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Entry version 211 (29 Sep 2021)
Sequence version 2 (16 Apr 2002)
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Protein

Arginine--tRNA ligase, cytoplasmic

Gene

RARS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775).

Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684).

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.9 µM for arginine (ATP-PPi exchange at 37 degrees Celsius)1 Publication
  2. KM=3.5 µM for arginine (arginylation at 37 degrees Celsius)1 Publication
  3. KM=1183 µM for ATP (ATP-PPi exchange at 37 Celsius)1 Publication
  4. KM=910 µM for ATP (arginylation at 37 Celsius)1 Publication
  5. KM=0.05 µM for calf liver tRNA-Arg (ATP-PPi exchange at 37 Celsius)1 Publication
  6. KM=0.41 µM for calf liver tRNA-Arg (arginylation at 37 Celsius)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei211L-arginineCombined sources1 Publication1
Binding sitei384L-arginineCombined sources1 Publication1
Binding sitei388L-arginineCombined sources1 Publication1
Binding sitei412L-arginineCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
6.1.1.19, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P54136

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2408522, Selenoamino acid metabolism
R-HSA-379716, Cytosolic tRNA aminoacylation

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P54136

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arginine--tRNA ligase, cytoplasmic (EC:6.1.1.192 Publications)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RARS1Imported
Synonyms:RARS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9870, RARS1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
107820, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P54136

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000113643

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Leukodystrophy, hypomyelinating, 9 (HLD9)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neurodegenerative disorder characterized by delayed psychomotor development, severe spasticity, nystagmus, and ataxia associated with diffuse hypomyelination apparent on brain MRI.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0726662D → G in HLD9. 1 PublicationCorresponds to variant dbSNP:rs672601372EnsemblClinVar.1
Natural variantiVAR_072667512R → Q in HLD9. 1 PublicationCorresponds to variant dbSNP:rs369398935EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Leukodystrophy

Organism-specific databases

DisGeNET

More...
DisGeNETi
5917

MalaCards human disease database

More...
MalaCardsi
RARS1
MIMi616140, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000113643

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
438114, RARS-related autosomal recessive hypomyelinating leukodystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34231

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P54136, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2824

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
RARS

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20178331

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000357971 – 660Arginine--tRNA ligase, cytoplasmicAdd BLAST660

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P54136

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P54136

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P54136

MaxQB - The MaxQuant DataBase

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MaxQBi
P54136

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P54136

PeptideAtlas

More...
PeptideAtlasi
P54136

PRoteomics IDEntifications database

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PRIDEi
P54136

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56650 [P54136-1]
56651 [P54136-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
P54136, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P54136

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
P54136

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P54136

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P54136

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000113643, Expressed in calcaneal tendon and 135 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P54136, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P54136, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000113643, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with AIMP1 (via N-terminus); this stimulates its catalytic activity (PubMed:10358004, PubMed:25288775).

Interacts (via N-terminus) with LARS2 (via C-terminus) (PubMed:16055448, PubMed:17443684). Monomer (PubMed:24859084).

Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:19131329, PubMed:19289464).

Interacts with QARS1 (PubMed:24656866).

Part of a complex composed of RARS1, QARS1 and AIMP1 (PubMed:25288775).

8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
111852, 218 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P54136

Protein interaction database and analysis system

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IntActi
P54136, 56 interactors

Molecular INTeraction database

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MINTi
P54136

STRING: functional protein association networks

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STRINGi
9606.ENSP00000231572

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P54136

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P54136, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1660
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P54136

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 72Could be involved in the assembly of the multisynthetase complexAdd BLAST72
Regioni200 – 202L-arginine bindingCombined sources1 Publication3
Regioni529 – 543Interaction with tRNABy similarityAdd BLAST15

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi201 – 212'HIGH' regionAdd BLAST12

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical N-terminus (residues 1-72) mediates interaction with AIMP1 and thereby contributes to the assembly of the multisynthetase complex.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4426, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00530000063407

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_006406_5_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P54136

Identification of Orthologs from Complete Genome Data

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OMAi
NKPLHLG

Database of Orthologous Groups

More...
OrthoDBi
463402at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P54136

TreeFam database of animal gene trees

More...
TreeFami
TF106111

Family and domain databases

Conserved Domains Database

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CDDi
cd00671, ArgRS_core, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.1360.70, 1 hit
3.40.50.620, 1 hit

HAMAP database of protein families

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HAMAPi
MF_00123, Arg_tRNA_synth, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001412, aa-tRNA-synth_I_CS
IPR001278, Arg-tRNA-ligase
IPR005148, Arg-tRNA-synth_N
IPR036695, Arg-tRNA-synth_N_sf
IPR035684, ArgRS_core
IPR008909, DALR_anticod-bd
IPR014729, Rossmann-like_a/b/a_fold
IPR009080, tRNAsynth_Ia_anticodon-bd

The PANTHER Classification System

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PANTHERi
PTHR11956, PTHR11956, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03485, Arg_tRNA_synt_N, 1 hit
PF05746, DALR_1, 1 hit
PF00750, tRNA-synt_1d, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01038, TRNASYNTHARG

