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UniProtKB - P53961 (GPI15_YEAST)
Protein
Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI15
Gene
GPI15
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
1 PublicationCatalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-α-D-glucosamine = a 6-(N-acetyl-α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H+ + UDPEC:2.4.1.198
: glycosylphosphatidylinositol-anchor biosynthesis Pathwayi
This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.
GO - Molecular functioni
- phosphatidylinositol N-acetylglucosaminyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- GPI anchor biosynthetic process Source: SGD
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | GPI-anchor biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00196 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI15 (EC:2.4.1.198)Short name: GPI-GlcNAc transferase complex subunit GPI5 Short name: GPI-GnT subunit GPI5 Alternative name(s): PIGH homolog |
Gene namesi | Name:GPI15 Ordered Locus Names:YNL038W ORF Names:N2687 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004983, GPI15 |
VEuPathDBi | FungiDB:YNL038W |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Endoplasmic reticulum
Other locations
- integral component of membrane Source: SGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 59 – 79 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 101 – 121 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087556 | 1 – 229 | Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI15Add BLAST | 229 |
Proteomic databases
MaxQBi | P53961 |
PaxDbi | P53961 |
PRIDEi | P53961 |
Interactioni
Subunit structurei
Component of the phosphatidylinositol N-acetylglucosaminyltransferase (GPI-GlcNAc transferase) complex composed of at least GPI1, GPI2, GPI3, GPI15, GPI19 and ERI1.
1 PublicationProtein-protein interaction databases
BioGRIDi | 35786, 276 interactors |
ComplexPortali | CPX-1274, Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase complex |
DIPi | DIP-6356N |
IntActi | P53961, 1 interactor |
STRINGi | 4932.YNL038W |
Miscellaneous databases
RNActi | P53961, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the PIGH family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S6Z2, Eukaryota |
HOGENOMi | CLU_106408_0_0_1 |
InParanoidi | P53961 |
OMAi | NASAFWI |
Family and domain databases
InterProi | View protein in InterPro IPR019328, GPI-GlcNAc_Trfase_PIG-H_dom IPR044215, PIG-H |
PANTHERi | PTHR15231, PTHR15231, 1 hit |
Pfami | View protein in Pfam PF10181, PIG-H, 1 hit |
i Sequence
Sequence statusi: Complete.
P53961-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MISKEYEFGK TSILNRKKYT LVIDEDKNGN FIRFTVLPVS NRKFKKVKQN
60 70 80 90 100
GRVEINMGIQ YHQIVLILLL NILFYVICLR SRFLEHINRT FEVTIARSFQ
110 120 130 140 150
ILIIMGLFAL GTIILVRGPS VETVTIFKES GLQLSRVKGM VIFPQQWNRK
160 170 180 190 200
FFEQVEFISN ERIIDVVINE GFCRGFRVIF YLAAIVRKSS TLKLLFPSNL
210 220
PSIDDQRLIY NISRKYLSKQ EKPLSRPKD
Sequence cautioni
The sequence AAT93131 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA95905 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | K → E in AAT93131 (PubMed:17322287).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71314 Genomic DNA Translation: CAA95905.1 Sequence problems. AY693112 Genomic DNA Translation: AAT93131.1 Sequence problems. BK006947 Genomic DNA Translation: DAA10507.1 |
PIRi | S62960 |
RefSeqi | NP_014360.2, NM_001182877.1 |
Genome annotation databases
EnsemblFungii | YNL038W_mRNA; YNL038W; YNL038W |
GeneIDi | 855690 |
KEGGi | sce:YNL038W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z71314 Genomic DNA Translation: CAA95905.1 Sequence problems. AY693112 Genomic DNA Translation: AAT93131.1 Sequence problems. BK006947 Genomic DNA Translation: DAA10507.1 |
PIRi | S62960 |
RefSeqi | NP_014360.2, NM_001182877.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 35786, 276 interactors |
ComplexPortali | CPX-1274, Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase complex |
DIPi | DIP-6356N |
IntActi | P53961, 1 interactor |
STRINGi | 4932.YNL038W |
Proteomic databases
MaxQBi | P53961 |
PaxDbi | P53961 |
PRIDEi | P53961 |
Genome annotation databases
EnsemblFungii | YNL038W_mRNA; YNL038W; YNL038W |
GeneIDi | 855690 |
KEGGi | sce:YNL038W |
Organism-specific databases
SGDi | S000004983, GPI15 |
VEuPathDBi | FungiDB:YNL038W |
Phylogenomic databases
eggNOGi | ENOG502S6Z2, Eukaryota |
HOGENOMi | CLU_106408_0_0_1 |
InParanoidi | P53961 |
OMAi | NASAFWI |
Enzyme and pathway databases
UniPathwayi | UPA00196 |
Miscellaneous databases
PROi | PR:P53961 |
RNActi | P53961, protein |
Family and domain databases
InterProi | View protein in InterPro IPR019328, GPI-GlcNAc_Trfase_PIG-H_dom IPR044215, PIG-H |
PANTHERi | PTHR15231, PTHR15231, 1 hit |
Pfami | View protein in Pfam PF10181, PIG-H, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GPI15_YEAST | |
Accessioni | P53961Primary (citable) accession number: P53961 Secondary accession number(s): D6W1E1, Q6B1G8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | December 20, 2005 | |
Last modified: | September 29, 2021 | |
This is version 133 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIV
Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families