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UniProtKB - P53985 (MOT1_HUMAN)

Entry version 191 (03 Jul 2019)
Sequence version 3 (30 Nov 2010)
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Protein

Monocarboxylate transporter 1

Gene

SLC16A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.1 Publication

Miscellaneous

Overexpression in pancreatic beta-cells triggers insulin secretion in response to pyruvate, causing hyperinsulemia and hypoglycemia during strenuous exercise.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:ENSG00000155380-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-210991 Basigin interactions
R-HSA-433692 Proton-coupled monocarboxylate transport
R-HSA-5619070 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)
R-HSA-70268 Pyruvate metabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P53985

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.1.13.1 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Monocarboxylate transporter 1
Short name:
MCT 1
Alternative name(s):
Solute carrier family 16 member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC16A1
Synonyms:MCT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10922 SLC16A1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600682 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P53985

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 59ExtracellularSequence analysisAdd BLAST23
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 86CytoplasmicSequence analysis6
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 111ExtracellularSequence analysis4
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 143CytoplasmicSequence analysisAdd BLAST11
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Topological domaini165 – 166ExtracellularSequence analysis2
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 262CytoplasmicSequence analysisAdd BLAST75
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 298ExtracellularSequence analysisAdd BLAST15
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 328CytoplasmicSequence analysis9
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Topological domaini350 – 353ExtracellularSequence analysis4
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Topological domaini375 – 389CytoplasmicSequence analysisAdd BLAST15
Transmembranei390 – 410HelicalSequence analysisAdd BLAST21
Topological domaini411 – 422ExtracellularSequence analysisAdd BLAST12
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 500CytoplasmicSequence analysisAdd BLAST57

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Symptomatic deficiency in lactate transport (SDLT)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionDeficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_010434204K → E in SDLT. 1 PublicationCorresponds to variant dbSNP:rs80358222EnsemblClinVar.1
Natural variantiVAR_010435472G → R in SDLT. 1 PublicationCorresponds to variant dbSNP:rs72552271EnsemblClinVar.1
Familial hyperinsulinemic hypoglycemia 7 (HHF7)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionDominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load.
Related information in OMIM
Monocarboxylate transporter 1 deficiency (MCT1D)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic disorder characterized by recurrent ketoacidosis, a pathologic state due to ketone formation exceeding ketone utilization. The clinical consequences of ketoacidosis are vomiting, osmotic diuresis, dehydration, and Kussmaul breathing. The condition may progress to decreased consciousness and, ultimately, death.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_072428313R → Q in MCT1D. 1 PublicationCorresponds to variant dbSNP:rs606231302EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		6566

MalaCards human disease database

More...MalaCardsi		SLC16A1
MIMi245340 phenotype
610021 phenotype
616095 phenotype

Open Targets

More...OpenTargetsi		ENSG00000155380

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		165991 Exercise-induced hyperinsulinism
438075 Ketoacidosis due to monocarboxylate transporter-1 deficiency
171690 Metabolic myopathy due to lactate transporter defect

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35813

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4360

Drug and drug target database

More...DrugBanki		DB04319 6-Deoxyglucose
DB03166 Acetic acid
DB01762 Acetoacetic Acid
DB04074 Alpha-ketoisovalerate
DB00345 Aminohippuric acid
DB00415 Ampicillin
DB08892 Arbaclofen Placarbil
DB03793 Benzoic Acid
DB03066 D-Lactic Acid
DB00529 Foscarnet
DB01440 Gamma Hydroxybutyric Acid
DB00142 L-Glutamic Acid
DB04398 Lactic Acid
DB00563 Methotrexate
DB00731 Nateglinide
DB00627 Niacin
DB04552 Niflumic Acid
DB00175 Pravastatin
DB01032 Probenecid
DB00119 Pyruvic acid
DB04216 Quercetin
DB00936 Salicylic acid
DB04348 Taurocholic Acid
DB00313 Valproic Acid

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		988

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC16A1

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104214

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002113811 – 500Monocarboxylate transporter 1Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei210PhosphoserineBy similarity1
Modified residuei213PhosphoserineCombined sources1
Modified residuei231PhosphothreonineBy similarity1
Modified residuei461PhosphoserineCombined sources1
Modified residuei466PhosphothreonineCombined sources1
Modified residuei467PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1
Modified residuei498PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P53985

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P53985

MaxQB - The MaxQuant DataBase

More...MaxQBi		P53985

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P53985

PeptideAtlas

More...PeptideAtlasi		P53985

PRoteomics IDEntifications database

More...PRIDEi		P53985

ProteomicsDB human proteome resource

More...ProteomicsDBi		56635

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P53985

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P53985

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P53985

Miscellaneous databases

CutDB - Proteolytic event database

More...PMAP-CutDBi		P53985

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000155380 Expressed in 237 organ(s), highest expression level in pigmented layer of retina

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P53985 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P53985 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB017489
CAB079035
HPA003324
HPA071055

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EMB. Interaction with either BSG or EMB is required for expression at the cell membrane (By similarity).

