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Protein

Stathmin

Gene

Stmn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis (By similarity). Involved in the control of the learned and innate fear.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin
Alternative name(s):
Leukemia-associated gene protein
Leukemia-associated phosphoprotein p18
Metablastin
Oncoprotein 18
Short name:
Op18
Phosphoprotein p19
Short name:
pp19
Prosolin
Protein Pr22
pp17
Gene namesi
Name:Stmn1
Synonyms:Lag, Lap18, Pr22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:96739 Stmn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Disruption phenotypei

Mice show deficits in spike-timing-dependent long-term potentiation, exhibit decreased memory in amygdala-dependent fear conditioning and fail to recognize danger in innately aversive environments.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001823902 – 149StathminAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei4PhosphoserineBy similarity1
Modified residuei9N6-acetyllysineBy similarity1
Modified residuei16Phosphoserine; by PKACombined sources1 Publication1
Modified residuei25Phosphoserine; by CDK1, MAPK1 and MAPK3Combined sources1 Publication1
Modified residuei29N6-methyllysineBy similarity1
Modified residuei31PhosphoserineBy similarity1
Modified residuei38Phosphoserine; by CDK1, MAPK1 and MAPK3Combined sources1 Publication1
Modified residuei63Phosphoserine; by PKA1 Publication1
Modified residuei100N6-acetyllysineBy similarity1
Modified residuei119N6-acetyllysineCombined sources1

Post-translational modificationi

Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF (Probable). Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity).By similarityCurated

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP54227
PaxDbiP54227
PeptideAtlasiP54227
PRIDEiP54227

2D gel databases

REPRODUCTION-2DPAGEiP54227
UCD-2DPAGEiP54227

PTM databases

iPTMnetiP54227
PhosphoSitePlusiP54227

Expressioni

Tissue specificityi

Highly expressed in the lateral nucleus of the amygdala.1 Publication

Gene expression databases

BgeeiENSMUSG00000028832 Expressed in 47 organ(s), highest expression level in brain
CleanExiMM_STMN1
ExpressionAtlasiP54227 baseline and differential
GenevisibleiP54227 MM

Interactioni

Subunit structurei

Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Cdkn1bP464142EBI-1006438,EBI-1005742

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201092, 10 interactors
IntActiP54227, 10 interactors
STRINGi10090.ENSMUSP00000030636

Structurei

3D structure databases

ProteinModelPortaliP54227
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 145SLDPROSITE-ProRule annotationAdd BLAST142

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 140Sequence analysisAdd BLAST100

Sequence similaritiesi

Belongs to the stathmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IN6S Eukaryota
ENOG4111KFP LUCA
GeneTreeiENSGT00390000003691
HOGENOMiHOG000013197
HOVERGENiHBG054037
InParanoidiP54227
KOiK04381
OMAiDAKSEFP
OrthoDBiEOG091G0Y2U
PhylomeDBiP54227
TreeFamiTF326935

Family and domain databases

InterProiView protein in InterPro
IPR030514 Stathmin_CS
IPR000956 Stathmin_fam
IPR036002 Stathmin_sf
PANTHERiPTHR10104 PTHR10104, 1 hit
PfamiView protein in Pfam
PF00836 Stathmin, 1 hit
PIRSFiPIRSF002285 Stathmin, 1 hit
PRINTSiPR00345 STATHMIN
SUPFAMiSSF101494 SSF101494, 1 hit
PROSITEiView protein in PROSITE
PS00563 STATHMIN_1, 1 hit
PS01041 STATHMIN_2, 1 hit
PS51663 STATHMIN_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P54227-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPDFPLSPP KKKDLSLEEI
60 70 80 90 100
QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK
110 120 130 140
LTHKMEANKE NREAQMAAKL ERLREKDKHV EEVRKNKESK DPADETEAD
Length:149
Mass (Da):17,274
Last modified:January 23, 2007 - v2
Checksum:i616526E0A6667BDA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z1Z8D3Z1Z8_MOUSE
Stathmin
Stmn1
102Annotation score:
D3Z5N2D3Z5N2_MOUSE
Stathmin
Stmn1
147Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20256 Genomic DNA No translation available.
L20257 Genomic DNA No translation available.
L20258 Genomic DNA No translation available.
X94915 mRNA Translation: CAA64401.1
BC010581 mRNA Translation: AAH10581.1
BC031831 mRNA Translation: AAH31831.1
BC054396 mRNA Translation: AAH54396.1
CCDSiCCDS18772.1
PIRiB48917
RefSeqiNP_062615.1, NM_019641.4
UniGeneiMm.378957

Genome annotation databases

EnsembliENSMUST00000030636; ENSMUSP00000030636; ENSMUSG00000028832
ENSMUST00000105868; ENSMUSP00000101494; ENSMUSG00000028832
GeneIDi16765
KEGGimmu:16765
UCSCiuc008vfc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20256 Genomic DNA No translation available.
L20257 Genomic DNA No translation available.
L20258 Genomic DNA No translation available.
X94915 mRNA Translation: CAA64401.1
BC010581 mRNA Translation: AAH10581.1
BC031831 mRNA Translation: AAH31831.1
BC054396 mRNA Translation: AAH54396.1
CCDSiCCDS18772.1
PIRiB48917
RefSeqiNP_062615.1, NM_019641.4
UniGeneiMm.378957

3D structure databases

ProteinModelPortaliP54227
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201092, 10 interactors
IntActiP54227, 10 interactors
STRINGi10090.ENSMUSP00000030636

PTM databases

iPTMnetiP54227
PhosphoSitePlusiP54227

2D gel databases

REPRODUCTION-2DPAGEiP54227
UCD-2DPAGEiP54227

Proteomic databases

EPDiP54227
PaxDbiP54227
PeptideAtlasiP54227
PRIDEiP54227

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030636; ENSMUSP00000030636; ENSMUSG00000028832
ENSMUST00000105868; ENSMUSP00000101494; ENSMUSG00000028832
GeneIDi16765
KEGGimmu:16765
UCSCiuc008vfc.2 mouse

Organism-specific databases

CTDi3925
MGIiMGI:96739 Stmn1

Phylogenomic databases

eggNOGiENOG410IN6S Eukaryota
ENOG4111KFP LUCA
GeneTreeiENSGT00390000003691
HOGENOMiHOG000013197
HOVERGENiHBG054037
InParanoidiP54227
KOiK04381
OMAiDAKSEFP
OrthoDBiEOG091G0Y2U
PhylomeDBiP54227
TreeFamiTF326935

Miscellaneous databases

ChiTaRSiStmn1 mouse
PROiPR:P54227
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028832 Expressed in 47 organ(s), highest expression level in brain
CleanExiMM_STMN1
ExpressionAtlasiP54227 baseline and differential
GenevisibleiP54227 MM

Family and domain databases

InterProiView protein in InterPro
IPR030514 Stathmin_CS
IPR000956 Stathmin_fam
IPR036002 Stathmin_sf
PANTHERiPTHR10104 PTHR10104, 1 hit
PfamiView protein in Pfam
PF00836 Stathmin, 1 hit
PIRSFiPIRSF002285 Stathmin, 1 hit
PRINTSiPR00345 STATHMIN
SUPFAMiSSF101494 SSF101494, 1 hit
PROSITEiView protein in PROSITE
PS00563 STATHMIN_1, 1 hit
PS01041 STATHMIN_2, 1 hit
PS51663 STATHMIN_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTMN1_MOUSE
AccessioniPrimary (citable) accession number: P54227
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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