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UniProtKB - P53916 (TEP1_YEAST)
Protein
Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1
Gene
TEP1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
May act as a phosphoinositide 3-phosphatase by regulating PtdIns(3,4,5)P3 levels.
1 PublicationCatalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphateEC:3.1.3.67
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 193 | Phosphocysteine intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Source: GO_Central
- protein tyrosine/serine/threonine phosphatase activity Source: InterPro
- protein tyrosine phosphatase activity Source: GO_Central
GO - Biological processi
- ascospore wall assembly Source: SGD
- dephosphorylation Source: GO_Central
- phosphatidylinositol 3-kinase signaling Source: GO_Central
- protein dephosphorylation Source: GO_Central
- regulation of protein kinase B signaling Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
Reactomei | R-SCE-1660499, Synthesis of PIPs at the plasma membrane R-SCE-1660514, Synthesis of PIPs at the Golgi membrane R-SCE-1855204, Synthesis of IP3 and IP4 in the cytosol R-SCE-199418, Negative regulation of the PI3K/AKT network R-SCE-202424, Downstream TCR signaling R-SCE-5689880, Ub-specific processing proteases R-SCE-8948747, Regulation of PTEN localization R-SCE-8948751, Regulation of PTEN stability and activity |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:TEP1 Ordered Locus Names:YNL128W ORF Names:N1220, N1872 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000005072, TEP1 |
VEuPathDBi | FungiDB:YNL128W |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cell projection Source: GO_Central
- cytoplasm Source: SGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215906 | 1 – 434 | Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1Add BLAST | 434 |
Proteomic databases
PaxDbi | P53916 |
PRIDEi | P53916 |
PTM databases
iPTMneti | P53916 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 35699, 120 interactors |
DIPi | DIP-4928N |
IntActi | P53916, 12 interactors |
MINTi | P53916 |
STRINGi | 4932.YNL128W |
Miscellaneous databases
RNActi | P53916, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 255 | Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST | 223 |
Phylogenomic databases
eggNOGi | KOG2283, Eukaryota |
GeneTreei | ENSGT00940000154335 |
HOGENOMi | CLU_020105_0_0_1 |
InParanoidi | P53916 |
OMAi | CWLNLYW |
Family and domain databases
Gene3Di | 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR000340, Dual-sp_phosphatase_cat-dom IPR029021, Prot-tyrosine_phosphatase-like IPR029023, Tensin_phosphatase IPR016130, Tyr_Pase_AS IPR000387, Tyr_Pase_dom |
Pfami | View protein in Pfam PF00782, DSPc, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS51181, PPASE_TENSIN, 1 hit |
i Sequence
Sequence statusi: Complete.
P53916-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MREEGSELEM EKGFLKWKPV NLMKKILSLP MKKTKNDIGL RLDISYILVN
60 70 80 90 100
LIVCSYPVNT YPKLLYRNSL DDLILFLTVY HGKGNFRIFN FRGEKEDSDY
110 120 130 140 150
KDNDLIGIAA KFESKDFEIQ ELRSTLINDG KIPISPIDLE TRTLVEEETN
160 170 180 190 200
NVICERIGWL DHFPPPFELL EEIVDGIENY LSVSKNRVAV LHCRMGKGRS
210 220 230 240 250
GMITVAYLMK YLQCPLGEAR LIFMQARFKY GMTNGVTIPS QLRYLRYHEF
260 270 280 290 300
FITHEKAAQE GISNEAVKFK FKFRLAKMTF LRPSSLITSE SAIVTTKIQH
310 320 330 340 350
YNDDRNALLT RKVVYSDIMA HECGGNMTFI FGRDYLTLEN DCRIEFTLGT
360 370 380 390 400
SKSKAASSII SWTSCASCWL NIYLETLMHI IKDDSSPDYF QVERLKRDEM
410 420 430
LGTTISWQEL DGFGELSTHG LKLFQALKLE WEII
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z46843 Genomic DNA Translation: CAA86897.1 Z71404 Genomic DNA Translation: CAA96010.1 BK006947 Genomic DNA Translation: DAA10421.1 |
PIRi | S55155 |
RefSeqi | NP_014271.3, NM_001182966.4 |
Genome annotation databases
EnsemblFungii | YNL128W_mRNA; YNL128W; YNL128W |
GeneIDi | 855595 |
KEGGi | sce:YNL128W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z46843 Genomic DNA Translation: CAA86897.1 Z71404 Genomic DNA Translation: CAA96010.1 BK006947 Genomic DNA Translation: DAA10421.1 |
PIRi | S55155 |
RefSeqi | NP_014271.3, NM_001182966.4 |
3D structure databases
AlphaFoldDBi | P53916 |
SMRi | P53916 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 35699, 120 interactors |
DIPi | DIP-4928N |
IntActi | P53916, 12 interactors |
MINTi | P53916 |
STRINGi | 4932.YNL128W |
PTM databases
iPTMneti | P53916 |
Proteomic databases
PaxDbi | P53916 |
PRIDEi | P53916 |
Genome annotation databases
EnsemblFungii | YNL128W_mRNA; YNL128W; YNL128W |
GeneIDi | 855595 |
KEGGi | sce:YNL128W |
Organism-specific databases
SGDi | S000005072, TEP1 |
VEuPathDBi | FungiDB:YNL128W |
Phylogenomic databases
eggNOGi | KOG2283, Eukaryota |
GeneTreei | ENSGT00940000154335 |
HOGENOMi | CLU_020105_0_0_1 |
InParanoidi | P53916 |
OMAi | CWLNLYW |
Enzyme and pathway databases
Reactomei | R-SCE-1660499, Synthesis of PIPs at the plasma membrane R-SCE-1660514, Synthesis of PIPs at the Golgi membrane R-SCE-1855204, Synthesis of IP3 and IP4 in the cytosol R-SCE-199418, Negative regulation of the PI3K/AKT network R-SCE-202424, Downstream TCR signaling R-SCE-5689880, Ub-specific processing proteases R-SCE-8948747, Regulation of PTEN localization R-SCE-8948751, Regulation of PTEN stability and activity |
Miscellaneous databases
PROi | PR:P53916 |
RNActi | P53916, protein |
Family and domain databases
Gene3Di | 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR000340, Dual-sp_phosphatase_cat-dom IPR029021, Prot-tyrosine_phosphatase-like IPR029023, Tensin_phosphatase IPR016130, Tyr_Pase_AS IPR000387, Tyr_Pase_dom |
Pfami | View protein in Pfam PF00782, DSPc, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS51181, PPASE_TENSIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TEP1_YEAST | |
Accessioni | P53916Primary (citable) accession number: P53916 Secondary accession number(s): D6W155 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIV
Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names