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UniProtKB - P53990 (IST1_HUMAN)

Entry version 176 (07 Apr 2021)
Sequence version 1 (01 Oct 1996)
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Protein

IST1 homolog

Gene

IST1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P53990

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6798695, Neutrophil degranulation
R-HSA-9668328, Sealing of the nuclear envelope (NE) by ESCRT-III

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
IST1 homolog
Short name:
hIST1
Alternative name(s):
Putative MAPK-activating protein PM28
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IST1
Synonyms:KIAA0174
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:28977, IST1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616434, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P53990

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000182149.20

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi323L → D: Diminishes interaction with VPS4A. Greatly diminishes interaction with VPS4A; when associated with A-353. 1 Publication1
Mutagenesisi326L → D: Diminishes interaction with VPS4A. Greatly diminishes interaction with VPS4A and abolishes interaction with VTA1; when associated with A-353. Greatly diminishes interaction with VPS4A; when associated with A-360. 1 Publication1
Mutagenesisi353L → A: Diminishes interaction with VPS4A. Greatly diminishes interaction with VPS4A and abolishes interaction with VTA1; when associated with D-326. Greatly diminishes interaction with VPS4A; when associated with D-323. 1 Publication1
Mutagenesisi360 – 361LK → AA: Abolishes interaction with VTA1, MITD1 and USP8; diminishes interaction with VPS4A. 1 Publication2
Mutagenesisi360L → A: Diminishes interaction with VPS4A. Greatly diminishes interaction with VPS4A; when associated with D-326. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		9798

Open Targets

More...OpenTargetsi		ENSG00000182149

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671633

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P53990, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IST1

Domain mapping of disease mutations (DMDM)

More...DMDMi		1723119

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000507271 – 364IST1 homologAdd BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4PhosphoserineCombined sources1
Modified residuei43PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P53990

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P53990

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P53990

MaxQB - The MaxQuant DataBase

More...MaxQBi		P53990

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P53990

PeptideAtlas

More...PeptideAtlasi		P53990

PRoteomics IDEntifications database

More...PRIDEi		P53990

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		1902
56636 [P53990-1]
56637 [P53990-2]
56638 [P53990-3]
56639 [P53990-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P53990

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P53990

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P53990

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P53990

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000182149, Expressed in left lobe of thyroid gland and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P53990, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P53990, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000182149, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CHMP1A, CHMP1B, VPS4A and VTA1.

Interacts with SPAST, STAMBP, and USP8. May interact with VPS37B. May associate with the ESCRT-I complex.

Interacts with MITD1, in competition with VSP4 (PubMed:23015756).

Interacts with SPART (via MIT domain); leading to the recruitment of SPART to midbodies (PubMed:20719964).

Interacts with SPAST (PubMed:23897888, PubMed:26040712).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115141, 62 interactors

Database of interacting proteins

More...DIPi		DIP-42546N

Protein interaction database and analysis system

More...IntActi		P53990, 38 interactors

Molecular INTeraction database

More...MINTi		P53990

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000438399

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P53990, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1364
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P53990

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P53990

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 168Interaction with CHMP1A and CHMP1BAdd BLAST168
Regioni64 – 279Interaction with VPS37B1 PublicationAdd BLAST216
Regioni190 – 364Interaction with VTA1Add BLAST175
Regioni348 – 364Interaction with VPS4A, VTA1, MITD1 STAMBP and USP81 PublicationAdd BLAST17

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi321 – 332Type-2 MIT-interacting motifAdd BLAST12
Motifi351 – 361MIT-interacting motifAdd BLAST11

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IST1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2027, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000007453

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P53990

Identification of Orthologs from Complete Genome Data

More...OMAi		PQPRSKM

Database of Orthologous Groups

More...OrthoDBi		1302348at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P53990

TreeFam database of animal gene trees

More...TreeFami		TF314258

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1260.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005061, Ist1
IPR042277, IST1-like

