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Entry version 176 (02 Dec 2020)
Sequence version 1 (01 Oct 1996)
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Protein

Chromaffin granule amine transporter

Gene

SLC18A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Strongly inhibited by reserpine. Also inhibited to a lesser extent by ketanserin and fenfluramine. Not significantly inhibited by tetrabenazine.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNeurotransmitter transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P54219

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-442660, Na+/Cl- dependent neurotransmitter transporters

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P54219

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.2.12, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromaffin granule amine transporter
Alternative name(s):
Solute carrier family 18 member 1
Vesicular amine transporter 1
Short name:
VAT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC18A1
Synonyms:VAT1, VMAT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000036565.14

Human Gene Nomenclature Database

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HGNCi
HGNC:10934, SLC18A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
193002, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P54219

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 138Lumenal, vesicleSequence analysisAdd BLAST96
Transmembranei139 – 158HelicalSequence analysisAdd BLAST20
Topological domaini159 – 167CytoplasmicSequence analysis9
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 197Lumenal, vesicleSequence analysis9
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 227CytoplasmicSequence analysis9
Transmembranei228 – 250HelicalSequence analysisAdd BLAST23
Topological domaini251 – 256Lumenal, vesicleSequence analysis6
Transmembranei257 – 279HelicalSequence analysisAdd BLAST23
Topological domaini280 – 299CytoplasmicSequence analysisAdd BLAST20
Transmembranei300 – 319HelicalSequence analysisAdd BLAST20
Topological domaini320 – 335Lumenal, vesicleSequence analysisAdd BLAST16
Transmembranei336 – 360HelicalSequence analysisAdd BLAST25
Topological domaini361 – 365CytoplasmicSequence analysis5
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Topological domaini387 – 397Lumenal, vesicleSequence analysisAdd BLAST11
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 422CytoplasmicSequence analysis4
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 448Lumenal, vesicleSequence analysis5
Transmembranei449 – 470HelicalSequence analysisAdd BLAST22
Topological domaini471 – 525CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6570

Open Targets

More...
OpenTargetsi
ENSG00000036565

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA324

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P54219, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1838

Drug and drug target database

More...
DrugBanki
DB01363, Ephedra sinica root
DB01577, Metamfetamine
DB01442, MMDA
DB00368, Norepinephrine
DB00206, Reserpine

DrugCentral

More...
DrugCentrali
P54219

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1011

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC18A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1722741

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001275101 – 525Chromaffin granule amine transporterAdd BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P54219

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P54219

PeptideAtlas

More...
PeptideAtlasi
P54219

PRoteomics IDEntifications database

More...
PRIDEi
P54219

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19679
56654 [P54219-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P54219, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P54219

