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UniProtKB - P53992 (SC24C_HUMAN)

Entry version 204 (25 May 2022)
Sequence version 3 (01 Sep 2009)
Previous versions | rss
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Protein

Protein transport protein Sec24C

Gene

SEC24C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317).

Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296).

May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317).

May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).

4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi425ZincCombined sources1
Metal bindingi428ZincCombined sources1
Metal bindingi447ZincCombined sources1
Metal bindingi450ZincCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • SNARE binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P53992

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1655829, Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-204005, COPII-mediated vesicle transport
R-HSA-2132295, MHC class II antigen presentation
R-HSA-5694530, Cargo concentration in the ER
R-HSA-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P53992

SIGNOR Signaling Network Open Resource

More...SIGNORi		P53992

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein transport protein Sec24CCurated
Alternative name(s):
SEC24-related protein C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC24CImported
Synonyms:KIAA0079Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10705, SEC24C

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607185, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P53992

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000176986

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi895 – 897LIL → AAA: Loss of packaging into COPII-coated vesicles of the IxM motif-containing cargos GOSR2 and STX5. 1 Publication3

Organism-specific databases

DisGeNET

More...DisGeNETi		9632

MalaCards human disease database

More...MalaCardsi		SEC24C

Open Targets

More...OpenTargetsi		ENSG00000176986

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		567, 22q11.2 deletion syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35628

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P53992, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SEC24C

Domain mapping of disease mutations (DMDM)

More...DMDMi		257051070

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002051561 – 1094Protein transport protein Sec24CAdd BLAST1094

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei214PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P53992

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P53992

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P53992

MaxQB - The MaxQuant DataBase

More...MaxQBi		P53992

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P53992

PeptideAtlas

More...PeptideAtlasi		P53992

PRoteomics IDEntifications database

More...PRIDEi		P53992

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5623
56640 [P53992-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P53992, 5 sites, 1 O-linked glycan (5 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P53992

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P53992

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P53992

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P53992

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000176986, Expressed in lower esophagus mucosa and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P53992, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P53992, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000176986, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (PubMed:10214955, PubMed:10075675, PubMed:17499046).

Interacts with TMED2 and TMED10 (PubMed:20427317).

Interacts with GOSR2 (via IxM motif) and STX5 (via IxM motif); recruits GOSR2 and STX5 into COPII-coated vesicles (PubMed:18843296).

Interacts with DDHD1 (PubMed:17428803).

Interacts with STING1; promoting STING1 translocation to the COPII vesicles (PubMed:30842662).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114991, 170 interactors

Database of interacting proteins

More...DIPi		DIP-30981N

Protein interaction database and analysis system

More...IntActi		P53992, 43 interactors

Molecular INTeraction database

More...MINTi		P53992

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000343405

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P53992, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11094
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P53992

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P53992

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P53992

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati962 – 1034Gelsolin-likeSequence analysisAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 338DisorderedSequence analysisAdd BLAST338
Regioni425 – 450Zinc finger-likeAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi20 – 34Polar residuesSequence analysisAdd BLAST15
Compositional biasi50 – 73Polar residuesSequence analysisAdd BLAST24
Compositional biasi86 – 107Polar residuesSequence analysisAdd BLAST22
Compositional biasi115 – 129Pro residuesSequence analysisAdd BLAST15
Compositional biasi131 – 145Polar residuesSequence analysisAdd BLAST15
Compositional biasi161 – 218Polar residuesSequence analysisAdd BLAST58
Compositional biasi236 – 255Polar residuesSequence analysisAdd BLAST20
Compositional biasi261 – 275Pro residuesSequence analysisAdd BLAST15
Compositional biasi276 – 290Polar residuesSequence analysisAdd BLAST15
Compositional biasi305 – 324Pro residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC24 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1984, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234851

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004589_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P53992

Identification of Orthologs from Complete Genome Data

More...OMAi		DRRVHDM

Database of Orthologous Groups

More...OrthoDBi		118368at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P53992

