UniProtKB - P54269 (CAUP_DROME)
Protein
Homeobox protein caupolican
Gene
caup
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Controls proneural and vein forming genes. Positive transcriptional controler of ac-sc (achaete-scute). May act as an activator that interacts with the transcriptional complex assembled on the ac and sc promoters and participates in transcription initiation.1 Publication
Miscellaneous
'Caupolican' is named after the Araucanian American-Indian tribe, also called mohawks, who shaved all but a medial stripe of hairs on the head.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 226 – 288 | Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST | 63 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: FlyBase
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: FlyBase
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- cell development Source: GO_Central
- compound eye morphogenesis Source: FlyBase
- equator specification Source: FlyBase
- imaginal disc-derived wing vein specification Source: FlyBase
- muscle cell fate commitment Source: FlyBase
- negative regulation of growth Source: FlyBase
- neuron differentiation Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: FlyBase
- regulation of mitotic cell cycle Source: FlyBase
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein caupolican |
Gene namesi | Name:caup ORF Names:CG10605 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0015919, caup |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: FlyBase
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048845 | 1 – 693 | Homeobox protein caupolicanAdd BLAST | 693 |
Proteomic databases
PaxDbi | P54269 |
Expressioni
Gene expression databases
Bgeei | FBgn0015919, Expressed in wing disc (Drosophila) and 42 other tissues |
Genevisiblei | P54269, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 64789, 15 interactors |
DIPi | DIP-18539N |
IntActi | P54269, 8 interactors |
STRINGi | 7227.FBpp0075641 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 300 – 303 | Poly-Asp | 4 | |
Compositional biasi | 405 – 418 | Poly-GlnAdd BLAST | 14 | |
Compositional biasi | 501 – 516 | Poly-GlnAdd BLAST | 16 | |
Compositional biasi | 517 – 528 | Poly-HisAdd BLAST | 12 | |
Compositional biasi | 565 – 572 | Poly-Ser | 8 | |
Compositional biasi | 613 – 624 | Poly-SerAdd BLAST | 12 |
Sequence similaritiesi
Belongs to the TALE/IRO homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0773, Eukaryota |
GeneTreei | ENSGT00940000165426 |
HOGENOMi | CLU_019586_0_0_1 |
InParanoidi | P54269 |
OMAi | AGYPTAN |
OrthoDBi | 814237at2759 |
PhylomeDBi | P54269 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR008422, Homeobox_KN_domain IPR003893, Iroquois_homeo |
Pfami | View protein in Pfam PF05920, Homeobox_KN, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00548, IRO, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P54269-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAYAQFGYA GYPTANQLTT ANTDSQSGHG GGSPLSGTNE ASLSPSGGST
60 70 80 90 100
ATGLTAGPLS PGAVSQSSHH AGHKGLSTSP AEDVVGGDVP VGLSSAAQDL
110 120 130 140 150
PSRGSCCENG RPIITDPVSG QTVCSCQYDP ARLAIGGYSR MALPSGGVGV
160 170 180 190 200
GVYGGPYPSN EQNPYPSIGV DNSAFYAPLS NPYGIKDTSP STEMSAWTSA
210 220 230 240 250
SLQSTTGYYS YDPTLAAYGY GPNYDLAARR KNATRESTAT LKAWLSEHKK
260 270 280 290 300
NPYPTKGEKI MLAIITKMTL TQVSTWFANA RRRLKKENKM TWEPKNKTED
310 320 330 340 350
DDDGMMSDDE KEKDAGDGGK LSTEAFDPGN QLIKSELGKA EKEVDSSGDQ
360 370 380 390 400
KLDLDREPHN LVAMRGLAPY ATPPGAHPMH AAYSSYAQSH NTHTHPHPQQ
410 420 430 440 450
MQHHQQQQQQ QQNQQQLQHH QMDQPYYHPG GYGQEESGEF AAQKNPLSRD
460 470 480 490 500
CGIPVPASKP KIWSVADTAA CKTPPPTAAY LGQNFYPPSS ADQQLPHQPL
510 520 530 540 550
QQHQQQQLQQ LQQQQQHHHH PHHHHPHHSM ELGSPLSMMS SYAGGSPYSR
560 570 580 590 600
IPTAYTEAMG MHLPSSSSSS SSTGKLPPTH IHPAPQRVGF PEIQPDTPPQ
610 620 630 640 650
TPPTMKLNSS GGSSSSSGSS HSSSMHSVTP VTVASMVNIL YSNTDSGYGH
660 670 680 690
GHSHGHGHGH GHGLGHGHGL GHGHGHMGVT SNAYLTEGGR SGS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 106 | C → R in CAA64485 (PubMed:8620542).Curated | 1 | |
Sequence conflicti | 316 | G → A in CAA64485 (PubMed:8620542).Curated | 1 | |
Sequence conflicti | 518 | H → N in AAV36871 (Ref. 4) Curated | 1 | |
Sequence conflicti | 678 | G → A in CAA64485 (PubMed:8620542).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X95178 mRNA Translation: CAA64485.1 AE014296 Genomic DNA Translation: AAF49895.1 BT015986 mRNA Translation: AAV36871.1 BT021246 mRNA Translation: AAX33394.1 AY122206 mRNA Translation: AAM52718.1 |
RefSeqi | NP_524046.2, NM_079322.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0075909; FBpp0075641; FBgn0015919 |
GeneIDi | 39440 |
KEGGi | dme:Dmel_CG10605 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X95178 mRNA Translation: CAA64485.1 AE014296 Genomic DNA Translation: AAF49895.1 BT015986 mRNA Translation: AAV36871.1 BT021246 mRNA Translation: AAX33394.1 AY122206 mRNA Translation: AAM52718.1 |
RefSeqi | NP_524046.2, NM_079322.3 |
3D structure databases
SMRi | P54269 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 64789, 15 interactors |
DIPi | DIP-18539N |
IntActi | P54269, 8 interactors |
STRINGi | 7227.FBpp0075641 |
Proteomic databases
PaxDbi | P54269 |
Genome annotation databases
EnsemblMetazoai | FBtr0075909; FBpp0075641; FBgn0015919 |
GeneIDi | 39440 |
KEGGi | dme:Dmel_CG10605 |
Organism-specific databases
CTDi | 39440 |
FlyBasei | FBgn0015919, caup |
Phylogenomic databases
eggNOGi | KOG0773, Eukaryota |
GeneTreei | ENSGT00940000165426 |
HOGENOMi | CLU_019586_0_0_1 |
InParanoidi | P54269 |
OMAi | AGYPTAN |
OrthoDBi | 814237at2759 |
PhylomeDBi | P54269 |
Miscellaneous databases
BioGRID-ORCSi | 39440, 0 hits in 3 CRISPR screens |
ChiTaRSi | caup, fly |
GenomeRNAii | 39440 |
PROi | PR:P54269 |
Gene expression databases
Bgeei | FBgn0015919, Expressed in wing disc (Drosophila) and 42 other tissues |
Genevisiblei | P54269, DM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR008422, Homeobox_KN_domain IPR003893, Iroquois_homeo |
Pfami | View protein in Pfam PF05920, Homeobox_KN, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00548, IRO, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAUP_DROME | |
Accessioni | P54269Primary (citable) accession number: P54269 Secondary accession number(s): Q5BIH8 Q9VU00 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | August 14, 2001 | |
Last modified: | April 7, 2021 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families