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P54219

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in chromaffin cells of the adrenal medulla (at protein level). Detected in peripheral sympathetic ganglia (at protein level). Found in some paracrine cells in stomach and duodenum (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000036565, Expressed in adrenal gland and 74 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P54219, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P54219, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000036565, Tissue enhanced (adrenal gland, intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Isoform 3 [P54219-3]
With#Exp.IntAct
AGTRAP - isoform 2 [Q6RW13-2]3EBI-17595455,EBI-11522760
ANKRD46 - isoform 1 [Q86W74-2]3EBI-17595455,EBI-12109402
APOL2 [Q9BQE5]3EBI-17595455,EBI-4290634
BRICD5 - isoform 2 [Q6PL45-2]3EBI-17595455,EBI-12244618
C2CD2L [O14523]3EBI-17595455,EBI-12822627
CCL4 [P13236]3EBI-17595455,EBI-2873970
CCL4L2 [Q8NHW4]3EBI-17595455,EBI-10271156
CNIH1 [O95406]3EBI-17595455,EBI-12172273
COL4A5 - isoform 2 [P29400-2]3EBI-17595455,EBI-12211159
CYB561D2 [O14569]3EBI-17595455,EBI-717654
FAM3C [Q92520]3EBI-17595455,EBI-2876774
FXYD3 - isoform 3 [Q14802-3]3EBI-17595455,EBI-12175685
GIMAP1 [Q8WWP7]3EBI-17595455,EBI-11991950
GJB2 [P29033]3EBI-17595455,EBI-3905204
GPR151 [Q8TDV0]3EBI-17595455,EBI-11955647
LAT - isoform 2 [O43561-2]3EBI-17595455,EBI-8070286
MALL [Q13021]3EBI-17595455,EBI-750078
MFSD6 [Q6ZSS7]3EBI-17595455,EBI-2858252
MGAM [O43451]3EBI-17595455,EBI-2829774
MIP [P30301]3EBI-17595455,EBI-8449636
MS4A1 [P11836]3EBI-17595455,EBI-2808234
MS4A13 [Q5J8X5]3EBI-17595455,EBI-12070086
NEU1 [Q99519]3EBI-17595455,EBI-721517
NRM [Q8IXM6]3EBI-17595455,EBI-10262547
OLFM4 [Q6UX06]3EBI-17595455,EBI-2804156
ORMDL1 [Q9P0S3]3EBI-17595455,EBI-1054848
PEX16 [Q9Y5Y5]3EBI-17595455,EBI-981985
PLP1 - isoform DM-20 [P60201-2]3EBI-17595455,EBI-12188331
PLP2 [Q04941]3EBI-17595455,EBI-608347
PMP22 [Q01453]3EBI-17595455,EBI-2845982
PNLIPRP1 [P54315]3EBI-17595455,EBI-8652812
PPGB [Q59EV6]3EBI-17595455,EBI-14210385
RPRM [Q9NS64]3EBI-17595455,EBI-1052363
SLC30A2 [Q9BRI3]3EBI-17595455,EBI-8644112
SLC30A8 [Q8IWU4]3EBI-17595455,EBI-10262251
SLC35B4 [Q969S0]3EBI-17595455,EBI-10281213
SLC35G1 [Q2M3R5]3EBI-17595455,EBI-13311257
SLC38A7 [Q9NVC3]3EBI-17595455,EBI-10314552
SLC39A2 [Q9NP94]3EBI-17595455,EBI-12898013
SMCO4 [Q9NRQ5]3EBI-17595455,EBI-8640191
SMIM1 [B2RUZ4]3EBI-17595455,EBI-12188413
STX2 - isoform 1 [P32856-2]3EBI-17595455,EBI-11956649
STX8 [Q9UNK0]3EBI-17595455,EBI-727240
TFRC [P02786]3EBI-17595455,EBI-355727
TMEM120B [A0PK00]3EBI-17595455,EBI-10171534
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-17595455,EBI-10694905
TMEM14A [Q9Y6G1]3EBI-17595455,EBI-2800360
TMEM14B [Q9NUH8]3EBI-17595455,EBI-8638294
TMEM203 [Q969S6]3EBI-17595455,EBI-12274070
TMEM218 [A2RU14]3EBI-17595455,EBI-10173151
TMEM239 - isoform 2 [Q8WW34-2]3EBI-17595455,EBI-11528917
TMEM42 [Q69YG0]3EBI-17595455,EBI-12038591
TMEM60 [Q9H2L4]3EBI-17595455,EBI-2852148
TMEM65 [Q6PI78]3EBI-17595455,EBI-6656213
TMEM86A [Q8N2M4]3EBI-17595455,EBI-12015604
VAMP5 [O95183]3EBI-17595455,EBI-10191195
YIPF4 [Q9BSR8]3EBI-17595455,EBI-751253
YIPF6 [Q96EC8]3EBI-17595455,EBI-751210

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
112458, 127 interactors

Protein interaction database and analysis system

More...
IntActi
P54219, 104 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000387549

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P54219

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P54219, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3764, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159352

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001265_10_9_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P54219

