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Entry version 168 (23 Feb 2022)
Sequence version 1 (01 Oct 1996)
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Protein

Uncharacterized transporter ESBP6

Gene

ESBP6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-352230, Amino acid transport across the plasma membrane
R-SCE-879518, Transport of organic anions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized transporter ESBP6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ESBP6
Synonyms:MCH3
Ordered Locus Names:YNL125C
ORF Names:N1223, N1882
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000005069, ESBP6

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YNL125C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 208CytoplasmicSequence analysisAdd BLAST208
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 255LumenalSequence analysisAdd BLAST26
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277CytoplasmicSequence analysis1
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 315LumenalSequence analysisAdd BLAST17
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Topological domaini337 – 339CytoplasmicSequence analysis3
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Topological domaini361 – 372LumenalSequence analysisAdd BLAST12
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 426CytoplasmicSequence analysisAdd BLAST33
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Topological domaini448 – 504LumenalSequence analysisAdd BLAST57
Transmembranei505 – 525HelicalSequence analysisAdd BLAST21
Topological domaini526 – 549CytoplasmicSequence analysisAdd BLAST24
Transmembranei550 – 570HelicalSequence analysisAdd BLAST21
Topological domaini571 – 584LumenalSequence analysisAdd BLAST14
Transmembranei585 – 605HelicalSequence analysisAdd BLAST21
Topological domaini606 – 673CytoplasmicSequence analysisAdd BLAST68

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002114051 – 673Uncharacterized transporter ESBP6Add BLAST673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei57PhosphoserineCombined sources1
Modified residuei112PhosphoserineCombined sources1
Modified residuei172PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi471N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi492N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei637PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P53918

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P53918

PRoteomics IDEntifications database

More...
PRIDEi
P53918

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P53918

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35702, 108 interactors

Database of interacting proteins

More...
DIPi
DIP-4797N

Protein interaction database and analysis system

More...
IntActi
P53918, 4 interactors

Molecular INTeraction database

More...
MINTi
P53918

STRING: functional protein association networks

More...
STRINGi
4932.YNL125C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P53918, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P53918

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2504, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001265_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P53918

Identification of Orthologs from Complete Genome Data

More...
OMAi
FWINATT

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1250.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011701, MFS
IPR036259, MFS_trans_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07690, MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53918-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTHSNDYFS ASSGMVSETS SEVSSINSSQ PVSFSKASIA APVPCSDLHS
60 70 80 90 100
TKSNDASRKL SISRTLTNRL NDIKKAVDDD NLQTEENSAD VNKILESRFD
110 120 130 140 150
VADAIRLQHN ESVQSKLNIP VTHTTTAGAS LSAPSSSAFS ASSIQNDTTE
160 170 180 190 200
HKASMDSKLM RNRLYPASTK HSGKDLEAQG ITEFEPDEPT VKKVFTNKST
210 220 230 240 250
GQLELPPDGG YGWVVTFCVF LTMFSTWGCN ASFGVDLAYY LNHDTYPGAS
260 270 280 290 300
KYDYALIAGL TVFLGQLLSP LVMALMRIIG LRTTMLFGDA VMLAAYLLAS
310 320 330 340 350
FTTKLWQLYV TQGFMVGCSI SLIFVPATTV LPGWFLKKRA VAMGVSLLGT
360 370 380 390 400
GAGGVVYGLA TNKMLSDFGN TRWCLRIIGI SCSISVLVAI ALLKERNPTP
410 420 430 440 450
AIGLKSPRAM FEQLKAMFSL KVITKPFVVL IALWFMFALF AYNMMVFTLS
460 470 480 490 500
SYAISKGLSS HDASTLTAIL NGSQSIGRPL MGLAGDKFGR ANVTIVLTTL
510 520 530 540 550
LTIYMFAFWI PAHTFVQLIF FSILVGSCVG VANVMNTVLI ADMVKPEEFL
560 570 580 590 600
PAWAFVNYCG APFLLVCEVI AQALTVEKDK SNPYLHAQIF CGCCFIAALI
610 620 630 640 650
LISILREYSI RMKLTERQAM TNEKLKEWKA SEYDTDSADE DWGKLKERKT
660 670
KYDLLLGPGI KKYFLRMVYP MKV
Length:673
Mass (Da):73,802
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4CA35AE50A79E7A
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA59327 differs from that shown. Reason: Frameshift.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z69382 Genomic DNA Translation: CAA93379.1
Z46843 Genomic DNA Translation: CAA86900.1
Z71401 Genomic DNA Translation: CAA96006.1
X84903 Genomic DNA Translation: CAA59327.1 Frameshift.
BK006947 Genomic DNA Translation: DAA10424.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S59263

NCBI Reference Sequences

More...
RefSeqi
NP_014274.1, NM_001182963.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YNL125C_mRNA; YNL125C; YNL125C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855598

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YNL125C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69382 Genomic DNA Translation: CAA93379.1
Z46843 Genomic DNA Translation: CAA86900.1
Z71401 Genomic DNA Translation: CAA96006.1
X84903 Genomic DNA Translation: CAA59327.1 Frameshift.
BK006947 Genomic DNA Translation: DAA10424.1
PIRiS59263
RefSeqiNP_014274.1, NM_001182963.1

3D structure databases

SMRiP53918
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi35702, 108 interactors
DIPiDIP-4797N
IntActiP53918, 4 interactors
MINTiP53918
STRINGi4932.YNL125C

PTM databases

iPTMnetiP53918

Proteomic databases

MaxQBiP53918
PaxDbiP53918
PRIDEiP53918

Genome annotation databases

EnsemblFungiiYNL125C_mRNA; YNL125C; YNL125C
GeneIDi855598
KEGGisce:YNL125C

Organism-specific databases

SGDiS000005069, ESBP6
VEuPathDBiFungiDB:YNL125C

Phylogenomic databases

eggNOGiKOG2504, Eukaryota
HOGENOMiCLU_001265_1_2_1
InParanoidiP53918
OMAiFWINATT

Enzyme and pathway databases

ReactomeiR-SCE-352230, Amino acid transport across the plasma membrane
R-SCE-879518, Transport of organic anions

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P53918
RNActiP53918, protein

Family and domain databases

Gene3Di1.20.1250.20, 2 hits
InterProiView protein in InterPro
IPR011701, MFS
IPR036259, MFS_trans_sf
PfamiView protein in Pfam
PF07690, MFS_1, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESBP6_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53918
Secondary accession number(s): D6W158
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 23, 2022
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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