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Entry version 163 (29 Sep 2021)
Sequence version 1 (01 Oct 1996)
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Protein

H/ACA ribonucleoprotein complex non-core subunit NAF1

Gene

NAF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by GAR1 to yield mature H/ACA snoRNPs complex. Acts as a competitive binder for CBF5 probably required to prevent non-cognate RNAs from being loaded during transport of the particle by inducing a non-productive conformation of CBF5.

5 Publications

Miscellaneous

Present with 1810 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processRibosome biogenesis, rRNA processing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
H/ACA ribonucleoprotein complex non-core subunit NAF1
Alternative name(s):
Nuclear assembly factor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NAF1
Ordered Locus Names:YNL124W
ORF Names:N1888
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000005068, NAF1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YNL124W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002034281 – 492H/ACA ribonucleoprotein complex non-core subunit NAF1Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei255PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P53919

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53919

PRoteomics IDEntifications database

More...
PRIDEi
P53919

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53919

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

During assembly of the complex, component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) which contains CBF5, NAF1, NHP2 and NOP10 proteins.

Interacts with SHQ1.

Interacts directly with CBF5.

Interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (RPB1).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35703, 212 interactors

Database of interacting proteins

More...
DIPi
DIP-4345N

Protein interaction database and analysis system

More...
IntActi
P53919, 257 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YNL124W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P53919, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1492
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P53919

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P53919

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 117DisorderedSequence analysisAdd BLAST117
Regioni172 – 230RNA-bindingAdd BLAST59
Regioni237 – 351DisorderedSequence analysisAdd BLAST115
Regioni472 – 492DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 46Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi51 – 72Polar residuesSequence analysisAdd BLAST22
Compositional biasi73 – 106Acidic residuesSequence analysisAdd BLAST34
Compositional biasi277 – 293Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi334 – 351Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The central region (136-221) reveals a striking structural homology with the core domain of GAR1.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NAF1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2236, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01040000244168

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025072_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P53919

Identification of Orthologs from Complete Genome Data

More...
OMAi
INTEDCD

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.230, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038664, Gar1/Naf1_Cbf5-bd_sf
IPR007504, H/ACA_rnp_Gar1/Naf1
IPR040309, Naf1
IPR009000, Transl_B-barrel_sf

The PANTHER Classification System

More...
PANTHERi
PTHR31633, PTHR31633, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04410, Gar1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50447, SSF50447, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53919-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDDLFSKAL ENPDQDLNVE LPKDDVDLGL LGDGGNERKT DEPVADAERS
60 70 80 90 100
TGLGSGSSES ESDSGSDSDS DSGSSGSEDD SADQDVEGED EGGDAIENED
110 120 130 140 150
EDEDPSPSGP ILSKNEILEE TVPELPEDYE ISEKTIITPI GVLKSAFENN
160 170 180 190 200
IIIHATMSGE KRVLKEGSIF CLEDRTLIGM LTEVFGPLQN PFYRIKLPDS
210 220 230 240 250
KKNLFDELKV RLGEKAFIVT PDAHWIDTFE LKRNKGTDAS NGYDEELPEE
260 270 280 290 300
EQEFSDDEKE ALFKKMKKQQ RQRKKRDNRK LANDSDNVKV KRARQPKANS
310 320 330 340 350
LPKLVPPLGM SSNAPMQHGY KSRNARENIK RESSATSNRN GSSPVPITQH
360 370 380 390 400
HQQQFSANNY PFPQQPNGMP YPPYSPFPQP TNFQYPPPPF GQATPAQFSN
410 420 430 440 450
TVPYGSLPPA YNNMSPPTQQ SFMPMTQSQP PLPYGVPPMN QMQNPMYIQP
460 470 480 490
PPQAPPQGNG NFQQVMELHQ ILLQQQQQQH QYQHQHQQDP RT
Length:492
Mass (Da):54,949
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A496278070F6255
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti378P → A in strain: YJM269, YJM270, YJM326 and YJM1129. 1 Publication1
Natural varianti423M → I in strain: YJM627. 1 Publication1
Natural varianti424P → S in strain: YJM269, YJM270, YJM326 and YJM1129. 1 Publication1
Natural varianti426T → A in strain: SK1, V1-09, YJM269, YJM270, YJM280, YJM320, YJM326, YJM339, YJM627, YJM789 and YJM1129. 1 Publication1
Natural varianti480H → N in strain: V1-09 and YJM627. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z69382 Genomic DNA Translation: CAA93381.1
Z71400 Genomic DNA Translation: CAA96005.1
EF125216 Genomic DNA Translation: ABN58535.1
EF125217 Genomic DNA Translation: ABN58543.1
EF125218 Genomic DNA Translation: ABN58552.1
EF125219 Genomic DNA Translation: ABN58561.1
EF125220 Genomic DNA Translation: ABN58570.1
EF125221 Genomic DNA Translation: ABN58579.1
EF125222 Genomic DNA Translation: ABN58588.1
EF125223 Genomic DNA Translation: ABN58597.1
EF125224 Genomic DNA Translation: ABN58606.1
EF125225 Genomic DNA Translation: ABN58615.1
EF125226 Genomic DNA Translation: ABN58624.1
EF125228 Genomic DNA Translation: ABN58642.1
BK006947 Genomic DNA Translation: DAA10425.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S63065