Identification of Orthologs from Complete Genome Data

More...
OMAi
RVGYHIP

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P54219

TreeFam database of animal gene trees

More...
TreeFami
TF313494

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR004734, Multidrug-R

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07690, MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00880, 2_A_01_02, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850, MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P54219-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRTILDAPQ RLLKEGRASR QLVLVVVFVA LLLDNMLFTV VVPIVPTFLY
60 70 80 90 100
DMEFKEVNSS LHLGHAGSSP HALASPAFST IFSFFNNNTV AVEESVPSGI
110 120 130 140 150
AWMNDTASTI PPPATEAISA HKNNCLQGTG FLEEEITRVG VLFASKAVMQ
160 170 180 190 200
LLVNPFVGPL TNRIGYHIPM FAGFVIMFLS TVMFAFSGTY TLLFVARTLQ
210 220 230 240 250
GIGSSFSSVA GLGMLASVYT DDHERGRAMG TALGGLALGL LVGAPFGSVM
260 270 280 290 300
YEFVGKSAPF LILAFLALLD GALQLCILQP SKVSPESAKG TPLFMLLKDP
310 320 330 340 350
YILVAAGSIC FANMGVAILE PTLPIWMMQT MCSPKWQLGL AFLPASVSYL
360 370 380 390 400
IGTNLFGVLA NKMGRWLCSL IGMLVVGTSL LCVPLAHNIF GLIGPNAGLG
410 420 430 440 450
LAIGMVDSSM MPIMGHLVDL RHTSVYGSVY AIADVAFCMG FAIGPSTGGA
460 470 480 490 500
IVKAIGFPWL MVITGVINIV YAPLCYYLRS PPAKEEKLAI LSQDCPMETR
510 520
MYATQKPTKE FPLGEDSDEE PDHEE
Length:525
Mass (Da):56,257
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i041F2959F4F2BFBC
GO
Isoform 2 (identifier: P54219-2) [UniParc]FASTAAdd to basket
Also known as: VMAT1delta15

The sequence of this isoform differs from the canonical sequence as follows:
     445-525: PSTGGAIVKA...DSDEEPDHEE → YSESGLPHGDPDVCNPEAHEGISSGGGQ

Note: Unable to uptake serotonin.Curated
Show »
Length:472
Mass (Da):50,026
Checksum:iAC98F90178CFEDC1
GO
Isoform 3 (identifier: P54219-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     307-338: Missing.

Show »
Length:493
Mass (Da):52,677
Checksum:i95F336015020D3B5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96GL6Q96GL6_HUMAN
Chromaffin granule amine transporte...
SLC18A1
385Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK12E5RK12_HUMAN
Chromaffin granule amine transporte...
SLC18A1
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0218564T → P1 PublicationCorresponds to variant dbSNP:rs2270641Ensembl.1
Natural variantiVAR_05200211R → Q. Corresponds to variant dbSNP:rs17092144Ensembl.1
Natural variantiVAR_02463274A → V. Corresponds to variant dbSNP:rs17215815Ensembl.1
Natural variantiVAR_02914982F → C. Corresponds to variant dbSNP:rs17215822Ensembl.1
Natural variantiVAR_02463384F → S. Corresponds to variant dbSNP:rs17215801Ensembl.1
Natural variantiVAR_02003398S → T. Corresponds to variant dbSNP:rs2270637Ensembl.1
Natural variantiVAR_024634101A → P. Corresponds to variant dbSNP:rs17222218Ensembl.1
Natural variantiVAR_012065136I → T1 PublicationCorresponds to variant dbSNP:rs1390938Ensembl.1
Natural variantiVAR_029150140G → R. Corresponds to variant dbSNP:rs17215808Ensembl.1
Natural variantiVAR_024635164I → M. Corresponds to variant dbSNP:rs17222092Ensembl.1
Natural variantiVAR_029151202I → T. Corresponds to variant dbSNP:rs17222120Ensembl.1
Natural variantiVAR_024636249V → I. Corresponds to variant dbSNP:rs17215759Ensembl.1
Natural variantiVAR_024637392L → V. Corresponds to variant dbSNP:rs17092104Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_046304307 – 338Missing in isoform 3. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_046305445 – 525PSTGG…PDHEE → YSESGLPHGDPDVCNPEAHE GISSGGGQ in isoform 2. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U39905 mRNA Translation: AAC50472.1
AC025853 Genomic DNA No translation available.
BC006317 mRNA Translation: AAH06317.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS47814.1 [P54219-3]
CCDS47815.1 [P54219-2]
CCDS6013.1 [P54219-1]

NCBI Reference Sequences

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RefSeqi
NP_001129163.1, NM_001135691.2 [P54219-1]
NP_001135796.1, NM_001142324.1 [P54219-3]
NP_001135797.1, NM_001142325.1 [P54219-2]
NP_003044.1, NM_003053.3 [P54219-1]
XP_011542928.1, XM_011544626.1 [P54219-3]
XP_011542929.1, XM_011544627.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000265808; ENSP00000265808; ENSG00000036565 [P54219-3]
ENST00000276373; ENSP00000276373; ENSG00000036565 [P54219-1]
ENST00000381608; ENSP00000371021; ENSG00000036565 [P54219-2]
ENST00000437980; ENSP00000413361; ENSG00000036565 [P54219-2]
ENST00000440926; ENSP00000387549; ENSG00000036565 [P54219-1]
ENST00000519026; ENSP00000429664; ENSG00000036565 [P54219-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6570