The PANTHER Classification System

More...PANTHERi		PTHR12161, PTHR12161, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03398, Ist1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P53990-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGSGFKAER LRVNLRLVIN RLKLLEKKKT ELAQKARKEI ADYLAAGKDE 
        60         70         80         90        100
RARIRVEHII REDYLVEAME ILELYCDLLL ARFGLIQSMK ELDSGLAESV 
       110        120        130        140        150
STLIWAAPRL QSEVAELKIV ADQLCAKYSK EYGKLCRTNQ IGTVNDRLMH 
       160        170        180        190        200
KLSVEAPPKI LVERYLIEIA KNYNVPYEPD SVVMAEAPPG VETDLIDVGF 
       210        220        230        240        250
TDDVKKGGPG RGGSGGFTAP VGGPDGTVPM PMPMPMPSAN TPFSYPLPKG 
       260        270        280        290        300
PSDFNGLPMG TYQAFPNIHP PQIPATPPSY ESVDDINADK NISSAQIVGP 
       310        320        330        340        350
GPKPEASAKL PSRPADNYDN FVLPELPSVP DTLPTASAGA STSASEDIDF 
       360 
DDLSRRFEEL KKKT
Length:364
Mass (Da):39,751
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0DD3C186A52A4380
GO
Isoform 2 (identifier: P53990-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-228: V → VPM
     252-282: Missing.

Show »
Length:335
Mass (Da):36,622
Checksum:i7D0714269380E835
GO
Isoform 5 (identifier: P53990-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVFKLKTKEEQHSM
     237-237: P → PMP

Show »
Length:379
Mass (Da):41,566
Checksum:i37E0FEF4BB93C054
GO
Isoform 4 (identifier: P53990-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-228: V → VPM

Show »
Length:366
Mass (Da):39,979
Checksum:iE25DE7D7A5693AF8
GO
Isoform 3 (identifier: P53990-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-228: V → VPM
     283-364: VDDINADKNI...RRFEELKKKT → MTLMLIRISL...LMIFPGGLKS

Show »
Length:360
Mass (Da):39,928
Checksum:i5D0DDB4113DAA2BC
GO
Isoform 6 (identifier: P53990-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-148: Missing.
     228-228: V → VPM

Show »
Length:218
Mass (Da):23,089
Checksum:iB0405956455B9777
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BUI0H3BUI0_HUMAN
IST1 homolog
IST1
253Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXM3F5GXM3_HUMAN
IST1 homolog
IST1
141Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMU1H3BMU1_HUMAN
IST1 homolog
IST1
206Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRE2H3BRE2_HUMAN
IST1 homolog
IST1
105Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQF7H3BQF7_HUMAN
IST1 homolog
IST1
166Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPP6H3BPP6_HUMAN
IST1 homolog
IST1
59Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQ38H3BQ38_HUMAN
IST1 homolog
IST1
40Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KR23J3KR23_HUMAN
IST1 homolog
IST1
289Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PF00E9PF00_HUMAN
IST1 homolog
IST1
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQP8J3QQP8_HUMAN
IST1 homolog
IST1
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA11491 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0551181 – 148Missing in isoform 6. CuratedAdd BLAST148
Alternative sequenceiVSP_0470751M → MVFKLKTKEEQHSM in isoform 5. 1 Publication1
Alternative sequenceiVSP_017118228V → VPM in isoform 2, isoform 3, isoform 4 and isoform 6. 2 Publications1
Alternative sequenceiVSP_047076237P → PMP in isoform 5. 1 Publication1
Alternative sequenceiVSP_017119252 – 282Missing in isoform 2. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_017120283 – 364VDDIN…LKKKT → MTLMLIRISLLHRLLVLDPS QKPLQSFLPDLQITMTTLSY QSCHLCQTHYQLHLLVPAPQ HLKTLTLMIFPGGLKS in isoform 3. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB097052 mRNA Translation: BAC77405.1
D79996 mRNA Translation: BAA11491.2 Different initiation.
AK057258 mRNA Translation: BAG51894.1
AK293022 mRNA Translation: BAF85711.1
AK293040 mRNA Translation: BAF85729.1
AC009127 Genomic DNA No translation available.
AC010653 Genomic DNA No translation available.
BC000116 mRNA Translation: AAH00116.1
BC000430 mRNA Translation: AAH00430.1
BC004359 mRNA Translation: AAH04359.1
BC103745 mRNA Translation: AAI03746.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10905.1 [P53990-3]
CCDS59271.1 [P53990-5]
CCDS59272.1 [P53990-4]
CCDS59273.1 [P53990-2]
CCDS59274.1 [P53990-6]

