Homeobox protein caupolican

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity Source: FlyBase <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • Ref.1

    "Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes."
    Gomez-Skarmeta J.-L., del Corral R.D., de la Calle-Mustienes E., Ferres-Marco D., Modolell J.
    Cell 85:95-105(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: FlyBaseInferred from sequence or structural similarityⁱ
  • Ref.1

    "Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes."
    Gomez-Skarmeta J.-L., del Corral R.D., de la Calle-Mustienes E., Ferres-Marco D., Modolell J.
    Cell 85:95-105(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
• sequence-specific DNA binding Source: InterPro

GO - Biological processⁱ

• cell development Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• compound eye morphogenesis Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Patterning the peripheral retina of the fly: decoding a gradient."
    Tomlinson A.
    Dev. Cell 5:799-809(2003) [PubMed] [Europe PMC] [Abstract]
• equator specification Source: FlyBase <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Sticking together and sorting things out: adhesion as a force in development."
    McNeill H.
    Nat. Rev. Genet. 1:100-108(2000) [PubMed] [Europe PMC] [Abstract]
• imaginal disc-derived wing vein specification Source: FlyBase <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • Ref.1

    "Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes."
    Gomez-Skarmeta J.-L., del Corral R.D., de la Calle-Mustienes E., Ferres-Marco D., Modolell J.
    Cell 85:95-105(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
• muscle cell fate commitment Source: FlyBaseInferred from genetic interactionⁱ
  • "Drosophila araucan and caupolican integrate intrinsic and signalling inputs for the acquisition by muscle progenitors of the lateral transverse fate."
    Carrasco-Rando M., Tutor A.S., Prieto-Sanchez S., Gonzalez-Perez E., Barrios N., Letizia A., Martin P., Campuzano S., Ruiz-Gomez M.
    PLoS Genet. 7:e1002186-e1002186(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of growth Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The Homeodomain Iroquois Proteins Control Cell Cycle Progression and Regulate the Size of Developmental Fields."
    Barrios N., Gonzalez-Perez E., Hernandez R., Campuzano S.
    PLoS Genet. 11:e1005463-e1005463(2015) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: FlyBaseInferred from sequence or structural similarityⁱ
  • Ref.1

    "Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes."
    Gomez-Skarmeta J.-L., del Corral R.D., de la Calle-Mustienes E., Ferres-Marco D., Modolell J.
    Cell 85:95-105(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
• regulation of mitotic cell cycle Source: FlyBaseInferred from genetic interactionⁱ
  • "The Homeodomain Iroquois Proteins Control Cell Cycle Progression and Regulate the Size of Developmental Fields."
    Barrios N., Gonzalez-Perez E., Hernandez R., Campuzano S.
    PLoS Genet. 11:e1005463-e1005463(2015) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAAYAQFGYA GYPTANQLTT ANTDSQSGHG GGSPLSGTNE ASLSPSGGST 
        60         70         80         90        100
ATGLTAGPLS PGAVSQSSHH AGHKGLSTSP AEDVVGGDVP VGLSSAAQDL 
       110        120        130        140        150
PSRGSCCENG RPIITDPVSG QTVCSCQYDP ARLAIGGYSR MALPSGGVGV 
       160        170        180        190        200
GVYGGPYPSN EQNPYPSIGV DNSAFYAPLS NPYGIKDTSP STEMSAWTSA 
       210        220        230        240        250
SLQSTTGYYS YDPTLAAYGY GPNYDLAARR KNATRESTAT LKAWLSEHKK 
       260        270        280        290        300
NPYPTKGEKI MLAIITKMTL TQVSTWFANA RRRLKKENKM TWEPKNKTED 
       310        320        330        340        350
DDDGMMSDDE KEKDAGDGGK LSTEAFDPGN QLIKSELGKA EKEVDSSGDQ 
       360        370        380        390        400
KLDLDREPHN LVAMRGLAPY ATPPGAHPMH AAYSSYAQSH NTHTHPHPQQ 
       410        420        430        440        450
MQHHQQQQQQ QQNQQQLQHH QMDQPYYHPG GYGQEESGEF AAQKNPLSRD 
       460        470        480        490        500
CGIPVPASKP KIWSVADTAA CKTPPPTAAY LGQNFYPPSS ADQQLPHQPL 
       510        520        530        540        550
QQHQQQQLQQ LQQQQQHHHH PHHHHPHHSM ELGSPLSMMS SYAGGSPYSR 
       560        570        580        590        600
IPTAYTEAMG MHLPSSSSSS SSTGKLPPTH IHPAPQRVGF PEIQPDTPPQ 
       610        620        630        640        650
TPPTMKLNSS GGSSSSSGSS HSSSMHSVTP VTVASMVNIL YSNTDSGYGH 
       660        670        680        690 
GHSHGHGHGH GHGLGHGHGL GHGHGHMGVT SNAYLTEGGR SGS        

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase
2. SIMILARITY comments
   Index of protein domains and families