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UniProtKB - P53971 (FAP1_YEAST)

Entry version 166 (17 Jun 2020)
Sequence version 1 (01 Oct 1996)
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Protein

FKBP12-associated protein 1

Gene

FAP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in transcription regulation.By similarity1 Publication

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri68 – 118RING-type; degeneratePROSITE-ProRule annotationAdd BLAST51
Zinc fingeri159 – 177NF-X1-type 1Add BLAST19
Zinc fingeri216 – 235NF-X1-type 2Add BLAST20
Zinc fingeri362 – 382NF-X1-type 3Add BLAST21
Zinc fingeri468 – 487NF-X1-type 4Add BLAST20
Zinc fingeri586 – 606NF-X1-type 5Add BLAST21

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		YEAST:G3O-33061-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FKBP12-associated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAP1
Ordered Locus Names:YNL023C
ORF Names:N2812
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		FungiDB:YNL023C

Saccharomyces Genome Database

More...SGDi		S000004968 FAP1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000563431 – 965FKBP12-associated protein 1Add BLAST965

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei951PhosphothreonineCombined sources1
Modified residuei958PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P53971

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P53971

PRoteomics IDEntifications database

More...PRIDEi		P53971

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P53971

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FPR1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		35803, 88 interactors

Database of interacting proteins

More...DIPi		DIP-967N

Protein interaction database and analysis system

More...IntActi		P53971, 14 interactors

Molecular INTeraction database

More...MINTi		P53971

STRING: functional protein association networks

More...STRINGi		4932.YNL023C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P53971 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini733 – 796R3HPROSITE-ProRule annotationAdd BLAST64

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NFX1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri68 – 118RING-type; degeneratePROSITE-ProRule annotationAdd BLAST51
Zinc fingeri159 – 177NF-X1-type 1Add BLAST19
Zinc fingeri216 – 235NF-X1-type 2Add BLAST20
Zinc fingeri362 – 382NF-X1-type 3Add BLAST21
Zinc fingeri468 – 487NF-X1-type 4Add BLAST20
Zinc fingeri586 – 606NF-X1-type 5Add BLAST21

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156325

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005714_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P53971

KEGG Orthology (KO)

More...KOi		K12236

Identification of Orthologs from Complete Genome Data

More...OMAi		HPCEHPP

Family and domain databases

Conserved Domains Database

More...CDDi		cd06006 R3H_unknown_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1370.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR034078 NFX1_fam
IPR001374 R3H_dom
IPR036867 R3H_dom_sf
IPR034077 R3H_FAP1
IPR000967 Znf_NFX1
IPR001841 Znf_RING

