FKBP12-associated protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity Source: SGD <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • Ref.4

    "FAP1, a homologue of human transcription factor NF-X1, competes with rapamycin for binding to FKBP12 in yeast."
    Kunz J., Loeschmann A., Deuter-Reinhard M., Hall M.N.
    Mol. Microbiol. 37:1480-1493(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH FPR1, SUBCELLULAR LOCATION.
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• negative regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MTEHESLGLE QNQDGGDTYR HHNLSDGCIS SVEDANEQPS SYEEESDDDM 
        60         70         80         90        100
QYYERAIQEI SSGDSYVCMI CTVEMDYTCQ MFACKRCYRV FDYGCIREWA 
       110        120        130        140        150
LKSTEKTVDR IWKCPNCYYV SKRVPVKNRP TCWCGKVVNP DPNPLDPNSC 
       160        170        180        190        200
GQTCNASTCM HGCSKICHLG PHPECTRMVE IMCHCGKHSK SIFCYQSKVM 
       210        220        230        240        250
KKNFNCQEVC GLPLSCSIHT CKKKCHPGLC GPCPEMIISK DSPKKQIKCY 
       260        270        280        290        300
CGNHTRANIK CSETKFPKSG KSSKDENGNR WIGVFACADN RVVDYSCRKH 
       310        320        330        340        350
SFIESCISPP TINGEKACPF LPSSLKTCPC GRTALEELTK PRKHCDDPIP 
       360        370        380        390        400
TCDSRCGKPL KCGKHSCPFT CHDKACMEPC LQIDSVKCAC EQSTFSVPCG 
       410        420        430        440        450
FQGRPRCNIK CESLMSCRRH RCTDRCCSGR PSAIRRKKNL FRTQDLLDES 
       460        470        480        490        500
LVEAKHICLK PCNLTLSCGI HKCQRKCHPG KCPPCLESDS NDLVCPCGNT 
       510        520        530        540        550
VVPAPVRCGT KLPTCNHPCI KVVRGESTCG HKPMPHTCHS LDVSCPPCTE 
       560        570        580        590        600
TVFKPCKCGK KTKVRTVCFQ TDVSCGIKCG IPLSYCYHTC QKTCHLPGNC 
       610        620        630        640        650
QKVCKQTCGQ KRLNCNHECP KPCHGKTECP DLPCATLVKI YCKCGRIKKS 
       660        670        680        690        700
VTCGAKSDRV SVTESSVLDC NEECEALKRL KELKEAFGIK EETNNFTSNE 
       710        720        730        740        750
LDALKKLVSV ATTFEELQLP FTEAALSVYS KQERWCSQIE AILNKLMDDK 
       760        770        780        790        800
TRSSLHFKPM RPPQRHFIRE LAKAYGLYSE SQDREPMRSV FIKKEDNGAS 
       810        820        830        840        850
NKPVLSLAEA YPLYESFKQL QKERKAQEFQ ARTTAKLINF EVQDTEPKVE 
       860        870        880        890        900
VAKKNGFLVQ NLVAGNTAED LRRFFEPHLK HTLVVNPQYL ILDDGKTALV 
       910        920        930        940        950
YPENYETASV NTERDMELLV GHFDFMAKEA FLADSISLCS TEEELERRLD 
       960 
TPVIQEDSPV MDNNT                                       

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
2. Yeast chromosome XIV
   Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
3. SIMILARITY comments
   Index of protein domains and families