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Entry version 199 (16 Oct 2019)
Sequence version 2 (16 Apr 2002)
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Protein

Arginine--tRNA ligase, cytoplasmic

Gene

RARS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.9 µM for arginine (ATP-PPi exchange at 37 degrees Celsius)1 Publication
  2. KM=3.5 µM for arginine (arginylation at 37 degrees Celsius)1 Publication
  3. KM=1183 µM for ATP (ATP-PPi exchange at 37 Celsius)1 Publication
  4. KM=910 µM for ATP (arginylation at 37 Celsius)1 Publication
  5. KM=0.05 µM for calf liver tRNA-Arg (ATP-PPi exchange at 37 Celsius)1 Publication
  6. KM=0.41 µM for calf liver tRNA-Arg (arginylation at 37 Celsius)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei211L-arginineCombined sources1 Publication1
    Binding sitei384L-arginineCombined sources1 Publication1
    Binding sitei388L-arginineCombined sources1 Publication1
    Binding sitei412L-arginineCombined sources1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAminoacyl-tRNA synthetase, Ligase
    Biological processProtein biosynthesis
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-2408522 Selenoamino acid metabolism
    R-HSA-379716 Cytosolic tRNA aminoacylation

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P54136

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Arginine--tRNA ligase, cytoplasmic (EC:6.1.1.192 Publications)
    Alternative name(s):
    Arginyl-tRNA synthetase
    Short name:
    ArgRS
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:RARS
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:9870 RARS

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    107820 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P54136

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Leukodystrophy, hypomyelinating, 9 (HLD9)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionAn autosomal recessive neurodegenerative disorder characterized by delayed psychomotor development, severe spasticity, nystagmus, and ataxia associated with diffuse hypomyelination apparent on brain MRI.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0726662D → G in HLD9. 1 PublicationCorresponds to variant dbSNP:rs672601372EnsemblClinVar.1
    Natural variantiVAR_072667512R → Q in HLD9. 1 PublicationCorresponds to variant dbSNP:rs369398935EnsemblClinVar.1

    Keywords - Diseasei

    Disease mutation, Leukodystrophy

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    5917

    MalaCards human disease database

    More...
    MalaCardsi
    RARS
    MIMi616140 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000113643

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    438114 RARS-related autosomal recessive hypomyelinating leukodystrophy

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA34231

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    P54136

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL2824

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    RARS

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    20178331

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000357971 – 660Arginine--tRNA ligase, cytoplasmicAdd BLAST660

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

    Keywords - PTMi

    Acetylation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P54136

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P54136

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P54136

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P54136

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P54136

    PeptideAtlas

    More...
    PeptideAtlasi
    P54136

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P54136

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    56650 [P54136-1]
    56651 [P54136-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P54136

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P54136

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    P54136

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000113643 Expressed in 112 organ(s), highest expression level in kidney

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P54136 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P54136 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA003979
    HPA004130

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts (via N-terminus) with AIMP1 (via N-terminus); this stimulates its catalytic activity (PubMed:10358004, PubMed:25288775).

    Interacts (via N-terminus) with LARS2 (via C-terminus) (PubMed:16055448, PubMed:17443684). Monomer (PubMed:24859084).

    Part of a multisubunit complex that groups tRNA ligases for Arg (RARS), Asp (DARS), Gln (QARS), Ile (IARS), Leu (LARS), Lys (KARS1), Met (MARS) the bifunctional ligase for Glu and Pro (EPRS) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:19131329, PubMed:19289464).

    Interacts with QARS (PubMed:24656866).

    Part of a complex composed of RARS, QARS and AIMP1 (PubMed:25288775).

