SLC16A1

Functionⁱ

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.1 Publication

Miscellaneous

Overexpression in pancreatic beta-cells triggers insulin secretion in response to pyruvate, causing hyperinsulemia and hypoglycemia during strenuous exercise.

GO - Molecular functionⁱ

lactate transmembrane transporter activity
Source: Reactome
Inferred from experimentⁱ
- 15917240
mevalonate transmembrane transporter activity
Source: ProtInc
Traceable author statementⁱ
- 1429658
monocarboxylic acid transmembrane transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
organic cyclic compound binding Source: Ensembl
protein homodimerization activity Source: Ensembl
symporter activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

behavioral response to nutrient Source: Ensembl
cellular response to organic cyclic compound Source: Ensembl
centrosome cycle
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23816619
glucose homeostasis Source: Ensembl
leukocyte migration Source: Reactome
lipid metabolic process Source: Ensembl
mevalonate transport
Source: ProtInc
Traceable author statementⁱ
- 1429658
monocarboxylic acid transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
plasma membrane lactate transport Source: UniProtKB
pyruvate metabolic process Source: Reactome
regulation of insulin secretion Source: Ensembl
response to food Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Symport, Transport

Biological process

Symport, Transport

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000155380-MONOMER
Reactomeⁱ	R-HSA-210991 Basigin interactions R-HSA-433692 Proton-coupled monocarboxylate transport R-HSA-5619070 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-70268 Pyruvate metabolism
SABIO-RKⁱ	P53985

Protein family/group databases

TCDBⁱ	2.A.1.13.1 the major facilitator superfamily (mfs)

TCDBⁱ

2.A.1.13.1 the major facilitator superfamily (mfs)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Monocarboxylate transporter 1 Short name: MCT 1 Alternative name(s): Solute carrier family 16 member 1
Gene namesⁱ	Name:SLC16A1 Synonyms:MCT1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000155380.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10922 SLC16A1
MIMⁱ	600682 gene
neXtProtⁱ	NX_P53985

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 15	CytoplasmicSequence analysisAdd BLAST	15
Transmembraneⁱ	16 – 36	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	37 – 59	ExtracellularSequence analysisAdd BLAST	23
Transmembraneⁱ	60 – 80	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	81 – 86	CytoplasmicSequence analysis	6
Transmembraneⁱ	87 – 107	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	108 – 111	ExtracellularSequence analysis	4
Transmembraneⁱ	112 – 132	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	133 – 143	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	144 – 164	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	165 – 166	ExtracellularSequence analysis	2
Transmembraneⁱ	167 – 187	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	188 – 262	CytoplasmicSequence analysisAdd BLAST	75
Transmembraneⁱ	263 – 283	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	284 – 298	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	299 – 319	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	320 – 328	CytoplasmicSequence analysis	9
Transmembraneⁱ	329 – 349	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	350 – 353	ExtracellularSequence analysis	4
Transmembraneⁱ	354 – 374	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	375 – 389	CytoplasmicSequence analysisAdd BLAST	15
Transmembraneⁱ	390 – 410	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	411 – 422	ExtracellularSequence analysisAdd BLAST	12
Transmembraneⁱ	423 – 443	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	444 – 500	CytoplasmicSequence analysisAdd BLAST	57

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Symptomatic deficiency in lactate transport (SDLT)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionDeficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_010434	204	K → E in SDLT. 1 PublicationCorresponds to variant dbSNP:rs80358222EnsemblClinVar.		1
Natural variantⁱVAR_010435	472	G → R in SDLT. 1 PublicationCorresponds to variant dbSNP:rs72552271EnsemblClinVar.		1

Monocarboxylate transporter 1 deficiency (MCT1D)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA metabolic disorder characterized by recurrent ketoacidosis, a pathologic state due to ketone formation exceeding ketone utilization. The clinical consequences of ketoacidosis are vomiting, osmotic diuresis, dehydration, and Kussmaul breathing. The condition may progress to decreased consciousness and, ultimately, death.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_072428	313	R → Q in MCT1D. 1 PublicationCorresponds to variant dbSNP:rs606231302EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6566
MalaCards human disease database More...MalaCardsⁱ	SLC16A1
MIMⁱ	245340 phenotype 610021 phenotype 616095 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000155380
Orphanetⁱ	165991 Exercise-induced hyperinsulinism 438075 Ketoacidosis due to monocarboxylate transporter-1 deficiency 171690 Metabolic myopathy due to lactate transporter defect
PharmGKBⁱ	PA35813