Interacts with BSG; this is required for expression at the cell membrane.

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		112454, 50 interactors

Protein interaction database and analysis system

More...IntActi		P53985, 30 interactors

Molecular INTeraction database

More...MINTi		P53985

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000441065

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P53985

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2504 Eukaryota
COG0477 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154955

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000280688

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P53985

KEGG Orthology (KO)

More...KOi		K08179

Identification of Orthologs from Complete Genome Data

More...OMAi		TVQELYF

Database of Orthologous Groups

More...OrthoDBi		916876at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P53985

TreeFam database of animal gene trees

More...TreeFami		TF313792

Family and domain databases

Conserved Domains Database

More...CDDi		cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004743 MCT
IPR030757 MCT1
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf

The PANTHER Classification System

More...PANTHERi		PTHR11360:SF24 PTHR11360:SF24, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07690 MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00892 2A0113, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50850 MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P53985-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPPAVGGPVG YTPPDGGWGW AVVIGAFISI GFSYAFPKSI TVFFKEIEGI 
        60         70         80         90        100
FHATTSEVSW ISSIMLAVMY GGGPISSILV NKYGSRIVMI VGGCLSGCGL 
       110        120        130        140        150
IAASFCNTVQ QLYVCIGVIG GLGLAFNLNP ALTMIGKYFY KRRPLANGLA 
       160        170        180        190        200
MAGSPVFLCT LAPLNQVFFG IFGWRGSFLI LGGLLLNCCV AGALMRPIGP 
       210        220        230        240        250
KPTKAGKDKS KASLEKAGKS GVKKDLHDAN TDLIGRHPKQ EKRSVFQTIN 
       260        270        280        290        300
QFLDLTLFTH RGFLLYLSGN VIMFFGLFAP LVFLSSYGKS QHYSSEKSAF 
       310        320        330        340        350
LLSILAFVDM VARPSMGLVA NTKPIRPRIQ YFFAASVVAN GVCHMLAPLS 
       360        370        380        390        400
TTYVGFCVYA GFFGFAFGWL SSVLFETLMD LVGPQRFSSA VGLVTIVECC 
       410        420        430        440        450
PVLLGPPLLG RLNDMYGDYK YTYWACGVVL IISGIYLFIG MGINYRLLAK 
       460        470        480        490        500
EQKANEQKKE SKEEETSIDV AGKPNEVTKA AESPDQKDTD GGPKEEESPV
Length:500
Mass (Da):53,944
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F5B048CB962ECC8
GO
Isoform 2 (identifier: P53985-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     411-500: RLNDMYGDYK...GGPKEEESPV → IVYLPTNVGLLQNKHVRWEC

Note: No experimental confirmation available.
Show »
Length:430
Mass (Da):46,234
Checksum:i28C6B55692E6C4BE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T8R5Q5T8R5_HUMAN
Monocarboxylate transporter 1
SLC16A1 hCG_37455
456Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T8R3Q5T8R3_HUMAN
Monocarboxylate transporter 1
SLC16A1
296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T8R4Q5T8R4_HUMAN
Monocarboxylate transporter 1
SLC16A1
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti480A → T in AAC41707 (PubMed:7835905).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05480485S → G. Corresponds to variant dbSNP:rs11551867Ensembl.1
Natural variantiVAR_010434204K → E in SDLT. 1 PublicationCorresponds to variant dbSNP:rs80358222EnsemblClinVar.1
Natural variantiVAR_072428313R → Q in MCT1D. 1 PublicationCorresponds to variant dbSNP:rs606231302EnsemblClinVar.1
Natural variantiVAR_010435472G → R in SDLT. 1 PublicationCorresponds to variant dbSNP:rs72552271EnsemblClinVar.1
Natural variantiVAR_010436490D → ECombined sources3 PublicationsCorresponds to variant dbSNP:rs1049434EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056191411 – 500RLNDM…EESPV → IVYLPTNVGLLQNKHVRWEC in isoform 2. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L31801 mRNA Translation: AAC41707.1
AJ438945 Genomic DNA Translation: CAD27707.1
AL162079 mRNA Translation: CAB82412.1
AL158844 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56552.1
BC026317 mRNA Translation: AAH26317.1
BC045664 mRNA Translation: AAH45664.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS858.1 [P53985-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A55568