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01016, Arg_tRNA_synt_N, 1 hit
SM00836, DALR_1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47323, SSF47323, 1 hit
SSF55190, SSF55190, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00456, argS, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00178, AA_TRNA_LIGASE_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Complexed (identifier: P54136-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVLVSECSA RLLQQEEEIK SLTAEIDRLK NCGCLGASPN LEQLQEENLK
60 70 80 90 100
LKYRLNILRK SLQAERNKPT KNMINIISRL QEVFGHAIKA AYPDLENPPL
110 120 130 140 150
LVTPSQQAKF GDYQCNSAMG ISQMLKTKEQ KVNPREIAEN ITKHLPDNEC
160 170 180 190 200
IEKVEIAGPG FINVHLRKDF VSEQLTSLLV NGVQLPALGE NKKVIVDFSS
210 220 230 240 250
PNIAKEMHVG HLRSTIIGES ISRLFEFAGY DVLRLNHVGD WGTQFGMLIA
260 270 280 290 300
HLQDKFPDYL TVSPPIGDLQ VFYKESKKRF DTEEEFKKRA YQCVVLLQGK
310 320 330 340 350
NPDITKAWKL ICDVSRQELN KIYDALDVSL IERGESFYQD RMNDIVKEFE
360 370 380 390 400
DRGFVQVDDG RKIVFVPGCS IPLTIVKSDG GYTYDTSDLA AIKQRLFEEK
410 420 430 440 450
ADMIIYVVDN GQSVHFQTIF AAAQMIGWYD PKVTRVFHAG FGVVLGEDKK
460 470 480 490 500
KFKTRSGETV RLMDLLGEGL KRSMDKLKEK ERDKVLTAEE LNAAQTSVAY
510 520 530 540 550
GCIKYADLSH NRLNDYIFSF DKMLDDRGNT AAYLLYAFTR IRSIARLANI
560 570 580 590 600
DEEMLQKAAR ETKILLDHEK EWKLGRCILR FPEILQKILD DLFLHTLCDY
610 620 630 640 650
IYELATAFTE FYDSCYCVEK DRQTGKILKV NMWRMLLCEA VAAVMAKGFD
660
ILGIKPVQRM
Length:660
Mass (Da):75,379
Last modified:April 16, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE9FB5C910709956
GO
Isoform Monomeric (identifier: P54136-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Show »
Length:588
Mass (Da):67,140
Checksum:i857EA1F69F3B6A3B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJM9E5RJM9_HUMAN
Arginine--tRNA ligase, cytoplasmic
RARS1
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RH09E5RH09_HUMAN
Arginine--tRNA ligase, cytoplasmic
RARS1
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI24E5RI24_HUMAN
Arginine--tRNA ligase, cytoplasmic
RARS1
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39P → S in AAB35627 (PubMed:7590355).Curated1
Sequence conflicti130 – 131QK → PE in AAB35627 (PubMed:7590355).Curated2
Sequence conflicti135 – 137REI → GEF in AAB35627 (PubMed:7590355).Curated3
Sequence conflicti147 – 156DNECIEKVEI → AMDVLKRVEF in AAB35627 (PubMed:7590355).Curated10
Sequence conflicti164V → G in AAB35627 (PubMed:7590355).Curated1
Sequence conflicti278K → N in BAG37326 (PubMed:14702039).Curated1
Sequence conflicti308 – 312WKLIC → YLLMS in AAB35627 (PubMed:7590355).Curated5
Sequence conflicti341R → G in BAD96517 (Ref. 4) Curated1
Sequence conflicti358D → G in BAG37326 (PubMed:14702039).Curated1
Sequence conflicti487T → A in BAD96517 (Ref. 4) Curated1
Sequence conflicti567D → V in AAB35627 (PubMed:7590355).Curated1
Sequence conflicti635 – 640MLLCEA → ILCET in AAB35627 (PubMed:7590355).Curated6
Sequence conflicti651I → T in AAB35627 (PubMed:7590355).Curated1
Sequence conflicti657 – 660VQRM → GPRV in AAB35627 (PubMed:7590355).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0726662D → G in HLD9. 1 PublicationCorresponds to variant dbSNP:rs672601372EnsemblClinVar.1
Natural variantiVAR_0201063V → I. Corresponds to variant dbSNP:rs244903EnsemblClinVar.1
Natural variantiVAR_052635135R → G. Corresponds to variant dbSNP:rs1059443Ensembl.1
Natural variantiVAR_020107397F → Y. Corresponds to variant dbSNP:rs2305734EnsemblClinVar.1
Natural variantiVAR_072667512R → Q in HLD9. 1 PublicationCorresponds to variant dbSNP:rs369398935EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0189051 – 72Missing in isoform Monomeric. CuratedAdd BLAST72

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
S80343 mRNA Translation: AAB35627.1
BT007394 mRNA Translation: AAP36058.1
AK314795 mRNA Translation: BAG37326.1
AK222797 mRNA Translation: BAD96517.1
BC000528 mRNA Translation: AAH00528.1
BC014619 mRNA Translation: AAH14619.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4367.1 [P54136-1]

Protein sequence database of the Protein Information Resource

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PIRi
JC4365

NCBI Reference Sequences

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RefSeqi
NP_002878.2, NM_002887.3 [P54136-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000231572; ENSP00000231572; ENSG00000113643 [P54136-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5917

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5917

UCSC genome browser

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UCSCi
uc003lzx.4, human [P54136-1]

Keywords - Coding sequence diversityi

Alternative initiation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80343 mRNA Translation: AAB35627.1
BT007394 mRNA Translation: AAP36058.1
AK314795 mRNA Translation: BAG37326.1
AK222797 mRNA Translation: BAD96517.1
BC000528 mRNA Translation: AAH00528.1
BC014619 mRNA Translation: AAH14619.1
CCDSiCCDS4367.1 [P54136-1]
PIRiJC4365
RefSeqiNP_002878.2, NM_002887.3 [P54136-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q2TX-ray2.40A/B73-660[»]
4Q2XX-ray2.80A/B73-660[»]
4Q2YX-ray2.80A/B73-660[»]
4R3ZX-ray4.03B1-660[»]
4ZAJX-ray2.22A73-660[»]
SMRiP54136
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111852, 218 interactors
CORUMiP54136
IntActiP54136, 56 interactors
MINTiP54136
STRINGi9606.ENSP00000231572

Chemistry databases

BindingDBiP54136
ChEMBLiCHEMBL2824

PTM databases

GlyGeniP54136, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP54136
MetOSiteiP54136
PhosphoSitePlusiP54136
SwissPalmiP54136

Genetic variation databases

BioMutaiRARS
DMDMi20178331

Proteomic databases

EPDiP54136
jPOSTiP54136
MassIVEiP54136
MaxQBiP54136
PaxDbiP54136
PeptideAtlasiP54136
PRIDEiP54136
ProteomicsDBi56650 [P54136-1]
56651 [P54136-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P54136, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

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Antibodypediai
1285, 238 antibodies

The DNASU plasmid repository

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DNASUi
5917

Genome annotation databases

EnsembliENST00000231572; ENSP00000231572; ENSG00000113643 [P54136-1]
GeneIDi5917
KEGGihsa:5917
UCSCiuc003lzx.4, human [P54136-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5917
DisGeNETi5917

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RARS1
HGNCiHGNC:9870, RARS1
HPAiENSG00000113643, Low tissue specificity
MalaCardsiRARS1
MIMi107820, gene
616140, phenotype
neXtProtiNX_P54136
OpenTargetsiENSG00000113643
Orphaneti438114, RARS-related autosomal recessive hypomyelinating leukodystrophy
PharmGKBiPA34231
VEuPathDBiHostDB:ENSG00000113643

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4426, Eukaryota
GeneTreeiENSGT00530000063407
HOGENOMiCLU_006406_5_1_1
InParanoidiP54136
OMAiNKPLHLG
OrthoDBi463402at2759
PhylomeDBiP54136
TreeFamiTF106111

Enzyme and pathway databases

BRENDAi6.1.1.19, 2681
PathwayCommonsiP54136
ReactomeiR-HSA-2408522, Selenoamino acid metabolism
R-HSA-379716, Cytosolic tRNA aminoacylation
SABIO-RKiP54136

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
5917, 617 hits in 992 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RARS, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RARS_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5917
PharosiP54136, Tchem

Protein Ontology

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PROi
PR:P54136
RNActiP54136, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113643, Expressed in calcaneal tendon and 135 other tissues
ExpressionAtlasiP54136, baseline and differential
GenevisibleiP54136, HS

Family and domain databases

CDDicd00671, ArgRS_core, 1 hit
Gene3Di3.30.1360.70, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00123, Arg_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412, aa-tRNA-synth_I_CS
IPR001278, Arg-tRNA-ligase
IPR005148, Arg-tRNA-synth_N
IPR036695, Arg-tRNA-synth_N_sf
IPR035684, ArgRS_core
IPR008909, DALR_anticod-bd
IPR014729, Rossmann-like_a/b/a_fold
IPR009080, tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956, PTHR11956, 1 hit
PfamiView protein in Pfam
PF03485, Arg_tRNA_synt_N, 1 hit
PF05746, DALR_1, 1 hit
PF00750, tRNA-synt_1d, 1 hit
PRINTSiPR01038, TRNASYNTHARG
SMARTiView protein in SMART
SM01016, Arg_tRNA_synt_N, 1 hit
SM00836, DALR_1, 1 hit
SUPFAMiSSF47323, SSF47323, 1 hit
SSF55190, SSF55190, 1 hit
TIGRFAMsiTIGR00456, argS, 1 hit
PROSITEiView protein in PROSITE
PS00178, AA_TRNA_LIGASE_I, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYRC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54136
Secondary accession number(s): B2RBS9, Q53GY4, Q9BWA1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 16, 2002
Last modified: September 29, 2021
This is version 211 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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