Chemistry databases

ChEMBLⁱ	CHEMBL4360
Drug and drug target database More...DrugBankⁱ	DB04319 6-Deoxyglucose DB03166 Acetic acid DB01762 Acetoacetic Acid DB04074 Alpha-ketoisovalerate DB00345 Aminohippuric acid DB00415 Ampicillin DB08892 Arbaclofen Placarbil DB03793 Benzoic Acid DB03066 D-Lactic Acid DB00529 Foscarnet DB01440 Gamma Hydroxybutyric Acid DB00142 L-Glutamic Acid DB04398 Lactic Acid DB00563 Methotrexate DB00731 Nateglinide DB00627 Niacin DB04552 Niflumic Acid DB00175 Pravastatin DB01032 Probenecid DB00119 Pyruvic acid DB04216 Quercetin DB00936 Salicylic acid DB04348 Taurocholic Acid DB00313 Valproic Acid
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	988

Polymorphism and mutation databases

BioMutaⁱ	SLC16A1
DMDMⁱ	313104214

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000211381	1 – 500	Monocarboxylate transporter 1Add BLAST		500

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	210	PhosphoserineBy similarity	1
Modified residueⁱ	213	PhosphoserineCombined sources	1
Modified residueⁱ	231	PhosphothreonineBy similarity	1
Modified residueⁱ	461	PhosphoserineCombined sources	1
Modified residueⁱ	466	PhosphothreonineCombined sources	1
Modified residueⁱ	467	PhosphoserineCombined sources	1
Modified residueⁱ	483	PhosphoserineCombined sources	1
Modified residueⁱ	498	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P53985
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P53985
PaxDbⁱ	P53985
PeptideAtlas More...PeptideAtlasⁱ	P53985
PRIDEⁱ	P53985
ProteomicsDBⁱ	56635

PTM databases

iPTMnetⁱ	P53985
PhosphoSitePlusⁱ	P53985
SwissPalmⁱ	P53985

Miscellaneous databases

PMAP-CutDBⁱ	P53985

PMAP-CutDBⁱ

P53985

Expressionⁱ

Tissue specificityⁱ

Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000155380 Expressed in 237 organ(s), highest expression level in pigmented layer of retina
CleanExⁱ	HS_SLC16A1
ExpressionAtlasⁱ	P53985 baseline and differential
Genevisibleⁱ	P53985 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB017489 CAB079035 HPA003324 HPA071055

HPAⁱ

CAB017489
CAB079035
HPA003324
HPA071055

Interactionⁱ

Subunit structureⁱ

Interacts with EMB. Interaction with either BSG or EMB is required for expression at the cell membrane (By similarity). Interacts with BSG; this is required for expression at the cell membrane.By similarity1 Publication

GO - Molecular functionⁱ

protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112454, 30 interactors
IntActⁱ	P53985, 24 interactors
Molecular INTeraction database More...MINTⁱ	P53985
STRINGⁱ	9606.ENSP00000358640

Chemistry databases

BindingDBⁱ

P53985

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P53985
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2504 Eukaryota COG0477 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118926
HOGENOMⁱ	HOG000280688
HOVERGENⁱ	HBG006384
InParanoidⁱ	P53985
KEGG Orthology (KO) More...KOⁱ	K08179
OMAⁱ	TVQELYF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05SW
PhylomeDBⁱ	P53985
TreeFamⁱ	TF313792

