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Entry version 133 (02 Jun 2021)
Sequence version 2 (18 Oct 2001)
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Protein

Protein SET

Gene

Set

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-2299718, Condensation of Prophase Chromosomes
R-DME-450520, HuR (ELAVL1) binds and stabilizes mRNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein SET
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Set
ORF Names:CG4299
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0014879, Set

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001856651 – 269Protein SETAdd BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei30Phosphoserine1 Publication1
Modified residuei148Phosphoserine1 Publication1
Modified residuei152Phosphoserine1 Publication1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53997

PRoteomics IDEntifications database

More...
PRIDEi
P53997

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53997

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0014879, Expressed in embryo and 55 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P53997, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts specifically with B-type cyclins.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
66908, 6 interactors

Database of interacting proteins

More...
DIPi
DIP-19697N

Protein interaction database and analysis system

More...
IntActi
P53997, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0082521

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P53997

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 33DisorderedSequence analysisAdd BLAST33
Regioni227 – 269DisorderedSequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi231 – 269Acidic residuesSequence analysisAdd BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1508, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169229

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_051687_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P53997

Identification of Orthologs from Complete Genome Data

More...
OMAi
LWPGAIK

Database of Orthologous Groups

More...
OrthoDBi
1191764at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P53997

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037231, NAP-like_sf
IPR002164, NAP_family

The PANTHER Classification System

More...
PANTHERi
PTHR11875, PTHR11875, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00956, NAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143113, SSF143113, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53997-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSVPKRAKL DGAPADGNTS AAAGNNEEES EALEQIDACQ NEIDALNEKA
60 70 80 90 100
SEEILKVEQK YNKLRKPCYE KRSELVKRIP NFWVTSFINH PQVSGILDEE
110 120 130 140 150
EEECLHALNK LEVEEFEDIK SGYRINFHFD ENPYFENKVL TKEFHLNSAA
160 170 180 190 200
ASENGDWPAS TSTPIKWKEG KNLLKLLLTK PYGNKKKRNS EYKTFFDWFS
210 220 230 240 250
DNTDPVNDEI AELIKDDLWP NPLQYYLVPD IEVEPEDEED NEDNDEEAFD
260
DEDGEDGEGE EEEEDEDDK
Length:269
Mass (Da):30,995
Last modified:October 18, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05F88CB85933BB09
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15Missing in AAA74264 (PubMed:7622566).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U30470 mRNA Translation: AAA74264.1
AM294381 Genomic DNA Translation: CAL26311.1
AM294382 Genomic DNA Translation: CAL26312.1
AM294383 Genomic DNA Translation: CAL26313.1
AM294384 Genomic DNA Translation: CAL26314.1
AM294385 Genomic DNA Translation: CAL26315.1
AM294386 Genomic DNA Translation: CAL26316.1
AM294387 Genomic DNA Translation: CAL26317.1
AM294388 Genomic DNA Translation: CAL26318.1
AM294389 Genomic DNA Translation: CAL26319.1
AM294390 Genomic DNA Translation: CAL26320.1
FM245455 Genomic DNA Translation: CAR93381.1
FM245456 Genomic DNA Translation: CAR93382.1
FM245457 Genomic DNA Translation: CAR93383.1
FM245458 Genomic DNA Translation: CAR93384.1
FM245459 Genomic DNA Translation: CAR93385.1
FM245460 Genomic DNA Translation: CAR93386.1
FM245461 Genomic DNA Translation: CAR93387.1
FM245462 Genomic DNA Translation: CAR93388.1
FM245463 Genomic DNA Translation: CAR93389.1
FM245464 Genomic DNA Translation: CAR93390.1
FM245465 Genomic DNA Translation: CAR93391.1
AE014297 Genomic DNA Translation: AAF55155.1
AY118922 mRNA Translation: AAM50782.1

NCBI Reference Sequences

More...
RefSeqi
NP_650438.2, NM_142181.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0083062; FBpp0082521; FBgn0014879

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41844

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG4299

UCSC genome browser

More...
UCSCi
CG4299-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30470 mRNA Translation: AAA74264.1
AM294381 Genomic DNA Translation: CAL26311.1
AM294382 Genomic DNA Translation: CAL26312.1
AM294383 Genomic DNA Translation: CAL26313.1
AM294384 Genomic DNA Translation: CAL26314.1
AM294385 Genomic DNA Translation: CAL26315.1
AM294386 Genomic DNA Translation: CAL26316.1
AM294387 Genomic DNA Translation: CAL26317.1
AM294388 Genomic DNA Translation: CAL26318.1
AM294389 Genomic DNA Translation: CAL26319.1
AM294390 Genomic DNA Translation: CAL26320.1
FM245455 Genomic DNA Translation: CAR93381.1
FM245456 Genomic DNA Translation: CAR93382.1
FM245457 Genomic DNA Translation: CAR93383.1
FM245458 Genomic DNA Translation: CAR93384.1
FM245459 Genomic DNA Translation: CAR93385.1
FM245460 Genomic DNA Translation: CAR93386.1
FM245461 Genomic DNA Translation: CAR93387.1
FM245462 Genomic DNA Translation: CAR93388.1
FM245463 Genomic DNA Translation: CAR93389.1
FM245464 Genomic DNA Translation: CAR93390.1
FM245465 Genomic DNA Translation: CAR93391.1
AE014297 Genomic DNA Translation: AAF55155.1
AY118922 mRNA Translation: AAM50782.1
RefSeqiNP_650438.2, NM_142181.3

3D structure databases

SMRiP53997
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi66908, 6 interactors
DIPiDIP-19697N
IntActiP53997, 2 interactors
STRINGi7227.FBpp0082521

PTM databases

iPTMnetiP53997

Proteomic databases

PaxDbiP53997
PRIDEiP53997

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
41844

Genome annotation databases

EnsemblMetazoaiFBtr0083062; FBpp0082521; FBgn0014879
GeneIDi41844
KEGGidme:Dmel_CG4299
UCSCiCG4299-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6418
FlyBaseiFBgn0014879, Set

Phylogenomic databases

eggNOGiKOG1508, Eukaryota
GeneTreeiENSGT00940000169229
HOGENOMiCLU_051687_4_0_1
InParanoidiP53997
OMAiLWPGAIK
OrthoDBi1191764at2759
PhylomeDBiP53997

Enzyme and pathway databases

ReactomeiR-DME-2299718, Condensation of Prophase Chromosomes
R-DME-450520, HuR (ELAVL1) binds and stabilizes mRNA

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
41844, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Set, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
41844

Protein Ontology

More...
PROi
PR:P53997

Gene expression databases

BgeeiFBgn0014879, Expressed in embryo and 55 other tissues
GenevisibleiP53997, DM

Family and domain databases

InterProiView protein in InterPro
IPR037231, NAP-like_sf
IPR002164, NAP_family
PANTHERiPTHR11875, PTHR11875, 1 hit
PfamiView protein in Pfam
PF00956, NAP, 1 hit
SUPFAMiSSF143113, SSF143113, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSET_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53997
Secondary accession number(s): Q540W9, Q9VFA5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 18, 2001
Last modified: June 2, 2021
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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