NCBI Reference Sequences

More...RefSeqi		NP_001257904.1, NM_001270975.1 [P53990-4]
NP_001257905.1, NM_001270976.1 [P53990-5]
NP_001257906.1, NM_001270977.1 [P53990-2]
NP_001257907.1, NM_001270978.1 [P53990-6]
NP_055576.2, NM_014761.3 [P53990-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000329908; ENSP00000330408; ENSG00000182149 [P53990-3]
ENST00000378798; ENSP00000368075; ENSG00000182149 [P53990-2]
ENST00000378799; ENSP00000368076; ENSG00000182149 [P53990-4]
ENST00000535424; ENSP00000438399; ENSG00000182149 [P53990-5]
ENST00000538850; ENSP00000463711; ENSG00000182149 [P53990-6]
ENST00000541571; ENSP00000455860; ENSG00000182149 [P53990-4]
ENST00000544564; ENSP00000457844; ENSG00000182149 [P53990-4]
ENST00000606369; ENSP00000475853; ENSG00000182149 [P53990-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9798

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9798

UCSC genome browser

More...UCSCi		uc002fbk.3, human [P53990-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097052 mRNA Translation: BAC77405.1
D79996 mRNA Translation: BAA11491.2 Different initiation.
AK057258 mRNA Translation: BAG51894.1
AK293022 mRNA Translation: BAF85711.1
AK293040 mRNA Translation: BAF85729.1
AC009127 Genomic DNA No translation available.
AC010653 Genomic DNA No translation available.
BC000116 mRNA Translation: AAH00116.1
BC000430 mRNA Translation: AAH00430.1
BC004359 mRNA Translation: AAH04359.1
BC103745 mRNA Translation: AAI03746.1
CCDSiCCDS10905.1 [P53990-3]
CCDS59271.1 [P53990-5]
CCDS59272.1 [P53990-4]
CCDS59273.1 [P53990-2]
CCDS59274.1 [P53990-6]
RefSeqiNP_001257904.1, NM_001270975.1 [P53990-4]
NP_001257905.1, NM_001270976.1 [P53990-5]
NP_001257906.1, NM_001270977.1 [P53990-2]
NP_001257907.1, NM_001270978.1 [P53990-6]
NP_055576.2, NM_014761.3 [P53990-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FRRX-ray1.80A1-189[»]
3FRSX-ray2.61A5-189[»]
3JC1electron microscopy4.00Aa/Ac/Ae/Ag/Ai/Ak/Am/Ao/Aq/As/Au/Aw/Ay/Ba/Bc/Be/Bg/Bi/Bk/Bm/Bo/Bq/Bs/Bu/Bw/By/Ca/Cc/Ce/Cg6-187[»]
4U7EX-ray1.60A341-364[»]
4U7IX-ray1.79B341-364[»]
4U7YX-ray2.50B341-364[»]
4WZXX-ray1.39E342-364[»]
6E8Gelectron microscopy2.90A/BA/BB/C/DA/DB/E/FA/FB/G/HA/HB/I/JA/JB/K/LA/LB/M/NA/NB/O/PA/PB/Q/RA/RB/S/TA/TB1-364[»]
6TZ4electron microscopy3.2001/AA/AB/B/CA/CB/D/EA/EB/F/GA/GB/H/IA/IB/J/KA/KB/L/MA/MB/N/OA/OB/P/QA/QB/R/SA/SB1-189[»]
6TZ5electron microscopy3.10A/BA/BB/C/DA/DB/E/FA/FB/G/HA/HB/I/JA/JB/K/LA/LB/M/NA/NB/O/PA/PB/Q/RA/S/TA/V/VA1-189[»]
6TZAelectron microscopy7.20A/B/C/D/E/F/G/H/I/J/K/L/M/N1-189[»]
SMRiP53990
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115141, 62 interactors
DIPiDIP-42546N
IntActiP53990, 38 interactors
MINTiP53990
STRINGi9606.ENSP00000438399