    8 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    LARSQ9P2J54EBI-355482,EBI-356077

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    111852, 169 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    P54136

    Protein interaction database and analysis system

    More...
    IntActi
    P54136, 43 interactors

    Molecular INTeraction database

    More...
    MINTi
    P54136

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000231572

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P54136

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1660
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P54136

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 72Could be involved in the assembly of the multisynthetase complexAdd BLAST72
    Regioni200 – 202L-arginine bindingCombined sources1 Publication3
    Regioni529 – 543Interaction with tRNABy similarityAdd BLAST15

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi201 – 212'HIGH' regionAdd BLAST12

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The alpha-helical N-terminus (residues 1-72) mediates interaction with AIMP1 and thereby contributes to the assembly of the multisynthetase complex.1 Publication

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1195 Eukaryota
    COG0018 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00530000063407

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000247212

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P54136

    KEGG Orthology (KO)

    More...
    KOi
    K01887

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    NKPLHLG

    Database of Orthologous Groups

    More...
    OrthoDBi
    463402at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P54136

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF106111

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00671 ArgRS_core, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.1360.70, 1 hit
    3.40.50.620, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_00123 Arg_tRNA_synth, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001412 aa-tRNA-synth_I_CS
    IPR001278 Arg-tRNA-ligase
    IPR005148 Arg-tRNA-synth_N
    IPR036695 Arg-tRNA-synth_N_sf
    IPR035684 ArgRS_core
    IPR008909 DALR_anticod-bd
    IPR014729 Rossmann-like_a/b/a_fold
    IPR009080 tRNAsynth_Ia_anticodon-bd

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11956 PTHR11956, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03485 Arg_tRNA_synt_N, 1 hit
    PF05746 DALR_1, 1 hit
    PF00750 tRNA-synt_1d, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR01038 TRNASYNTHARG

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM01016 Arg_tRNA_synt_N, 1 hit
    SM00836 DALR_1, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF47323 SSF47323, 1 hit
    SSF55190 SSF55190, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00456 argS, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00178 AA_TRNA_LIGASE_I, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket

    This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform Complexed (identifier: P54136-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MDVLVSECSA RLLQQEEEIK SLTAEIDRLK NCGCLGASPN LEQLQEENLK
    60 70 80 90 100
    LKYRLNILRK SLQAERNKPT KNMINIISRL QEVFGHAIKA AYPDLENPPL
    110 120 130 140 150
    LVTPSQQAKF GDYQCNSAMG ISQMLKTKEQ KVNPREIAEN ITKHLPDNEC
    160 170 180 190 200
    IEKVEIAGPG FINVHLRKDF VSEQLTSLLV NGVQLPALGE NKKVIVDFSS
    210 220 230 240 250
    PNIAKEMHVG HLRSTIIGES ISRLFEFAGY DVLRLNHVGD WGTQFGMLIA
    260 270 280 290 300
    HLQDKFPDYL TVSPPIGDLQ VFYKESKKRF DTEEEFKKRA YQCVVLLQGK
    310 320 330 340 350
    NPDITKAWKL ICDVSRQELN KIYDALDVSL IERGESFYQD RMNDIVKEFE
    360 370 380 390 400
    DRGFVQVDDG RKIVFVPGCS IPLTIVKSDG GYTYDTSDLA AIKQRLFEEK
    410 420 430 440 450
    ADMIIYVVDN GQSVHFQTIF AAAQMIGWYD PKVTRVFHAG FGVVLGEDKK
    460 470 480 490 500
    KFKTRSGETV RLMDLLGEGL KRSMDKLKEK ERDKVLTAEE LNAAQTSVAY
    510 520 530 540 550
    GCIKYADLSH NRLNDYIFSF DKMLDDRGNT AAYLLYAFTR IRSIARLANI
    560 570 580 590 600
    DEEMLQKAAR ETKILLDHEK EWKLGRCILR FPEILQKILD DLFLHTLCDY
    610 620 630 640 650
    IYELATAFTE FYDSCYCVEK DRQTGKILKV NMWRMLLCEA VAAVMAKGFD
    660
    ILGIKPVQRM
    Length:660
    Mass (Da):75,379
    Last modified:April 16, 2002 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE9FB5C910709956
    GO
    Isoform Monomeric (identifier: P54136-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-72: Missing.