NCBI Reference Sequences

More...
RefSeqi
NP_014275.3, NM_001182962.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YNL124W_mRNA; YNL124W; YNL124W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855599

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YNL124W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69382 Genomic DNA Translation: CAA93381.1
Z71400 Genomic DNA Translation: CAA96005.1
EF125216 Genomic DNA Translation: ABN58535.1
EF125217 Genomic DNA Translation: ABN58543.1
EF125218 Genomic DNA Translation: ABN58552.1
EF125219 Genomic DNA Translation: ABN58561.1
EF125220 Genomic DNA Translation: ABN58570.1
EF125221 Genomic DNA Translation: ABN58579.1
EF125222 Genomic DNA Translation: ABN58588.1
EF125223 Genomic DNA Translation: ABN58597.1
EF125224 Genomic DNA Translation: ABN58606.1
EF125225 Genomic DNA Translation: ABN58615.1
EF125226 Genomic DNA Translation: ABN58624.1
EF125228 Genomic DNA Translation: ABN58642.1
BK006947 Genomic DNA Translation: DAA10425.1
PIRiS63065
RefSeqiNP_014275.3, NM_001182962.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V3MX-ray2.74A/B/C/D/E/F109-232[»]
SMRiP53919
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi35703, 212 interactors
DIPiDIP-4345N
IntActiP53919, 257 interactors
STRINGi4932.YNL124W

PTM databases

iPTMnetiP53919

Proteomic databases

MaxQBiP53919
PaxDbiP53919
PRIDEiP53919

Genome annotation databases

EnsemblFungiiYNL124W_mRNA; YNL124W; YNL124W
GeneIDi855599
KEGGisce:YNL124W

Organism-specific databases

SGDiS000005068, NAF1
VEuPathDBiFungiDB:YNL124W

Phylogenomic databases

eggNOGiKOG2236, Eukaryota
GeneTreeiENSGT01040000244168
HOGENOMiCLU_025072_1_0_1
InParanoidiP53919
OMAiINTEDCD

Miscellaneous databases

EvolutionaryTraceiP53919

Protein Ontology

More...
PROi
PR:P53919
RNActiP53919, protein

Family and domain databases

Gene3Di2.40.10.230, 1 hit
InterProiView protein in InterPro
IPR038664, Gar1/Naf1_Cbf5-bd_sf
IPR007504, H/ACA_rnp_Gar1/Naf1
IPR040309, Naf1
IPR009000, Transl_B-barrel_sf
PANTHERiPTHR31633, PTHR31633, 1 hit
PfamiView protein in Pfam
PF04410, Gar1, 1 hit
SUPFAMiSSF50447, SSF50447, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAF1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53919
Secondary accession number(s): B0KZR2
, B0KZS1, B0KZT9, B0KZZ3, B0L002, D6W159
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 29, 2021
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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