PTM databases

iPTMnetiP53990
MetOSiteiP53990
PhosphoSitePlusiP53990
SwissPalmiP53990

Genetic variation databases

BioMutaiIST1
DMDMi1723119

Proteomic databases

EPDiP53990
jPOSTiP53990
MassIVEiP53990
MaxQBiP53990
PaxDbiP53990
PeptideAtlasiP53990
PRIDEiP53990
ProteomicsDBi1902
56636 [P53990-1]
56637 [P53990-2]
56638 [P53990-3]
56639 [P53990-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		44614, 128 antibodies

The DNASU plasmid repository

More...DNASUi		9798

Genome annotation databases

EnsembliENST00000329908; ENSP00000330408; ENSG00000182149 [P53990-3]
ENST00000378798; ENSP00000368075; ENSG00000182149 [P53990-2]
ENST00000378799; ENSP00000368076; ENSG00000182149 [P53990-4]
ENST00000535424; ENSP00000438399; ENSG00000182149 [P53990-5]
ENST00000538850; ENSP00000463711; ENSG00000182149 [P53990-6]
ENST00000541571; ENSP00000455860; ENSG00000182149 [P53990-4]
ENST00000544564; ENSP00000457844; ENSG00000182149 [P53990-4]
ENST00000606369; ENSP00000475853; ENSG00000182149 [P53990-6]
GeneIDi9798
KEGGihsa:9798
UCSCiuc002fbk.3, human [P53990-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9798
DisGeNETi9798

GeneCards: human genes, protein and diseases

More...GeneCardsi		IST1
HGNCiHGNC:28977, IST1
HPAiENSG00000182149, Low tissue specificity
MIMi616434, gene
neXtProtiNX_P53990
OpenTargetsiENSG00000182149
PharmGKBiPA142671633
VEuPathDBiHostDB:ENSG00000182149.20

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2027, Eukaryota
GeneTreeiENSGT00390000007453
InParanoidiP53990
OMAiPQPRSKM
OrthoDBi1302348at2759
PhylomeDBiP53990
TreeFamiTF314258

Enzyme and pathway databases

PathwayCommonsiP53990
ReactomeiR-HSA-6798695, Neutrophil degranulation
R-HSA-9668328, Sealing of the nuclear envelope (NE) by ESCRT-III

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9798, 88 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IST1, human
EvolutionaryTraceiP53990

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9798
PharosiP53990, Tbio

Protein Ontology

More...PROi		PR:P53990
RNActiP53990, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000182149, Expressed in left lobe of thyroid gland and 246 other tissues
ExpressionAtlasiP53990, baseline and differential
GenevisibleiP53990, HS

Family and domain databases

Gene3Di1.20.1260.60, 1 hit
InterProiView protein in InterPro
IPR005061, Ist1
IPR042277, IST1-like
PANTHERiPTHR12161, PTHR12161, 1 hit
PfamiView protein in Pfam
PF03398, Ist1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIST1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53990
Secondary accession number(s): A8KAH5
, J3QLU7, Q3SYM4, Q9BQ81, Q9BWN2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 7, 2021
This is version 176 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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