Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 141 (02 Jun 2021)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
Add a publicationFeedback
Protein

Stress response protein NST1

Gene

NST1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

With MSL1, acts as a negative regulator of salt tolerance.

1 Publication

Miscellaneous

Present with 217 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • response to salt stress Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processStress response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Stress response protein NST1
Alternative name(s):
Negatively-affecting salt tolerance protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NST1
Ordered Locus Names:YNL091W
ORF Names:N2231
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000005035, NST1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YNL091W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002034421 – 1240Stress response protein NST1Add BLAST1240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei266PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P53935

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53935

PRoteomics IDEntifications database

More...
PRIDEi
P53935

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53935

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MSL1.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35733, 436 interactors

Database of interacting proteins

More...
DIPi
DIP-872N

Protein interaction database and analysis system

More...
IntActi
P53935, 16 interactors

Molecular INTeraction database

More...
MINTi
P53935

STRING: functional protein association networks

More...
STRINGi
4932.YNL091W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P53935, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P53935

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 76DisorderedSequence analysisAdd BLAST76
Regioni446 – 593DisorderedSequence analysisAdd BLAST148
Regioni634 – 744DisorderedSequence analysisAdd BLAST111
Regioni951 – 980DisorderedSequence analysisAdd BLAST30
Regioni998 – 1029DisorderedSequence analysisAdd BLAST32
Regioni1214 – 1240DisorderedSequence analysisAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili616 – 777Sequence analysisAdd BLAST162

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 17Basic residuesSequence analysisAdd BLAST17
Compositional biasi456 – 483Acidic residuesSequence analysisAdd BLAST28
Compositional biasi484 – 514Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi524 – 559Basic and acidic residuesSequence analysisAdd BLAST36
Compositional biasi560 – 587Acidic residuesSequence analysisAdd BLAST28
Compositional biasi951 – 969Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NST1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSSK, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_267374_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P53935

