UniProtKB - P53985 (MOT1_HUMAN)
Protein
Monocarboxylate transporter 1
Gene
SLC16A1
Organism
Homo sapiens (Human)
Status
Functioni
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.1 Publication
Miscellaneous
Overexpression in pancreatic beta-cells triggers insulin secretion in response to pyruvate, causing hyperinsulemia and hypoglycemia during strenuous exercise.
GO - Molecular functioni
- carboxylic acid transmembrane transporter activity Source: ARUK-UCL
- identical protein binding Source: Ensembl
- lactate transmembrane transporter activity Source: ARUK-UCL
- mevalonate transmembrane transporter activity Source: ProtInc
- monocarboxylic acid transmembrane transporter activity Source: ARUK-UCL
- organic cyclic compound binding Source: Ensembl
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- behavioral response to nutrient Source: Ensembl
- carboxylic acid transmembrane transport Source: ARUK-UCL
- cellular response to organic cyclic compound Source: Ensembl
- centrosome cycle Source: UniProtKB
- glucose homeostasis Source: Ensembl
- leukocyte migration Source: Reactome
- lipid metabolic process Source: Ensembl
- mevalonate transport Source: ProtInc
- monocarboxylic acid transport Source: ARUK-UCL
- plasma membrane lactate transport Source: UniProtKB
- pyruvate metabolic process Source: Reactome
- regulation of insulin secretion Source: Ensembl
- response to food Source: Ensembl
- transport across blood-brain barrier Source: ARUK-UCL
Keywordsi
Biological process | Symport, Transport |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000155380-MONOMER |
PathwayCommonsi | P53985 |
Reactomei | R-HSA-210991, Basigin interactions R-HSA-433692, Proton-coupled monocarboxylate transport R-HSA-5619070, Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-70268, Pyruvate metabolism |
SABIO-RKi | P53985 |
Protein family/group databases
TCDBi | 2.A.1.13.1, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Monocarboxylate transporter 1Short name: MCT 1 Alternative name(s): Solute carrier family 16 member 1 |
Gene namesi | Name:SLC16A1 Synonyms:MCT1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000155380.11 |
HGNCi | HGNC:10922, SLC16A1 |
MIMi | 600682, gene |
neXtProti | NX_P53985 |
Subcellular locationi
Plasma membrane
- Cell membrane 4 Publications; Multi-pass membrane protein Sequence analysis
Cytoskeleton
- centrosome Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: ARUK-UCL
- basal plasma membrane Source: ARUK-UCL
- basolateral plasma membrane Source: ARUK-UCL
- integral component of plasma membrane Source: UniProtKB
- lateral plasma membrane Source: ARUK-UCL
- plasma membrane Source: UniProtKB
Other locations
- cell junction Source: HPA
- integral component of membrane Source: GO_Central
- intracellular membrane-bounded organelle Source: HPA
- membrane Source: UniProtKB
- synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 15 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 16 – 36 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 37 – 59 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 60 – 80 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 81 – 86 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 108 – 111 | ExtracellularSequence analysis | 4 | |
Transmembranei | 112 – 132 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 133 – 143 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 144 – 164 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 165 – 166 | ExtracellularSequence analysis | 2 | |
Transmembranei | 167 – 187 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 188 – 262 | CytoplasmicSequence analysisAdd BLAST | 75 | |
Transmembranei | 263 – 283 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 284 – 298 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 299 – 319 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 320 – 328 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 329 – 349 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 350 – 353 | ExtracellularSequence analysis | 4 | |
Transmembranei | 354 – 374 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 375 – 389 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 390 – 410 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 411 – 422 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 423 – 443 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 444 – 500 | CytoplasmicSequence analysisAdd BLAST | 57 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Symptomatic deficiency in lactate transport (SDLT)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionDeficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_010434 | 204 | K → E in SDLT. 1 PublicationCorresponds to variant dbSNP:rs80358222EnsemblClinVar. | 1 | |
Natural variantiVAR_010435 | 472 | G → R in SDLT. 1 PublicationCorresponds to variant dbSNP:rs72552271EnsemblClinVar. | 1 |
Familial hyperinsulinemic hypoglycemia 7 (HHF7)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionDominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load.
