Transcriptional regulator CRZ1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cis-regulatory region sequence-specific DNA binding Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Promoter sequences regulated by the calcineurin-activated transcription factor Crz1 in the yeast ENA1 gene."
    Mendizabal I., Pascual-Ahuir A., Serrano R., de Larrinoa I.F.
    Mol Genet Genomics 265:801-811(2001) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: SGDInferred from direct assayⁱ
  • "Promoter sequences regulated by the calcineurin-activated transcription factor Crz1 in the yeast ENA1 gene."
    Mendizabal I., Pascual-Ahuir A., Serrano R., de Larrinoa I.F.
    Mol Genet Genomics 265:801-811(2001) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of Trk-dependent potassium transport by the calcineurin pathway involves the Hal5 kinase."
    Casado C., Yenush L., Melero C., Ruiz M.d.e.l. C., Serrano R., Perez-Valle J., Arino J., Ramos J.
    FEBS Lett 584:2415-2420(2010) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: SGDInferred from high throughput direct assayⁱ
  • "A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters."
    Badis G., Chan E.T., van Bakel H., Pena-Castillo L., Tillo D., Tsui K., Carlson C.D., Gossett A.J., Hasinoff M.J., Warren C.L., Gebbia M., Talukder S., Yang A., Mnaimneh S., Terterov D., Coburn D., Li Yeo A., Yeo Z.X.

    , Clarke N.D., Lieb J.D., Ansari A.Z., Nislow C., Hughes T.R.
    Mol. Cell 32:878-887(2008) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to blue light Source: SGDInferred from direct assayⁱ
  • "The yeast transcription factor Crz1 is activated by light in a Ca2+/calcineurin-dependent and PKA-independent manner."
    Bodvard K., Jorhov A., Blomberg A., Molin M., Kall M.
    PLoS One 8:e53404-e53404(2013) [PubMed] [Europe PMC] [Abstract]
• cell wall chitin biosynthetic process Source: SGD <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Survival strategies of yeast and filamentous fungi against the antifungal protein AFP."
    Ouedraogo J.P., Hagen S., Spielvogel A., Engelhardt S., Meyer V.
    J Biol Chem 286:13859-13868(2011) [PubMed] [Europe PMC] [Abstract]
• ion homeostasis Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast."
    Stathopoulos A.M., Cyert M.S.
    Genes Dev 11:3432-3444(1997) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cellular response to drug Source: SGDInferred from mutant phenotypeⁱ
  • "Genetic architecture of Hsp90-dependent drug resistance."
    Cowen L.E., Carpenter A.E., Matangkasombut O., Fink G.R., Lindquist S.
    Eukaryot. Cell 5:2184-2188(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: SGDInferred from direct assayⁱ
  • "Promoter sequences regulated by the calcineurin-activated transcription factor Crz1 in the yeast ENA1 gene."
    Mendizabal I., Pascual-Ahuir A., Serrano R., de Larrinoa I.F.
    Mol Genet Genomics 265:801-811(2001) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of Trk-dependent potassium transport by the calcineurin pathway involves the Hal5 kinase."
    Casado C., Yenush L., Melero C., Ruiz M.d.e.l. C., Serrano R., Perez-Valle J., Arino J., Ramos J.
    FEBS Lett 584:2415-2420(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Compositional bias

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSFSNGNMAS YMTSSNGEEQ SINNKNDIDD NSAYRRNNFR NSSNSGSHTF 
        60         70         80         90        100
QLSDLDLDVD MRMDSANSSE KISKNLSSGI PDSFDSNVNS LLSPSSGSYS 
       110        120        130        140        150
ADLNYQSLYK PDLPQQQLQQ QQLQQQQQQQ QQQQQQQQKQ TPTLKVEQSD 
       160        170        180        190        200
TFQWDDILTP ADNQHRPSLT NQFLSPRSNY DGTTRSSGID SNYSDTESNY 
       210        220        230        240        250
HTPYLYPQDL VSSPAMSHLT ANNDDFDDLL SVASMNSNYL LPVNSHGYKH 
       260        270        280        290        300
ISNLDELDDL LSLTYSDNNL LSASNNSDFN NSNNGIINTA DTQNSTIAIN 
       310        320        330        340        350
KSKVGTNQKM LLTIPTSSTP SPSTHAAPVT PIISIQEFNE GHFPVKNEDD 
       360        370        380        390        400
GTLQLKVRDN ESYSATNNNN LLRPDDNDYN NEALSDIDRS FEDIINGRKL 
       410        420        430        440        450
KLKKSRRRSS QTSNNSFTSR RSSRSRSISP DEKAKSISAN REKLLEMADL 
       460        470        480        490        500
LPSSENDNNR ERYDNDSKTS YNTINSSNFN EDNNNNNLLT SKPKIESGIV 
       510        520        530        540        550
NIKNELDDTS KDLGILLDID SLGQFEQKVG FKNDDNHENN DNGTFSVKKN 
       560        570        580        590        600
DNLEKLDSVT NNRKNPANFA CDVCGKKFTR PYNLKSHLRT HTNERPFICS 
       610        620        630        640        650
ICGKAFARQH DRKRHEDLHT GKKRYVCGGK LKDGKPWGCG KKFARSDALG 
       660        670 
RHFKTESGRR CITPLYEEAR QEKSGQES                         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast chromosome XIV
   Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
2. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD