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UniProtKB - P53847 (DSL1_YEAST)

Entry version 148 (23 Feb 2022)
Sequence version 1 (01 Oct 1996)
Previous versions | rss
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Protein

Protein transport protein DSL1

Gene

DSL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for protein transport between the Golgi and the endoplasmic reticulum. May tether coatomer-coated retrograde transport vesicles to the ER membrane through interaction with coatomer as well as the SNARE complex. May contribute to the stabilization of the SNARE complex.

3 Publications

Miscellaneous

Present with 8970 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SCE-6811434, COPI-dependent Golgi-to-ER retrograde traffic

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein transport protein DSL1
Alternative name(s):
Dependent on SLY1-20 protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSL1
Ordered Locus Names:YNL258C
ORF Names:N0842
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000005202, DSL1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YNL258C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi413W → A: Viable and reduced interaction with RET2, strong Golgi-ER retrograde transport defect. Loss of interaction with RET2; when associated with A-455. Lethal and loss of interactions with RET1 and RET2; when associated with A-425. 1 Publication1
Mutagenesisi425W → A: Loss of interaction with RET1; when associated with A-413. 1 Publication1
Mutagenesisi455W → A: Viable and no effect. Lethal and loss of interaction with RET2 and reduced interaction with RET1; when associated with A-413. 1 Publication1
Mutagenesisi725 – 754Missing in dsl1-22; strong Golgi-ER retrograde transport defect. 1 PublicationAdd BLAST30

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002033831 – 754Protein transport protein DSL1Add BLAST754

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P53847

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P53847

PRoteomics IDEntifications database

More...PRIDEi		P53847

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P53847

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a peripheral membrane protein complex consisting of DSL1, SEC39/DSL3 and TIP20. Bound to a SNARE complex consisting of UFE1, USE1, SEC20 and SEC22 or YKT6 through direct interaction of TIP20 with SEC20. Binds the coatomer complex through direct interaction with RET2/COPD and RET1/COPA. Binds TIP20 and SEC39/DSL3.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		35581, 75 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1786, Dsl1 tethering complex

Database of interacting proteins

More...DIPi		DIP-4274N

Protein interaction database and analysis system

More...IntActi		P53847, 9 interactors

STRING: functional protein association networks

More...STRINGi		4932.YNL258C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P53847, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1754
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P53847

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P53847

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 200Interaction with TIP201 PublicationAdd BLAST200
Regioni406 – 459Interaction with RET2Add BLAST54
Regioni406 – 440Interaction with RET11 PublicationAdd BLAST35
Regioni425 – 454DisorderedSequence analysisAdd BLAST30

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QR7Q, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_357169_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P53847

Identification of Orthologs from Complete Genome Data

More...OMAi		DFYLFST

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.58.2230, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR021876, Dsl1_C
IPR021875, Dsl1_N_dom
IPR038442, Dsl1_N_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11989, Dsl1_C, 1 hit
PF11988, Dsl1_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P53847-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESLFPNKGE IIRELLKDPL ILKNDSKRSN GSELELDSSD LLQREAILAN 
        60         70         80         90        100
ELNILDNLKT FLNLIKEVKT NLNILELENC YYSLQSLRKK MRNNAAYLKQ 
       110        120        130        140        150
SFNFQQSIST YVDTLHLELV STLYKILTNG FWKITENSIQ FTPTVEWGKD 
       160        170        180        190        200
KVHIEYDTFM DFVAQQYFPK GSLDNQAWFI LDMTSADSQE QVRAKLNTIM 
       210        220        230        240        250
KEYMNLSRIV SMIKNSIFIS GKEISYENEK NILVFSKSSS HGQHCVSTVL 
       260        270        280        290        300
TSFEAVCDFM LDGLAFRDRK TLSYELGPLF NTEFTKFVKN NASIILESLD 
       310        320        330        340        350
SPLKNLVSVI NNKLTRLVAK SEVTNWTHSG KEIQDLLMNK QLYYNLLLDK 
       360        370        380        390        400
VLESHISEIR SIFEDPKKSW QNLEVVELTT SNTNTMSEKI GKNDSDVQNE 
       410        420        430        440        450
KELHNAVSKD DDWNWEVEDD DADAWGDEID VNIDDEEEKT NQEKEKEPEE 
       460        470        480        490        500
EENAWDEAWA IDENIDDASL ENGKEHLKAH DVGSLDKDHI EVTQLPKLFL 
       510        520        530        540        550
AISQNFKSSF ADSHVDEQYF AYKYNLLQTS YMAMCTANFS HNWCQLYVDM 
       560        570        580        590        600
RYLIERDEKL YRIKELTRNL LETKLNMKYR IVCQLIRHQL TEFRENERNP 
       610        620        630        640        650
SWDATIEKLL PYILKEIVRP LQKIRGEEGS RYLLSFLNFL YNDCVTKEIL 
       660        670        680        690        700
KWQIISEVNS ENLGELVSLL VNNTDIQLLA KEPSYKKMRE KFATMGKFLP 
       710        720        730        740        750
LHLKEIMEMF YNGDFYLFAT DELIQWIELL FADTPLRRNA IDDIYEIRGT 

ALDD
Length:754
Mass (Da):88,072
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51EDB17F2C55A917
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X96722 Genomic DNA Translation: CAA65486.1
Z71534 Genomic DNA Translation: CAA96165.1
BK006947 Genomic DNA Translation: DAA10301.1

Protein sequence database of the Protein Information Resource

More...PIRi		S63231

NCBI Reference Sequences

More...RefSeqi		NP_014141.1, NM_001183096.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YNL258C_mRNA; YNL258C; YNL258C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		855463

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YNL258C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96722 Genomic DNA Translation: CAA65486.1
Z71534 Genomic DNA Translation: CAA96165.1
BK006947 Genomic DNA Translation: DAA10301.1
PIRiS63231
RefSeqiNP_014141.1, NM_001183096.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ETUX-ray2.40A1-361[»]
3ETVX-ray1.94A37-339[»]
5FJWX-ray2.80L/M/N/O/P/Q/R/S411-419[»]
5FJZX-ray1.90P/Q/R/S411-419[»]
SMRiP53847
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi35581, 75 interactors
ComplexPortaliCPX-1786, Dsl1 tethering complex
DIPiDIP-4274N
IntActiP53847, 9 interactors
STRINGi4932.YNL258C

PTM databases

iPTMnetiP53847

Proteomic databases

MaxQBiP53847
PaxDbiP53847
PRIDEiP53847

Genome annotation databases

EnsemblFungiiYNL258C_mRNA; YNL258C; YNL258C
GeneIDi855463
KEGGisce:YNL258C

Organism-specific databases

SGDiS000005202, DSL1
VEuPathDBiFungiDB:YNL258C

Phylogenomic databases

eggNOGiENOG502QR7Q, Eukaryota
HOGENOMiCLU_357169_0_0_1
InParanoidiP53847
OMAiDFYLFST

Enzyme and pathway databases

ReactomeiR-SCE-6811434, COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

EvolutionaryTraceiP53847

Protein Ontology

More...PROi		PR:P53847
RNActiP53847, protein

Family and domain databases

Gene3Di1.20.58.2230, 1 hit
InterProiView protein in InterPro
IPR021876, Dsl1_C
IPR021875, Dsl1_N_dom
IPR038442, Dsl1_N_sf
PfamiView protein in Pfam
PF11989, Dsl1_C, 1 hit
PF11988, Dsl1_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDSL1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P53847
Secondary accession number(s): D6W0T5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 23, 2022
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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