Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 161 (16 Oct 2019)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Cysteine-rich secretory protein 3

Gene

CRISP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cysteine-rich secretory protein 3
Short name:
CRISP-3
Alternative name(s):
Specific granule protein of 28 kDa
Short name:
SGP28
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRISP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16904 CRISP3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618062 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P54108

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10321

Open Targets

More...
OpenTargetsi
ENSG00000096006

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134880440

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P54108

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CRISP3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1706135

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000626821 – 245Cysteine-rich secretory protein 3Add BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi191 ↔ 198PROSITE-ProRule annotation
Disulfide bondi194 ↔ 203PROSITE-ProRule annotation
Disulfide bondi207 ↔ 240PROSITE-ProRule annotation
Disulfide bondi216 ↔ 234PROSITE-ProRule annotation
Disulfide bondi225 ↔ 238PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P54108

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P54108

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P54108

PeptideAtlas

More...
PeptideAtlasi
P54108

PRoteomics IDEntifications database

More...
PRIDEi
P54108

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56646 [P54108-1]
56647 [P54108-2]
56648 [P54108-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P54108-1 [P54108-1]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1163

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P54108

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P54108

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Salivary gland, pancreas and prostate > epididymis, ovary, thymus and colon.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000096006 Expressed in 123 organ(s), highest expression level in saliva-secreting gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P54108 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P54108 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA054392

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with A1BG.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115605, 2 interactors

Protein interaction database and analysis system

More...
IntActi
P54108, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000389026

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P54108

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 171SCPAdd BLAST129
Domaini207 – 240ShKTPROSITE-ProRule annotationAdd BLAST34

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3017 Eukaryota
COG2340 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162013

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236338

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P54108

KEGG Orthology (KO)

More...
KOi
K19919

Database of Orthologous Groups

More...
OrthoDBi
1528782at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P54108

TreeFam database of animal gene trees

More...
TreeFami
TF316148

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05383 CAP_CRISP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.740, 1 hit
3.40.33.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR042076 Crisp-like_dom
IPR001283 CRISP-related
IPR013871 Cysteine_rich_secretory
IPR034117 SCP_CRISP
IPR003582 ShKT_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10334 PTHR10334, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00188 CAP, 1 hit
PF08562 Crisp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00837 V5TPXLIKE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00198 SCP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55797 SSF55797, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01009 CRISP_1, 1 hit
PS01010 CRISP_2, 1 hit
PS51670 SHKT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P54108-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTLFPVLLFL VAGLLPSFPA NEDKDPAFTA LLTTQTQVQR EIVNKHNELR
60 70 80 90 100
RAVSPPARNM LKMEWNKEAA ANAQKWANQC NYRHSNPKDR MTSLKCGENL
110 120 130 140 150
YMSSASSSWS QAIQSWFDEY NDFDFGVGPK TPNAVVGHYT QVVWYSSYLV
160 170 180 190 200
GCGNAYCPNQ KVLKYYYVCQ YCPAGNWANR LYVPYEQGAP CASCPDNCDD
210 220 230 240
GLCTNGCKYE DLYSNCKSLK LTLTCKHQLV RDSCKASCNC SNSIY
Length:245
Mass (Da):27,630
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB4DD79CB7AE9E5F9
GO
Isoform 2 (identifier: P54108-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKQILHPALETTAM

Show »
Length:258
Mass (Da):29,065
Checksum:i4371D621491B8427
GO
Isoform 3 (identifier: P54108-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKQILHPALETTDPCSTGFVFPAM

Show »
Length:268
Mass (Da):30,116
Checksum:i4DA3F68D69A9953D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KPA1J3KPA1_HUMAN
Cysteine-rich secretory protein 3
CRISP3
276Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0A1I3L0A1_HUMAN
Cysteine-rich secretory protein 3
CRISP3
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH69580 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH69602 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG36185 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA63984 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA64527 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti79Q → R in BAF85475 (PubMed:14702039).Curated1
Sequence conflicti130K → R in BAD97100 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_011718106S → P2 PublicationsCorresponds to variant dbSNP:rs495335Ensembl.1
Natural variantiVAR_011719134A → S1 PublicationCorresponds to variant dbSNP:rs1864312Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0427581M → MKQILHPALETTAM in isoform 2. 2 Publications1
Alternative sequenceiVSP_0427591M → MKQILHPALETTDPCSTGFV FPAM in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X94323 mRNA Translation: CAA63984.1 Different initiation.
AK292786 mRNA Translation: BAF85475.1
AK313387 mRNA Translation: BAG36185.1 Different initiation.
DB205467 mRNA No translation available.
AK223380 mRNA Translation: BAD97100.1
AL121950 Genomic DNA No translation available.
AL121974 Genomic DNA No translation available.
BC069580 mRNA Translation: AAH69580.1 Different initiation.
BC069602 mRNA Translation: AAH69602.1 Different initiation.
BC101539 mRNA Translation: AAI01540.1
X95240 mRNA Translation: CAA64527.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4929.2 [P54108-2]
CCDS55019.1 [P54108-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
S68691

