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Protein

Protein transport protein Sec24C

Gene

SEC24C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi425ZincCombined sources1
Metal bindingi428ZincCombined sources1
Metal bindingi447ZincCombined sources1
Metal bindingi450ZincCombined sources1

GO - Molecular functioni

  • SNARE binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-2132295 MHC class II antigen presentation
R-HSA-5694530 Cargo concentration in the ER
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec24CCurated
Alternative name(s):
SEC24-related protein C
Gene namesi
Name:SEC24CImported
Synonyms:KIAA0079Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000176986.15
HGNCiHGNC:10705 SEC24C
MIMi607185 gene
neXtProtiNX_P53992

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi895 – 897LIL → AAA: Loss of packaging into COPII-coated vesicles of the IxM motif-containing cargos GOSR2 and STX5. 1 Publication3

Organism-specific databases

DisGeNETi9632
MalaCardsiSEC24C
OpenTargetsiENSG00000176986
Orphaneti567 22q11.2 deletion syndrome
PharmGKBiPA35628

Polymorphism and mutation databases

BioMutaiSEC24C
DMDMi257051070

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002051561 – 1094Protein transport protein Sec24CAdd BLAST1094

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei214PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP53992
MaxQBiP53992
PaxDbiP53992
PeptideAtlasiP53992
PRIDEiP53992
ProteomicsDBi56640

PTM databases

iPTMnetiP53992
PhosphoSitePlusiP53992

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000176986 Expressed in 232 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_SEC24C
ExpressionAtlasiP53992 baseline and differential
GenevisibleiP53992 HS

Organism-specific databases

HPAiHPA040196
HPA040213

Interactioni

Subunit structurei

COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (PubMed:10214955, PubMed:10075675, PubMed:17499046). Interacts with TMED2 and TMED10 (PubMed:20427317). Interacts with GOSR2 (via IxM motif) and STX5 (via IxM motif); recruits GOSR2 and STX5 into COPII-coated vesicles (PubMed:18843296). Interacts with DDHD1 (PubMed:17428803).6 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114991, 76 interactors
DIPiDIP-30981N
IntActiP53992, 36 interactors
MINTiP53992
STRINGi9606.ENSP00000321845

Structurei

Secondary structure

11094
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP53992
SMRiP53992
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53992

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati962 – 1034Gelsolin-likeSequence analysisAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni425 – 450Zinc finger-likeAdd BLAST26

Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC24 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1985 Eukaryota
COG5028 LUCA
GeneTreeiENSGT00590000082962
HOGENOMiHOG000196365
HOVERGENiHBG062229
InParanoidiP53992
KOiK14007
OMAiPIVNFGD
OrthoDBiEOG091G0288
PhylomeDBiP53992
TreeFamiTF300464

