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Entry version 161 (17 Jun 2020)
Sequence version 1 (01 Oct 1996)
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Protein

Cysteine-rich secretory protein 1

Gene

CRISP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May have a role in sperm-egg fusion and maturation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cysteine-rich secretory protein 1
Short name:
CRISP-1
Alternative name(s):
AEG-like protein
ARP
Acidic epididymal glycoprotein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRISP1
Synonyms:AEGL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000124812.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:304 CRISP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601193 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P54107

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
167

Open Targets

More...
OpenTargetsi
ENSG00000124812

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24605

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P54107 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CRISP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1706134

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 211 PublicationAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000626022 – 249Cysteine-rich secretory protein 1Add BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi195 ↔ 202PROSITE-ProRule annotation
Disulfide bondi198 ↔ 207PROSITE-ProRule annotation
Disulfide bondi211 ↔ 244PROSITE-ProRule annotation
Disulfide bondi220 ↔ 238PROSITE-ProRule annotation
Disulfide bondi229 ↔ 242PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi230N-linked (GlcNAc...) asparagine1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P54107

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P54107

PeptideAtlas

More...
PeptideAtlasi
P54107

PRoteomics IDEntifications database

More...
PRIDEi
P54107

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
56644 [P54107-1]
56645 [P54107-2]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P54107

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Caput, corpus, and cauda regions of the epididymis, the ductus deferens, sperm and seminal plasma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124812 Expressed in cauda epididymis and 22 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P54107 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P54107 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000124812 Tissue enriched (epididymis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000338276

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P54107 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P54107

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 175SCPAdd BLAST131
Domaini211 – 244ShKTPROSITE-ProRule annotationAdd BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3017 Eukaryota
COG2340 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162362

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_035730_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P54107

KEGG Orthology (KO)

More...
KOi
K19919

Identification of Orthologs from Complete Genome Data

More...
OMAi
YDEYTDC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P54107

TreeFam database of animal gene trees

More...
TreeFami
TF316148

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05383 CAP_CRISP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.740, 1 hit
3.40.33.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR042076 Crisp-like_dom
IPR001283 CRISP-related
IPR013871 Cysteine_rich_secretory
IPR034117 SCP_CRISP
IPR003582 ShKT_dom
IPR002413 V5_allergen-like

The PANTHER Classification System

More...
PANTHERi
PTHR10334 PTHR10334, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00188 CAP, 1 hit
PF08562 Crisp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00838 V5ALLERGEN
PR00837 V5TPXLIKE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00198 SCP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55797 SSF55797, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01009 CRISP_1, 1 hit
PS01010 CRISP_2, 1 hit
PS51670 SHKT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Long (identifier: P54107-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIKHLLFLV AAACLLPMLS MKKKSARDQF NKLVTDLPNV QEEIVNIHNA
60 70 80 90 100
LRRRVVPPAS NMLKMSWSEE AAQNARIFSK YCDMTESNPL ERRLPNTFCG
110 120 130 140 150
ENMHMTSYPV SWSSVIGVWY SESTSFKHGE WTTTDDDITT DHYTQIVWAT
160 170 180 190 200
SYLIGCAIAS CRQQGSPRYL YVCHYCHEGN DPETKNEPYK TGVPCEACPS
210 220 230 240
NCEDKLCTNP CIYYDEYFDC DIQVHYLGCN HSTTILFCKA TCLCDTEIK
Length:249
Mass (Da):28,481
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i85BED3DDEAD62A9C
GO
Isoform Short (identifier: P54107-2) [UniParc]FASTAAdd to basket
Also known as: CRISP-1 delta

The sequence of this isoform differs from the canonical sequence as follows:
     178-178: E → D
     179-249: Missing.

Show »
Length:178
Mass (Da):20,462
Checksum:i18739B2B6EBF7F84
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22K → E in AAB35899 (PubMed:8543280).Curated1
Sequence conflicti22K → E in BAA07483 (PubMed:8838800).Curated1
Sequence conflicti97T → A in AAB35899 (PubMed:8543280).Curated1
Sequence conflicti97T → A in BAA07483 (PubMed:8838800).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006027178E → D in isoform Short. 2 Publications1
Alternative sequenceiVSP_006028179 – 249Missing in isoform Short. 2 PublicationsAdd BLAST71

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X95237 mRNA Translation: CAA64524.1
X95238 mRNA Translation: CAA64525.1
S80310 mRNA Translation: AAB35899.1
D38451 mRNA Translation: BAA07483.1
AB451334 mRNA Translation: BAG70148.1
AB451479 mRNA Translation: BAG70293.1
AL359458 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4931.1 [P54107-1]
CCDS4932.1 [P54107-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
S68681
S68684

NCBI Reference Sequences

More...
RefSeqi
NP_001122.2, NM_001131.2 [P54107-1]
NP_001192149.1, NM_001205220.1 [P54107-1]
NP_733758.1, NM_170609.1 [P54107-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329411; ENSP00000331317; ENSG00000124812 [P54107-2]
ENST00000335847; ENSP00000338276; ENSG00000124812 [P54107-1]
ENST00000505118; ENSP00000427589; ENSG00000124812 [P54107-1]
ENST00000507853; ENSP00000425020; ENSG00000124812 [P54107-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
167

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:167

UCSC genome browser

More...
UCSCi
uc003ozw.3 human [P54107-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95237 mRNA Translation: CAA64524.1
X95238 mRNA Translation: CAA64525.1
S80310 mRNA Translation: AAB35899.1
D38451 mRNA Translation: BAA07483.1
AB451334 mRNA Translation: BAG70148.1
AB451479 mRNA Translation: BAG70293.1
AL359458 Genomic DNA No translation available.
CCDSiCCDS4931.1 [P54107-1]
CCDS4932.1 [P54107-2]
PIRiS68681
S68684
RefSeqiNP_001122.2, NM_001131.2 [P54107-1]
NP_001192149.1, NM_001205220.1 [P54107-1]
NP_733758.1, NM_170609.1 [P54107-2]

3D structure databases

SMRiP54107
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000338276

PTM databases

PhosphoSitePlusiP54107

Polymorphism and mutation databases

BioMutaiCRISP1
DMDMi1706134

Proteomic databases

MassIVEiP54107
PaxDbiP54107
PeptideAtlasiP54107
PRIDEiP54107
ProteomicsDBi56644 [P54107-1]
56645 [P54107-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
30849 131 antibodies

The DNASU plasmid repository

More...
DNASUi
167

Genome annotation databases

EnsembliENST00000329411; ENSP00000331317; ENSG00000124812 [P54107-2]
ENST00000335847; ENSP00000338276; ENSG00000124812 [P54107-1]
ENST00000505118; ENSP00000427589; ENSG00000124812 [P54107-1]
ENST00000507853; ENSP00000425020; ENSG00000124812 [P54107-2]
GeneIDi167
KEGGihsa:167
UCSCiuc003ozw.3 human [P54107-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
167
DisGeNETi167
EuPathDBiHostDB:ENSG00000124812.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CRISP1
HGNCiHGNC:304 CRISP1
HPAiENSG00000124812 Tissue enriched (epididymis)
MIMi601193 gene
neXtProtiNX_P54107
OpenTargetsiENSG00000124812
PharmGKBiPA24605

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00940000162362
HOGENOMiCLU_035730_2_1_1
InParanoidiP54107
KOiK19919
OMAiYDEYTDC
PhylomeDBiP54107
TreeFamiTF316148

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
167 9 hits in 780 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CRISP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
167
PharosiP54107 Tbio

Protein Ontology

More...
PROi
PR:P54107
RNActiP54107 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000124812 Expressed in cauda epididymis and 22 other tissues
ExpressionAtlasiP54107 baseline and differential
GenevisibleiP54107 HS

Family and domain databases

CDDicd05383 CAP_CRISP, 1 hit
Gene3Di1.10.10.740, 1 hit
3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR042076 Crisp-like_dom
IPR001283 CRISP-related
IPR013871 Cysteine_rich_secretory
IPR034117 SCP_CRISP
IPR003582 ShKT_dom
IPR002413 V5_allergen-like
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PF08562 Crisp, 1 hit
PRINTSiPR00838 V5ALLERGEN
PR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit
PS01010 CRISP_2, 1 hit
PS51670 SHKT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRIS1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P54107
Secondary accession number(s): B5BU98
, O00698, Q13248, Q14082, Q96SF6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 17, 2020
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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