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UniProtKB - P54070 (KTR6_YEAST)
Protein
Mannosyltransferase KTR6
Gene
KTR6
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. Required for addition of mannosylphosphate in yeast mannan. Recognizes any oligosaccharides with at least one alpha-1,2-linked mannobiose unit.
Miscellaneous
Present with 4380 molecules/cell in log phase SD medium.1 Publication
: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 334 | NucleophileSequence analysis | 1 |
GO - Molecular functioni
- alpha-1,2-mannosyltransferase activity Source: GO_Central
- mannosylphosphate transferase activity Source: SGD
GO - Biological processi
- cell wall mannoprotein biosynthetic process Source: GO_Central
- fungal-type cell wall organization Source: SGD
- mannosylation Source: GO_Central
- protein N-linked glycosylation Source: SGD
- protein O-linked glycosylation Source: GO_Central
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Protein family/group databases
CAZyi | GT15, Glycosyltransferase Family 15 |
Names & Taxonomyi
Protein namesi | Recommended name: Mannosyltransferase KTR6 (EC:2.4.1.-)Alternative name(s): Mannosylphosphate transferase MNN6 |
Gene namesi | Name:KTR6 Synonyms:MNN6 Ordered Locus Names:YPL053C ORF Names:LPE19C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000005974, KTR6 |
VEuPathDBi | FungiDB:YPL053C |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type II membrane protein Curated
Golgi apparatus
- Golgi apparatus Source: GO_Central
Vacuole
- fungal-type vacuole Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: SGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 8 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 9 – 29 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 30 – 446 | LumenalSequence analysisAdd BLAST | 417 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208247 | 1 – 446 | Mannosyltransferase KTR6Add BLAST | 446 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 82 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 98 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | P54070 |
PaxDbi | P54070 |
PRIDEi | P54070 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 36127, 73 interactors |
DIPi | DIP-5329N |
IntActi | P54070, 4 interactors |
STRINGi | 4932.YPL053C |
Miscellaneous databases
RNActi | P54070, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 30 – 114 | Stem regionBy similarityAdd BLAST | 85 | |
Regioni | 115 – 446 | CatalyticBy similarityAdd BLAST | 332 |
Sequence similaritiesi
Belongs to the glycosyltransferase 15 family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4472, Eukaryota |
GeneTreei | ENSGT00940000176287 |
HOGENOMi | CLU_024327_1_0_1 |
InParanoidi | P54070 |
OMAi | NCNCDQG |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR002685, Glyco_trans_15 IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR31121, PTHR31121, 1 hit |
Pfami | View protein in Pfam PF01793, Glyco_transf_15, 1 hit |
PIRSFi | PIRSF018153, Glyco_trans_15, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
i Sequence
Sequence statusi: Complete.
P54070-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHVLLSKKIA RFLLISFVFV LALMVTINHP KTKQMSEQYV TPYLPKSLQP
60 70 80 90 100
IAKISAEEQR RIQSEQEEAE LKQSLEGEAI RNATVNAIKE KIKSYGGNET
110 120 130 140 150
TLGFMVPSYI NHRGSPPKAC FVSLITERDS MTQILQSIDE VQVKFNKNFA
160 170 180 190 200
YPWVFISQGE LDGMKQEMIR QAITDSMNGD PELINIKFAE IPADEWVYPE
210 220 230 240 250
WIDENKAAES LISLANVPDG DSRAVRYQAR YFAGFFWRHP VLDEFDWYWR
260 270 280 290 300
VDPGIKLYCD IDHDLFRWMQ DEGKVFGFTL SMSEAKEANE KIWDVTKKFA
310 320 330 340 350
KDFPKFISEN NFKSFITKKD SEDFNNCEFT SNFEIGNLNF YRSPAYRKFF
360 370 380 390 400
NYIDEEGGIF YWKWSDSIIH TIGLSMLLPK DKIHFFENIG FHYDKYNNCP
410 420 430 440
LNDDIWNQYN CNCDQGNDFT FRSGSCGGHY FDIMKKDKPE GWDRLP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U43922 Genomic DNA Translation: AAC49761.1 U39205 Genomic DNA Translation: AAB68312.1 BK006949 Genomic DNA Translation: DAA11377.1 |
PIRi | S61089 |
RefSeqi | NP_015272.1, NM_001183867.1 |
Genome annotation databases
EnsemblFungii | YPL053C_mRNA; YPL053C; YPL053C |
GeneIDi | 856054 |
KEGGi | sce:YPL053C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U43922 Genomic DNA Translation: AAC49761.1 U39205 Genomic DNA Translation: AAB68312.1 BK006949 Genomic DNA Translation: DAA11377.1 |
PIRi | S61089 |
RefSeqi | NP_015272.1, NM_001183867.1 |
3D structure databases
SMRi | P54070 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36127, 73 interactors |
DIPi | DIP-5329N |
IntActi | P54070, 4 interactors |
STRINGi | 4932.YPL053C |
Protein family/group databases
CAZyi | GT15, Glycosyltransferase Family 15 |
Proteomic databases
MaxQBi | P54070 |
PaxDbi | P54070 |
PRIDEi | P54070 |
Genome annotation databases
EnsemblFungii | YPL053C_mRNA; YPL053C; YPL053C |
GeneIDi | 856054 |
KEGGi | sce:YPL053C |
Organism-specific databases
SGDi | S000005974, KTR6 |
VEuPathDBi | FungiDB:YPL053C |
Phylogenomic databases
eggNOGi | KOG4472, Eukaryota |
GeneTreei | ENSGT00940000176287 |
HOGENOMi | CLU_024327_1_0_1 |
InParanoidi | P54070 |
OMAi | NCNCDQG |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Miscellaneous databases
PROi | PR:P54070 |
RNActi | P54070, protein |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR002685, Glyco_trans_15 IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR31121, PTHR31121, 1 hit |
Pfami | View protein in Pfam PF01793, Glyco_transf_15, 1 hit |
PIRSFi | PIRSF018153, Glyco_trans_15, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KTR6_YEAST | |
Accessioni | P54070Primary (citable) accession number: P54070 Secondary accession number(s): D6W3W1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | September 29, 2021 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families