NCBI Reference Sequences

More...
RefSeqi
NP_001177915.1, NM_001190986.2 [P54108-3]
NP_006052.2, NM_006061.3 [P54108-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263045; ENSP00000263045; ENSG00000096006 [P54108-2]
ENST00000433368; ENSP00000389026; ENSG00000096006 [P54108-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10321

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10321

UCSC genome browser

More...
UCSCi
uc003ozs.5 human [P54108-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94323 mRNA Translation: CAA63984.1 Different initiation.
AK292786 mRNA Translation: BAF85475.1
AK313387 mRNA Translation: BAG36185.1 Different initiation.
DB205467 mRNA No translation available.
AK223380 mRNA Translation: BAD97100.1
AL121950 Genomic DNA No translation available.
AL121974 Genomic DNA No translation available.
BC069580 mRNA Translation: AAH69580.1 Different initiation.
BC069602 mRNA Translation: AAH69602.1 Different initiation.
BC101539 mRNA Translation: AAI01540.1
X95240 mRNA Translation: CAA64527.1 Different initiation.
CCDSiCCDS4929.2 [P54108-2]
CCDS55019.1 [P54108-3]
PIRiS68691
RefSeqiNP_001177915.1, NM_001190986.2 [P54108-3]
NP_006052.2, NM_006061.3 [P54108-2]

3D structure databases

SMRiP54108
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115605, 2 interactors
IntActiP54108, 1 interactor
STRINGi9606.ENSP00000389026

PTM databases

GlyConnecti1163
iPTMnetiP54108
PhosphoSitePlusiP54108

Polymorphism and mutation databases

BioMutaiCRISP3
DMDMi1706135

Proteomic databases

jPOSTiP54108
MassIVEiP54108
PaxDbiP54108
PeptideAtlasiP54108
PRIDEiP54108
ProteomicsDBi56646 [P54108-1]
56647 [P54108-2]
56648 [P54108-3]
TopDownProteomicsiP54108-1 [P54108-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10321

Genome annotation databases

EnsembliENST00000263045; ENSP00000263045; ENSG00000096006 [P54108-2]
ENST00000433368; ENSP00000389026; ENSG00000096006 [P54108-3]
GeneIDi10321
KEGGihsa:10321
UCSCiuc003ozs.5 human [P54108-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10321
DisGeNETi10321

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CRISP3
HGNCiHGNC:16904 CRISP3
HPAiHPA054392
MIMi618062 gene
neXtProtiNX_P54108
OpenTargetsiENSG00000096006
PharmGKBiPA134880440

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00940000162013
HOGENOMiHOG000236338
InParanoidiP54108
KOiK19919
OrthoDBi1528782at2759
PhylomeDBiP54108
TreeFamiTF316148

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CRISP3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CRISP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10321
PharosiP54108

Protein Ontology

More...
PROi
PR:P54108

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000096006 Expressed in 123 organ(s), highest expression level in saliva-secreting gland
ExpressionAtlasiP54108 baseline and differential
GenevisibleiP54108 HS

Family and domain databases

CDDicd05383 CAP_CRISP, 1 hit
Gene3Di1.10.10.740, 1 hit
3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR042076 Crisp-like_dom
IPR001283 CRISP-related
IPR013871 Cysteine_rich_secretory
IPR034117 SCP_CRISP
IPR003582 ShKT_dom
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PF08562 Crisp, 1 hit
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit
PS01010 CRISP_2, 1 hit
PS51670 SHKT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRIS3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54108
Secondary accession number(s): A8K9S1
, B2R8I8, Q15512, Q3MJ82, Q53FA9, Q5JW83, Q9H108
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 16, 2019
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again