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Protein

Serine/threonine-protein kinase CBK1

Gene

CBK1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein kinase that seems to play a role in the regulation of cell morphogenesis and proliferation.

Miscellaneous

Present with 450 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei381ATPPROSITE-ProRule annotation1
Active sitei475Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi358 – 366ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33177-MONOMER
BRENDAi2.7.11.1 984
ReactomeiR-SCE-2028269 Signaling by Hippo
R-SCE-3928662 EPHB-mediated forward signaling
R-SCE-416482 G alpha (12/13) signalling events
R-SCE-416572 Sema4D induced cell migration and growth-cone collapse
R-SCE-4420097 VEGFA-VEGFR2 Pathway
R-SCE-5625900 RHO GTPases activate CIT
R-SCE-5627117 RHO GTPases Activate ROCKs
R-SCE-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase CBK1 (EC:2.7.11.1)
Alternative name(s):
Cell wall biosynthesis kinase
Gene namesi
Name:CBK1
Ordered Locus Names:YNL161W
ORF Names:N1727
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL161W
SGDiS000005105 CBK1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000856971 – 756Serine/threonine-protein kinase CBK1Add BLAST756

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei109PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53894
PaxDbiP53894
PRIDEiP53894

PTM databases

iPTMnetiP53894

Interactioni

Subunit structurei

Associates with PAG1/TAO3 and interacts with MOB2.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi35668, 128 interactors
ComplexPortaliCPX-1684 CBK1-MOB2 kinase complex
DIPiDIP-5656N
ELMiP53894
IntActiP53894, 56 interactors
MINTiP53894
STRINGi4932.YNL161W

Structurei

Secondary structure

1756
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP53894
SMRiP53894
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini352 – 672Protein kinasePROSITE-ProRule annotationAdd BLAST321
Domaini673 – 754AGC-kinase C-terminalAdd BLAST82

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 34Poly-GlnAdd BLAST12
Compositional biasi160 – 164Poly-Ser5
Compositional biasi214 – 232Poly-GlnAdd BLAST19
Compositional biasi235 – 250Poly-GlnAdd BLAST16

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00760000118994
HOGENOMiHOG000233033
InParanoidiP53894
KOiK08286
OMAiENDFSNN
OrthoDBiEOG092C0HH3

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P53894-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYNSSTNHHE GAPTSGHGYY MSQQQDQQHQ QQQQYANEMN PYQQIPRPPA
60 70 80 90 100
AGFSSNYMKE QGSHQSLQEH LQRETGNLGS GFTDVPALNY PATPPPHNNY
110 120 130 140 150
AASNQMINTP PPSMGGLYRH NNNSQSMVQN GNGSGNAQLP QLSPGQYSIE
160 170 180 190 200
SEYNQNLNGS SSSSPFHQPQ TLRSNGSYSS GLRSVKSFQR LQQEQENVQV
210 220 230 240 250
QQQLSQAQQQ NSRQQQQQLQ YQQQQQQQQQ QQHMQIQQQQ QQQQQQQQSQ
260 270 280 290 300
SPVQSGFNNG TISNYMYFER RPDLLTKGTQ DKAAAVKLKI ENFYQSSVKY
310 320 330 340 350
AIERNERRVE LETELTSHNW SEERKSRQLS SLGKKESQFL RLRRTRLSLE
360 370 380 390 400
DFHTVKVIGK GAFGEVRLVQ KKDTGKIYAM KTLLKSEMYK KDQLAHVKAE
410 420 430 440 450
RDVLAGSDSP WVVSLYYSFQ DAQYLYLIME FLPGGDLMTM LIRWQLFTED
460 470 480 490 500
VTRFYMAECI LAIETIHKLG FIHRDIKPDN ILIDIRGHIK LSDFGLSTGF
510 520 530 540 550
HKTHDSNYYK KLLQQDEATN GISKPGTYNA NTTDTANKRQ TMVVDSISLT
560 570 580 590 600
MSNRQQIQTW RKSRRLMAYS TVGTPDYIAP EIFLYQGYGQ ECDWWSLGAI
610 620 630 640 650
MYECLIGWPP FCSETPQETY RKIMNFEQTL QFPDDIHISY EAEDLIRRLL
660 670 680 690 700
THADQRLGRH GGADEIKSHP FFRGVDWNTI RQVEAPYIPK LSSITDTRFF
710 720 730 740 750
PTDELENVPD SPAMAQAAKQ REQMTKQGGS APVKEDLPFI GYTYSRFDYL

TRKNAL
Length:756
Mass (Da):86,946
Last modified:October 1, 1996 - v1
Checksum:i87EBCD2C3C96EE11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92517 Genomic DNA Translation: CAA63278.1
Z71437 Genomic DNA Translation: CAA96048.1
BK006947 Genomic DNA Translation: DAA10388.1
PIRiS60966
RefSeqiNP_014238.3, NM_001182999.3

Genome annotation databases

EnsemblFungiiYNL161W; YNL161W; YNL161W
GeneIDi855561
KEGGisce:YNL161W

Similar proteinsi

Entry informationi

Entry nameiCBK1_YEAST
AccessioniPrimary (citable) accession number: P53894
Secondary accession number(s): D6W122
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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