    Show »
    Length:588
    Mass (Da):67,140
    Checksum:i857EA1F69F3B6A3B
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E5RJM9E5RJM9_HUMAN
    Arginine--tRNA ligase, cytoplasmic
    RARS
    129Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E5RH09E5RH09_HUMAN
    Arginine--tRNA ligase, cytoplasmic
    RARS
    113Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E5RI24E5RI24_HUMAN
    Arginine--tRNA ligase, cytoplasmic
    RARS
    58Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39P → S in AAB35627 (PubMed:7590355).Curated1
    Sequence conflicti130 – 131QK → PE in AAB35627 (PubMed:7590355).Curated2
    Sequence conflicti135 – 137REI → GEF in AAB35627 (PubMed:7590355).Curated3
    Sequence conflicti147 – 156DNECIEKVEI → AMDVLKRVEF in AAB35627 (PubMed:7590355).Curated10
    Sequence conflicti164V → G in AAB35627 (PubMed:7590355).Curated1
    Sequence conflicti278K → N in BAG37326 (PubMed:14702039).Curated1
    Sequence conflicti308 – 312WKLIC → YLLMS in AAB35627 (PubMed:7590355).Curated5
    Sequence conflicti341R → G in BAD96517 (Ref. 4) Curated1
    Sequence conflicti358D → G in BAG37326 (PubMed:14702039).Curated1
    Sequence conflicti487T → A in BAD96517 (Ref. 4) Curated1
    Sequence conflicti567D → V in AAB35627 (PubMed:7590355).Curated1
    Sequence conflicti635 – 640MLLCEA → ILCET in AAB35627 (PubMed:7590355).Curated6
    Sequence conflicti651I → T in AAB35627 (PubMed:7590355).Curated1
    Sequence conflicti657 – 660VQRM → GPRV in AAB35627 (PubMed:7590355).Curated4

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_0726662D → G in HLD9. 1 PublicationCorresponds to variant dbSNP:rs672601372EnsemblClinVar.1
    Natural variantiVAR_0201063V → I. Corresponds to variant dbSNP:rs244903EnsemblClinVar.1
    Natural variantiVAR_052635135R → G. Corresponds to variant dbSNP:rs1059443Ensembl.1
    Natural variantiVAR_020107397F → Y. Corresponds to variant dbSNP:rs2305734EnsemblClinVar.1
    Natural variantiVAR_072667512R → Q in HLD9. 1 PublicationCorresponds to variant dbSNP:rs369398935EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0189051 – 72Missing in isoform Monomeric. CuratedAdd BLAST72

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    S80343 mRNA Translation: AAB35627.1
    BT007394 mRNA Translation: AAP36058.1
    AK314795 mRNA Translation: BAG37326.1
    AK222797 mRNA Translation: BAD96517.1
    BC000528 mRNA Translation: AAH00528.1
    BC014619 mRNA Translation: AAH14619.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS4367.1 [P54136-1]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    JC4365

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_002878.2, NM_002887.3 [P54136-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000231572; ENSP00000231572; ENSG00000113643 [P54136-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    5917

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:5917

    UCSC genome browser

    More...
    UCSCi
    uc003lzx.4 human [P54136-1]

    Keywords - Coding sequence diversityi

    Alternative initiation, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    S80343 mRNA Translation: AAB35627.1
    BT007394 mRNA Translation: AAP36058.1
    AK314795 mRNA Translation: BAG37326.1
    AK222797 mRNA Translation: BAD96517.1
    BC000528 mRNA Translation: AAH00528.1
    BC014619 mRNA Translation: AAH14619.1
    CCDSiCCDS4367.1 [P54136-1]
    PIRiJC4365
    RefSeqiNP_002878.2, NM_002887.3 [P54136-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4Q2TX-ray2.40A/B73-660[»]
    4Q2XX-ray2.80A/B73-660[»]
    4Q2YX-ray2.80A/B73-660[»]
    4R3ZX-ray4.03B1-660[»]
    4ZAJX-ray2.22A73-660[»]
    SMRiP54136
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi111852, 169 interactors
    CORUMiP54136
    IntActiP54136, 43 interactors
    MINTiP54136
    STRINGi9606.ENSP00000231572

