UniProtKB - P53968 (CRZ1_YEAST)
Protein
Transcriptional regulator CRZ1
Gene
CRZ1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in the regulation of calcium ion homeostasis. Binds to the calcineurin-dependent response element. Transcriptionally regulates PMC1, PMR1, PMR2A and FKS2.1 Publication
Miscellaneous
Present with 1160 molecules/cell in log phase SD medium.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 569 – 591 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 597 – 619 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: SGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: SGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: SGD
GO - Biological processi
- cellular response to blue light Source: SGD
- cell wall chitin biosynthetic process Source: SGD
- ion homeostasis Source: SGD
- positive regulation of cellular response to drug Source: SGD
- positive regulation of transcription by RNA polymerase II Source: SGD
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-SCE-6807505, RNA polymerase II transcribes snRNA genes |
Names & Taxonomyi
Protein namesi | Recommended name: Transcriptional regulator CRZ1 |
Gene namesi | Name:CRZ1 Synonyms:HAL8, TCN1 Ordered Locus Names:YNL027W ORF Names:N2760 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YNL027W |
SGDi | S000004972, CRZ1 |
Subcellular locationi
Nucleus
- nuclear chromatin Source: GO_Central
- nucleus Source: SGD
Other locations
- cytoplasm Source: SGD
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046804 | 1 – 678 | Transcriptional regulator CRZ1Add BLAST | 678 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 170 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 175 | PhosphoserineCombined sources | 1 | |
Modified residuei | 245 | PhosphoserineCombined sources | 1 | |
Modified residuei | 385 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated. Dephosphorylated by calcineurin which leads to rapid translocation from the cytoplasm to the nucleus. Phosphorylated by the cyclin-CDK PHO80-PHO85.2 Publications
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P53968 |
PaxDbi | P53968 |
PRIDEi | P53968 |
PTM databases
iPTMneti | P53968 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 35799, 214 interactors |
DIPi | DIP-2724N |
ELMi | P53968 |
IntActi | P53968, 21 interactors |
MINTi | P53968 |
STRINGi | 4932.YNL027W |
Miscellaneous databases
RNActi | P53968, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 115 – 140 | Poly-GlnAdd BLAST | 26 | |
Compositional biasi | 367 – 370 | Poly-Asn | 4 | |
Compositional biasi | 483 – 487 | Poly-Asn | 5 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 569 – 591 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 597 – 619 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
HOGENOMi | CLU_030450_0_0_1 |
InParanoidi | P53968 |
OMAi | GNINDSW |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
i Sequence
Sequence statusi: Complete.
P53968-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFSNGNMAS YMTSSNGEEQ SINNKNDIDD NSAYRRNNFR NSSNSGSHTF
60 70 80 90 100
QLSDLDLDVD MRMDSANSSE KISKNLSSGI PDSFDSNVNS LLSPSSGSYS
110 120 130 140 150
ADLNYQSLYK PDLPQQQLQQ QQLQQQQQQQ QQQQQQQQKQ TPTLKVEQSD
160 170 180 190 200
TFQWDDILTP ADNQHRPSLT NQFLSPRSNY DGTTRSSGID SNYSDTESNY
210 220 230 240 250
HTPYLYPQDL VSSPAMSHLT ANNDDFDDLL SVASMNSNYL LPVNSHGYKH
260 270 280 290 300
ISNLDELDDL LSLTYSDNNL LSASNNSDFN NSNNGIINTA DTQNSTIAIN
310 320 330 340 350
KSKVGTNQKM LLTIPTSSTP SPSTHAAPVT PIISIQEFNE GHFPVKNEDD
360 370 380 390 400
GTLQLKVRDN ESYSATNNNN LLRPDDNDYN NEALSDIDRS FEDIINGRKL
410 420 430 440 450
KLKKSRRRSS QTSNNSFTSR RSSRSRSISP DEKAKSISAN REKLLEMADL
460 470 480 490 500
LPSSENDNNR ERYDNDSKTS YNTINSSNFN EDNNNNNLLT SKPKIESGIV
510 520 530 540 550
NIKNELDDTS KDLGILLDID SLGQFEQKVG FKNDDNHENN DNGTFSVKKN
560 570 580 590 600
DNLEKLDSVT NNRKNPANFA CDVCGKKFTR PYNLKSHLRT HTNERPFICS
610 620 630 640 650
ICGKAFARQH DRKRHEDLHT GKKRYVCGGK LKDGKPWGCG KKFARSDALG
660 670
RHFKTESGRR CITPLYEEAR QEKSGQES
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71303 Genomic DNA Translation: CAA95889.1 BK006947 Genomic DNA Translation: DAA10517.1 |
PIRi | S62939 |
RefSeqi | NP_014371.1, NM_001182866.1 |
Genome annotation databases
EnsemblFungii | YNL027W_mRNA; YNL027W; YNL027W |
GeneIDi | 855704 |
KEGGi | sce:YNL027W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71303 Genomic DNA Translation: CAA95889.1 BK006947 Genomic DNA Translation: DAA10517.1 |
PIRi | S62939 |
RefSeqi | NP_014371.1, NM_001182866.1 |
3D structure databases
SMRi | P53968 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 35799, 214 interactors |
DIPi | DIP-2724N |
ELMi | P53968 |
IntActi | P53968, 21 interactors |
MINTi | P53968 |
STRINGi | 4932.YNL027W |
PTM databases
iPTMneti | P53968 |
Proteomic databases
MaxQBi | P53968 |
PaxDbi | P53968 |
PRIDEi | P53968 |
Genome annotation databases
EnsemblFungii | YNL027W_mRNA; YNL027W; YNL027W |
GeneIDi | 855704 |
KEGGi | sce:YNL027W |
Organism-specific databases
EuPathDBi | FungiDB:YNL027W |
SGDi | S000004972, CRZ1 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
HOGENOMi | CLU_030450_0_0_1 |
InParanoidi | P53968 |
OMAi | GNINDSW |
Enzyme and pathway databases
Reactomei | R-SCE-6807505, RNA polymerase II transcribes snRNA genes |
Miscellaneous databases
PROi | PR:P53968 |
RNActi | P53968, protein |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CRZ1_YEAST | |
Accessioni | P53968Primary (citable) accession number: P53968 Secondary accession number(s): D6W1F1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast chromosome XIV
Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD