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Entry version 171 (02 Jun 2021)
Sequence version 1 (01 Oct 1996)
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Protein

Pro-apoptotic serine protease NMA111

Gene

NMA111

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nuclear serine protease which mediates apoptosis through proteolysis of the apoptotic inhibitor BIR1.

3 Publications

Miscellaneous

Present with 3150 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei121Charge relay systemSequence analysis1
Active sitei152Charge relay systemSequence analysis1
Active sitei235Charge relay systemSequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processApoptosis

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.434

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pro-apoptotic serine protease NMA111 (EC:3.4.21.-)
Alternative name(s):
111 kDa nuclear mediator of apoptosis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NMA111
Synonyms:YNM3
Ordered Locus Names:YNL123W
ORF Names:N1897
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000005067, NMA111

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YNL123W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi235S → C: Impairs BIR1 degradation and death-promoting activity. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002034291 – 997Pro-apoptotic serine protease NMA111Add BLAST997

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P53920

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53920

PRoteomics IDEntifications database

More...
PRIDEi
P53920

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53920

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BIR1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35704, 85 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YNL123W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P53920, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini300 – 378PDZ 1Add BLAST79
Domaini779 – 854PDZ 2Add BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 43DisorderedSequence analysisAdd BLAST43
Regioni83 – 273Serine proteaseAdd BLAST191

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1C family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1421, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003212_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P53920

Identification of Orthologs from Complete Genome Data

More...
OMAi
VPYDLCD

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478, PDZ
IPR025926, PDZ-like_dom
IPR036034, PDZ_sf
IPR009003, Peptidase_S1_PA
IPR001940, Peptidase_S1C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595, PDZ, 1 hit
PF12812, PDZ_1, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00834, PROTEASES2C

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156, SSF50156, 3 hits
SSF50494, SSF50494, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53920-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTISLSNIKK RDHSKISDGT SGESSLVKRK QLESATGDQE EEYTDHEIII
60 70 80 90 100
EPLHFANNNN TVLTDSENYL RWQNTISNVV KSVVSIHFSQ VAPFDCDSAL
110 120 130 140 150
VSEATGFVVD AKLGIILTNR HVVGPGPFVG YVVFDNHEEC DVIPIYRDPV
160 170 180 190 200
HDFGFLKFDP KNIKYSKIKA LTLKPSLAKV GSEIRVVGND AGEKLSILAG
210 220 230 240 250
FISRIDRNAP EYGELTYNDF NTEYIQAAAS ASGGSSGSPV VNIDGYAVAL
260 270 280 290 300
QAGGSTEAST DFFLPLDRIL RALICIQTNK PITRGTIQVQ WLLKPYDECR
310 320 330 340 350
RLGLTSERES EARAKFPENI GLLVAETVLR EGPGYDKIKE GDTLISINGE
360 370 380 390 400
TISSFMQVDK IQDENVGKEI QLVIQRGGVE CTVTCTVGDL HAITPHRYVE
410 420 430 440 450
VCGATFHELS YQMARFYALP VRGVFLSSAS GSFNFDSKER VGWIVDSIDN
460 470 480 490 500
KETPDLDTFI EIMKTIPDRK RVTVRYHHLT DQHSPLVTSI YIDRHWCNEF
510 520 530 540 550
RVYTRNDTTG IWDYKNVADP LPADALKPRS AKIIPIPVNN EKVAKLSSSL
560 570 580 590 600
CTVATMAAVP LDSLSADILK TSGLIIDAEK GYVLVSRRVV PHDCLDTFVT
610 620 630 640 650
IADSLVVPAT VEFLHPTHNF AIVKYDPELV KAPLITPKLS TTRMKRGDKL
660 670 680 690 700
QFIGFTQNDR IVTSETTVTD ISSVSIPSNL IPRYRATNLE AISIDCNVST
710 720 730 740 750
RCNSGILTDN DGTVRGLWLP FLGERLENKE KVYLMGLDIM DCREVIDILK
760 770 780 790 800
NGGKPRVSIV DAGFGSISVL QARIRGVPEE WIMRMEHESN NRLQFITVSR
810 820 830 840 850
VSYTEDKIHL ETGDVILSVN GKLVTEMNDL NGVVSSADGI LPSAMLDFKV
860 870 880 890 900
VRDGNIVDLK IKTVEVQETD RFVIFAGSIL QKPHHAVLQA MVDVPKGVYC
910 920 930 940 950
TFRGESSPAL QYGISATNFI THVNEIETPD LDTFLKVVKT IPDNSYCKMR
960 970 980 990
LMTFDNVPFA ISLKTNYHYF PTAELKRDNI THKWIEKEFT GNSQSEK
Length:997
Mass (Da):110,881
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA26005C1DDDB932C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti162N → S in strain: YJM269, YJM270 and YJM1129. 1 Publication1
Natural varianti241V → L in strain: YJM269 and YJM270. 1 Publication1
Natural varianti331E → G in strain: YJM326. 1 Publication1
Natural varianti343T → S in strain: YJM269 and YJM270. 1 Publication1
Natural varianti386T → I in strain: YJM269, YJM270 and YJM1129. 1 Publication1
Natural varianti457D → G in strain: YJM269 and YJM270. 1 Publication1
Natural varianti530S → P in strain: YJM627. 1 Publication1
Natural varianti580K → N in strain: YJM627. 1 Publication1
Natural varianti621A → T in strain: YJM269 and YJM270. 1 Publication1
Natural varianti942P → F in strain: YJM627. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF125216 Genomic DNA Translation: ABN58534.1
EF125217 Genomic DNA Translation: ABN58544.1
EF125218 Genomic DNA Translation: ABN58553.1
EF125219 Genomic DNA Translation: ABN58562.1
EF125220 Genomic DNA Translation: ABN58571.1
EF125221 Genomic DNA Translation: ABN58580.1
EF125222 Genomic DNA Translation: ABN58589.1
EF125223 Genomic DNA Translation: ABN58598.1
EF125224 Genomic DNA Translation: ABN58607.1
EF125225 Genomic DNA Translation: ABN58616.1
EF125226 Genomic DNA Translation: ABN58625.1
EF125228 Genomic DNA Translation: ABN58643.1
Z69382 Genomic DNA Translation: CAA93384.1
Z71399 Genomic DNA Translation: CAA96004.1
BK006947 Genomic DNA Translation: DAA10426.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S63064

NCBI Reference Sequences

More...
RefSeqi
NP_014276.1, NM_001182961.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YNL123W_mRNA; YNL123W; YNL123W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855600

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YNL123W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF125216 Genomic DNA Translation: ABN58534.1
EF125217 Genomic DNA Translation: ABN58544.1
EF125218 Genomic DNA Translation: ABN58553.1
EF125219 Genomic DNA Translation: ABN58562.1
EF125220 Genomic DNA Translation: ABN58571.1
EF125221 Genomic DNA Translation: ABN58580.1
EF125222 Genomic DNA Translation: ABN58589.1
EF125223 Genomic DNA Translation: ABN58598.1
EF125224 Genomic DNA Translation: ABN58607.1
EF125225 Genomic DNA Translation: ABN58616.1
EF125226 Genomic DNA Translation: ABN58625.1
EF125228 Genomic DNA Translation: ABN58643.1
Z69382 Genomic DNA Translation: CAA93384.1
Z71399 Genomic DNA Translation: CAA96004.1
BK006947 Genomic DNA Translation: DAA10426.1
PIRiS63064
RefSeqiNP_014276.1, NM_001182961.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi35704, 85 interactors
STRINGi4932.YNL123W

Protein family/group databases

MEROPSiS01.434

PTM databases

iPTMnetiP53920

Proteomic databases

MaxQBiP53920
PaxDbiP53920
PRIDEiP53920

Genome annotation databases

EnsemblFungiiYNL123W_mRNA; YNL123W; YNL123W
GeneIDi855600
KEGGisce:YNL123W

Organism-specific databases

SGDiS000005067, NMA111
VEuPathDBiFungiDB:YNL123W

Phylogenomic databases

eggNOGiKOG1421, Eukaryota
HOGENOMiCLU_003212_0_0_1
InParanoidiP53920
OMAiVPYDLCD

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P53920
RNActiP53920, protein

Family and domain databases

Gene3Di2.30.42.10, 2 hits
InterProiView protein in InterPro
IPR001478, PDZ
IPR025926, PDZ-like_dom
IPR036034, PDZ_sf
IPR009003, Peptidase_S1_PA
IPR001940, Peptidase_S1C
PfamiView protein in Pfam
PF00595, PDZ, 1 hit
PF12812, PDZ_1, 2 hits
PRINTSiPR00834, PROTEASES2C
SMARTiView protein in SMART
SM00228, PDZ, 2 hits
SUPFAMiSSF50156, SSF50156, 3 hits
SSF50494, SSF50494, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNM111_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53920
Secondary accession number(s): B0KZR3
, B0KZU0, B0KZX6, B0L003, B0L021, D6W160
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 2, 2021
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families
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