Identification of Orthologs from Complete Genome Data

More...
OMAi
HEVRDIN

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025279, NST1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13945, NST1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53935-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPNSKSKRR KNKSKQHNKK NGNSDPEQSI NPTQLVPRME PELYHTESDY
60 70 80 90 100
PTSRVIKRAP NGDVIVEPIN TDDDKKERTA NLTHNKDSMD SASSLAFTLD
110 120 130 140 150
SHWESLSPEE KKTILRIEKE EVFNVIRNYQ DDHSCSCSVC GRRHLAMDQE
160 170 180 190 200
MERIYNTLYA MDKDKDPETN PIKFHLGIIK ELQISKNQQQ NDLSSTKGEV
210 220 230 240 250
VKNFLSSSTV GSLKEEVLHF KQKQLSKQEQ AHNETADNTS LLEENLNNIH
260 270 280 290 300
INKTSSEISA NFNSVSDEEL QQKYSNFTKT FISSHPKIAE EYVQKMMMYP
310 320 330 340 350
NIRALTDDLM NSNGQGFLNA IEDFVRDGQI QASKKDDSIT EDEASSTDLT
360 370 380 390 400
DPKEFTTMLH SGKPLTEDEY ADLQRNIAER MTNAYDTASK KFKDVSQLEK
410 420 430 440 450
ELFTRFMSGR DKKSFRELII QSFKNKFDGE LGPSVLAATL SSCFSSQSKD
460 470 480 490 500
TSLDTDSIYE DEDEEDYDDY SEYAEDSEEV SEYEGIEAVE KPEHDEKSNG
510 520 530 540 550
IRETLHLSYD HDHKRQNHPH HHYHSTSTHS EDELSEEEYI SDIELPHDPH
560 570 580 590 600
KHFHRDDDIL DGDEDEPEEE DENEGDDEED TYDSGLDETD RLEEGRKLIQ
610 620 630 640 650
IAITKLLQSR IMASYHEKQA DNNRLKLLQE LEEEKRKKRE KEEKKQKKRE
660 670 680 690 700
KEKEKKRLQQ LAKEEEKRKR EEEKERLKKE LEEREMRRRE AQRKKVEEAK
710 720 730 740 750
RKKDEERKRR LEEQQRREEM QEKQRKQKEE LKRKREEEKK RIREQKRLEQ
760 770 780 790 800
EKLQKEKEEE ERQRLIAEDA LRKQKLNEEQ TSANILSAKP FTENGVGNPV
810 820 830 840 850
SSQSHPNMTN YQEDNSCSIN DEILKMVNSV AASKPVSPTG FNVHDLLLPS
860 870 880 890 900
TNNQMPAMEQ SHLPQPGNQN NHFGTTTIPN ALDLATKSSL QTENNYLMNS
910 920 930 940 950
QTLENTSLLM HNNSSPTKLL PNDFGLSSWG GLTNTMSINP TCKPPVIQTS
960 970 980 990 1000
EMESQAHKSS PQATMPSFGL PNGGTHRKSF TDELNTLTSM LSSSGFADTS
1010 1020 1030 1040 1050
LSSSGFPPSQ RSVWNDQKSS FSGPSTAGNF NNSSIQSGML LAPTLGSVES
1060 1070 1080 1090 1100
FPNRTSIWDS STTPMMNKSE LSGRNITSTA QDSPAFMASN IWSSNSQYNS
1110 1120 1130 1140 1150
PYLTSNVLQS PQISSGVDES HILDSIYNTY LAISPQDSLN PYIAIGTLFQ
1160 1170 1180 1190 1200
NLVGLNLDYS TFINKLISMQ GAYNCEFFTD NNGSITHVRF ARQTPAGHSK
1210 1220 1230 1240
GLLNQLFSGL NDPTATPFTS RPHTSTRASF PIASSTTQTS
Length:1,240
Mass (Da):141,514
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3FE9D265822D5778
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti162D → A in strain: SK1. 1 Publication1
Natural varianti208S → G in strain: SK1. 1 Publication1
Natural varianti354E → D in strain: SK1. 1 Publication1
Natural varianti899N → D in strain: SK1. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ115393 Genomic DNA Translation: AAZ22517.1
X85811 Genomic DNA Translation: CAA59826.1
Z71367 Genomic DNA Translation: CAA95967.1
BK006947 Genomic DNA Translation: DAA10455.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S52734

NCBI Reference Sequences

More...
RefSeqi
NP_014308.1, NM_001182929.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YNL091W_mRNA; YNL091W; YNL091W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855633

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YNL091W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ115393 Genomic DNA Translation: AAZ22517.1
X85811 Genomic DNA Translation: CAA59826.1
Z71367 Genomic DNA Translation: CAA95967.1
BK006947 Genomic DNA Translation: DAA10455.1
PIRiS52734
RefSeqiNP_014308.1, NM_001182929.1

3D structure databases

SMRiP53935
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi35733, 436 interactors
DIPiDIP-872N
IntActiP53935, 16 interactors
MINTiP53935
STRINGi4932.YNL091W

PTM databases

iPTMnetiP53935

Proteomic databases

MaxQBiP53935
PaxDbiP53935
PRIDEiP53935

Genome annotation databases

EnsemblFungiiYNL091W_mRNA; YNL091W; YNL091W
GeneIDi855633
KEGGisce:YNL091W

Organism-specific databases

SGDiS000005035, NST1
VEuPathDBiFungiDB:YNL091W

Phylogenomic databases

eggNOGiENOG502QSSK, Eukaryota
HOGENOMiCLU_267374_0_0_1
InParanoidiP53935
OMAiHEVRDIN

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P53935
RNActiP53935, protein

Family and domain databases

InterProiView protein in InterPro
IPR025279, NST1
PfamiView protein in Pfam
PF13945, NST1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNST1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53935
Secondary accession number(s): D6W189, Q45TZ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 2, 2021
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again