci. U.S.A. 105:14198-14203(2008) [PubMed] [Europe PMC] [Abstract]
• phosphoprotein binding Source: RGDInferred from physical interactionⁱ
  • "CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation."
    Abiria S.A., Colbran R.J.
    J. Neurochem. 112:150-161(2010) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: RGDInferred from physical interactionⁱ
  • "CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation."
    Abiria S.A., Colbran R.J.
    J. Neurochem. 112:150-161(2010) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits."
    Grueter C.E., Abiria S.A., Wu Y., Anderson M.E., Colbran R.J.
    Biochemistry 47:1760-1767(2008) [PubMed] [Europe PMC] [Abstract]
• voltage-gated calcium channel activity Source: RGDInferred from sequence orthologyⁱ
  • "Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel."
    Perez-Reyes E., Castellano A., Kim H.S., Bertrand P., Baggstrom E., Lacerda A.E., Wei X.Y., Birnbaumer L.
    J. Biol. Chem. 267:1792-1797(1992) [PubMed] [Europe PMC] [Abstract]
  • "A beta-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes."
    Mezler M., Barghorn S., Schoemaker H., Gross G., Nimmrich V.
    Br. J. Pharmacol. 165:1572-1583(2012) [PubMed] [Europe PMC] [Abstract]
  • "Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling."
    Gregg R.G., Messing A., Strube C., Beurg M., Moss R., Behan M., Sukhareva M., Haynes S., Powell J.A., Coronado R., Powers P.A.
    Proc. Natl. Acad. Sci. U.S.A. 93:13961-13966(1996) [PubMed] [Europe PMC] [Abstract]
  • "Ca2+ sparks in embryonic mouse skeletal muscle selectively deficient in dihydropyridine receptor alpha1S or beta1a subunits."
    Conklin M.W., Powers P., Gregg R.G., Coronado R.
    Biophys. J. 76:657-669(1999) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• calcium ion transport Source: RGDInferred from sequence orthologyⁱ
  • "Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling."
    Gregg R.G., Messing A., Strube C., Beurg M., Moss R., Behan M., Sukhareva M., Haynes S., Powell J.A., Coronado R., Powers P.A.
    Proc. Natl. Acad. Sci. U.S.A. 93:13961-13966(1996) [PubMed] [Europe PMC] [Abstract]
  • "Ca2+ sparks in embryonic mouse skeletal muscle selectively deficient in dihydropyridine receptor alpha1S or beta1a subunits."
    Conklin M.W., Powers P., Gregg R.G., Coronado R.
    Biophys. J. 76:657-669(1999) [PubMed] [Europe PMC] [Abstract]
• cellular response to amyloid-beta Source: RGDInferred from sequence orthologyⁱ
  • "A beta-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes."
    Mezler M., Barghorn S., Schoemaker H., Gross G., Nimmrich V.
    Br. J. Pharmacol. 165:1572-1583(2012) [PubMed] [Europe PMC] [Abstract]
• chemical synaptic transmission Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• neuromuscular junction development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein targeting to membrane Source: RGDInferred from sequence orthologyⁱ
  • "Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling."
    Gregg R.G., Messing A., Strube C., Beurg M., Moss R., Behan M., Sukhareva M., Haynes S., Powell J.A., Coronado R., Powers P.A.
    Proc. Natl. Acad. Sci. U.S.A. 93:13961-13966(1996) [PubMed] [Europe PMC] [Abstract]
• regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source: RGDInferred from sequence orthologyⁱ
  • "A beta-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes."
    Mezler M., Barghorn S., Schoemaker H., Gross G., Nimmrich V.
    Br. J. Pharmacol. 165:1572-1583(2012) [PubMed] [Europe PMC] [Abstract]
• regulation of voltage-gated calcium channel activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "The guanylate kinase domain of the beta-subunit of voltage-gated calcium channels suffices to modulate gating."
    Gonzalez-Gutierrez G., Miranda-Laferte E., Nothmann D., Schmidt S., Neely A., Hidalgo P.
    Proc. Natl. Acad. Sci. U.S.A. 105:14198-14203(2008) [PubMed] [Europe PMC] [Abstract]
• phosphoprotein binding Source: RGDInferred from physical interactionⁱ
  • "CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation."
    Abiria S.A., Colbran R.J.
    J. Neurochem. 112:150-161(2010) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: RGDInferred from physical interactionⁱ
  • "CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation."
    Abiria S.A., Colbran R.J.
    J. Neurochem. 112:150-161(2010) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: RGDInferred from direct assayⁱ
  • "Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits."
    Grueter C.E., Abiria S.A., Wu Y., Anderson M.E., Colbran R.J.
    Biochemistry 47:1760-1767(2008) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MVQKSGMSRG PYPPSQEIPM EVFDPSPQGK YSKRKGRFKR SDGSTSSDTT 
        60         70         80         90        100
SNSFVRQGSA ESYTSRPSDS DVSLEEDREA LRKEAERQAL AQLEKAKTKP 
       110        120        130        140        150
VAFAVRTNVG YNPSPGDEVP VQGVAITFEP KDFLHIKEKY NNDWWIGRLV 
       160        170        180        190        200
KEGCEVGFIP SPVKLDSLRL LQEQTLRQNR LSSSKSGDNS SSSLGDVVTG 
       210        220        230        240        250
TRRPTPPASA KQKQKSTEHV PPYDVVPSMR PIILVGPSLK GYEVTDMMQK 
       260        270        280        290        300
ALFDFLKHRF DGRISITRVT ADISLAKRSV LNNPSKHIII ERSNTRSSLA 
       310        320        330        340        350
EVQSEIERIF ELARTLQLVA LDADTINHPA QLSKTSLAPI IVYIKITSPK 
       360        370        380        390        400
VLQRLIKSRG KSQSKHLNVQ IAASEKLAQC PPEMFDIILD ENQLEDACEH 
       410        420        430        440        450
LAEYLEAYWK ATHPPSRTPP NPLLNRTMAT AALAVSPAPV SNLQGPYLVS 
       460        470        480        490        500
GDQPLDRATG EHASVHEYPG ELGQPPGLYP SNHPPGRAGT LWALSRQDTF 
       510        520        530        540        550
DADTPGSRNS VYTEPGDSCV DMETDPSEGP GPGDPAGGGT PPARQGSWEE 
       560        570        580        590 
EEDYEEEMTD NRNRGRNKAR YCAEGGGPVL GRNKNELEGW GQGVYIR    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families