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UniProtKB - P53959 (COG6_YEAST)

Entry version 161 (23 Feb 2022)
Sequence version 1 (01 Oct 1996)
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Protein

Conserved oligomeric Golgi complex subunit 6

Gene

COG6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.

2 Publications

Miscellaneous

Present with 1720 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 6
Short name:
COG complex subunit 6
Alternative name(s):
Complexed with DOR1 protein 2
Component of oligomeric Golgi complex 6
Protein SEC37
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COG6
Synonyms:COD2, SEC37, TFI2
Ordered Locus Names:YNL041C
ORF Names:N2675
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000004986, COG6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YNL041C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002135171 – 839Conserved oligomeric Golgi complex subunit 6Add BLAST839

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P53959

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P53959

PRoteomics IDEntifications database

More...PRIDEi		P53959

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P53959

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the conserved oligomeric Golgi (COG or Sec34/Sec35) complex which consists of eight different proteins COG1-COG8.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		35783, 532 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1840, COG Golgi transport complex

Database of interacting proteins

More...DIPi		DIP-4373N

Protein interaction database and analysis system

More...IntActi		P53959, 18 interactors

Molecular INTeraction database

More...MINTi		P53959

STRING: functional protein association networks

More...STRINGi		4932.YNL041C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P53959, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P53959

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni14 – 38DisorderedSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the COG6 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3758, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000013518

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_017837_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P53959

Identification of Orthologs from Complete Genome Data

More...OMAi		INCFDLI

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010490, COG6

The PANTHER Classification System

More...PANTHERi		PTHR21506, PTHR21506, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06419, COG6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01087, COG6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53959-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFVVDYQTY AMADTATPEL PEPEPRLNLT SDAQSQPTGK LDLQFKLPDL 
        60         70         80         90        100
QRYSNNNATL PVDNDGAGSK DLHKKMTHYA MSSIDKIQLS NPSKQLGQNS 
       110        120        130        140        150
QDEKLSQQES QNFTNYEPKN LDLSKLVSPS SGSNKNTTNL VLSNKLSKIL 
       160        170        180        190        200
NNYTLINYQA TVQLRKSLKV LEENKERLSL DEQKLMNPEY VGTLARRALR 
       210        220        230        240        250
TDLESQLLKE HITVLEEFKP IIRRIKRLSS SVEKIQRTSE KLLSNETNEV 
       260        270        280        290        300
PTNNVVLQEI DQYRLKAEQL KLKKKILLSI RDRFTLNQVE DDVITNGTID 
       310        320        330        340        350
NIFFEVVKKV INIKDESSFL LTLPNLNAGN ALIMGVNEIL EKTNKKIFNY 
       360        370        380        390        400
LIDFLYSFES SSNLLNDHGT TEQESLNIFR KSLVFLSSDL ELFNELLKRV 
       410        420        430        440        450
TTLRSKSILD EFLSQFDMNS TTSKPIILSA HDPIRYIGDV LASVHSIIAN 
       460        470        480        490        500
EADFVKSLFD FQDEDLKDTP ISILQQNKTF LKGIDNKLLN DIIQSLSNSC 
       510        520        530        540        550
RIRIEQIVRF EENPIINFEI VRLLKLYRVM FERKGIQDDS SIINNLKSLE 
       560        570        580        590        600
DISKNRIIGY YEDYMKQTVM AETKNSSDDL LPPEWLSEYM NKLVELFEIY 
       610        620        630        640        650
EKTHAAEDEE SEDNKLLSSK NLQTIVEQPI KDVLLKQLQT SFPLAKKNEK 
       660        670        680        690        700
EKASLLTIEI NCFDLIKSRL QPFEGLFAQD DDSRKITIWV CDKLKEYTKQ 
       710        720        730        740        750
MLTLQIKFLF ENTGLDLYSN LVNMIFPVDS VKDELDYDMY LALRDNSLME 
       760        770        780        790        800
LDMVRKNVHD KLNYYLPQAL TDVQGNLLFK LTSPMIADEI CDECFKKLSL 
       810        820        830 
FYNIFRKLLI HLYPNKKDQV FEILNFSTDE FDMLIGIDH
Length:839
Mass (Da):96,976
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6484A40F999AD787
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z71317 Genomic DNA Translation: CAA95908.1
BK006947 Genomic DNA Translation: DAA10504.1

Protein sequence database of the Protein Information Resource

More...PIRi		S62963

NCBI Reference Sequences

More...RefSeqi		NP_014357.1, NM_001182880.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YNL041C_mRNA; YNL041C; YNL041C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		855687

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YNL041C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71317 Genomic DNA Translation: CAA95908.1
BK006947 Genomic DNA Translation: DAA10504.1
PIRiS62963
RefSeqiNP_014357.1, NM_001182880.1

3D structure databases

SMRiP53959
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi35783, 532 interactors
ComplexPortaliCPX-1840, COG Golgi transport complex
DIPiDIP-4373N
IntActiP53959, 18 interactors
MINTiP53959
STRINGi4932.YNL041C

PTM databases

iPTMnetiP53959

Proteomic databases

MaxQBiP53959
PaxDbiP53959
PRIDEiP53959

Genome annotation databases

EnsemblFungiiYNL041C_mRNA; YNL041C; YNL041C
GeneIDi855687
KEGGisce:YNL041C

Organism-specific databases

SGDiS000004986, COG6
VEuPathDBiFungiDB:YNL041C

Phylogenomic databases

eggNOGiKOG3758, Eukaryota
GeneTreeiENSGT00390000013518
HOGENOMiCLU_017837_0_0_1
InParanoidiP53959
OMAiINCFDLI

Miscellaneous databases

Protein Ontology

More...PROi		PR:P53959
RNActiP53959, protein

Family and domain databases

InterProiView protein in InterPro
IPR010490, COG6
PANTHERiPTHR21506, PTHR21506, 1 hit
PfamiView protein in Pfam
PF06419, COG6, 1 hit
SMARTiView protein in SMART
SM01087, COG6, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOG6_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53959
Secondary accession number(s): D6W1D8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 23, 2022
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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