The PANTHER Classification System

More...PANTHERi		PTHR12360 PTHR12360, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01424 R3H, 1 hit
PF01422 zf-NF-X1, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00393 R3H, 1 hit
SM00438 ZnF_NFX, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF82708 SSF82708, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51061 R3H, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53971-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEHESLGLE QNQDGGDTYR HHNLSDGCIS SVEDANEQPS SYEEESDDDM 
        60         70         80         90        100
QYYERAIQEI SSGDSYVCMI CTVEMDYTCQ MFACKRCYRV FDYGCIREWA 
       110        120        130        140        150
LKSTEKTVDR IWKCPNCYYV SKRVPVKNRP TCWCGKVVNP DPNPLDPNSC 
       160        170        180        190        200
GQTCNASTCM HGCSKICHLG PHPECTRMVE IMCHCGKHSK SIFCYQSKVM 
       210        220        230        240        250
KKNFNCQEVC GLPLSCSIHT CKKKCHPGLC GPCPEMIISK DSPKKQIKCY 
       260        270        280        290        300
CGNHTRANIK CSETKFPKSG KSSKDENGNR WIGVFACADN RVVDYSCRKH 
       310        320        330        340        350
SFIESCISPP TINGEKACPF LPSSLKTCPC GRTALEELTK PRKHCDDPIP 
       360        370        380        390        400
TCDSRCGKPL KCGKHSCPFT CHDKACMEPC LQIDSVKCAC EQSTFSVPCG 
       410        420        430        440        450
FQGRPRCNIK CESLMSCRRH RCTDRCCSGR PSAIRRKKNL FRTQDLLDES 
       460        470        480        490        500
LVEAKHICLK PCNLTLSCGI HKCQRKCHPG KCPPCLESDS NDLVCPCGNT 
       510        520        530        540        550
VVPAPVRCGT KLPTCNHPCI KVVRGESTCG HKPMPHTCHS LDVSCPPCTE 
       560        570        580        590        600
TVFKPCKCGK KTKVRTVCFQ TDVSCGIKCG IPLSYCYHTC QKTCHLPGNC 
       610        620        630        640        650
QKVCKQTCGQ KRLNCNHECP KPCHGKTECP DLPCATLVKI YCKCGRIKKS 
       660        670        680        690        700
VTCGAKSDRV SVTESSVLDC NEECEALKRL KELKEAFGIK EETNNFTSNE 
       710        720        730        740        750
LDALKKLVSV ATTFEELQLP FTEAALSVYS KQERWCSQIE AILNKLMDDK 
       760        770        780        790        800
TRSSLHFKPM RPPQRHFIRE LAKAYGLYSE SQDREPMRSV FIKKEDNGAS 
       810        820        830        840        850
NKPVLSLAEA YPLYESFKQL QKERKAQEFQ ARTTAKLINF EVQDTEPKVE 
       860        870        880        890        900
VAKKNGFLVQ NLVAGNTAED LRRFFEPHLK HTLVVNPQYL ILDDGKTALV 
       910        920        930        940        950
YPENYETASV NTERDMELLV GHFDFMAKEA FLADSISLCS TEEELERRLD 
       960 
TPVIQEDSPV MDNNT
Length:965
Mass (Da):108,495
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i121C57BB07C6FA9D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z71299 Genomic DNA Translation: CAA95885.1
BK006947 Genomic DNA Translation: DAA10522.1

Protein sequence database of the Protein Information Resource

More...PIRi		S62935

NCBI Reference Sequences

More...RefSeqi		NP_014375.1, NM_001182862.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YNL023C_mRNA; YNL023C; YNL023C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		855708

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YNL023C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71299 Genomic DNA Translation: CAA95885.1
BK006947 Genomic DNA Translation: DAA10522.1
PIRiS62935
RefSeqiNP_014375.1, NM_001182862.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi35803, 88 interactors
DIPiDIP-967N
IntActiP53971, 14 interactors
MINTiP53971
STRINGi4932.YNL023C

PTM databases

iPTMnetiP53971

Proteomic databases

MaxQBiP53971
PaxDbiP53971
PRIDEiP53971

Genome annotation databases

EnsemblFungiiYNL023C_mRNA; YNL023C; YNL023C
GeneIDi855708
KEGGisce:YNL023C

Organism-specific databases

EuPathDBiFungiDB:YNL023C
SGDiS000004968 FAP1

Phylogenomic databases

GeneTreeiENSGT00940000156325
HOGENOMiCLU_005714_2_2_1
InParanoidiP53971
KOiK12236
OMAiHPCEHPP

Enzyme and pathway databases

BioCyciYEAST:G3O-33061-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P53971
RNActiP53971 protein

Family and domain databases

CDDicd06006 R3H_unknown_2, 1 hit
Gene3Di3.30.1370.50, 1 hit
InterProiView protein in InterPro
IPR034078 NFX1_fam
IPR001374 R3H_dom
IPR036867 R3H_dom_sf
IPR034077 R3H_FAP1
IPR000967 Znf_NFX1
IPR001841 Znf_RING
PANTHERiPTHR12360 PTHR12360, 1 hit
PfamiView protein in Pfam
PF01424 R3H, 1 hit
PF01422 zf-NF-X1, 5 hits
SMARTiView protein in SMART
SM00393 R3H, 1 hit
SM00438 ZnF_NFX, 7 hits
SUPFAMiSSF82708 SSF82708, 1 hit
PROSITEiView protein in PROSITE
PS51061 R3H, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAP1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53971
Secondary accession number(s): D6W1F6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 17, 2020
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
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