TreeFam database of animal gene trees

More...TreeFami		TF300464

Family and domain databases

Conserved Domains Database

More...CDDi		cd01479, Sec24-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.20.10, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR007123, Gelsolin-like_dom
IPR036180, Gelsolin-like_dom_sf
IPR006900, Sec23/24_helical_dom
IPR036175, Sec23/24_helical_dom_sf
IPR006896, Sec23/24_trunk_dom
IPR012990, Sec23_24_beta_S
IPR041742, Sec24-like_trunk_dom
IPR036465, vWFA_dom_sf
IPR006895, Znf_Sec23_Sec24
IPR036174, Znf_Sec23_Sec24_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00626, Gelsolin, 1 hit
PF08033, Sec23_BS, 1 hit
PF04815, Sec23_helical, 1 hit
PF04811, Sec23_trunk, 1 hit
PF04810, zf-Sec23_Sec24, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53300, SSF53300, 1 hit
SSF81811, SSF81811, 1 hit
SSF82754, SSF82754, 1 hit
SSF82919, SSF82919, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P53992-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNVNQSVPPV PPFGQPQPIY PGYHQSSYGG QSGSTAPAIP YGAYNGPVPG 
        60         70         80         90        100
YQQTPPQGMS RAPPSSGAPP ASTAQAPCGQ AAYGQFGQGD VQNGPSSTVQ 
       110        120        130        140        150
MQRLPGSQPF GSPLAPVGNQ PPVLQPYGPP PTSAQVATQL SGMQISGAVA 
       160        170        180        190        200
PAPPSSGLGF GPPTSLASAS GSFPNSGLYG SYPQGQAPPL SQAQGHPGIQ 
       210        220        230        240        250
TPQRSAPSQA SSFTPPASGG PRLPSMTGPL LPGQSFGGPS VSQPNHVSSP 
       260        270        280        290        300
PQALPPGTQM TGPLGPLPPM HSPQQPGYQP QQNGSFGPAR GPQSNYGGPY 
       310        320        330        340        350
PAAPTFGSQP GPPQPLPPKR LDPDAIPSPI QVIEDDRNNR GTEPFVTGVR 
       360        370        380        390        400
GQVPPLVTTN FLVKDQGNAS PRYIRCTSYN IPCTSDMAKQ AQVPLAAVIK 
       410        420        430        440        450
PLARLPPEEA SPYVVDHGES GPLRCNRCKA YMCPFMQFIE GGRRFQCCFC 
       460        470        480        490        500
SCINDVPPQY FQHLDHTGKR VDAYDRPELS LGSYEFLATV DYCKNNKFPS 
       510        520        530        540        550
PPAFIFMIDV SYNAIRTGLV RLLCEELKSL LDFLPREGGA EESAIRVGFV 
       560        570        580        590        600
TYNKVLHFYN VKSSLAQPQM MVVSDVADMF VPLLDGFLVN VNESRAVITS 
       610        620        630        640        650
LLDQIPEMFA DTRETETVFV PVIQAGMEAL KAAECAGKLF LFHTSLPIAE 
       660        670        680        690        700
APGKLKNRDD RKLINTDKEK TLFQPQTGAY QTLAKECVAQ GCCVDLFLFP 
       710        720        730        740        750
NQYVDVATLS VVPQLTGGSV YKYASFQVEN DQERFLSDLR RDVQKVVGFD 
       760        770        780        790        800
AVMRVRTSTG IRAVDFFGAF YMSNTTDVEL AGLDGDKTVT VEFKHDDRLN 
       810        820        830        840        850
EESGALLQCA LLYTSCAGQR RLRIHNLALN CCTQLADLYR NCETDTLINY 
       860        870        880        890        900
MAKFAYRGVL NSPVKAVRDT LITQCAQILA CYRKNCASPS SAGQLILPEC 
       910        920        930        940        950
MKLLPVYLNC VLKSDVLQPG AEVTTDDRAY VRQLVTSMDV TETNVFFYPR 
       960        970        980        990       1000
LLPLTKSPVE STTEPPAVRA SEERLSNGDI YLLENGLNLF LWVGASVQQG 
      1010       1020       1030       1040       1050
VVQSLFSVSS FSQITSGLSV LPVLDNPLSK KVRGLIDSLR AQRSRYMKLT 
      1060       1070       1080       1090 
VVKQEDKMEM LFKHFLVEDK SLSGGASYVD FLCHMHKEIR QLLS
Length:1,094
Mass (Da):118,325
Last modified:September 1, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E308E4B8E596ECE
GO
Isoform 2 (identifier: P53992-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-752: Missing.

Show »
Length:342
Mass (Da):38,181
Checksum:i9FE10EE8578DBE79
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5EA31G5EA31_HUMAN
Protein transport protein Sec24C
SEC24C hCG_19035
1,042Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RR49A0A0U1RR49_HUMAN
Protein transport protein Sec24C
SEC24C
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RR58A0A0U1RR58_HUMAN
Protein transport protein Sec24C
SEC24C
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA07558 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_058690109P → S1 PublicationCorresponds to variant dbSNP:rs17851695Ensembl.1
Natural variantiVAR_057174934L → P. Corresponds to variant dbSNP:rs16930872Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0565161 – 752Missing in isoform 2. 1 PublicationAdd BLAST752

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D38555 mRNA Translation: BAA07558.2 Sequence problems.
AK303085 mRNA Translation: BAG64196.1
AC022400 Genomic DNA No translation available.
BC018928 mRNA Translation: AAH18928.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7332.1 [P53992-1]

NCBI Reference Sequences

More...RefSeqi		NP_004913.2, NM_004922.3 [P53992-1]
NP_940999.1, NM_198597.2 [P53992-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000339365.2; ENSP00000343405.2; ENSG00000176986.16
ENST00000345254.9; ENSP00000321845.6; ENSG00000176986.16

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9632

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9632

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000345254.9; ENSP00000321845.6; NM_198597.3; NP_940999.1

UCSC genome browser

More...UCSCi		uc001juw.4, human [P53992-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38555 mRNA Translation: BAA07558.2 Sequence problems.
AK303085 mRNA Translation: BAG64196.1
AC022400 Genomic DNA No translation available.
BC018928 mRNA Translation: AAH18928.1
CCDSiCCDS7332.1 [P53992-1]
RefSeqiNP_004913.2, NM_004922.3 [P53992-1]
NP_940999.1, NM_198597.2 [P53992-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EH2X-ray2.35A/B/C329-1094[»]
6PU1X-ray2.28B228-242[»]
AlphaFoldDBiP53992
SMRiP53992
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114991, 170 interactors
DIPiDIP-30981N
IntActiP53992, 43 interactors
MINTiP53992
STRINGi9606.ENSP00000343405

PTM databases

GlyGeniP53992, 5 sites, 1 O-linked glycan (5 sites)
iPTMnetiP53992
MetOSiteiP53992
PhosphoSitePlusiP53992
SwissPalmiP53992

Genetic variation databases

BioMutaiSEC24C
DMDMi257051070

Proteomic databases

EPDiP53992
jPOSTiP53992
MassIVEiP53992
MaxQBiP53992
PaxDbiP53992
PeptideAtlasiP53992
PRIDEiP53992
ProteomicsDBi5623
56640 [P53992-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		45407, 162 antibodies from 26 providers

The DNASU plasmid repository

More...DNASUi		9632

Genome annotation databases

EnsembliENST00000339365.2; ENSP00000343405.2; ENSG00000176986.16
ENST00000345254.9; ENSP00000321845.6; ENSG00000176986.16
GeneIDi9632
KEGGihsa:9632
MANE-SelectiENST00000345254.9; ENSP00000321845.6; NM_198597.3; NP_940999.1
UCSCiuc001juw.4, human [P53992-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9632
DisGeNETi9632

GeneCards: human genes, protein and diseases

More...GeneCardsi		SEC24C
HGNCiHGNC:10705, SEC24C
HPAiENSG00000176986, Low tissue specificity
MalaCardsiSEC24C
MIMi607185, gene
neXtProtiNX_P53992
OpenTargetsiENSG00000176986
Orphaneti567, 22q11.2 deletion syndrome
PharmGKBiPA35628
VEuPathDBiHostDB:ENSG00000176986

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1984, Eukaryota
GeneTreeiENSGT01030000234851
HOGENOMiCLU_004589_1_1_1
InParanoidiP53992
OMAiDRRVHDM
OrthoDBi118368at2759
PhylomeDBiP53992
TreeFamiTF300464

Enzyme and pathway databases

PathwayCommonsiP53992
ReactomeiR-HSA-1655829, Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-204005, COPII-mediated vesicle transport
R-HSA-2132295, MHC class II antigen presentation
R-HSA-5694530, Cargo concentration in the ER
R-HSA-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SignaLinkiP53992
SIGNORiP53992

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9632, 16 hits in 1079 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SEC24C, human
EvolutionaryTraceiP53992

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SEC24C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9632
PharosiP53992, Tbio

Protein Ontology

More...PROi		PR:P53992
RNActiP53992, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000176986, Expressed in lower esophagus mucosa and 245 other tissues
ExpressionAtlasiP53992, baseline and differential
GenevisibleiP53992, HS

Family and domain databases

CDDicd01479, Sec24-like, 1 hit
Gene3Di3.40.20.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR007123, Gelsolin-like_dom
IPR036180, Gelsolin-like_dom_sf
IPR006900, Sec23/24_helical_dom
IPR036175, Sec23/24_helical_dom_sf
IPR006896, Sec23/24_trunk_dom
IPR012990, Sec23_24_beta_S
IPR041742, Sec24-like_trunk_dom
IPR036465, vWFA_dom_sf
IPR006895, Znf_Sec23_Sec24
IPR036174, Znf_Sec23_Sec24_sf
PfamiView protein in Pfam
PF00626, Gelsolin, 1 hit
PF08033, Sec23_BS, 1 hit
PF04815, Sec23_helical, 1 hit
PF04811, Sec23_trunk, 1 hit
PF04810, zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300, SSF53300, 1 hit
SSF81811, SSF81811, 1 hit
SSF82754, SSF82754, 1 hit
SSF82919, SSF82919, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC24C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53992
Secondary accession number(s): B4DZT4, Q8WV25
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 1, 2009
Last modified: May 25, 2022
This is version 204 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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