Related information in OMIMMonocarboxylate transporter 1 deficiency (MCT1D)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic disorder characterized by recurrent ketoacidosis, a pathologic state due to ketone formation exceeding ketone utilization. The clinical consequences of ketoacidosis are vomiting, osmotic diuresis, dehydration, and Kussmaul breathing. The condition may progress to decreased consciousness and, ultimately, death.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072428 | 313 | R → Q in MCT1D. 1 PublicationCorresponds to variant dbSNP:rs606231302EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 6566 |
MalaCardsi | SLC16A1 |
MIMi | 245340, phenotype 610021, phenotype 616095, phenotype |
OpenTargetsi | ENSG00000155380 |
Orphaneti | 165991, Exercise-induced hyperinsulinism 438075, Ketoacidosis due to monocarboxylate transporter-1 deficiency 171690, Metabolic myopathy due to lactate transporter defect |
PharmGKBi | PA35813 |
Miscellaneous databases
Pharosi | P53985, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4360 |
DrugBanki | DB03166, Acetic acid DB01762, Acetoacetic acid DB03773, alpha-D-quinovopyranose DB04074, alpha-Ketoisovalerate DB00345, Aminohippuric acid DB00415, Ampicillin DB08892, Arbaclofen Placarbil DB03793, Benzoic acid DB03066, D-Lactic acid DB00529, Foscarnet DB01440, gamma-Hydroxybutyric acid DB00142, Glutamic acid DB04398, Lactic acid DB09338, Mersalyl DB00563, Methotrexate DB00731, Nateglinide DB00627, Niacin DB04552, Niflumic acid DB00175, Pravastatin DB01032, Probenecid DB00119, Pyruvic acid DB04216, Quercetin DB00936, Salicylic acid DB04348, Taurocholic acid DB00313, Valproic acid |
GuidetoPHARMACOLOGYi | 988 |
Polymorphism and mutation databases
BioMutai | SLC16A1 |
DMDMi | 313104214 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211381 | 1 – 500 | Monocarboxylate transporter 1Add BLAST | 500 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 210 | PhosphoserineBy similarity | 1 | |
Modified residuei | 213 | PhosphoserineCombined sources | 1 | |
Modified residuei | 231 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 461 | PhosphoserineCombined sources | 1 | |
Modified residuei | 466 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 467 | PhosphoserineCombined sources | 1 | |
Modified residuei | 483 | PhosphoserineCombined sources | 1 | |
Modified residuei | 498 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P53985 |
jPOSTi | P53985 |
MassIVEi | P53985 |
MaxQBi | P53985 |
PaxDbi | P53985 |
PeptideAtlasi | P53985 |
PRIDEi | P53985 |
ProteomicsDBi | 56635 [P53985-1] 62023 |
PTM databases
iPTMneti | P53985 |
PhosphoSitePlusi | P53985 |
SwissPalmi | P53985 |
Expressioni
Tissue specificityi
Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000155380, Expressed in pigmented layer of retina and 245 other tissues |
ExpressionAtlasi | P53985, baseline and differential |
Genevisiblei | P53985, HS |
Organism-specific databases
HPAi | ENSG00000155380, Low tissue specificity |
Interactioni
Subunit structurei
GO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 112454, 66 interactors |
IntActi | P53985, 38 interactors |
MINTi | P53985 |
STRINGi | 9606.ENSP00000441065 |
Chemistry databases
BindingDBi | P53985 |
Miscellaneous databases
RNActi | P53985, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2504, Eukaryota |
GeneTreei | ENSGT00940000154955 |
InParanoidi | P53985 |
OMAi | VCFGWGM |
PhylomeDBi | P53985 |
TreeFami | TF313792 |
Family and domain databases
InterProi | View protein in InterPro IPR004743, MCT IPR030757, MCT1 IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