NCBI Reference Sequences

More...RefSeqi		NP_001159968.1, NM_001166496.1 [P53985-1]
NP_003042.3, NM_003051.3 [P53985-1]
XP_011540328.1, XM_011542026.2
XP_011540329.1, XM_011542027.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369626; ENSP00000358640; ENSG00000155380 [P53985-1]
ENST00000538576; ENSP00000441065; ENSG00000155380 [P53985-1]
ENST00000628110; ENSP00000485688; ENSG00000281917 [P53985-1]
ENST00000630362; ENSP00000486000; ENSG00000281917 [P53985-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6566

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6566

UCSC genome browser

More...UCSCi		uc001ecx.4 human [P53985-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31801 mRNA Translation: AAC41707.1
AJ438945 Genomic DNA Translation: CAD27707.1
AL162079 mRNA Translation: CAB82412.1
AL158844 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56552.1
BC026317 mRNA Translation: AAH26317.1
BC045664 mRNA Translation: AAH45664.1
CCDSiCCDS858.1 [P53985-1]
PIRiA55568
RefSeqiNP_001159968.1, NM_001166496.1 [P53985-1]
NP_003042.3, NM_003051.3 [P53985-1]
XP_011540328.1, XM_011542026.2
XP_011540329.1, XM_011542027.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi112454, 50 interactors
IntActiP53985, 30 interactors
MINTiP53985
STRINGi9606.ENSP00000441065

Chemistry databases

BindingDBiP53985
ChEMBLiCHEMBL4360
DrugBankiDB04319 6-Deoxyglucose
DB03166 Acetic acid
DB01762 Acetoacetic Acid
DB04074 Alpha-ketoisovalerate
DB00345 Aminohippuric acid
DB00415 Ampicillin
DB08892 Arbaclofen Placarbil
DB03793 Benzoic Acid
DB03066 D-Lactic Acid
DB00529 Foscarnet
DB01440 Gamma Hydroxybutyric Acid
DB00142 L-Glutamic Acid
DB04398 Lactic Acid
DB00563 Methotrexate
DB00731 Nateglinide
DB00627 Niacin
DB04552 Niflumic Acid
DB00175 Pravastatin
DB01032 Probenecid
DB00119 Pyruvic acid
DB04216 Quercetin
DB00936 Salicylic acid
DB04348 Taurocholic Acid
DB00313 Valproic Acid
GuidetoPHARMACOLOGYi988

Protein family/group databases

TCDBi2.A.1.13.1 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiP53985
PhosphoSitePlusiP53985
SwissPalmiP53985

Polymorphism and mutation databases

BioMutaiSLC16A1
DMDMi313104214

Proteomic databases

EPDiP53985
jPOSTiP53985
MaxQBiP53985
PaxDbiP53985
PeptideAtlasiP53985
PRIDEiP53985
ProteomicsDBi56635

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		6566
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369626; ENSP00000358640; ENSG00000155380 [P53985-1]
ENST00000538576; ENSP00000441065; ENSG00000155380 [P53985-1]
ENST00000628110; ENSP00000485688; ENSG00000281917 [P53985-1]
ENST00000630362; ENSP00000486000; ENSG00000281917 [P53985-1]
GeneIDi6566
KEGGihsa:6566
UCSCiuc001ecx.4 human [P53985-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6566
DisGeNETi6566

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC16A1

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0000897
HGNCiHGNC:10922 SLC16A1
HPAiCAB017489
CAB079035
HPA003324
HPA071055
MalaCardsiSLC16A1
MIMi245340 phenotype
600682 gene
610021 phenotype
616095 phenotype
neXtProtiNX_P53985
OpenTargetsiENSG00000155380
Orphaneti165991 Exercise-induced hyperinsulinism
438075 Ketoacidosis due to monocarboxylate transporter-1 deficiency
171690 Metabolic myopathy due to lactate transporter defect
PharmGKBiPA35813

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2504 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00940000154955
HOGENOMiHOG000280688
InParanoidiP53985
KOiK08179
OMAiTVQELYF
OrthoDBi916876at2759
PhylomeDBiP53985
TreeFamiTF313792

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000155380-MONOMER
ReactomeiR-HSA-210991 Basigin interactions
R-HSA-433692 Proton-coupled monocarboxylate transport
R-HSA-5619070 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)
R-HSA-70268 Pyruvate metabolism
SABIO-RKiP53985

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC16A1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6566
PMAP-CutDBiP53985

Protein Ontology

More...PROi		PR:P53985

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000155380 Expressed in 237 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiP53985 baseline and differential
GenevisibleiP53985 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR004743 MCT
IPR030757 MCT1
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PANTHERiPTHR11360:SF24 PTHR11360:SF24, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00892 2A0113, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53985
Secondary accession number(s): Q49A45, Q5T8R6, Q9NSJ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 30, 2010
Last modified: July 3, 2019
This is version 191 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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