    Chemistry databases

    BindingDBiP54136
    ChEMBLiCHEMBL2824

    PTM databases

    iPTMnetiP54136
    PhosphoSitePlusiP54136
    SwissPalmiP54136

    Polymorphism and mutation databases

    BioMutaiRARS
    DMDMi20178331

    Proteomic databases

    EPDiP54136
    jPOSTiP54136
    MassIVEiP54136
    MaxQBiP54136
    PaxDbiP54136
    PeptideAtlasiP54136
    PRIDEiP54136
    ProteomicsDBi56650 [P54136-1]
    56651 [P54136-2]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    5917

    Genome annotation databases

    EnsembliENST00000231572; ENSP00000231572; ENSG00000113643 [P54136-1]
    GeneIDi5917
    KEGGihsa:5917
    UCSCiuc003lzx.4 human [P54136-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    5917
    DisGeNETi5917

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    RARS
    HGNCiHGNC:9870 RARS
    HPAiHPA003979
    HPA004130
    MalaCardsiRARS
    MIMi107820 gene
    616140 phenotype
    neXtProtiNX_P54136
    OpenTargetsiENSG00000113643
    Orphaneti438114 RARS-related autosomal recessive hypomyelinating leukodystrophy
    PharmGKBiPA34231

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1195 Eukaryota
    COG0018 LUCA
    GeneTreeiENSGT00530000063407
    HOGENOMiHOG000247212
    InParanoidiP54136
    KOiK01887
    OMAiNKPLHLG
    OrthoDBi463402at2759
    PhylomeDBiP54136
    TreeFamiTF106111

    Enzyme and pathway databases

    ReactomeiR-HSA-2408522 Selenoamino acid metabolism
    R-HSA-379716 Cytosolic tRNA aminoacylation
    SABIO-RKiP54136

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    RARS human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    RARS_(gene)

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    5917
    PharosiP54136

    Protein Ontology

    More...
    PROi
    PR:P54136

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000113643 Expressed in 112 organ(s), highest expression level in kidney
    ExpressionAtlasiP54136 baseline and differential
    GenevisibleiP54136 HS

    Family and domain databases

    CDDicd00671 ArgRS_core, 1 hit
    Gene3Di3.30.1360.70, 1 hit
    3.40.50.620, 1 hit
    HAMAPiMF_00123 Arg_tRNA_synth, 1 hit
    InterProiView protein in InterPro
    IPR001412 aa-tRNA-synth_I_CS
    IPR001278 Arg-tRNA-ligase
    IPR005148 Arg-tRNA-synth_N
    IPR036695 Arg-tRNA-synth_N_sf
    IPR035684 ArgRS_core
    IPR008909 DALR_anticod-bd
    IPR014729 Rossmann-like_a/b/a_fold
    IPR009080 tRNAsynth_Ia_anticodon-bd
    PANTHERiPTHR11956 PTHR11956, 1 hit
    PfamiView protein in Pfam
    PF03485 Arg_tRNA_synt_N, 1 hit
    PF05746 DALR_1, 1 hit
    PF00750 tRNA-synt_1d, 1 hit
    PRINTSiPR01038 TRNASYNTHARG
    SMARTiView protein in SMART
    SM01016 Arg_tRNA_synt_N, 1 hit
    SM00836 DALR_1, 1 hit
    SUPFAMiSSF47323 SSF47323, 1 hit
    SSF55190 SSF55190, 1 hit
    TIGRFAMsiTIGR00456 argS, 1 hit
    PROSITEiView protein in PROSITE
    PS00178 AA_TRNA_LIGASE_I, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYRC_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54136
    Secondary accession number(s): B2RBS9, Q53GY4, Q9BWA1
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: April 16, 2002
    Last modified: October 16, 2019
    This is version 199 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
    4. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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