UniProtKB - P53992 (SC24C_HUMAN)
Protein transport protein Sec24C
SEC24C
Functioni
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317).
Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296).
May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317).
May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).
4 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 425 | ZincCombined sources | 1 | |
Metal bindingi | 428 | ZincCombined sources | 1 | |
Metal bindingi | 447 | ZincCombined sources | 1 | |
Metal bindingi | 450 | ZincCombined sources | 1 |
GO - Molecular functioni
- SNARE binding Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- COPII-coated vesicle cargo loading Source: UniProtKB
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: UniProtKB
- intracellular protein transport Source: InterPro
- in utero embryonic development Source: Ensembl
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P53992 |
Reactomei | R-HSA-1655829, Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-204005, COPII-mediated vesicle transport R-HSA-2132295, MHC class II antigen presentation R-HSA-5694530, Cargo concentration in the ER R-HSA-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
SignaLinki | P53992 |
SIGNORi | P53992 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein transport protein Sec24CCuratedAlternative name(s): SEC24-related protein C |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10705, SEC24C |
MIMi | 607185, gene |
neXtProti | NX_P53992 |
VEuPathDBi | HostDB:ENSG00000176986 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 2 Publications; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Cytoplasm and Cytosol
- cytosol 1 Publication
Other locations
- COPII-coated vesicle membrane 2 Publications; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Cytosol
- cytosol Source: UniProtKB
Endoplasmic reticulum
- endoplasmic reticulum exit site Source: GO_Central
- endoplasmic reticulum membrane Source: Reactome
Other locations
- COPII vesicle coat Source: UniProtKB
- ER to Golgi transport vesicle membrane Source: Reactome
Keywords - Cellular componenti
Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 895 – 897 | LIL → AAA: Loss of packaging into COPII-coated vesicles of the IxM motif-containing cargos GOSR2 and STX5. 1 Publication | 3 |
Organism-specific databases
DisGeNETi | 9632 |
MalaCardsi | SEC24C |
OpenTargetsi | ENSG00000176986 |
Orphaneti | 567, 22q11.2 deletion syndrome |
PharmGKBi | PA35628 |
Miscellaneous databases
Pharosi | P53992, Tbio |
Genetic variation databases
BioMutai | SEC24C |
DMDMi | 257051070 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000205156 | 1 – 1094 | Protein transport protein Sec24CAdd BLAST | 1094 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 214 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P53992 |
jPOSTi | P53992 |
MassIVEi | P53992 |
MaxQBi | P53992 |
PaxDbi | P53992 |
PeptideAtlasi | P53992 |
PRIDEi | P53992 |
ProteomicsDBi | 5623 56640 [P53992-1] |
PTM databases
GlyGeni | P53992, 5 sites, 1 O-linked glycan (5 sites) |
iPTMneti | P53992 |
MetOSitei | P53992 |
PhosphoSitePlusi | P53992 |
SwissPalmi | P53992 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000176986, Expressed in lower esophagus mucosa and 245 other tissues |
ExpressionAtlasi | P53992, baseline and differential |
Genevisiblei | P53992, HS |
Organism-specific databases
HPAi | ENSG00000176986, Low tissue specificity |
Interactioni
Subunit structurei
COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (PubMed:10214955, PubMed:10075675, PubMed:17499046).
Interacts with TMED2 and TMED10 (PubMed:20427317).
Interacts with GOSR2 (via IxM motif) and STX5 (via IxM motif); recruits GOSR2 and STX5 into COPII-coated vesicles (PubMed:18843296).
Interacts with DDHD1 (PubMed:17428803).
Interacts with STING1; promoting STING1 translocation to the COPII vesicles (PubMed:30842662).