Family and domain databases

Gene3Di3.40.20.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR036180 Gelsolin-like_dom_sf
IPR006900 Sec23/24_helical_dom
IPR036175 Sec23/24_helical_dom_sf
IPR006896 Sec23/24_trunk_dom
IPR012990 Sec23_24_beta_S
IPR036465 vWFA_dom_sf
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf
PfamiView protein in Pfam
PF00626 Gelsolin, 1 hit
PF08033 Sec23_BS, 1 hit
PF04815 Sec23_helical, 1 hit
PF04811 Sec23_trunk, 1 hit
PF04810 zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF81811 SSF81811, 1 hit
SSF82754 SSF82754, 1 hit
SSF82919 SSF82919, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P53992-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNVNQSVPPV PPFGQPQPIY PGYHQSSYGG QSGSTAPAIP YGAYNGPVPG
60 70 80 90 100
YQQTPPQGMS RAPPSSGAPP ASTAQAPCGQ AAYGQFGQGD VQNGPSSTVQ
110 120 130 140 150
MQRLPGSQPF GSPLAPVGNQ PPVLQPYGPP PTSAQVATQL SGMQISGAVA
160 170 180 190 200
PAPPSSGLGF GPPTSLASAS GSFPNSGLYG SYPQGQAPPL SQAQGHPGIQ
210 220 230 240 250
TPQRSAPSQA SSFTPPASGG PRLPSMTGPL LPGQSFGGPS VSQPNHVSSP
260 270 280 290 300
PQALPPGTQM TGPLGPLPPM HSPQQPGYQP QQNGSFGPAR GPQSNYGGPY
310 320 330 340 350
PAAPTFGSQP GPPQPLPPKR LDPDAIPSPI QVIEDDRNNR GTEPFVTGVR
360 370 380 390 400
GQVPPLVTTN FLVKDQGNAS PRYIRCTSYN IPCTSDMAKQ AQVPLAAVIK
410 420 430 440 450
PLARLPPEEA SPYVVDHGES GPLRCNRCKA YMCPFMQFIE GGRRFQCCFC
460 470 480 490 500
SCINDVPPQY FQHLDHTGKR VDAYDRPELS LGSYEFLATV DYCKNNKFPS
510 520 530 540 550
PPAFIFMIDV SYNAIRTGLV RLLCEELKSL LDFLPREGGA EESAIRVGFV
560 570 580 590 600
TYNKVLHFYN VKSSLAQPQM MVVSDVADMF VPLLDGFLVN VNESRAVITS
610 620 630 640 650
LLDQIPEMFA DTRETETVFV PVIQAGMEAL KAAECAGKLF LFHTSLPIAE
660 670 680 690 700
APGKLKNRDD RKLINTDKEK TLFQPQTGAY QTLAKECVAQ GCCVDLFLFP
710 720 730 740 750
NQYVDVATLS VVPQLTGGSV YKYASFQVEN DQERFLSDLR RDVQKVVGFD
760 770 780 790 800
AVMRVRTSTG IRAVDFFGAF YMSNTTDVEL AGLDGDKTVT VEFKHDDRLN
810 820 830 840 850
EESGALLQCA LLYTSCAGQR RLRIHNLALN CCTQLADLYR NCETDTLINY
860 870 880 890 900
MAKFAYRGVL NSPVKAVRDT LITQCAQILA CYRKNCASPS SAGQLILPEC
910 920 930 940 950
MKLLPVYLNC VLKSDVLQPG AEVTTDDRAY VRQLVTSMDV TETNVFFYPR
960 970 980 990 1000
LLPLTKSPVE STTEPPAVRA SEERLSNGDI YLLENGLNLF LWVGASVQQG
1010 1020 1030 1040 1050
VVQSLFSVSS FSQITSGLSV LPVLDNPLSK KVRGLIDSLR AQRSRYMKLT
1060 1070 1080 1090
VVKQEDKMEM LFKHFLVEDK SLSGGASYVD FLCHMHKEIR QLLS
Length:1,094
Mass (Da):118,325
Last modified:September 1, 2009 - v3
Checksum:i5E308E4B8E596ECE
GO
Isoform 2 (identifier: P53992-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-752: Missing.

Note: No experimental confirmation available.
Show »
Length:342
Mass (Da):38,181
Checksum:i9FE10EE8578DBE79
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5EA31G5EA31_HUMAN
Protein transport protein Sec24C
SEC24C hCG_19035
1,042Annotation score:
A0A0U1RR49A0A0U1RR49_HUMAN
Protein transport protein Sec24C
SEC24C
183Annotation score:
A0A0U1RR58A0A0U1RR58_HUMAN
Protein transport protein Sec24C
SEC24C
180Annotation score:

Sequence cautioni

The sequence BAA07558 differs from that shown. Reason: Frameshift at position 1041.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058690109P → S1 PublicationCorresponds to variant dbSNP:rs17851695Ensembl.1
Natural variantiVAR_057174934L → P. Corresponds to variant dbSNP:rs16930872Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565161 – 752Missing in isoform 2. 1 PublicationAdd BLAST752

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38555 mRNA Translation: BAA07558.2 Sequence problems.
AK303085 mRNA Translation: BAG64196.1
AC022400 Genomic DNA No translation available.
BC018928 mRNA Translation: AAH18928.1
CCDSiCCDS7332.1 [P53992-1]
RefSeqiNP_004913.2, NM_004922.3 [P53992-1]
NP_940999.1, NM_198597.2 [P53992-1]
UniGeneiHs.81964

