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UniProtKB - P53971 (FAP1_YEAST)
Protein
FKBP12-associated protein 1
Gene
FAP1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
May play a role in transcription regulation.
By similarity1 PublicationMiscellaneous
Present with 589 molecules/cell in log phase SD medium.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 68 – 118 | RING-type; degeneratePROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 159 – 177 | NF-X1-type 1Add BLAST | 19 | |
Zinc fingeri | 216 – 235 | NF-X1-type 2Add BLAST | 20 | |
Zinc fingeri | 362 – 382 | NF-X1-type 3Add BLAST | 21 | |
Zinc fingeri | 468 – 487 | NF-X1-type 4Add BLAST | 20 | |
Zinc fingeri | 586 – 606 | NF-X1-type 5Add BLAST | 21 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: SGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: FKBP12-associated protein 1 |
Gene namesi | Name:FAP1 Ordered Locus Names:YNL023C ORF Names:N2812 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004968, FAP1 |
VEuPathDBi | FungiDB:YNL023C |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056343 | 1 – 965 | FKBP12-associated protein 1Add BLAST | 965 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 951 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 958 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P53971 |
PaxDbi | P53971 |
PRIDEi | P53971 |
PTM databases
iPTMneti | P53971 |
Interactioni
Subunit structurei
Interacts with FPR1.
1 PublicationProtein-protein interaction databases
BioGRIDi | 35803, 105 interactors |
DIPi | DIP-967N |
IntActi | P53971, 14 interactors |
MINTi | P53971 |
STRINGi | 4932.YNL023C |
Miscellaneous databases
RNActi | P53971, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 733 – 796 | R3HPROSITE-ProRule annotationAdd BLAST | 64 |
Sequence similaritiesi
Belongs to the NFX1 family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 68 – 118 | RING-type; degeneratePROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 159 – 177 | NF-X1-type 1Add BLAST | 19 | |
Zinc fingeri | 216 – 235 | NF-X1-type 2Add BLAST | 20 | |
Zinc fingeri | 362 – 382 | NF-X1-type 3Add BLAST | 21 | |
Zinc fingeri | 468 – 487 | NF-X1-type 4Add BLAST | 20 | |
Zinc fingeri | 586 – 606 | NF-X1-type 5Add BLAST | 21 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1952, Eukaryota |
GeneTreei | ENSGT00940000156325 |
HOGENOMi | CLU_005714_2_2_1 |
InParanoidi | P53971 |
OMAi | WCEKEVD |
Family and domain databases
CDDi | cd06006, R3H_unknown_2, 1 hit |
Gene3Di | 3.30.1370.50, 1 hit |
InterProi | View protein in InterPro IPR034078, NFX1_fam IPR001374, R3H_dom IPR036867, R3H_dom_sf IPR034077, R3H_FAP1 IPR000967, Znf_NFX1 IPR001841, Znf_RING |
PANTHERi | PTHR12360, PTHR12360, 1 hit |
Pfami | View protein in Pfam PF01424, R3H, 1 hit PF01422, zf-NF-X1, 5 hits |
SMARTi | View protein in SMART SM00393, R3H, 1 hit SM00438, ZnF_NFX, 7 hits |
SUPFAMi | SSF82708, SSF82708, 1 hit |
PROSITEi | View protein in PROSITE PS51061, R3H, 1 hit PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P53971-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEHESLGLE QNQDGGDTYR HHNLSDGCIS SVEDANEQPS SYEEESDDDM
60 70 80 90 100
QYYERAIQEI SSGDSYVCMI CTVEMDYTCQ MFACKRCYRV FDYGCIREWA
110 120 130 140 150
LKSTEKTVDR IWKCPNCYYV SKRVPVKNRP TCWCGKVVNP DPNPLDPNSC
160 170 180 190 200
GQTCNASTCM HGCSKICHLG PHPECTRMVE IMCHCGKHSK SIFCYQSKVM
210 220 230 240 250
KKNFNCQEVC GLPLSCSIHT CKKKCHPGLC GPCPEMIISK DSPKKQIKCY
260 270 280 290 300
CGNHTRANIK CSETKFPKSG KSSKDENGNR WIGVFACADN RVVDYSCRKH
310 320 330 340 350
SFIESCISPP TINGEKACPF LPSSLKTCPC GRTALEELTK PRKHCDDPIP
360 370 380 390 400
TCDSRCGKPL KCGKHSCPFT CHDKACMEPC LQIDSVKCAC EQSTFSVPCG
410 420 430 440 450
FQGRPRCNIK CESLMSCRRH RCTDRCCSGR PSAIRRKKNL FRTQDLLDES
460 470 480 490 500
LVEAKHICLK PCNLTLSCGI HKCQRKCHPG KCPPCLESDS NDLVCPCGNT
510 520 530 540 550
VVPAPVRCGT KLPTCNHPCI KVVRGESTCG HKPMPHTCHS LDVSCPPCTE
560 570 580 590 600
TVFKPCKCGK KTKVRTVCFQ TDVSCGIKCG IPLSYCYHTC QKTCHLPGNC
610 620 630 640 650
QKVCKQTCGQ KRLNCNHECP KPCHGKTECP DLPCATLVKI YCKCGRIKKS
660 670 680 690 700
VTCGAKSDRV SVTESSVLDC NEECEALKRL KELKEAFGIK EETNNFTSNE
710 720 730 740 750
LDALKKLVSV ATTFEELQLP FTEAALSVYS KQERWCSQIE AILNKLMDDK
760 770 780 790 800
TRSSLHFKPM RPPQRHFIRE LAKAYGLYSE SQDREPMRSV FIKKEDNGAS
810 820 830 840 850
NKPVLSLAEA YPLYESFKQL QKERKAQEFQ ARTTAKLINF EVQDTEPKVE
860 870 880 890 900
VAKKNGFLVQ NLVAGNTAED LRRFFEPHLK HTLVVNPQYL ILDDGKTALV
910 920 930 940 950
YPENYETASV NTERDMELLV GHFDFMAKEA FLADSISLCS TEEELERRLD
960
TPVIQEDSPV MDNNT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71299 Genomic DNA Translation: CAA95885.1 BK006947 Genomic DNA Translation: DAA10522.1 |
PIRi | S62935 |
RefSeqi | NP_014375.1, NM_001182862.1 |
Genome annotation databases
EnsemblFungii | YNL023C_mRNA; YNL023C; YNL023C |
GeneIDi | 855708 |
KEGGi | sce:YNL023C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71299 Genomic DNA Translation: CAA95885.1 BK006947 Genomic DNA Translation: DAA10522.1 |
PIRi | S62935 |
RefSeqi | NP_014375.1, NM_001182862.1 |
3D structure databases
AlphaFoldDBi | P53971 |
SMRi | P53971 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 35803, 105 interactors |
DIPi | DIP-967N |
IntActi | P53971, 14 interactors |
MINTi | P53971 |
STRINGi | 4932.YNL023C |
PTM databases
iPTMneti | P53971 |
Proteomic databases
MaxQBi | P53971 |
PaxDbi | P53971 |
PRIDEi | P53971 |
Genome annotation databases
EnsemblFungii | YNL023C_mRNA; YNL023C; YNL023C |
GeneIDi | 855708 |
KEGGi | sce:YNL023C |
Organism-specific databases
SGDi | S000004968, FAP1 |
VEuPathDBi | FungiDB:YNL023C |
Phylogenomic databases
eggNOGi | KOG1952, Eukaryota |
GeneTreei | ENSGT00940000156325 |
HOGENOMi | CLU_005714_2_2_1 |
InParanoidi | P53971 |
OMAi | WCEKEVD |
Miscellaneous databases
PROi | PR:P53971 |
RNActi | P53971, protein |
Family and domain databases
CDDi | cd06006, R3H_unknown_2, 1 hit |
Gene3Di | 3.30.1370.50, 1 hit |
InterProi | View protein in InterPro IPR034078, NFX1_fam IPR001374, R3H_dom IPR036867, R3H_dom_sf IPR034077, R3H_FAP1 IPR000967, Znf_NFX1 IPR001841, Znf_RING |
PANTHERi | PTHR12360, PTHR12360, 1 hit |
Pfami | View protein in Pfam PF01424, R3H, 1 hit PF01422, zf-NF-X1, 5 hits |
SMARTi | View protein in SMART SM00393, R3H, 1 hit SM00438, ZnF_NFX, 7 hits |
SUPFAMi | SSF82708, SSF82708, 1 hit |
PROSITEi | View protein in PROSITE PS51061, R3H, 1 hit PS50089, ZF_RING_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FAP1_YEAST | |
Accessioni | P53971Primary (citable) accession number: P53971 Secondary accession number(s): D6W1F6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIV
Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names - SIMILARITY comments
Index of protein domains and families