7 PublicationsBinary interactionsi
P53992
With | #Exp. | IntAct |
---|---|---|
MOS [P00540] | 4 | EBI-81134,EBI-1757866 |
SEC23A [Q15436] | 5 | EBI-81134,EBI-81088 |
WIPF1 [O43516] | 3 | EBI-81134,EBI-346356 |
GO - Molecular functioni
- SNARE binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114991, 170 interactors |
DIPi | DIP-30981N |
IntActi | P53992, 43 interactors |
MINTi | P53992 |
STRINGi | 9606.ENSP00000343405 |
Miscellaneous databases
RNActi | P53992, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P53992 |
SMRi | P53992 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P53992 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 962 – 1034 | Gelsolin-likeSequence analysisAdd BLAST | 73 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 338 | DisorderedSequence analysisAdd BLAST | 338 | |
Regioni | 425 – 450 | Zinc finger-likeAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 20 – 34 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 50 – 73 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 86 – 107 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 115 – 129 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 131 – 145 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 161 – 218 | Polar residuesSequence analysisAdd BLAST | 58 | |
Compositional biasi | 236 – 255 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 261 – 275 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 276 – 290 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 305 – 324 | Pro residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1984, Eukaryota |
GeneTreei | ENSGT01030000234851 |
HOGENOMi | CLU_004589_1_1_1 |
InParanoidi | P53992 |
OMAi | DRRVHDM |
OrthoDBi | 118368at2759 |
PhylomeDBi | P53992 |
TreeFami | TF300464 |
Family and domain databases
CDDi | cd01479, Sec24-like, 1 hit |
Gene3Di | 3.40.20.10, 1 hit 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR029006, ADF-H/Gelsolin-like_dom_sf IPR007123, Gelsolin-like_dom IPR036180, Gelsolin-like_dom_sf IPR006900, Sec23/24_helical_dom IPR036175, Sec23/24_helical_dom_sf IPR006896, Sec23/24_trunk_dom IPR012990, Sec23_24_beta_S IPR041742, Sec24-like_trunk_dom IPR036465, vWFA_dom_sf IPR006895, Znf_Sec23_Sec24 IPR036174, Znf_Sec23_Sec24_sf |
Pfami | View protein in Pfam PF00626, Gelsolin, 1 hit PF08033, Sec23_BS, 1 hit PF04815, Sec23_helical, 1 hit PF04811, Sec23_trunk, 1 hit PF04810, zf-Sec23_Sec24, 1 hit |
SUPFAMi | SSF53300, SSF53300, 1 hit SSF81811, SSF81811, 1 hit SSF82754, SSF82754, 1 hit SSF82919, SSF82919, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNVNQSVPPV PPFGQPQPIY PGYHQSSYGG QSGSTAPAIP YGAYNGPVPG
60 70 80 90 100
YQQTPPQGMS RAPPSSGAPP ASTAQAPCGQ AAYGQFGQGD VQNGPSSTVQ
110 120 130 140 150
MQRLPGSQPF GSPLAPVGNQ PPVLQPYGPP PTSAQVATQL SGMQISGAVA
160 170 180 190 200
PAPPSSGLGF GPPTSLASAS GSFPNSGLYG SYPQGQAPPL SQAQGHPGIQ
210 220 230 240 250
TPQRSAPSQA SSFTPPASGG PRLPSMTGPL LPGQSFGGPS VSQPNHVSSP
260 270 280 290 300
PQALPPGTQM TGPLGPLPPM HSPQQPGYQP QQNGSFGPAR GPQSNYGGPY
310 320 330 340 350
PAAPTFGSQP GPPQPLPPKR LDPDAIPSPI QVIEDDRNNR GTEPFVTGVR
360 370 380 390 400
GQVPPLVTTN FLVKDQGNAS PRYIRCTSYN IPCTSDMAKQ AQVPLAAVIK
410 420 430 440 450
PLARLPPEEA SPYVVDHGES GPLRCNRCKA YMCPFMQFIE GGRRFQCCFC
460 470 480 490 500
SCINDVPPQY FQHLDHTGKR VDAYDRPELS LGSYEFLATV DYCKNNKFPS
510 520 530 540 550
PPAFIFMIDV SYNAIRTGLV RLLCEELKSL LDFLPREGGA EESAIRVGFV
560 570 580 590 600
TYNKVLHFYN VKSSLAQPQM MVVSDVADMF VPLLDGFLVN VNESRAVITS
610 620 630 640 650
LLDQIPEMFA DTRETETVFV PVIQAGMEAL KAAECAGKLF LFHTSLPIAE
660 670 680 690 700
APGKLKNRDD RKLINTDKEK TLFQPQTGAY QTLAKECVAQ GCCVDLFLFP
710 720 730 740 750
NQYVDVATLS VVPQLTGGSV YKYASFQVEN DQERFLSDLR RDVQKVVGFD
760 770 780 790 800
AVMRVRTSTG IRAVDFFGAF YMSNTTDVEL AGLDGDKTVT VEFKHDDRLN
810 820 830 840 850
EESGALLQCA LLYTSCAGQR RLRIHNLALN CCTQLADLYR NCETDTLINY
860 870 880 890 900
MAKFAYRGVL NSPVKAVRDT LITQCAQILA CYRKNCASPS SAGQLILPEC
910 920 930 940 950
MKLLPVYLNC VLKSDVLQPG AEVTTDDRAY VRQLVTSMDV TETNVFFYPR
960 970 980 990 1000
LLPLTKSPVE STTEPPAVRA SEERLSNGDI YLLENGLNLF LWVGASVQQG
1010 1020 1030 1040 1050
VVQSLFSVSS FSQITSGLSV LPVLDNPLSK KVRGLIDSLR AQRSRYMKLT
1060 1070 1080 1090
VVKQEDKMEM LFKHFLVEDK SLSGGASYVD FLCHMHKEIR QLLS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5EA31 | G5EA31_HUMAN | Protein transport protein Sec24C | SEC24C hCG_19035 | 1,042 | Annotation score: | ||
A0A0U1RR49 | A0A0U1RR49_HUMAN | Protein transport protein Sec24C | SEC24C | 183 | Annotation score: | ||
A0A0U1RR58 | A0A0U1RR58_HUMAN | Protein transport protein Sec24C | SEC24C | 180 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058690 | 109 | P → S1 PublicationCorresponds to variant dbSNP:rs17851695Ensembl. | 1 | |
Natural variantiVAR_057174 | 934 | L → P. Corresponds to variant dbSNP:rs16930872Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056516 | 1 – 752 | Missing in isoform 2. 1 PublicationAdd BLAST | 752 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D38555 mRNA Translation: BAA07558.2 Sequence problems. AK303085 mRNA Translation: BAG64196.1 AC022400 Genomic DNA No translation available. BC018928 mRNA Translation: AAH18928.1 |
CCDSi | CCDS7332.1 [P53992-1] |
RefSeqi | NP_004913.2, NM_004922.3 [P53992-1] NP_940999.1, NM_198597.2 [P53992-1] |
Genome annotation databases
Ensembli | ENST00000339365.2; ENSP00000343405.2; ENSG00000176986.16 ENST00000345254.9; ENSP00000321845.6; ENSG00000176986.16 |
GeneIDi | 9632 |
KEGGi | hsa:9632 |
MANE-Selecti | ENST00000345254.9; ENSP00000321845.6; NM_198597.3; NP_940999.1 |
UCSCi | uc001juw.4, human [P53992-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D38555 mRNA Translation: BAA07558.2 Sequence problems. AK303085 mRNA Translation: BAG64196.1 AC022400 Genomic DNA No translation available. BC018928 mRNA Translation: AAH18928.1 |
CCDSi | CCDS7332.1 [P53992-1] |
RefSeqi | NP_004913.2, NM_004922.3 [P53992-1] NP_940999.1, NM_198597.2 [P53992-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3EH2 | X-ray | 2.35 | A/B/C | 329-1094 | [»] | |
6PU1 | X-ray | 2.28 | B | 228-242 | [»] | |
AlphaFoldDBi | P53992 | |||||
SMRi | P53992 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114991, 170 interactors |
DIPi | DIP-30981N |
IntActi | P53992, 43 interactors |
MINTi | P53992 |
STRINGi | 9606.ENSP00000343405 |
PTM databases
GlyGeni | P53992, 5 sites, 1 O-linked glycan (5 sites) |
iPTMneti | P53992 |
MetOSitei | P53992 |
PhosphoSitePlusi | P53992 |
SwissPalmi | P53992 |