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6570

UCSC genome browser

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UCSCi
uc003wzm.3, human [P54219-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39905 mRNA Translation: AAC50472.1
AC025853 Genomic DNA No translation available.
BC006317 mRNA Translation: AAH06317.1
CCDSiCCDS47814.1 [P54219-3]
CCDS47815.1 [P54219-2]
CCDS6013.1 [P54219-1]
RefSeqiNP_001129163.1, NM_001135691.2 [P54219-1]
NP_001135796.1, NM_001142324.1 [P54219-3]
NP_001135797.1, NM_001142325.1 [P54219-2]
NP_003044.1, NM_003053.3 [P54219-1]
XP_011542928.1, XM_011544626.1 [P54219-3]
XP_011542929.1, XM_011544627.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi112458, 127 interactors
IntActiP54219, 104 interactors
STRINGi9606.ENSP00000387549

Chemistry databases

BindingDBiP54219
ChEMBLiCHEMBL1838
DrugBankiDB01363, Ephedra sinica root
DB01577, Metamfetamine
DB01442, MMDA
DB00368, Norepinephrine
DB00206, Reserpine
DrugCentraliP54219
GuidetoPHARMACOLOGYi1011

Protein family/group databases

TCDBi2.A.1.2.12, the major facilitator superfamily (mfs)

PTM databases

GlyGeniP54219, 3 sites
iPTMnetiP54219
PhosphoSitePlusiP54219

Polymorphism and mutation databases

BioMutaiSLC18A1
DMDMi1722741

Proteomic databases

MassIVEiP54219
PaxDbiP54219
PeptideAtlasiP54219
PRIDEiP54219
ProteomicsDBi19679
56654 [P54219-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1514, 159 antibodies

The DNASU plasmid repository

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DNASUi
6570

Genome annotation databases

EnsembliENST00000265808; ENSP00000265808; ENSG00000036565 [P54219-3]
ENST00000276373; ENSP00000276373; ENSG00000036565 [P54219-1]
ENST00000381608; ENSP00000371021; ENSG00000036565 [P54219-2]
ENST00000437980; ENSP00000413361; ENSG00000036565 [P54219-2]
ENST00000440926; ENSP00000387549; ENSG00000036565 [P54219-1]
ENST00000519026; ENSP00000429664; ENSG00000036565 [P54219-3]
GeneIDi6570
KEGGihsa:6570
UCSCiuc003wzm.3, human [P54219-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6570
DisGeNETi6570
EuPathDBiHostDB:ENSG00000036565.14

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC18A1
HGNCiHGNC:10934, SLC18A1
HPAiENSG00000036565, Tissue enhanced (adrenal gland, intestine)
MIMi193002, gene
neXtProtiNX_P54219
OpenTargetsiENSG00000036565
PharmGKBiPA324

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3764, Eukaryota
GeneTreeiENSGT00940000159352
HOGENOMiCLU_001265_10_9_1
InParanoidiP54219
OMAiRVGYHIP
PhylomeDBiP54219
TreeFamiTF313494

Enzyme and pathway databases

PathwayCommonsiP54219
ReactomeiR-HSA-442660, Na+/Cl- dependent neurotransmitter transporters
SIGNORiP54219

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
6570, 4 hits in 844 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC18A1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6570
PharosiP54219, Tchem

Protein Ontology

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PROi
PR:P54219
RNActiP54219, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000036565, Expressed in adrenal gland and 74 other tissues
ExpressionAtlasiP54219, baseline and differential
GenevisibleiP54219, HS

Family and domain databases

InterProiView protein in InterPro
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR004734, Multidrug-R
PfamiView protein in Pfam
PF07690, MFS_1, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR00880, 2_A_01_02, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVMAT1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54219
Secondary accession number(s): E9PDJ5, Q9BRE4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 2, 2020
This is version 176 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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