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR004743 MCT IPR030757 MCT1 IPR011701 MFS IPR020846 MFS_dom IPR036259 MFS_trans_sf
PANTHERⁱ	PTHR11360:SF24 PTHR11360:SF24, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07690 MFS_1, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
TIGRFAMsⁱ	TIGR00892 2A0113, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P53985-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPAVGGPVG YTPPDGGWGW AVVIGAFISI GFSYAFPKSI TVFFKEIEGI 
        60         70         80         90        100
FHATTSEVSW ISSIMLAVMY GGGPISSILV NKYGSRIVMI VGGCLSGCGL 
       110        120        130        140        150
IAASFCNTVQ QLYVCIGVIG GLGLAFNLNP ALTMIGKYFY KRRPLANGLA 
       160        170        180        190        200
MAGSPVFLCT LAPLNQVFFG IFGWRGSFLI LGGLLLNCCV AGALMRPIGP 
       210        220        230        240        250
KPTKAGKDKS KASLEKAGKS GVKKDLHDAN TDLIGRHPKQ EKRSVFQTIN 
       260        270        280        290        300
QFLDLTLFTH RGFLLYLSGN VIMFFGLFAP LVFLSSYGKS QHYSSEKSAF 
       310        320        330        340        350
LLSILAFVDM VARPSMGLVA NTKPIRPRIQ YFFAASVVAN GVCHMLAPLS 
       360        370        380        390        400
TTYVGFCVYA GFFGFAFGWL SSVLFETLMD LVGPQRFSSA VGLVTIVECC 
       410        420        430        440        450
PVLLGPPLLG RLNDMYGDYK YTYWACGVVL IISGIYLFIG MGINYRLLAK 
       460        470        480        490        500
EQKANEQKKE SKEEETSIDV AGKPNEVTKA AESPDQKDTD GGPKEEESPV

Length:500

Mass (Da):53,944

Last modified:November 30, 2010 - v3

Checksum:ⁱ3F5B048CB962ECC8

GO

Isoform 2 (identifier: P53985-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
411-500: RLNDMYGDYK...GGPKEEESPV → IVYLPTNVGLLQNKHVRWEC

« Hide

        10         20         30         40         50
MPPAVGGPVG YTPPDGGWGW AVVIGAFISI GFSYAFPKSI TVFFKEIEGI 
        60         70         80         90        100
FHATTSEVSW ISSIMLAVMY GGGPISSILV NKYGSRIVMI VGGCLSGCGL 
       110        120        130        140        150
IAASFCNTVQ QLYVCIGVIG GLGLAFNLNP ALTMIGKYFY KRRPLANGLA 
       160        170        180        190        200
MAGSPVFLCT LAPLNQVFFG IFGWRGSFLI LGGLLLNCCV AGALMRPIGP 
       210        220        230        240        250
KPTKAGKDKS KASLEKAGKS GVKKDLHDAN TDLIGRHPKQ EKRSVFQTIN 
       260        270        280        290        300
QFLDLTLFTH RGFLLYLSGN VIMFFGLFAP LVFLSSYGKS QHYSSEKSAF 
       310        320        330        340        350
LLSILAFVDM VARPSMGLVA NTKPIRPRIQ YFFAASVVAN GVCHMLAPLS 
       360        370        380        390        400
TTYVGFCVYA GFFGFAFGWL SSVLFETLMD LVGPQRFSSA VGLVTIVECC 
       410        420        430
PVLLGPPLLG IVYLPTNVGL LQNKHVRWEC

Note: No experimental confirmation available.

Show »

Length:430

Mass (Da):46,234

Checksum:ⁱ28C6B55692E6C4BE

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5T8R5	Q5T8R5_HUMAN	Monocarboxylate transporter 1 Monocarboxylate transporter 1 (Solute carrier family 16 (Monocarboxylic acid transporters), member 1, isoform CRA_a)	SLC16A1 hCG_37455	456	Annotation score:
Q5T8R3	Q5T8R3_HUMAN	Monocarboxylate transporter 1 Monocarboxylate transporter 1	SLC16A1	296	Annotation score:
Q5T8R4	Q5T8R4_HUMAN	Monocarboxylate transporter 1 Monocarboxylate transporter 1	SLC16A1	215	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	480	A → T in AAC41707 (PubMed:7835905).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_054804	85	S → G. Corresponds to variant dbSNP:rs11551867Ensembl.	1
Natural variantⁱVAR_010434	204	K → E in SDLT. 1 PublicationCorresponds to variant dbSNP:rs80358222EnsemblClinVar.	1
Natural variantⁱVAR_072428	313	R → Q in MCT1D. 1 PublicationCorresponds to variant dbSNP:rs606231302EnsemblClinVar.	1
Natural variantⁱVAR_010435	472	G → R in SDLT. 1 PublicationCorresponds to variant dbSNP:rs72552271EnsemblClinVar.	1
Natural variantⁱVAR_010436	490	D → ECombined sources3 PublicationsCorresponds to variant dbSNP:rs1049434EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056191	411 – 500	RLNDM…EESPV → IVYLPTNVGLLQNKHVRWEC in isoform 2. 1 PublicationAdd BLAST		90

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L31801 mRNA Translation: AAC41707.1 AJ438945 Genomic DNA Translation: CAD27707.1 AL162079 mRNA Translation: CAB82412.1 AL158844 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56552.1 BC026317 mRNA Translation: AAH26317.1 BC045664 mRNA Translation: AAH45664.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS858.1 [P53985-1]
PIRⁱ	A55568
NCBI Reference Sequences More...RefSeqⁱ	NP_001159968.1, NM_001166496.1 [P53985-1] NP_003042.3, NM_003051.3 [P53985-1] XP_011540328.1, XM_011542026.2 XP_011540329.1, XM_011542027.2
UniGeneⁱ	Hs.75231

Genome annotation databases

Ensemblⁱ	ENST00000369626; ENSP00000358640; ENSG00000155380 [P53985-1] ENST00000538576; ENSP00000441065; ENSG00000155380 [P53985-1] ENST00000628110; ENSP00000485688; ENSG00000281917 [P53985-1] ENST00000630362; ENSP00000486000; ENSG00000281917 [P53985-1]
GeneIDⁱ	6566
KEGGⁱ	hsa:6566
UCSC genome browser More...UCSCⁱ	uc001ecx.4 human [P53985-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P53985	Solute carrier family 16 (Monocarboxylic acid transporters), member 1, isoform CRA_b		HUMAN		500	UniRef100_P53985
Monocarboxylate transporter 1 (Fragment)		HUMAN		456
Monocarboxylate transporter 1 (Fragment)		HUMAN		296
Monocarboxylate transporter 1 (Fragment)		HUMAN		215

Protein	Similar proteins		Species	Score	Length	Source
P53985	Solute carrier family 16 (Monocarboxylic acid transporters), member 1, isoform CRA_b		HUMAN		500	UniRef90_P53985
Monocarboxylate transporter 1		MACMU		500
SLC16A1 isoform 2		PANTR		500
Uncharacterized protein		PANPA		500
SLC16A1 isoform 5 (Fragment)		PONAB		456
+32

Protein	Similar proteins		Species	Score	Length	Source
P53985	Monocarboxylate transporter 1		BOVIN		501	UniRef50_P53985
Monocarboxylate transporter 1 (Fragment)		MERUN		76
Monocarboxylate transporter 1		CRILO		494
Solute carrier family 16 (Monocarboxylic acid transporters), member 1, isoform CRA_b		HUMAN		500
Uncharacterized protein		NOMLE		500
+250

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L31801 mRNA Translation: AAC41707.1 AJ438945 Genomic DNA Translation: CAD27707.1 AL162079 mRNA Translation: CAB82412.1 AL158844 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56552.1 BC026317 mRNA Translation: AAH26317.1 BC045664 mRNA Translation: AAH45664.1
CCDSⁱ	CCDS858.1 [P53985-1]
PIRⁱ	A55568
RefSeqⁱ	NP_001159968.1, NM_001166496.1 [P53985-1] NP_003042.3, NM_003051.3 [P53985-1] XP_011540328.1, XM_011542026.2 XP_011540329.1, XM_011542027.2
UniGeneⁱ	Hs.75231

3D structure databases

ProteinModelPortalⁱ	P53985
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112454, 30 interactors
IntActⁱ	P53985, 24 interactors
MINTⁱ	P53985
STRINGⁱ	9606.ENSP00000358640

Chemistry databases

BindingDBⁱ	P53985
ChEMBLⁱ	CHEMBL4360
DrugBankⁱ	DB04319 6-Deoxyglucose DB03166 Acetic acid DB01762 Acetoacetic Acid DB04074 Alpha-ketoisovalerate DB00345 Aminohippuric acid DB00415 Ampicillin DB08892 Arbaclofen Placarbil DB03793 Benzoic Acid DB03066 D-Lactic Acid DB00529 Foscarnet DB01440 Gamma Hydroxybutyric Acid DB00142 L-Glutamic Acid DB04398 Lactic Acid DB00563 Methotrexate DB00731 Nateglinide DB00627 Niacin DB04552 Niflumic Acid DB00175 Pravastatin DB01032 Probenecid DB00119 Pyruvic acid DB04216 Quercetin DB00936 Salicylic acid DB04348 Taurocholic Acid DB00313 Valproic Acid
GuidetoPHARMACOLOGYⁱ	988

Protein family/group databases

TCDBⁱ	2.A.1.13.1 the major facilitator superfamily (mfs)

TCDBⁱ

2.A.1.13.1 the major facilitator superfamily (mfs)

PTM databases

iPTMnetⁱ	P53985
PhosphoSitePlusⁱ	P53985
SwissPalmⁱ	P53985

Polymorphism and mutation databases

BioMutaⁱ	SLC16A1
DMDMⁱ	313104214

Proteomic databases

EPDⁱ	P53985
MaxQBⁱ	P53985
PaxDbⁱ	P53985
PeptideAtlasⁱ	P53985
PRIDEⁱ	P53985
ProteomicsDBⁱ	56635

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6566
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369626; ENSP00000358640; ENSG00000155380 [P53985-1] ENST00000538576; ENSP00000441065; ENSG00000155380 [P53985-1] ENST00000628110; ENSP00000485688; ENSG00000281917 [P53985-1] ENST00000630362; ENSP00000486000; ENSG00000281917 [P53985-1]
GeneIDⁱ	6566
KEGGⁱ	hsa:6566
UCSCⁱ	uc001ecx.4 human [P53985-1]

Organism-specific databases

CTDⁱ	6566
DisGeNETⁱ	6566
EuPathDBⁱ	HostDB:ENSG00000155380.11
GeneCardsⁱ	SLC16A1
H-InvDBⁱ	HIX0000897
HGNCⁱ	HGNC:10922 SLC16A1
HPAⁱ	CAB017489 CAB079035 HPA003324 HPA071055
MalaCardsⁱ	SLC16A1
MIMⁱ	245340 phenotype 600682 gene 610021 phenotype 616095 phenotype
neXtProtⁱ	NX_P53985
OpenTargetsⁱ	ENSG00000155380
Orphanetⁱ	165991 Exercise-induced hyperinsulinism 438075 Ketoacidosis due to monocarboxylate transporter-1 deficiency 171690 Metabolic myopathy due to lactate transporter defect
PharmGKBⁱ	PA35813
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2504 Eukaryota COG0477 LUCA
GeneTreeⁱ	ENSGT00760000118926
HOGENOMⁱ	HOG000280688
HOVERGENⁱ	HBG006384
InParanoidⁱ	P53985
KOⁱ	K08179
OMAⁱ	TVQELYF
OrthoDBⁱ	EOG091G05SW
PhylomeDBⁱ	P53985
TreeFamⁱ	TF313792

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000155380-MONOMER
Reactomeⁱ	R-HSA-210991 Basigin interactions R-HSA-433692 Proton-coupled monocarboxylate transport R-HSA-5619070 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-70268 Pyruvate metabolism
SABIO-RKⁱ	P53985

Miscellaneous databases

ChiTaRSⁱ	SLC16A1 human
GenomeRNAiⁱ	6566
PMAP-CutDBⁱ	P53985
Protein Ontology More...PROⁱ	PR:P53985
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000155380 Expressed in 237 organ(s), highest expression level in pigmented layer of retina
CleanExⁱ	HS_SLC16A1
ExpressionAtlasⁱ	P53985 baseline and differential
Genevisibleⁱ	P53985 HS

Family and domain databases

CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR004743 MCT IPR030757 MCT1 IPR011701 MFS IPR020846 MFS_dom IPR036259 MFS_trans_sf
PANTHERⁱ	PTHR11360:SF24 PTHR11360:SF24, 1 hit
Pfamⁱ	View protein in Pfam PF07690 MFS_1, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
TIGRFAMsⁱ	TIGR00892 2A0113, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MOT1_HUMAN
Accessionⁱ	P53985Primary (citable) accession number: P53985 Secondary accession number(s): Q49A45, Q5T8R6, Q9NSJ9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	November 30, 2010
	Last modified:	November 7, 2018
	This is version 185 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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Supporting data

UniProtKB - P53985 (MOT1_HUMAN)

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Monocarboxylate transporter 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytoskeleton

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