Genetic variation databases
BioMutai | SEC24C |
DMDMi | 257051070 |
Proteomic databases
EPDi | P53992 |
jPOSTi | P53992 |
MassIVEi | P53992 |
MaxQBi | P53992 |
PaxDbi | P53992 |
PeptideAtlasi | P53992 |
PRIDEi | P53992 |
ProteomicsDBi | 5623 56640 [P53992-1] |
Protocols and materials databases
Antibodypediai | 45407, 162 antibodies from 26 providers |
DNASUi | 9632 |
Genome annotation databases
Ensembli | ENST00000339365.2; ENSP00000343405.2; ENSG00000176986.16 ENST00000345254.9; ENSP00000321845.6; ENSG00000176986.16 |
GeneIDi | 9632 |
KEGGi | hsa:9632 |
MANE-Selecti | ENST00000345254.9; ENSP00000321845.6; NM_198597.3; NP_940999.1 |
UCSCi | uc001juw.4, human [P53992-1] |
Organism-specific databases
CTDi | 9632 |
DisGeNETi | 9632 |
GeneCardsi | SEC24C |
HGNCi | HGNC:10705, SEC24C |
HPAi | ENSG00000176986, Low tissue specificity |
MalaCardsi | SEC24C |
MIMi | 607185, gene |
neXtProti | NX_P53992 |
OpenTargetsi | ENSG00000176986 |
Orphaneti | 567, 22q11.2 deletion syndrome |
PharmGKBi | PA35628 |
VEuPathDBi | HostDB:ENSG00000176986 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1984, Eukaryota |
GeneTreei | ENSGT01030000234851 |
HOGENOMi | CLU_004589_1_1_1 |
InParanoidi | P53992 |
OMAi | DRRVHDM |
OrthoDBi | 118368at2759 |
PhylomeDBi | P53992 |
TreeFami | TF300464 |
Enzyme and pathway databases
PathwayCommonsi | P53992 |
Reactomei | R-HSA-1655829, Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-204005, COPII-mediated vesicle transport R-HSA-2132295, MHC class II antigen presentation R-HSA-5694530, Cargo concentration in the ER R-HSA-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
SignaLinki | P53992 |
SIGNORi | P53992 |
Miscellaneous databases
BioGRID-ORCSi | 9632, 16 hits in 1079 CRISPR screens |
ChiTaRSi | SEC24C, human |
EvolutionaryTracei | P53992 |
GeneWikii | SEC24C |
GenomeRNAii | 9632 |
Pharosi | P53992, Tbio |
PROi | PR:P53992 |
RNActi | P53992, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000176986, Expressed in lower esophagus mucosa and 245 other tissues |
ExpressionAtlasi | P53992, baseline and differential |
Genevisiblei | P53992, HS |
Family and domain databases
CDDi | cd01479, Sec24-like, 1 hit |
Gene3Di | 3.40.20.10, 1 hit 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR029006, ADF-H/Gelsolin-like_dom_sf IPR007123, Gelsolin-like_dom IPR036180, Gelsolin-like_dom_sf IPR006900, Sec23/24_helical_dom IPR036175, Sec23/24_helical_dom_sf IPR006896, Sec23/24_trunk_dom IPR012990, Sec23_24_beta_S IPR041742, Sec24-like_trunk_dom IPR036465, vWFA_dom_sf IPR006895, Znf_Sec23_Sec24 IPR036174, Znf_Sec23_Sec24_sf |
Pfami | View protein in Pfam PF00626, Gelsolin, 1 hit PF08033, Sec23_BS, 1 hit PF04815, Sec23_helical, 1 hit PF04811, Sec23_trunk, 1 hit PF04810, zf-Sec23_Sec24, 1 hit |
SUPFAMi | SSF53300, SSF53300, 1 hit SSF81811, SSF81811, 1 hit SSF82754, SSF82754, 1 hit SSF82919, SSF82919, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SC24C_HUMAN | |
Accessioni | P53992Primary (citable) accession number: P53992 Secondary accession number(s): B4DZT4, Q8WV25 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | September 1, 2009 | |
Last modified: | May 25, 2022 | |
This is version 204 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families