PANTHERi | PTHR11360:SF24, PTHR11360:SF24, 1 hit |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00892, 2A0113, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P53985-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPPAVGGPVG YTPPDGGWGW AVVIGAFISI GFSYAFPKSI TVFFKEIEGI
60 70 80 90 100
FHATTSEVSW ISSIMLAVMY GGGPISSILV NKYGSRIVMI VGGCLSGCGL
110 120 130 140 150
IAASFCNTVQ QLYVCIGVIG GLGLAFNLNP ALTMIGKYFY KRRPLANGLA
160 170 180 190 200
MAGSPVFLCT LAPLNQVFFG IFGWRGSFLI LGGLLLNCCV AGALMRPIGP
210 220 230 240 250
KPTKAGKDKS KASLEKAGKS GVKKDLHDAN TDLIGRHPKQ EKRSVFQTIN
260 270 280 290 300
QFLDLTLFTH RGFLLYLSGN VIMFFGLFAP LVFLSSYGKS QHYSSEKSAF
310 320 330 340 350
LLSILAFVDM VARPSMGLVA NTKPIRPRIQ YFFAASVVAN GVCHMLAPLS
360 370 380 390 400
TTYVGFCVYA GFFGFAFGWL SSVLFETLMD LVGPQRFSSA VGLVTIVECC
410 420 430 440 450
PVLLGPPLLG RLNDMYGDYK YTYWACGVVL IISGIYLFIG MGINYRLLAK
460 470 480 490 500
EQKANEQKKE SKEEETSIDV AGKPNEVTKA AESPDQKDTD GGPKEEESPV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5T8R5 | Q5T8R5_HUMAN | Monocarboxylate transporter 1 | SLC16A1 hCG_37455 | 456 | Annotation score: | ||
Q5T8R3 | Q5T8R3_HUMAN | Monocarboxylate transporter 1 | SLC16A1 | 296 | Annotation score: | ||
Q5T8R4 | Q5T8R4_HUMAN | Monocarboxylate transporter 1 | SLC16A1 | 215 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 480 | A → T in AAC41707 (PubMed:7835905).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054804 | 85 | S → G. Corresponds to variant dbSNP:rs11551867Ensembl. | 1 | |
Natural variantiVAR_010434 | 204 | K → E in SDLT. 1 PublicationCorresponds to variant dbSNP:rs80358222EnsemblClinVar. | 1 | |
Natural variantiVAR_072428 | 313 | R → Q in MCT1D. 1 PublicationCorresponds to variant dbSNP:rs606231302EnsemblClinVar. | 1 | |
Natural variantiVAR_010435 | 472 | G → R in SDLT. 1 PublicationCorresponds to variant dbSNP:rs72552271EnsemblClinVar. | 1 | |
Natural variantiVAR_010436 | 490 | D → ECombined sources3 PublicationsCorresponds to variant dbSNP:rs1049434EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056191 | 411 – 500 | RLNDM…EESPV → IVYLPTNVGLLQNKHVRWEC in isoform 2. 1 PublicationAdd BLAST | 90 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L31801 mRNA Translation: AAC41707.1 AJ438945 Genomic DNA Translation: CAD27707.1 AL162079 mRNA Translation: CAB82412.1 AL158844 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56552.1 BC026317 mRNA Translation: AAH26317.1 BC045664 mRNA Translation: AAH45664.1 |
CCDSi | CCDS858.1 [P53985-1] |
PIRi | A55568 |
RefSeqi | NP_001159968.1, NM_001166496.1 [P53985-1] NP_003042.3, NM_003051.3 [P53985-1] XP_011540328.1, XM_011542026.2 XP_011540329.1, XM_011542027.2 |
Genome annotation databases
Ensembli | ENST00000369626; ENSP00000358640; ENSG00000155380 [P53985-1] ENST00000538576; ENSP00000441065; ENSG00000155380 [P53985-1] ENST00000628110; ENSP00000485688; ENSG00000281917 [P53985-1] ENST00000630362; ENSP00000486000; ENSG00000281917 [P53985-1] |
GeneIDi | 6566 |
KEGGi | hsa:6566 |
UCSCi | uc001ecx.4, human [P53985-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L31801 mRNA Translation: AAC41707.1 AJ438945 Genomic DNA Translation: CAD27707.1 AL162079 mRNA Translation: CAB82412.1 AL158844 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56552.1 BC026317 mRNA Translation: AAH26317.1 BC045664 mRNA Translation: AAH45664.1 |
CCDSi | CCDS858.1 [P53985-1] |
PIRi | A55568 |
RefSeqi | NP_001159968.1, NM_001166496.1 [P53985-1] NP_003042.3, NM_003051.3 [P53985-1] XP_011540328.1, XM_011542026.2 XP_011540329.1, XM_011542027.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 112454, 66 interactors |
IntActi | P53985, 38 interactors |
MINTi | P53985 |
STRINGi | 9606.ENSP00000441065 |
Chemistry databases