Genome annotation databases

EnsembliENST00000339365; ENSP00000343405; ENSG00000176986 [P53992-1]
ENST00000345254; ENSP00000321845; ENSG00000176986 [P53992-1]
GeneIDi9632
KEGGihsa:9632
UCSCiuc001juw.4 human [P53992-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38555 mRNA Translation: BAA07558.2 Sequence problems.
AK303085 mRNA Translation: BAG64196.1
AC022400 Genomic DNA No translation available.
BC018928 mRNA Translation: AAH18928.1
CCDSiCCDS7332.1 [P53992-1]
RefSeqiNP_004913.2, NM_004922.3 [P53992-1]
NP_940999.1, NM_198597.2 [P53992-1]
UniGeneiHs.81964

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EH2X-ray2.35A/B/C329-1094[»]
ProteinModelPortaliP53992
SMRiP53992
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114991, 76 interactors
DIPiDIP-30981N
IntActiP53992, 36 interactors
MINTiP53992
STRINGi9606.ENSP00000321845

PTM databases

iPTMnetiP53992
PhosphoSitePlusiP53992

Polymorphism and mutation databases

BioMutaiSEC24C
DMDMi257051070

Proteomic databases

EPDiP53992
MaxQBiP53992
PaxDbiP53992
PeptideAtlasiP53992
PRIDEiP53992
ProteomicsDBi56640

Protocols and materials databases

DNASUi9632
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339365; ENSP00000343405; ENSG00000176986 [P53992-1]
ENST00000345254; ENSP00000321845; ENSG00000176986 [P53992-1]
GeneIDi9632
KEGGihsa:9632
UCSCiuc001juw.4 human [P53992-1]

Organism-specific databases

CTDi9632
DisGeNETi9632
EuPathDBiHostDB:ENSG00000176986.15
GeneCardsiSEC24C
H-InvDBiHIX0008930
HGNCiHGNC:10705 SEC24C
HPAiHPA040196
HPA040213
MalaCardsiSEC24C
MIMi607185 gene
neXtProtiNX_P53992
OpenTargetsiENSG00000176986
Orphaneti567 22q11.2 deletion syndrome
PharmGKBiPA35628
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1985 Eukaryota
COG5028 LUCA
GeneTreeiENSGT00590000082962
HOGENOMiHOG000196365
HOVERGENiHBG062229
InParanoidiP53992
KOiK14007
OMAiPIVNFGD
OrthoDBiEOG091G0288
PhylomeDBiP53992
TreeFamiTF300464

Enzyme and pathway databases

ReactomeiR-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-2132295 MHC class II antigen presentation
R-HSA-5694530 Cargo concentration in the ER
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

ChiTaRSiSEC24C human
EvolutionaryTraceiP53992
GeneWikiiSEC24C
GenomeRNAii9632
PROiPR:P53992
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176986 Expressed in 232 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_SEC24C
ExpressionAtlasiP53992 baseline and differential
GenevisibleiP53992 HS

Family and domain databases

Gene3Di3.40.20.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR007123 Gelsolin-like_dom
IPR036180 Gelsolin-like_dom_sf
IPR006900 Sec23/24_helical_dom
IPR036175 Sec23/24_helical_dom_sf
IPR006896 Sec23/24_trunk_dom
IPR012990 Sec23_24_beta_S
IPR036465 vWFA_dom_sf
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf
PfamiView protein in Pfam
PF00626 Gelsolin, 1 hit
PF08033 Sec23_BS, 1 hit
PF04815 Sec23_helical, 1 hit
PF04811 Sec23_trunk, 1 hit
PF04810 zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF81811 SSF81811, 1 hit
SSF82754 SSF82754, 1 hit
SSF82919 SSF82919, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSC24C_HUMAN
AccessioniPrimary (citable) accession number: P53992
Secondary accession number(s): B4DZT4, Q8WV25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 1, 2009
Last modified: November 7, 2018
This is version 181 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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