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Protein

Prefoldin subunit 4

Gene

GIM3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Miscellaneous

Present with 7470 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • chaperone binding Source: GO_Central
  • tubulin binding Source: SGD
  • unfolded protein binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-33170-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 4
Alternative name(s):
Genes involved in microtubule biogenesis protein 3
Gim complex subunit 3
Short name:
GimC subunit 3
Gene namesi
Name:GIM3
Synonyms:PFD4
Ordered Locus Names:YNL153C
ORF Names:N1761
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL153C
SGDiS000005097 GIM3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001248481 – 129Prefoldin subunit 4Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP53900
PaxDbiP53900
PRIDEiP53900

PTM databases

iPTMnetiP53900

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PAC10P483633EBI-13246,EBI-13239

GO - Molecular functioni

Protein-protein interaction databases

BioGridi35676, 830 interactors
ComplexPortaliCPX-1671 Prefoldin complex
DIPiDIP-3000N
IntActiP53900, 11 interactors
MINTiP53900
STRINGi4932.YNL153C

Structurei

3D structure databases

ProteinModelPortaliP53900
SMRiP53900
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000006696
HOGENOMiHOG000204477
InParanoidiP53900
KOiK09550
OMAiMTQLKVE
OrthoDBiEOG092C5KAA

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR002777 PFD_beta-like
IPR016661 PFDN4
IPR009053 Prefoldin
PANTHERiPTHR21100 PTHR21100, 1 hit
PfamiView protein in Pfam
PF01920 Prefoldin_2, 1 hit
PIRSFiPIRSF016477 Prefoldin_subunit_4, 1 hit

Sequencei

Sequence statusi: Complete.

P53900-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELLPQGQRN NTQVTFEDQQ KINEFSKLIM RKDAIAQELS LQREEKEYLD
60 70 80 90 100
DVSLEIELID EDEPVQYKVG DLFIFMKQSK VTAQLEKDAE RLDNKIETLE
110 120
DKQRDIDSRL DALKAILYAK FGDNINLER
Length:129
Mass (Da):15,180
Last modified:October 1, 1996 - v1
Checksum:i4738F9EA813E04A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92517 Genomic DNA Translation: CAA63286.1
Z71429 Genomic DNA Translation: CAA96040.1
AY692812 Genomic DNA Translation: AAT92831.1
BK006947 Genomic DNA Translation: DAA10396.1
PIRiS60974
RefSeqiNP_014246.1, NM_001182991.1

Genome annotation databases

EnsemblFungiiYNL153C; YNL153C; YNL153C
GeneIDi855569
KEGGisce:YNL153C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92517 Genomic DNA Translation: CAA63286.1
Z71429 Genomic DNA Translation: CAA96040.1
AY692812 Genomic DNA Translation: AAT92831.1
BK006947 Genomic DNA Translation: DAA10396.1
PIRiS60974
RefSeqiNP_014246.1, NM_001182991.1

3D structure databases

ProteinModelPortaliP53900
SMRiP53900
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35676, 830 interactors
ComplexPortaliCPX-1671 Prefoldin complex
DIPiDIP-3000N
IntActiP53900, 11 interactors
MINTiP53900
STRINGi4932.YNL153C

PTM databases

iPTMnetiP53900

Proteomic databases

MaxQBiP53900
PaxDbiP53900
PRIDEiP53900

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL153C; YNL153C; YNL153C
GeneIDi855569
KEGGisce:YNL153C

Organism-specific databases

EuPathDBiFungiDB:YNL153C
SGDiS000005097 GIM3

Phylogenomic databases

GeneTreeiENSGT00390000006696
HOGENOMiHOG000204477
InParanoidiP53900
KOiK09550
OMAiMTQLKVE
OrthoDBiEOG092C5KAA

Enzyme and pathway databases

BioCyciYEAST:G3O-33170-MONOMER

Miscellaneous databases

PROiPR:P53900

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR002777 PFD_beta-like
IPR016661 PFDN4
IPR009053 Prefoldin
PANTHERiPTHR21100 PTHR21100, 1 hit
PfamiView protein in Pfam
PF01920 Prefoldin_2, 1 hit
PIRSFiPIRSF016477 Prefoldin_subunit_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPFD4_YEAST
AccessioniPrimary (citable) accession number: P53900
Secondary accession number(s): D6W130
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
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Main funding by: National Institutes of Health

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