BindingDBi | P53985 |
ChEMBLi | CHEMBL4360 |
DrugBanki | DB03166, Acetic acid DB01762, Acetoacetic acid DB03773, alpha-D-quinovopyranose DB04074, alpha-Ketoisovalerate DB00345, Aminohippuric acid DB00415, Ampicillin DB08892, Arbaclofen Placarbil DB03793, Benzoic acid DB03066, D-Lactic acid DB00529, Foscarnet DB01440, gamma-Hydroxybutyric acid DB00142, Glutamic acid DB04398, Lactic acid DB09338, Mersalyl DB00563, Methotrexate DB00731, Nateglinide DB00627, Niacin DB04552, Niflumic acid DB00175, Pravastatin DB01032, Probenecid DB00119, Pyruvic acid DB04216, Quercetin DB00936, Salicylic acid DB04348, Taurocholic acid DB00313, Valproic acid |
GuidetoPHARMACOLOGYi | 988 |
Protein family/group databases
TCDBi | 2.A.1.13.1, the major facilitator superfamily (mfs) |
PTM databases
iPTMneti | P53985 |
PhosphoSitePlusi | P53985 |
SwissPalmi | P53985 |
Polymorphism and mutation databases
BioMutai | SLC16A1 |
DMDMi | 313104214 |
Proteomic databases
EPDi | P53985 |
jPOSTi | P53985 |
MassIVEi | P53985 |
MaxQBi | P53985 |
PaxDbi | P53985 |
PeptideAtlasi | P53985 |
PRIDEi | P53985 |
ProteomicsDBi | 56635 [P53985-1] 62023 |
Protocols and materials databases
Antibodypediai | 4301, 322 antibodies |
DNASUi | 6566 |
Genome annotation databases
Ensembli | ENST00000369626; ENSP00000358640; ENSG00000155380 [P53985-1] ENST00000538576; ENSP00000441065; ENSG00000155380 [P53985-1] ENST00000628110; ENSP00000485688; ENSG00000281917 [P53985-1] ENST00000630362; ENSP00000486000; ENSG00000281917 [P53985-1] |
GeneIDi | 6566 |
KEGGi | hsa:6566 |
UCSCi | uc001ecx.4, human [P53985-1] |
Organism-specific databases
CTDi | 6566 |
DisGeNETi | 6566 |
EuPathDBi | HostDB:ENSG00000155380.11 |
GeneCardsi | SLC16A1 |
HGNCi | HGNC:10922, SLC16A1 |
HPAi | ENSG00000155380, Low tissue specificity |
MalaCardsi | SLC16A1 |
MIMi | 245340, phenotype 600682, gene 610021, phenotype 616095, phenotype |
neXtProti | NX_P53985 |
OpenTargetsi | ENSG00000155380 |
Orphaneti | 165991, Exercise-induced hyperinsulinism 438075, Ketoacidosis due to monocarboxylate transporter-1 deficiency 171690, Metabolic myopathy due to lactate transporter defect |
PharmGKBi | PA35813 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2504, Eukaryota |
GeneTreei | ENSGT00940000154955 |
InParanoidi | P53985 |
OMAi | VCFGWGM |
PhylomeDBi | P53985 |
TreeFami | TF313792 |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000155380-MONOMER |
PathwayCommonsi | P53985 |
Reactomei | R-HSA-210991, Basigin interactions R-HSA-433692, Proton-coupled monocarboxylate transport R-HSA-5619070, Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) R-HSA-70268, Pyruvate metabolism |
SABIO-RKi | P53985 |
Miscellaneous databases
BioGRID-ORCSi | 6566, 62 hits in 850 CRISPR screens |
ChiTaRSi | SLC16A1, human |
GenomeRNAii | 6566 |
Pharosi | P53985, Tchem |
PROi | PR:P53985 |
RNActi | P53985, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000155380, Expressed in pigmented layer of retina and 245 other tissues |
ExpressionAtlasi | P53985, baseline and differential |
Genevisiblei | P53985, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004743, MCT IPR030757, MCT1 IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
PANTHERi | PTHR11360:SF24, PTHR11360:SF24, 1 hit |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00892, 2A0113, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MOT1_HUMAN | |
Accessioni | P53985Primary (citable) accession number: P53985 Secondary accession number(s): Q49A45, Q5T8R6, Q9NSJ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | November 30, 2010 | |
Last modified: | December 2, 2020 | |
This is version 202 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations